#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P21707	uniprotkb:Q9JIH7	intact:EBI-458098|uniprotkb:Q3S2E6|uniprotkb:Q707P5|ensembl:ENSRNOP00000049624|ensembl:ENSRNOP00000069194	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	psi-mi:syt1_rat(display_long)|uniprotkb:Syt1(gene name)|psi-mi:Syt1(display_short)|uniprotkb:Synaptotagmin I(gene name synonym)|uniprotkb:p65(gene name synonym)	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-458125	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3803|refseq:NP_001028852.2|ensembl:ENSRNOG00000006426(gene)|ensembl:ENSRNOT00000048880(transcript)|ensembl:ENSRNOT00000088950(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051291"(protein heterooligomerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0061891"(calcium ion sensor activity)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071911"(synchronous neurotransmitter secretion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098746"(fast, calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903235"(positive regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903305"(regulation of regulated secretory pathway)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|mint:P21707|rcsb pdb:1BYN|rcsb pdb:1K5W|rcsb pdb:1RSY|rcsb pdb:1TJM|rcsb pdb:1TJX|rcsb pdb:1UOV|rcsb pdb:1UOW|rcsb pdb:2YOA|rcsb pdb:4WEE|rcsb pdb:5CCG|rcsb pdb:5CCH|rcsb pdb:5CCI|rcsb pdb:5CCJ|rcsb pdb:5KJ7|rcsb pdb:5KJ8|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6CXW|rcsb pdb:6MTI|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-888590|refseq:XP_017450168.1|dip:DIP-29064N	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/22	2014/10/16	rogid:fr7zfj22zAOY/bJ7psjrgnsb0g810116	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	intact-crc:A0C8DC39ED5CB1AA|rigid:6VFPkQlyGK4gsysrkhwRlwqNvkY	false	-	binding-associated region:217-494(IPR008271)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JIH7	uniprotkb:P29101	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	intact:EBI-458017	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-458224	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	rgd:3804|refseq:NP_036797.1|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|go:"GO:0031045"(dense core granule)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|dip:DIP-32642N|mint:P29101	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/22	2014/10/16	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	intact-crc:708EBE2B58A93DAD|rigid:QOzateTa2ERYdrbZbRq5Hq5hRUU	false	binding-associated region:217-494(IPR008271)|mutation decreasing interaction:318-318	mutation decreasing interaction:231-231|binding-associated region:141-268(IPR008973)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JIH7	uniprotkb:P29101	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	intact:EBI-458017	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-458240	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	rgd:3804|refseq:NP_036797.1|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|go:"GO:0031045"(dense core granule)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|dip:DIP-32642N|mint:P29101	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/22	2014/10/16	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	intact-crc:2C27231835612776|rigid:QOzateTa2ERYdrbZbRq5Hq5hRUU	false	mutation decreasing interaction:318-318|binding-associated region:217-494	mutation decreasing interaction:310-310|binding-associated region:266-422	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JIH7	uniprotkb:P29101	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	intact:EBI-458017	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-458254	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	rgd:3804|refseq:NP_036797.1|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|go:"GO:0031045"(dense core granule)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|dip:DIP-32642N|mint:P29101	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/22	2014/10/16	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	intact-crc:52ED54E076522F43|rigid:QOzateTa2ERYdrbZbRq5Hq5hRUU	false	mutation decreasing interaction:318-318|binding-associated region:217-494	mutation