#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P68390 uniprotkb:P08246 intact:EBI-8549664|intact:MINT-1505027|uniprotkb:P01004 intact:EBI-986345|uniprotkb:P09649|uniprotkb:Q6B0D9|uniprotkb:Q6LDP5|ensembl:ENSP00000263621|ensembl:ENSP00000466090|ensembl:ENSP00000480128|ensembl:ENSP00000488075 psi-mi:iovo_melga(display_long) psi-mi:elne_human(display_long)|uniprotkb:Elastase-2(gene name synonym)|uniprotkb:ELANE(gene name)|psi-mi:ELANE(display_short)|uniprotkb:PMN elastase(gene name synonym)|uniprotkb:Bone marrow serine protease(gene name synonym)|uniprotkb:Medullasin(gene name synonym)|uniprotkb:Human leukocyte elastase(gene name synonym)|uniprotkb:ELA2(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Bode et al. (1986) mint:MINT-5220255|pubmed:3640709|imex:IM-13913 taxid:9103(melga)|taxid:9103("Meleagris gallopavo (Common turkey)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8550560|mint:MINT-24931|imex:IM-13913-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:1PPF|rcsb pdb:1SGR|rcsb pdb:1YU6|rcsb pdb:1CT4|rcsb pdb:2SGQ|rcsb pdb:1SGP|rcsb pdb:1SGQ|rcsb pdb:2SGP|rcsb pdb:1CHO|rcsb pdb:2GKT|rcsb pdb:1SGN|rcsb pdb:3SGB|rcsb pdb:1TUR|rcsb pdb:1CT2|rcsb pdb:2GKV|rcsb pdb:2GKR|rcsb pdb:1OMU|rcsb pdb:2SGF|rcsb pdb:2SGE|rcsb pdb:1OMT|rcsb pdb:1Z7K|rcsb pdb:1SGE|rcsb pdb:1TUS|rcsb pdb:1SGD|rcsb pdb:1DS3|rcsb pdb:1SGY|rcsb pdb:1HJA|rcsb pdb:1CT0|rcsb pdb:1CSO|rcsb pdb:3SGQ|rcsb pdb:1DS2|rcsb pdb:1R0R|rcsb pdb:2SGD|interpro:IPR036058|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|interpro:IPR001239(Proteinase inhibitor I1, Kazal metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|mint:MINT-1505082(identity) ensembl:ENSG00000197561(gene)|ensembl:ENSG00000277571(gene)|ensembl:ENST00000263621(transcript)|ensembl:ENST00000590230(transcript)|ensembl:ENST00000615489(transcript)|ensembl:ENST00000632488(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001878"(response to yeast)|go:"GO:0002020"(protease binding)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002812"(biosynthetic process of antibacterial peptides active against Gram-negative bacteria)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006909"(phagocytosis)|go:"GO:0008201"(heparin binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0009986"(cell surface)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019955"(cytokine binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030163"(protein catabolic process)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032682"(negative regulation of chemokine production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0050922"(negative regulation of chemotaxis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070269"(pyroptosis)|go:"GO:0070945"(neutrophil-mediated killing of gram-negative bacterium)|go:"GO:0070947"(neutrophil-mediated killing of fungus)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P08246|rcsb pdb:1B0F|rcsb pdb:1H1B|rcsb pdb:1HNE|rcsb pdb:1PPF|rcsb pdb:1PPG|rcsb pdb:2RG3|rcsb pdb:2Z7F|rcsb pdb:3Q76|rcsb pdb:3Q77|rcsb pdb:4NZL|rcsb pdb:4WVP|rcsb pdb:5A09|rcsb pdb:5A0A|rcsb pdb:5A0B|rcsb pdb:5A0C|rcsb pdb:5A8X|rcsb pdb:5A8Y|rcsb pdb:5A8Z|rcsb pdb:5ABW|rcsb pdb:6E69|rcsb pdb:6F5M|rcsb pdb:6SMA|rcsb pdb:7CBK|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-5620971|reactome:R-HSA-6798695|reactome:R-HSA-6803157|reactome:R-HSA-977606|refseq:NP_001963.1|refseq:XP_011526078.1|refseq:XP_011526077.1|mint:MINT-1505075(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:In the xray complex 1ppf, P08246 is chain E and P01004 is chain I Resolution 1.800|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/02/12 2014/10/16 rogid:XwndO1447ytHRMIBaNXlIYl1scQ9103 rogid:0XCflWhF346d7Dy2+ENeMyDHPmA9606 intact-crc:2129D5EB7BAD600E|rigid:E39K3h8oFHp4PKzrF7Eh6IffJt8 false tag:?-?(MINT-1505083) tag:?-?(MINT-1505076) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)