#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P14340 uniprotkb:Q9UHY1 intact:EBI-465733|uniprotkb:Q66347|uniprotkb:Q66348|uniprotkb:Q66349|uniprotkb:Q66350|uniprotkb:Q66351|uniprotkb:Q66352|uniprotkb:Q66353|uniprotkb:Q66354|uniprotkb:Q66355|uniprotkb:Q66356|uniprotkb:Q89579 intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181 psi-mi:polg_den2n(display_long) psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym) psi-mi:"MI:0018"(two hybrid) Chua et al. (2004) pubmed:15084397 taxid:11065(den2n)|taxid:11065("Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-465775 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027287|rcsb pdb:4UIH|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|rcsb pdb:4CBF|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|rcsb pdb:6FLA|rcsb pdb:6FLB|rcsb pdb:6FLC|rcsb pdb:3IYA|interpro:IPR026470|interpro:IPR026490|rcsb pdb:3J27|rcsb pdb:3J2P|interpro:IPR027417|interpro:IPR038688|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504|rcsb pdb:6IZX|rcsb pdb:6IZY refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280 - - - - taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/12/07 2014/10/16 rogid:3PlUUTVZmb2B65iEGCxa/+0bIe811065 rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606 intact-crc:CB8DDB87A617B594|rigid:4PIPDdGzR2f04cBN/lPIVkXgg1w false binding-associated region:1476-2093(IPR001850) binding-associated region:272-535 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P14340 uniprotkb:Q9UHY1 intact:EBI-465733|uniprotkb:Q66347|uniprotkb:Q66348|uniprotkb:Q66349|uniprotkb:Q66350|uniprotkb:Q66351|uniprotkb:Q66352|uniprotkb:Q66353|uniprotkb:Q66354|uniprotkb:Q66355|uniprotkb:Q66356|uniprotkb:Q89579 intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181 psi-mi:polg_den2n(display_long) psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chua et al. (2004) pubmed:15084397 taxid:11065(den2n)|taxid:11065("Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-465982 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027287|rcsb pdb:4UIH|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|rcsb pdb:4CBF|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|rcsb pdb:6FLA|rcsb pdb:6FLB|rcsb pdb:6FLC|rcsb pdb:3IYA|interpro:IPR026470|interpro:IPR026490|rcsb pdb:3J27|rcsb pdb:3J2P|interpro:IPR027417|interpro:IPR038688|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504|rcsb pdb:6IZX|rcsb pdb:6IZY refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280 - - - - taxid:10036(mesau-bhk21)|taxid:10036(Mesocricetus auratus_BHK21) - 2004/12/07 2014/10/16 rogid:3PlUUTVZmb2B65iEGCxa/+0bIe811065 rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606 intact-crc:EFC4413165B13E7A|rigid:4PIPDdGzR2f04cBN/lPIVkXgg1w false binding-associated region:1476-2093|v5 tag:n-n binding-associated region:272-535|myc tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P14340 uniprotkb:Q9UHY1 intact:EBI-465733|uniprotkb:Q66347|uniprotkb:Q66348|uniprotkb:Q66349|uniprotkb:Q66350|uniprotkb:Q66351|uniprotkb:Q66352|uniprotkb:Q66353|uniprotkb:Q66354|uniprotkb:Q66355|uniprotkb:Q66356|uniprotkb:Q89579 intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181 psi-mi:polg_den2n(display_long) psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Chua et al. (2004) pubmed:15084397 taxid:11065(den2n)|taxid:11065("Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-465994 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027287|rcsb pdb:4UIH|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|rcsb pdb:4CBF|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|rcsb pdb:6FLA|rcsb pdb:6FLB|rcsb pdb:6FLC|rcsb pdb:3IYA|interpro:IPR026470|interpro:IPR026490|rcsb pdb:3J27|rcsb pdb:3J2P|interpro:IPR027417|interpro:IPR038688|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504|rcsb pdb:6IZX|rcsb pdb:6IZY refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280 - - - - taxid:10036(mesau-bhk21)|taxid:10036(Mesocricetus auratus_BHK21) - 2004/12/07 2014/10/16 rogid:3PlUUTVZmb2B65iEGCxa/+0bIe811065 rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606 intact-crc:145150896FC99EAF|rigid:4PIPDdGzR2f04cBN/lPIVkXgg1w false v5 tag:n-n|binding-associated region:1476-2093 binding-associated region:272-535|myc tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P14340 uniprotkb:Q9UHY1 intact:EBI-465733|uniprotkb:Q66347|uniprotkb:Q66348|uniprotkb:Q66349|uniprotkb:Q66350|uniprotkb:Q66351|uniprotkb:Q66352|uniprotkb:Q66353|uniprotkb:Q66354|uniprotkb:Q66355|uniprotkb:Q66356|uniprotkb:Q89579 intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181 psi-mi:polg_den2n(display_long) psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym) psi-mi:"MI:0428"(imaging technique) Chua et al. (2004) pubmed:15084397 taxid:11065(den2n)|taxid:11065("Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-466008 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR027287|rcsb pdb:4UIH|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|rcsb pdb:4CBF|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR029063|rcsb pdb:6FLA|rcsb pdb:6FLB|rcsb pdb:6FLC|rcsb pdb:3IYA|interpro:IPR026470|interpro:IPR026490|rcsb pdb:3J27|rcsb pdb:3J2P|interpro:IPR027417|interpro:IPR038688|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504|rcsb pdb:6IZX|rcsb pdb:6IZY refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280 go:"GO:0048471"(perinuclear region of cytoplasm) - - - taxid:10036(mesau-bhk21)|taxid:10036(Mesocricetus auratus_BHK21) - 2004/12/07 2014/10/16 rogid:3PlUUTVZmb2B65iEGCxa/+0bIe811065 rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606 intact-crc:D799A9054D02CF3F|rigid:4PIPDdGzR2f04cBN/lPIVkXgg1w false v5 tag:n-n|binding-associated region:1476-2093 binding-associated region:272-535|tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)