decreasing interaction:310-310|binding-associated region:141-422	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9JIH7	uniprotkb:P21707	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	intact:EBI-458098|uniprotkb:Q3S2E6|uniprotkb:Q707P5|ensembl:ENSRNOP00000049624|ensembl:ENSRNOP00000069194	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:syt1_rat(display_long)|uniprotkb:Syt1(gene name)|psi-mi:Syt1(display_short)|uniprotkb:Synaptotagmin I(gene name synonym)|uniprotkb:p65(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2643941	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	rgd:3803|refseq:NP_001028852.2|ensembl:ENSRNOG00000006426(gene)|ensembl:ENSRNOT00000048880(transcript)|ensembl:ENSRNOT00000088950(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030348"(syntaxin-3 binding)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051291"(protein heterooligomerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061669"(spontaneous neurotransmitter secretion)|go:"GO:0061891"(calcium ion sensor activity)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071911"(synchronous neurotransmitter secretion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098746"(fast, calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903235"(positive regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903305"(regulation of regulated secretory pathway)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|mint:P21707|rcsb pdb:1BYN|rcsb pdb:1K5W|rcsb pdb:1RSY|rcsb pdb:1TJM|rcsb pdb:1TJX|rcsb pdb:1UOV|rcsb pdb:1UOW|rcsb pdb:2YOA|rcsb pdb:4WEE|rcsb pdb:5CCG|rcsb pdb:5CCH|rcsb pdb:5CCI|rcsb pdb:5CCJ|rcsb pdb:5KJ7|rcsb pdb:5KJ8|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6CXW|rcsb pdb:6MTI|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-888590|refseq:XP_017450168.1|dip:DIP-29064N	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/22	2014/10/16	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	rogid:fr7zfj22zAOY/bJ7psjrgnsb0g810116	intact-crc:A0C8DC39ED5CB1AA|rigid:6VFPkQlyGK4gsysrkhwRlwqNvkY	false	binding-associated region:217-494(IPR008271)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q925C0	uniprotkb:Q9JIH7	intact:EBI-458115|uniprotkb:Q62748|ensembl:ENSRNOP00000026607	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	psi-mi:syt9_rat(display_long)|uniprotkb:Syt9(gene name)|psi-mi:Syt9(display_short)|uniprotkb:Syt5(gene name synonym)|uniprotkb:Synaptotagmin IX(gene name synonym)|uniprotkb:Synaptotagmin V(gene name synonym)|uniprotkb:Synaptotagmin 5(gene name synonym)	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2643947	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042802"(identical protein binding)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028691|interpro:IPR035892|reactome:R-RNO-8856825|reactome:R-RNO-8856828|ensembl:ENSRNOG00000019613(gene)|ensembl:ENSRNOT00000026607(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031045"(dense core granule)|rgd:621169|refseq:NP_445776.1	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/22	2014/10/16	rogid:v880S2MBvWsOTw2bEUSu2suJjRc10116	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	intact-crc:9E1004FD09E70311|rigid:EtyggtXF8Wj+N4/4i/JQLKh6I2s	false	-	binding-associated region:217-494(IPR008271)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29101	uniprotkb:Q9JIH7	intact:EBI-458017	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-458046	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3804|refseq:NP_036797.1|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|go:"GO:0031045"(dense core granule)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|dip:DIP-32642N|mint:P29101	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	-	-	-	stimulant:"binding is Ca 2+ sensitive (positive effect)"|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/11/22	2014/10/16	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	intact-crc:3BCE03E551C80021|rigid:QOzateTa2ERYdrbZbRq5Hq5hRUU	false	binding-associated region:141-422(IPR008973)|his tag:?-?	