#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01315	uniprotkb:P01315	intact:EBI-8437944|intact:MINT-1505666|uniprotkb:Q9TSJ5|ensembl:ENSSSCP00000044635|ensembl:ENSSSCP00015002060|ensembl:ENSSSCP00025013482|ensembl:ENSSSCP00030047908|ensembl:ENSSSCP00035009642|ensembl:ENSSSCP00040009750|ensembl:ENSSSCP00045005838|ensembl:ENSSSCP00050004834|ensembl:ENSSSCP00055025559|ensembl:ENSSSCP00060020355|ensembl:ENSSSCP00065038365|ensembl:ENSSSCP00070024989	intact:EBI-8437944|intact:MINT-1505666|uniprotkb:Q9TSJ5|ensembl:ENSSSCP00000044635|ensembl:ENSSSCP00015002060|ensembl:ENSSSCP00025013482|ensembl:ENSSSCP00030047908|ensembl:ENSSSCP00035009642|ensembl:ENSSSCP00040009750|ensembl:ENSSSCP00045005838|ensembl:ENSSSCP00050004834|ensembl:ENSSSCP00055025559|ensembl:ENSSSCP00060020355|ensembl:ENSSSCP00065038365|ensembl:ENSSSCP00070024989	psi-mi:ins_pig(display_long)|uniprotkb:INS(gene name)|psi-mi:INS(display_short)	psi-mi:ins_pig(display_long)|uniprotkb:INS(gene name)|psi-mi:INS(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Whittingham et al. (1995)	pubmed:7492558|mint:MINT-5220314	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8555877|mint:MINT-25101	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103242.1|ensembl:ENSSSCG00000033740(gene)|ensembl:ENSSSCG00015004005(gene)|ensembl:ENSSSCG00025023773(gene)|ensembl:ENSSSCG00030073948(gene)|ensembl:ENSSSCG00035019667(gene)|ensembl:ENSSSCG00040017207(gene)|ensembl:ENSSSCG00045005189(gene)|ensembl:ENSSSCG00050008342(gene)|ensembl:ENSSSCG00055016292(gene)|ensembl:ENSSSCG00060035069(gene)|ensembl:ENSSSCG00065063887(gene)|ensembl:ENSSSCG00070015252(gene)|ensembl:ENSSSCT00000064136(transcript)|ensembl:ENSSSCT00015005290(transcript)|ensembl:ENSSSCT00025032226(transcript)|ensembl:ENSSSCT00030103634(transcript)|ensembl:ENSSSCT00035025488(transcript)|ensembl:ENSSSCT00040023180(transcript)|ensembl:ENSSSCT00045008618(transcript)|ensembl:ENSSSCT00050011348(transcript)|ensembl:ENSSSCT00055032104(transcript)|ensembl:ENSSSCT00060047539(transcript)|ensembl:ENSSSCT00065087685(transcript)|ensembl:ENSSSCT00070029958(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002020"(protease binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006521"(regulation of cellular amino acid metabolic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009101"(glycoprotein biosynthetic process)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045818"(negative regulation of glycogen catabolic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903576"(response to L-arginine)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR004825(Insulin/IGF/relaxin)|interpro:IPR016179(Insulin-like)|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|rcsb pdb:1B17|rcsb pdb:1B18|rcsb pdb:1B19|rcsb pdb:1B2A|rcsb pdb:1B2B|rcsb pdb:1B2C|rcsb pdb:1B2D|rcsb pdb:1B2E|rcsb pdb:1B2F|rcsb pdb:1B2G|rcsb pdb:1DEI|rcsb pdb:1IZA|rcsb pdb:1IZB|rcsb pdb:1M5A|rcsb pdb:1MPJ|rcsb pdb:1SDB|rcsb pdb:1WAV|rcsb pdb:1ZEI|rcsb pdb:1ZNI|rcsb pdb:2EFA|rcsb pdb:2G4M|rcsb pdb:2TCI|rcsb pdb:2ZPP|rcsb pdb:3FHP|rcsb pdb:3GKY|rcsb pdb:3INS|rcsb pdb:3MTH|rcsb pdb:3RTO|rcsb pdb:3T2A|rcsb pdb:4A7E|rcsb pdb:4INS|rcsb pdb:5D52|rcsb pdb:5D53|rcsb pdb:5D54|rcsb pdb:5D5E|rcsb pdb:5FB6|rcsb