#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9VMA3	uniprotkb:O18409	intact:EBI-95398|uniprotkb:O02432|intact:EBI-3427114|ensemblmetazoa:FBpp0288761|ensemblmetazoa:FBpp0312102	intact:EBI-300250	psi-mi:cup_drome(display_long)|uniprotkb:cup(gene name)|psi-mi:cup(display_short)|uniprotkb:"fs(2)cup"(gene name synonym)|uniprotkb:Oskar ribonucleoprotein complex 147 kDa subunit(gene name synonym)|uniprotkb:CG11181(orf name)	psi-mi:o18409_drome(display_long)|uniprotkb:bru1(gene name)|psi-mi:bru1(display_short)|uniprotkb:aret(gene name synonym)|uniprotkb:bruno(gene name synonym)|uniprotkb:CG31762(orf name)	psi-mi:"MI:0018"(two hybrid)	Nakamura et al. (2004)	pubmed:14723848	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-300240	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001285687.1|refseq:NP_523493.3|flybase:FBgn0000392|ensemblmetazoa:FBgn0000392(gene)|ensemblmetazoa:FBtr0290322(transcript)|ensemblmetazoa:FBtr0346452(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007297"(ovarian follicle cell migration)|go:"GO:0007317"(regulation of pole plasm oskar mRNA localization)|go:"GO:0007319"(negative regulation of oskar mRNA translation)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030715"(oocyte growth in germarium-derived egg chamber)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043195"(terminal bouton)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048477"(oogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR018862|rcsb pdb:4AXG|dip:DIP-17920N	go:"GO:0045214"(sarcomere organization)|go:"GO:0048477"(oogenesis)|rcsb pdb:2KHC|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000738"(positive regulation of stem cell differentiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034196|interpro:IPR035979|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0007281"(germ cell development)|go:"GO:0007319"(negative regulation of oskar mRNA translation)|go:"GO:0014881"(regulation of myofibril size)|go:"GO:0016604"(nuclear body)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0031965"(nuclear membrane)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0043186"(P granule)|flybase:FBgn0000114	-	-	-	comment:AA 821-1132 of Cup used as bait. AA 320-520 of Bru used as prey.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/03/19	2014/10/16	rogid:xiN4nWnlbAAHM/WDCZDRsbgoyH47227	rogid:M+YCvNo1dUTIDEIq82r58lujnYc7227	intact-crc:780C8987A1CDB86A|rigid:rpKH+9Ux5IaPMwFzQ1FhUVLSCog	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9VMA3	uniprotkb:P48598	intact:EBI-95398|uniprotkb:O02432|intact:EBI-3427114|ensemblmetazoa:FBpp0288761|ensemblmetazoa:FBpp0312102	intact:EBI-198574|uniprotkb:Q95SV3|uniprotkb:Q9VSX8|uniprotkb:Q9VSX9|uniprotkb:A4V1Q6|ensemblmetazoa:FBpp0076215|ensemblmetazoa:FBpp0076217|ensemblmetazoa:FBpp0076218|ensemblmetazoa:FBpp0076219|ensemblmetazoa:FBpp0076220|ensemblmetazoa:FBpp0076221|ensemblmetazoa:FBpp0306016|ensemblmetazoa:FBpp0306017	psi-mi:cup_drome(display_long)|uniprotkb:cup(gene name)|psi-mi:cup(display_short)|uniprotkb:"fs(2)cup"(gene name synonym)|uniprotkb:Oskar ribonucleoprotein complex 147 kDa subunit(gene name synonym)|uniprotkb:CG11181(orf name)	psi-mi:if4e_drome(display_long)|uniprotkb:eIF4E1(gene name)|psi-mi:eIF4E1(display_short)|uniprotkb:Eif4e(gene name synonym)|uniprotkb:eIF-4E(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:CG4035(orf name)	psi-mi:"MI:0096"(pull down)	Nakamura et al. (2004)	pubmed:14723848	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-300242	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001285687.1|refseq:NP_523493.3|flybase:FBgn0000392|ensemblmetazoa:FBgn0000392(gene)|ensemblmetazoa:FBtr0290322(transcript)|ensemblmetazoa:FBtr0346452(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007297"(ovarian follicle cell migration)|go:"GO:0007317"(regulation of pole plasm oskar mRNA localization)|go:"GO:0007319"(negative regulation of oskar mRNA