binding-associated region:1-639(IPR008271)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29101	uniprotkb:Q9JIH7	intact:EBI-458017	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-458063	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3804|refseq:NP_036797.1|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|go:"GO:0031045"(dense core granule)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|dip:DIP-32642N|mint:P29101	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2004/11/22	2014/10/16	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	intact-crc:CCCEF211CD20E091|rigid:QOzateTa2ERYdrbZbRq5Hq5hRUU	false	flag tag:?-?|binding-associated region:141-422(IPR008973)	binding-associated region:180-555(IPR008271)|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29101	uniprotkb:Q9H4A3	intact:EBI-458017	intact:EBI-457907|uniprotkb:O15052|uniprotkb:P54963|uniprotkb:Q86WL5|uniprotkb:Q8N673|uniprotkb:Q9P1S9|uniprotkb:Q4VBX9|intact:EBI-948424|uniprotkb:A1L4B0|uniprotkb:Q6IFS5|uniprotkb:C5HTZ5|uniprotkb:C5HTZ6|uniprotkb:C5HTZ7|uniprotkb:H6WZW3|uniprotkb:Q96CZ6|ensembl:ENSP00000313059	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:wnk1_human(display_long)|uniprotkb:WNK1(gene name)|psi-mi:WNK1(display_short)|uniprotkb:KDP(gene name synonym)|uniprotkb:KIAA0344(gene name synonym)|uniprotkb:PRKWNK1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Erythrocyte 65 kDa protein(gene name synonym)|uniprotkb:Kinase deficient protein(gene name synonym)|uniprotkb:HSN2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-458073	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3804|refseq:NP_036797.1|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|go:"GO:0031045"(dense core granule)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|dip:DIP-32642N|mint:P29101	ensembl:ENSP00000313059|ensembl:ENST00000340908|ensembl:ENSP00000341292|ensembl:ENST00000530271|ensembl:ENSP00000433548|ensembl:ENST00000537687|ensembl:ENSP00000444465|ensembl:ENST00000675631|ensembl:ENSP00000502415|refseq:NP_001171914.1|refseq:NP_055638.2|refseq:NP_061852.3|refseq:NP_998820.3|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|mint:Q9H4A3|rcsb pdb:4PWN|rcsb pdb:5TF9|rcsb pdb:5WDY|rcsb pdb:5WE8|rcsb pdb:6FBK|reactome:R-HSA-2672351|go:"GO:0097022"(lymphocyte migration into lymph node)|ensembl:ENSG00000060237(gene)|ensembl:ENST00000315939(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048666"(neuron development)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|refseq:XP_016875326.1|refseq:XP_016875327.1|dip:DIP-32648N	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2004/11/22	2014/10/16	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	rogid:Jt4cvhSumyRRIZDmWgj4GsG7wjQ9606	intact-crc:8DD8713AC1B19B4F|rigid:ji7Ri+OVF9Sctzqkf0HqJIBCDGc	false	flag tag:?-?|binding-associated region:141-422(IPR008973)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29101	uniprotkb:Q9JIH7	intact:EBI-458017	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-458073	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3804|refseq:NP_036797.1|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|go:"GO:0031045"(dense core granule)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|dip:DIP-32642N|mint:P29101	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2004/11/22	2014/10/16	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	intact-crc:8DD8713AC1B19B4F|rigid:ji7Ri+OVF9Sctzqkf0HqJIBCDGc	false	flag tag:?-?|binding-associated region:141-422(IPR008973)	binding-associated region:180-555(IPR008271)|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29101	uniprotkb:Q9H4A3	intact:EBI-458017	intact:EBI-457907|uniprotkb:O15052|uniprotkb:P54963|uniprotkb:Q86WL5|uniprotkb:Q8N673|uniprotkb:Q9P1S9|uniprotkb:Q4VBX9|intact:EBI-948424|uniprotkb:A1L4B0|uniprotkb:Q6IFS5|uniprotkb:C5HTZ5|uniprotkb:C5HTZ6|uniprotkb:C5HTZ7|uniprotkb:H6WZW3|uniprotkb:Q96CZ6|ensembl:ENSP00000313059	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:wnk1_human(display_long)|uniprotkb:WNK1(gene name)|psi-mi:WNK1(display_short)|uniprotkb:KDP(gene name synonym)|uniprotkb:KIAA0344(gene name synonym)|uniprotkb:PRKWNK1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Erythrocyte 65 kDa protein(gene name synonym)|uniprotkb:Kinase deficient protein(gene name synonym)|uniprotkb:HSN2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-458091	