pdb:5LIS|rcsb pdb:6INS|rcsb pdb:6Z7Z|rcsb pdb:7INS|rcsb pdb:9INS|mint:MINT-1505697(identity)	refseq:NP_001103242.1|ensembl:ENSSSCG00000033740(gene)|ensembl:ENSSSCG00015004005(gene)|ensembl:ENSSSCG00025023773(gene)|ensembl:ENSSSCG00030073948(gene)|ensembl:ENSSSCG00035019667(gene)|ensembl:ENSSSCG00040017207(gene)|ensembl:ENSSSCG00045005189(gene)|ensembl:ENSSSCG00050008342(gene)|ensembl:ENSSSCG00055016292(gene)|ensembl:ENSSSCG00060035069(gene)|ensembl:ENSSSCG00065063887(gene)|ensembl:ENSSSCG00070015252(gene)|ensembl:ENSSSCT00000064136(transcript)|ensembl:ENSSSCT00015005290(transcript)|ensembl:ENSSSCT00025032226(transcript)|ensembl:ENSSSCT00030103634(transcript)|ensembl:ENSSSCT00035025488(transcript)|ensembl:ENSSSCT00040023180(transcript)|ensembl:ENSSSCT00045008618(transcript)|ensembl:ENSSSCT00050011348(transcript)|ensembl:ENSSSCT00055032104(transcript)|ensembl:ENSSSCT00060047539(transcript)|ensembl:ENSSSCT00065087685(transcript)|ensembl:ENSSSCT00070029958(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002020"(protease binding)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006521"(regulation of cellular amino acid metabolic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009101"(glycoprotein biosynthetic process)|go:"GO:0010750"(positive regulation of nitric oxide mediated signal transduction)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033861"("negative regulation of NAD(P)H oxidase activity")|go:"GO:0038060"(nitric oxide-cGMP-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045818"(negative regulation of glycogen catabolic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0060267"(positive regulation of respiratory burst)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903576"(response to L-arginine)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000252"(negative regulation of feeding behavior)|interpro:IPR004825(Insulin/IGF/relaxin)|interpro:IPR016179(Insulin-like)|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|rcsb pdb:1B17|rcsb pdb:1B18|rcsb pdb:1B19|rcsb pdb:1B2A|rcsb pdb:1B2B|rcsb pdb:1B2C|rcsb pdb:1B2D|rcsb pdb:1B2E|rcsb pdb:1B2F|rcsb pdb:1B2G|rcsb pdb:1DEI|rcsb pdb:1IZA|rcsb pdb:1IZB|rcsb pdb:1M5A|rcsb pdb:1MPJ|rcsb pdb:1SDB|rcsb pdb:1WAV|rcsb pdb:1ZEI|rcsb pdb:1ZNI|rcsb pdb:2EFA|rcsb pdb:2G4M|rcsb pdb:2TCI|rcsb pdb:2ZPP|rcsb pdb:3FHP|rcsb pdb:3GKY|rcsb pdb:3INS|rcsb pdb:3MTH|rcsb pdb:3RTO|rcsb pdb:3T2A|rcsb pdb:4A7E|rcsb pdb:4INS|rcsb pdb:5D52|rcsb pdb:5D53|rcsb pdb:5D54|rcsb pdb:5D5E|rcsb pdb:5FB6|rcsb pdb:5LIS|rcsb pdb:6INS|rcsb pdb:6Z7Z|rcsb pdb:7INS|rcsb pdb:9INS|mint:MINT-1505690(identity)	-	function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver|comment:mint|comment:"Stoichiometry: 1.0"	function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver|comment:mint|comment:"Stoichiometry: 1.0"	comment:In the xray complex 2tci, P01315 is chain B and P01315 is chain D Resolution 1.800|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/02/12	2014/10/16	rogid:jJtfIrm2VcLfHHHuPKRkLde+nW09823	rogid:jJtfIrm2VcLfHHHuPKRkLde+nW09823	intact-crc:FC4D2858C8638898|rigid:Kel3BPpjGvsKkiK0z6qwVwXWg4M	false	tag:?-?(MINT-1505698)	tag:?-?(MINT-1505691)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)