#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16333	uniprotkb:Q7L0Q8	intact:EBI-389883|uniprotkb:B7Z751|ensembl:ENSP00000288986|ensembl:ENSP00000417273|intact:EBI-3448658|uniprotkb:D3DNE3	intact:EBI-1638043|uniprotkb:B1AKN1|uniprotkb:Q59FE9|uniprotkb:Q8TDQ2|ensembl:ENSP00000355652|ensembl:ENSP00000494673	psi-mi:nck1_human(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:rhou_human(display_long)|uniprotkb:RHOU(gene name)|psi-mi:RHOU(display_short)|uniprotkb:ARHU(gene name synonym)|uniprotkb:CDC42L1(gene name synonym)|uniprotkb:G28K(gene name synonym)|uniprotkb:WRCH1(gene name synonym)|uniprotkb:SB128(orf name)|uniprotkb:Wnt-1 responsive Cdc42 homolog 1(gene name synonym)|uniprotkb:Ryu GTPase(gene name synonym)|uniprotkb:CDC42-like GTPase 1(gene name synonym)|uniprotkb:Rho GTPase-like protein ARHU(gene name synonym)|uniprotkb:GTP-binding protein-like 1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Shutes et al. (2004)	pubmed:15556869|mint:MINT-5217345	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7394194|mint:MINT-50689	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278928.1|ensembl:ENSG00000158092(gene)|ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007172"(signal complex assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|refseq:NP_001177725.1|refseq:NP_006144.1|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|mint:P16333|rcsb pdb:2CI8|rcsb pdb:2CI9|rcsb pdb:2CUB|rcsb pdb:2JS0|rcsb pdb:2JS2|rcsb pdb:2JW4|rcsb pdb:5QU1|rcsb pdb:5QU2|rcsb pdb:5QU3|rcsb pdb:5QU4|rcsb pdb:5QU5|rcsb pdb:5QU6|rcsb pdb:5QU7|rcsb pdb:5QU8|rcsb pdb:5QUA|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-373753|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9664422|reactome:R-HSA-983695|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|dip:DIP-639N|mint:MINT-1211145(identity)	refseq:NP_067028.1|ensembl:ENSG00000116574(gene)|ensembl:ENST00000366691(transcript)|ensembl:ENST00000646945(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002102"(podosome)|ensembl:ENSG00000284984(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030031"(cell projection assembly)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q7L0Q8|rcsb pdb:2Q3H|reactome:R-HSA-6785807|reactome:R-HSA-9013420|mint:MINT-1211137(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	negative:the interactions are not observed under these experimental conditions|figure legend:F4D|comment:homomint|comment:mint|negative:true|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2004/12/06	2014/10/16	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	rogid:wrOPjo6G3FraKiREmUiUqoHYuEc9606	intact-crc:48A3966DAC6899FB|rigid:opveKcnvlDlAQbznNH0KP0AIf6s	true	-	binding-associated region:1-47(MINT-1211138)|tag:?-?(MINT-1211140)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P19174	uniprotkb:Q7L0Q8	intact:EBI-79387|uniprotkb:Q2V575|uniprotkb:B9EGH4|uniprotkb:B7ZLY7|uniprotkb:E1P5W4|intact:EBI-3959906|ensembl:ENSP00000362368	intact:EBI-1638043|uniprotkb:B1AKN1|uniprotkb:Q59FE9|uniprotkb:Q8TDQ2|ensembl:ENSP00000355652|ensembl:ENSP00000494673	psi-mi:plcg1_human(display_long)|uniprotkb:PLC-148(gene name synonym)|uniprotkb:PLC1(gene name synonym)|uniprotkb:Phospholipase C-II(gene name synonym)|uniprotkb:PLCG1(gene name)|psi-mi:PLCG1(display_short)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:rhou_human(display_long)|uniprotkb:RHOU(gene name)|psi-mi:RHOU(display_short)|uniprotkb:ARHU(gene name synonym)|uniprotkb:CDC42L1(gene name synonym)|uniprotkb:G28K(gene name synonym)|uniprotkb:WRCH1(gene name synonym)|uniprotkb:SB128(orf name)|uniprotkb:Wnt-1 responsive Cdc42 homolog 1(gene name synonym)|uniprotkb:Ryu GTPase(gene name synonym)|uniprotkb:CDC42-like GTPase 1(gene name synonym)|uniprotkb:Rho GTPase-like protein ARHU(gene name synonym)|uniprotkb:GTP-binding protein-like 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shutes et al. (2004)	pubmed:15556869|mint:MINT-5217345	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7394281|mint:MINT-50690	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002651.2|refseq:NP_877963.1|dip:DIP-100N|ensembl:ENSG00000124181(gene)|ensembl:ENST00000373271(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P19174|rcsb pdb:1HSQ|rcsb pdb:2HSP|rcsb pdb:4EY0|rcsb pdb:4FBN|rcsb pdb:7NXE|reactome:R-HSA-1169408|reactome:R-HSA-1236382|reactome:R-HSA-1251932|reactome:R-HSA-1489509|reactome:R-HSA-167021|reactome:R-HSA-1855204|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029485|reactome:R-HSA-210990|reactome:R-HSA-212718|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-418890|reactome:R-HSA-5218921|reactome:R-HSA-5637810|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9026527|reactome:R-HSA-9027277|reactome:R-HSA-9034793|reactome:R-HSA-9664323|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|mint:MINT-1211179(identity)	refseq:NP_067028.1|ensembl:ENSG00000116574(gene)|ensembl:ENST00000366691(transcript)|ensembl:ENST00000646945(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002102"(podosome)|ensembl:ENSG00000284984(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030031"(cell projection assembly)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q7L0Q8|rcsb pdb:2Q3H|reactome:R-HSA-6785807|reactome:R-HSA-9013420|mint:MINT-1211173(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	negative:the interactions are not observed under these experimental conditions|figure legend:F4D|comment:homomint|comment:mint|negative:true|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2004/12/06	2014/10/16	rogid:pJsNLrqg3cUj0SdjoyLf+/91yBo9606	rogid:wrOPjo6G3FraKiREmUiUqoHYuEc9606	intact-crc:016F83A6904A2386|rigid:Ygcuigwr+Ad+au7PBlGwb6oAnkw	true	-	tag:?-?(MINT-1211174)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)