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3804|refseq:NP_036797.1|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|go:"GO:0031045"(dense core granule)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|dip:DIP-32642N|mint:P29101	ensembl:ENSP00000313059|ensembl:ENST00000340908|ensembl:ENSP00000341292|ensembl:ENST00000530271|ensembl:ENSP00000433548|ensembl:ENST00000537687|ensembl:ENSP00000444465|ensembl:ENST00000675631|ensembl:ENSP00000502415|refseq:NP_001171914.1|refseq:NP_055638.2|refseq:NP_061852.3|refseq:NP_998820.3|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|mint:Q9H4A3|rcsb pdb:4PWN|rcsb pdb:5TF9|rcsb pdb:5WDY|rcsb pdb:5WE8|rcsb pdb:6FBK|reactome:R-HSA-2672351|go:"GO:0097022"(lymphocyte migration into lymph node)|ensembl:ENSG00000060237(gene)|ensembl:ENST00000315939(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048666"(neuron development)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|refseq:XP_016875326.1|refseq:XP_016875327.1|dip:DIP-32648N	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2004/11/22	2014/10/16	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	rogid:Jt4cvhSumyRRIZDmWgj4GsG7wjQ9606	intact-crc:BDCC48216BFFFF81|rigid:mSZITqP3SXKn/V6Q7pQYL07GbPU	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35681	uniprotkb:Q9JIH7	intact:EBI-457995|uniprotkb:P97791|uniprotkb:Q80WV1	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	psi-mi:syt3_mouse(display_long)|uniprotkb:Syt3(gene name)|psi-mi:Syt3(display_short)|uniprotkb:Synaptotagmin III(gene name synonym)	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lee et al. (2004)	pubmed:15350218	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-457906	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001107588.1|refseq:NP_057872.3|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR028682|mint:O35681|interpro:IPR035892	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	-	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/22	2014/10/16	rogid:mkfffZn3WWGhztw/udRiKd0LUJ010090	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	intact-crc:C0FAF25EECB30CF6|rigid:v5j/vyKKHg8jjbYELcE5AiaLuiQ	false	-	binding-associated region:217-494(IPR008271)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P46097	uniprotkb:Q9JIH7	intact:EBI-457969|uniprotkb:Q8R0E1	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	psi-mi:syt2_mouse(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Inositol polyphosphate-binding protein(gene name synonym)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lee et al. (2004)	pubmed:15350218	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2649739	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033333.2|refseq:XP_006529385.1|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NP0|rcsb pdb:4KBB|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|dip:DIP-32645N|mint:P46097|refseq:XP_006529386.1	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	-	-	-	figure legend:Fig. 1A|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/22	2014/10/16	rogid:rGZ9RcldKTata4wFKxyBGR3sDOc10090	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	intact-crc:D955AB40E0AD118D|rigid:lxlvFTn51aWW+pzVzFcsja2g/oQ	false	-	binding-associated region:217-494(IPR008271)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIH7	uniprotkb:Q9R0N9	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	intact:EBI-458006|uniprotkb:Q3U0R7|uniprotkb:Q8C280|ensembl:ENSMUSP00000073164	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:syt9_mouse(display_long)|uniprotkb:Syt9(gene name)|psi-mi:Syt9(display_short)|uniprotkb:Syt5(gene name synonym)|uniprotkb:Synaptotagmin IX(gene name synonym)|uniprotkb:Synaptotagmin V(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2649746	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	refseq:NP_068689.2|reactome:R-MMU-8856828|ensembl:ENSMUSG00000062542(gene)|ensembl:ENSMUST00000073459(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031045"(dense core granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028691|interpro:IPR035892|reactome:R-MMU-8856825	-	-	-	figure legend:Fig. 1A|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/11/22	2014/10/16	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	