#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P21580	uniprotkb:Q8IUC6	intact:EBI-527670|uniprotkb:Q9NSR6|uniprotkb:Q2HIX9|uniprotkb:Q5VXQ7|uniprotkb:B2R767|uniprotkb:E1P588|ensembl:ENSP00000237289|ensembl:ENSP00000481570	intact:EBI-525995|uniprotkb:O75532|uniprotkb:Q86XP8|uniprotkb:Q96GA0|uniprotkb:B3Y691|ensembl:ENSP00000248244	psi-mi:tnap3_human(display_long)|uniprotkb:Putative DNA-binding protein A20(gene name synonym)|uniprotkb:Zinc finger protein A20(gene name synonym)|uniprotkb:TNFAIP3(gene name)|psi-mi:TNFAIP3(display_short)|uniprotkb:OTUD7C(gene name synonym)|uniprotkb:OTU domain-containing protein 7C(gene name synonym)	psi-mi:tcam1_human(display_long)|uniprotkb:PRVTIRB(gene name synonym)|uniprotkb:TRIF(gene name synonym)|uniprotkb:Proline-rich, vinculin and TIR domain-containing protein B(gene name synonym)|uniprotkb:Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 502H(gene name synonym)|uniprotkb:TICAM1(gene name)|psi-mi:TICAM1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2004)	pubmed:15474016|imex:IM-13905|mint:MINT-5217223	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7339352|mint:MINT-50566|imex:IM-13905-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-33804N|refseq:NP_006281.1|ensembl:ENSG00000118503(gene)|ensembl:ENST00000237289(transcript)|ensembl:ENST00000612899(transcript)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019900"(kinase binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034148"(negative regulation of toll-like receptor 5 signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0061043"(regulation of vascular wound healing)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070429"(negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0072573"(tolerance induction to lipopolysaccharide)|go:"GO:0072666"(establishment of protein localization to vacuole)|go:"GO:0090291"(negative regulation of osteoclast proliferation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR033478|mint:P21580|rcsb pdb:2EQE|rcsb pdb:2EQF|rcsb pdb:2EQG|rcsb pdb:2VFJ|rcsb pdb:3DKB|rcsb pdb:3OJ3|rcsb pdb:3OJ4|rcsb pdb:3VUW|rcsb pdb:3VUX|rcsb pdb:3VUY|rcsb pdb:3ZJD|rcsb pdb:3ZJE|rcsb pdb:3ZJF|rcsb pdb:3ZJG|rcsb pdb:5LRX|rcsb pdb:5V3B|rcsb pdb:5V3P|reactome:R-HSA-168638|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:XP_011534397.1|refseq:NP_001257436.1|refseq:NP_001257437.1|refseq:XP_005267176.1|mint:MINT-1206143(identity)	refseq:NP_891549.1|ensembl:ENSG00000127666(gene)|ensembl:ENST00000248244(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002735"(positive regulation of myeloid dendritic cell cytokine production)|go:"GO:0005739"(mitochondrion)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0010008"(endosome membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097342"(ripoptosome)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017278(Toll-interleukin I receptor domain-containing adaptor protein, Ticam)|interpro:IPR025735|interpro:IPR035897|interpro:IPR040886|rcsb pdb:2M1X|rcsb pdb:2M63|rcsb pdb:3RC4|rcsb pdb:4BSX|rcsb pdb:4C0M|rcsb pdb:5JEL|reactome:R-HSA-140534|reactome:R-HSA-166166|reactome:R-HSA-168164|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-2562578|reactome:R-HSA-5602566|reactome:R-HSA-5602571|reactome:R-HSA-9013957|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-975163|dip:DIP-33490N|mint:MINT-1206137(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2004/11/26	2014/10/16	rogid:+D5JkFvXGge36r13YBqkpk99DLo9606	rogid:QolsJvUL2R6GSyE8ZmpFyJIBoH89606	intact-crc:7D02ADC0292882CF|rigid:dx3DG4dofF912GwfgAUUzmU+Rwk	false	tag:?-?(MINT-1206144)	tag:?-?(MINT-1206138)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)