translation)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030715"(oocyte growth in germarium-derived egg chamber)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043195"(terminal bouton)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048477"(oogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR018862|rcsb pdb:4AXG|dip:DIP-17920N	refseq:NP_001261626.1|refseq:NP_001261627.1|refseq:NP_524829.1|refseq:NP_729480.1|refseq:NP_729481.1|refseq:NP_729482.1|refseq:NP_729483.1|refseq:NP_729484.1|refseq:NP_729485.1|flybase:FBgn0015218|dip:DIP-17448N|ensemblmetazoa:FBgn0015218(gene)|ensemblmetazoa:FBtr0076487(transcript)|ensemblmetazoa:FBtr0076489(transcript)|ensemblmetazoa:FBtr0076490(transcript)|ensemblmetazoa:FBtr0076491(transcript)|ensemblmetazoa:FBtr0076492(transcript)|ensemblmetazoa:FBtr0076493(transcript)|ensemblmetazoa:FBtr0333884(transcript)|ensemblmetazoa:FBtr0333885(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045182"(translation regulator activity)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098794"(postsynapse)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|rcsb pdb:4AXG|rcsb pdb:4UE8|rcsb pdb:4UE9|rcsb pdb:4UEA|rcsb pdb:4UEB|rcsb pdb:4UEC|rcsb pdb:5ABU|rcsb pdb:5ABV|rcsb pdb:5T47|rcsb pdb:5T48|reactome:R-DME-110523|reactome:R-DME-1169408|reactome:R-DME-156827|reactome:R-DME-159227|reactome:R-DME-159230|reactome:R-DME-159231|reactome:R-DME-166208|reactome:R-DME-429947|reactome:R-DME-72649|reactome:R-DME-72662|reactome:R-DME-72702	-	-	-	comment:Full length cup cDNA was used to synthesize Cup protein in vitro using TNT T7 Quick kit. GST-EIF4E were expressed in E. coli. The interaction was RNase resistant.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/03/19	2014/10/16	rogid:xiN4nWnlbAAHM/WDCZDRsbgoyH47227	rogid:htX4CrNeZ/TE59IjlVxQ9GeQdxk7227	intact-crc:F2F5794DF7AC4DC5|rigid:cxprloZIUitNWhMtj8Gd11jQ7BM	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P23128	uniprotkb:P48598	intact:EBI-300281|ensemblmetazoa:FBpp0079565|uniprotkb:Q8IPC9|uniprotkb:Q961D2|uniprotkb:Q9VL17	intact:EBI-198574|uniprotkb:Q95SV3|uniprotkb:Q9VSX8|uniprotkb:Q9VSX9|uniprotkb:A4V1Q6|ensemblmetazoa:FBpp0076215|ensemblmetazoa:FBpp0076217|ensemblmetazoa:FBpp0076218|ensemblmetazoa:FBpp0076219|ensemblmetazoa:FBpp0076220|ensemblmetazoa:FBpp0076221|ensemblmetazoa:FBpp0306016|ensemblmetazoa:FBpp0306017	psi-mi:ddx6_drome(display_long)|uniprotkb:me31B(gene name)|psi-mi:me31B(display_short)|uniprotkb:CG4916(orf name)|uniprotkb:Maternal expression at 31B(gene name synonym)	psi-mi:if4e_drome(display_long)|uniprotkb:eIF4E1(gene name)|psi-mi:eIF4E1(display_short)|uniprotkb:Eif4e(gene name synonym)|uniprotkb:eIF-4E(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:CG4035(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Nakamura et al. (2004)	pubmed:14723848	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-300277	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0004419(gene)|ensemblmetazoa:FBtr0079975(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007279"(pole cell formation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043186"(P granule)|go:"GO:0046959"(habituation)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0060148"(positive regulation of posttranscriptional gene silencing)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0071683"(sensory dendrite)|go:"GO:0090328"(regulation of olfactory learning)|go:"GO:0098794"(postsynapse)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|rcsb pdb:6S8R|reactome:R-DME-430039|refseq:NP_523533.2|refseq:NP_723539.1|flybase:FBgn0004419	refseq:NP_001261626.1|refseq:NP_001261627.1|refseq:NP_524829.1|refseq:NP_729480.1|refseq:NP_729481.1|refseq:NP_729482.1|refseq:NP_729483.1|refseq:NP_729484.1|refseq:NP_729485.1|flybase:FBgn0015218|dip:DIP-17448N|ensemblmetazoa:FBgn0015218(gene)|ensemblmetazoa:FBtr0076487(transcript)|ensemblmetazoa:FBtr0076489(transcript)|ensemblmetazoa:FBtr0076490(transcript)|ensemblmetazoa:FBtr0076491(transcript)|ensemblmetazoa:FBtr0076492(transcript)|ensemblmetazoa:FBtr0076493(transcript)|ensemblmetazoa:FBtr0333884(transcript)|ensemblmetazoa:FBtr0333885(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045182"(translation