#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P00995	uniprotkb:P00766	intact:EBI-8054204|intact:MINT-1504272|ensembl:ENSP00000296695	intact:EBI-6664027	psi-mi:isk1_human(display_long)|uniprotkb:SPINK1(gene name)|psi-mi:SPINK1(display_short)|uniprotkb:PSTI(gene name synonym)|uniprotkb:Tumor-associated trypsin inhibitor(gene name synonym)|uniprotkb:Pancreatic secretory trypsin inhibitor(gene name synonym)	psi-mi:ctra_bovin(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Hecht et al. (1991)	pubmed:1870127|mint:MINT-5220162	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8054227|mint:MINT-25044	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003113.2|ensembl:ENSG00000164266(gene)|ensembl:ENST00000296695(transcript)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0048240"(sperm capacitation)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060046"(regulation of acrosome reaction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090281"(negative regulation of calcium ion import)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR001239(Proteinase inhibitor I1, Kazal metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR036058|rcsb pdb:1CGI|rcsb pdb:1CGJ|rcsb pdb:1HPT|mint:MINT-1504300(identity)	go:"GO:0007586"(digestion)|go:"GO:0097180"(serine protease inhibitor complex)|go:"GO:0097655"(serpin family protein binding)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|go:"GO:0004252"(serine-type endopeptidase activity)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|go:"GO:0005615"(extracellular space)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|go:"GO:0006508"(proteolysis)|rcsb pdb:1AB9|rcsb pdb:1ACB|rcsb pdb:1AFQ|rcsb pdb:1CA0|rcsb pdb:1CBW|rcsb pdb:1CGI|rcsb pdb:1CGJ|rcsb pdb:1CHG|rcsb pdb:1CHO|rcsb pdb:1DLK|rcsb pdb:1EX3|rcsb pdb:1GCD|rcsb pdb:1GCT|rcsb pdb:1GG6|rcsb pdb:1GGD|rcsb pdb:1GHA|rcsb pdb:1GHB|rcsb pdb:1GL0|rcsb pdb:1GL1|rcsb pdb:1GMC|rcsb pdb:1GMD|rcsb pdb:1GMH|rcsb pdb:1HJA|rcsb pdb:1K2I|rcsb pdb:1MTN|rcsb pdb:1N8O|rcsb pdb:1OXG|rcsb pdb:1P2M|rcsb pdb:1P2N|rcsb pdb:1P2O|rcsb pdb:1P2Q|rcsb pdb:1T7C|rcsb pdb:1T8L|rcsb pdb:1T8M|rcsb pdb:1T8N|rcsb pdb:1T8O|rcsb pdb:1VGC|rcsb pdb:1YPH|rcsb pdb:2CGA|rcsb pdb:2CHA|rcsb pdb:2GCH|rcsb pdb:2GCT|rcsb pdb:2VGC|rcsb pdb:2Y6T|rcsb pdb:2GMT|rcsb pdb:3BG4|rcsb pdb:3GCH|rcsb pdb:3GCT|rcsb pdb:3RU4|rcsb pdb:3T62|rcsb pdb:2P8O|rcsb pdb:3VGC|rcsb pdb:4CHA|rcsb pdb:4GCH|rcsb pdb:4Q2K|rcsb pdb:4VGC|rcsb pdb:5CHA|rcsb pdb:5GCH|rcsb pdb:5J4Q|rcsb pdb:5J4S|rcsb pdb:6CHA|rcsb pdb:6GCH|rcsb pdb:7GCH|rcsb pdb:7KTY|rcsb pdb:7KTZ|rcsb pdb:7KU0|rcsb pdb:7KU1|rcsb pdb:7KU2|rcsb pdb:7KU3|rcsb pdb:8GCH|dip:DIP-6068N|mint:MINT-1504293(identity)	-	comment:mint|function:This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas|function:"Defects in SPINK1 are a cause of hereditary pancreatitis (HPC) [MIM:167800]; also known as chronic pancreatitis (CP). HPC is an autosomal dominant disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks"|function:"Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP) [MIM:608189]. TCP is an idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:In the xray complex 1cgj, P00766 is chain E and P00995 is chain I Resolution 2.300|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/02/12	2014/10/16	rogid:IdX3h9dpkLeGGAGgpPij4MVlwSI9606	rogid:EjOlpE0S5b8sCcON1Jy3W9SjLKs9913	intact-crc:39A49BA3EFE9225B|rigid:c2RIsJVOIx40MVpUxAvkkzzHb3M	false	tag:?-?(MINT-1504301)	tag:?-?(MINT-1504294)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)