rogid:9Gi1R7pVRz5blcyuZL3dL6cKOx010090	intact-crc:2F2D707DBB3C5B77|rigid:2QDpYhumd/iFEoRVc+Ur0z8pNrs	false	binding-associated region:217-494(IPR008271)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIH7	uniprotkb:P29101	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	intact:EBI-458017	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:"MI:0401"(biochemical)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-458277	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	rgd:3804|refseq:NP_036797.1|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|go:"GO:0031045"(dense core granule)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|dip:DIP-32642N|mint:P29101	-	-	-	resulting-ptm:syt2 is phosphorylated on Thr202 and Thr386 as detected by mass spectrometry|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/11/22	2014/10/16	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	intact-crc:224B5067D6585DAA|rigid:QOzateTa2ERYdrbZbRq5Hq5hRUU	false	binding-associated region:193-483|glutathione s tranferase tag:?-?|phosphorylated residue:?-?	his tag:?-?|binding-associated region:141-422	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P29101	uniprotkb:Q9JIH7	intact:EBI-458017	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:"MI:0401"(biochemical)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-458297	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3804|refseq:NP_036797.1|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|go:"GO:0031045"(dense core granule)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|dip:DIP-32642N|mint:P29101	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	-	-	-	resulting-ptm:Syt2 is phosphorylated in vivo as shown with 32P incorporation.|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2004/11/22	2014/10/16	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	intact-crc:A47A9FF994E0CAAC|rigid:QOzateTa2ERYdrbZbRq5Hq5hRUU	false	binding-associated region:141-422(IPR008973)|flag tag:?-?	binding-associated region:216-491(IPR008271)|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29101	uniprotkb:Q9JIH7	intact:EBI-458017	intact:EBI-457953|uniprotkb:Q6IFS7|ensembl:ENSRNOP00000072173|uniprotkb:Q3S2I2	psi-mi:syt2_rat(display_long)|uniprotkb:Syt2(gene name)|psi-mi:Syt2(display_short)|uniprotkb:Synaptotagmin II(gene name synonym)	psi-mi:wnk1_rat(display_long)|uniprotkb:Wnk1(gene name)|psi-mi:Wnk1(display_short)|uniprotkb:Prkwnk1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Hsn2(gene name synonym)	psi-mi:"MI:0401"(biochemical)	Lee et al. (2004)	pubmed:15350218	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-458314	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3804|refseq:NP_036797.1|go:"GO:0000149"(SNARE binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|interpro:IPR015428(Synaptotagmin 1,2)|interpro:IPR035892|rcsb pdb:2NM1|rcsb pdb:4ISR|go:"GO:0031045"(dense core granule)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042584"(chromaffin granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0043533"(inositol 1,3,4,5 tetrakisphosphate binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0099502"(calcium-dependent activation of synaptic vesicle fusion)|go:"GO:1903861"(positive regulation of dendrite extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|dip:DIP-32642N|mint:P29101	rgd:621141|refseq:NP_001002823.2|refseq:NP_001186024.1|refseq:NP_446246.2|ensembl:ENSRNOG00000009956(gene)|ensembl:ENSRNOT00000080788(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097022"(lymphocyte migration into lymph node)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|rcsb pdb:2LRU|rcsb pdb:4Q2A|rcsb pdb:5DRB|rcsb pdb:5W7T|rcsb pdb:6CN9|rcsb pdb:6OL2|reactome:R-RNO-2672351	-	-	-	resulting-ptm:in vivo syt2 phosphorylation T202 detected with an antibody anti-phospho-T202-syt2|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2004/11/22	2014/10/16	rogid:8gq8JFiYjNR21IjwMvs4cxgKIL010116	rogid:Dm/KY9LGoaYrdWooUd0R9U7GQk010116	intact-crc:763B95A5E3F38254|rigid:QOzateTa2ERYdrbZbRq5Hq5hRUU	false	binding-associated region:141-422(IPR008973)|flag tag:?-?	binding-associated region:216-491(IPR008271)|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)