regulator activity)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098794"(postsynapse)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|rcsb pdb:4AXG|rcsb pdb:4UE8|rcsb pdb:4UE9|rcsb pdb:4UEA|rcsb pdb:4UEB|rcsb pdb:4UEC|rcsb pdb:5ABU|rcsb pdb:5ABV|rcsb pdb:5T47|rcsb pdb:5T48|reactome:R-DME-110523|reactome:R-DME-1169408|reactome:R-DME-156827|reactome:R-DME-159227|reactome:R-DME-159230|reactome:R-DME-159231|reactome:R-DME-166208|reactome:R-DME-429947|reactome:R-DME-72649|reactome:R-DME-72662|reactome:R-DME-72702	-	-	-	comment:Similar interaction was observed using anti eIF4E. The interaction was RNase sensitive.	taxid:7227(drome-ovary)|taxid:7227(Drosophila melanogaster ovary)	-	2004/03/19	2014/10/16	rogid:qN9bybi82EScbklfgAdPnCZV/G07227	rogid:htX4CrNeZ/TE59IjlVxQ9GeQdxk7227	intact-crc:1ACFB97B82D17C57|rigid:eofj0Sz4SfVER368UJmKVjjgyIw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P23128	uniprotkb:Q9VMA3	intact:EBI-300281|ensemblmetazoa:FBpp0079565|uniprotkb:Q8IPC9|uniprotkb:Q961D2|uniprotkb:Q9VL17	intact:EBI-95398|uniprotkb:O02432|intact:EBI-3427114|ensemblmetazoa:FBpp0288761|ensemblmetazoa:FBpp0312102	psi-mi:ddx6_drome(display_long)|uniprotkb:me31B(gene name)|psi-mi:me31B(display_short)|uniprotkb:CG4916(orf name)|uniprotkb:Maternal expression at 31B(gene name synonym)	psi-mi:cup_drome(display_long)|uniprotkb:cup(gene name)|psi-mi:cup(display_short)|uniprotkb:"fs(2)cup"(gene name synonym)|uniprotkb:Oskar ribonucleoprotein complex 147 kDa subunit(gene name synonym)|uniprotkb:CG11181(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Nakamura et al. (2004)	pubmed:14723848	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-300277	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0004419(gene)|ensemblmetazoa:FBtr0079975(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007279"(pole cell formation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043186"(P granule)|go:"GO:0046959"(habituation)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0060148"(positive regulation of posttranscriptional gene silencing)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0071683"(sensory dendrite)|go:"GO:0090328"(regulation of olfactory learning)|go:"GO:0098794"(postsynapse)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|rcsb pdb:6S8R|reactome:R-DME-430039|refseq:NP_523533.2|refseq:NP_723539.1|flybase:FBgn0004419	refseq:NP_001285687.1|refseq:NP_523493.3|flybase:FBgn0000392|ensemblmetazoa:FBgn0000392(gene)|ensemblmetazoa:FBtr0290322(transcript)|ensemblmetazoa:FBtr0346452(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007297"(ovarian follicle cell migration)|go:"GO:0007317"(regulation of pole plasm oskar mRNA localization)|go:"GO:0007319"(negative regulation of oskar mRNA translation)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030715"(oocyte growth in germarium-derived egg chamber)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043195"(terminal bouton)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048477"(oogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR018862|rcsb pdb:4AXG|dip:DIP-17920N	-	-	-	comment:Similar interaction was observed using anti eIF4E. The interaction was RNase sensitive.	taxid:7227(drome-ovary)|taxid:7227(Drosophila melanogaster ovary)	-	2004/03/19	2014/10/16	rogid:qN9bybi82EScbklfgAdPnCZV/G07227	rogid:xiN4nWnlbAAHM/WDCZDRsbgoyH47227	intact-crc:1ACFB97B82D17C57|rigid:eofj0Sz4SfVER368UJmKVjjgyIw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P23128	uniprotkb:O18409	intact:EBI-300281|ensemblmetazoa:FBpp0079565|uniprotkb:Q8IPC9|uniprotkb:Q961D2|uniprotkb:Q9VL17	intact:EBI-300250	psi-mi:ddx6_drome(display_long)|uniprotkb:me31B(gene name)|psi-mi:me31B(display_short)|uniprotkb:CG4916(orf name)|uniprotkb:Maternal expression at 31B(gene name synonym)	psi-mi:o18409_drome(display_long)|uniprotkb:bru1(gene name)|psi-mi:bru1(display_short)|uniprotkb:aret(gene name synonym)|uniprotkb:bruno(gene name synonym)|uniprotkb:CG31762(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Nakamura et al. (2004)	pubmed:14723848	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-300293	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0004419(gene)|ensemblmetazoa:FBtr0079975(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007279"(pole cell formation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043186"(P granule)|go:"GO:0046959"(habituation)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0060148"(positive regulation of posttranscriptional gene silencing)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0071683"(sensory dendrite)|go:"GO:0090328"(regulation of olfactory learning)|go:"GO:0098794"(postsynapse)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|rcsb pdb:6S8R|reactome:R-DME-430039|refseq:NP_523533.2|refseq:NP_723539.1|flybase:FBgn0004419	go:"GO:0045214"(sarcomere organization)|go:"GO:0048477"(oogenesis)|rcsb pdb:2KHC|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000738"(positive regulation of stem cell differentiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034196|interpro:IPR035979|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0007281"(germ cell development)|go:"GO:0007319"(negative regulation of oskar mRNA translation)|go:"GO:0014881"(regulation of myofibril size)|go:"GO:0016604"(nuclear body)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0031965"(nuclear membrane)|go:"GO:0036099"(female germ-line stem cell population maintenance)|go:"GO:0043186"(P granule)|flybase:FBgn0000114	-	-	-	comment:This complex was RNase sensitive. However, the complex between eIF4E-Cup-Bru is RNase resistant	taxid:7227(drome-ovary)|taxid:7227(Drosophila melanogaster ovary)	-	2004/03/19	2014/10/16	rogid:qN9bybi82EScbklfgAdPnCZV/G07227	rogid:M+YCvNo1dUTIDEIq82r58lujnYc7227	intact-crc:3993EAD513E5F9E0|rigid:9gRNkK4LkKd9WHE5lC1XiseDGyE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P23128	uniprotkb:Q9VMA3	intact:EBI-300281|ensemblmetazoa:FBpp0079565|uniprotkb:Q8IPC9|uniprotkb:Q961D2|uniprotkb:Q9VL17	intact:EBI-95398|uniprotkb:O02432|intact:EBI-3427114|ensemblmetazoa:FBpp0288761|ensemblmetazoa:FBpp0312102	psi-mi:ddx6_drome(display_long)|uniprotkb:me31B(gene name)|psi-mi:me31B(display_short)|uniprotkb:CG4916(orf name)|uniprotkb:Maternal expression at 31B(gene name synonym)	psi-mi:cup_drome(display_long)|uniprotkb:cup(gene name)|psi-mi:cup(display_short)|uniprotkb:"fs(2)cup"(gene name synonym)|uniprotkb:Oskar ribonucleoprotein complex 147 kDa subunit(gene name synonym)|uniprotkb:CG11181(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Nakamura et al. (2004)	pubmed:14723848	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-300293	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0004419(gene)|ensemblmetazoa:FBtr0079975(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007279"(pole cell formation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043186"(P granule)|go:"GO:0046959"(habituation)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0060148"(positive regulation of posttranscriptional gene silencing)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0071683"(sensory dendrite)|go:"GO:0090328"(regulation of olfactory learning)|go:"GO:0098794"(postsynapse)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|rcsb pdb:6S8R|reactome:R-DME-430039|refseq:NP_523533.2|refseq:NP_723539.1|flybase:FBgn0004419	refseq:NP_001285687.1|refseq:NP_523493.3|flybase:FBgn0000392|ensemblmetazoa:FBgn0000392(gene)|ensemblmetazoa:FBtr0290322(transcript)|ensemblmetazoa:FBtr0346452(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007297"(ovarian follicle cell migration)|go:"GO:0007317"(regulation of pole plasm oskar mRNA localization)|go:"GO:0007319"(negative regulation of oskar mRNA translation)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030715"(oocyte growth in germarium-derived egg chamber)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043195"(terminal bouton)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048477"(oogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:1905536"(negative regulation of eukaryotic translation initiation factor 4F complex assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR018862|rcsb pdb:4AXG|dip:DIP-17920N	-	-	-	comment:This complex was RNase sensitive. However, the complex between eIF4E-Cup-Bru is RNase resistant	taxid:7227(drome-ovary)|taxid:7227(Drosophila melanogaster ovary)	-	2004/03/19	2014/10/16	rogid:qN9bybi82EScbklfgAdPnCZV/G07227	rogid:xiN4nWnlbAAHM/WDCZDRsbgoyH47227	intact-crc:3993EAD513E5F9E0|rigid:9gRNkK4LkKd9WHE5lC1XiseDGyE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P23128	uniprotkb:P48598	intact:EBI-300281|ensemblmetazoa:FBpp0079565|uniprotkb:Q8IPC9|uniprotkb:Q961D2|uniprotkb:Q9VL17	intact:EBI-198574|uniprotkb:Q95SV3|uniprotkb:Q9VSX8|uniprotkb:Q9VSX9|uniprotkb:A4V1Q6|ensemblmetazoa:FBpp0076215|ensemblmetazoa:FBpp0076217|ensemblmetazoa:FBpp0076218|ensemblmetazoa:FBpp0076219|ensemblmetazoa:FBpp0076220|ensemblmetazoa:FBpp0076221|ensemblmetazoa:FBpp0306016|ensemblmetazoa:FBpp0306017	psi-mi:ddx6_drome(display_long)|uniprotkb:me31B(gene name)|psi-mi:me31B(display_short)|uniprotkb:CG4916(orf name)|uniprotkb:Maternal expression at 31B(gene name synonym)	psi-mi:if4e_drome(display_long)|uniprotkb:eIF4E1(gene name)|psi-mi:eIF4E1(display_short)|uniprotkb:Eif4e(gene name synonym)|uniprotkb:eIF-4E(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:CG4035(orf name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Nakamura et al. (2004)	pubmed:14723848	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-300293	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblmetazoa:FBgn0004419(gene)|ensemblmetazoa:FBtr0079975(transcript)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007279"(pole cell formation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043186"(P granule)|go:"GO:0046959"(habituation)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0060148"(positive regulation of posttranscriptional gene silencing)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0071683"(sensory dendrite)|go:"GO:0090328"(regulation of olfactory learning)|go:"GO:0098794"(postsynapse)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|rcsb pdb:6S8R|reactome:R-DME-430039|refseq:NP_523533.2|refseq:NP_723539.1|flybase:FBgn0004419	refseq:NP_001261626.1|refseq:NP_001261627.1|refseq:NP_524829.1|refseq:NP_729480.1|refseq:NP_729481.1|refseq:NP_729482.1|refseq:NP_729483.1|refseq:NP_729484.1|refseq:NP_729485.1|flybase:FBgn0015218|dip:DIP-17448N|ensemblmetazoa:FBgn0015218(gene)|ensemblmetazoa:FBtr0076487(transcript)|ensemblmetazoa:FBtr0076489(transcript)|ensemblmetazoa:FBtr0076490(transcript)|ensemblmetazoa:FBtr0076491(transcript)|ensemblmetazoa:FBtr0076492(transcript)|ensemblmetazoa:FBtr0076493(transcript)|ensemblmetazoa:FBtr0333884(transcript)|ensemblmetazoa:FBtr0333885(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006412"(translation)|go:"GO:0006413"(translational initiation)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045182"(translation regulator activity)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098794"(postsynapse)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|rcsb pdb:4AXG|rcsb pdb:4UE8|rcsb pdb:4UE9|rcsb pdb:4UEA|rcsb pdb:4UEB|rcsb pdb:4UEC|rcsb pdb:5ABU|rcsb pdb:5ABV|rcsb pdb:5T47|rcsb pdb:5T48|reactome:R-DME-110523|reactome:R-DME-1169408|reactome:R-DME-156827|reactome:R-DME-159227|reactome:R-DME-159230|reactome:R-DME-159231|reactome:R-DME-166208|reactome:R-DME-429947|reactome:R-DME-72649|reactome:R-DME-72662|reactome:R-DME-72702	-	-	-	comment:This complex was RNase sensitive. However, the complex between eIF4E-Cup-Bru is RNase resistant	taxid:7227(drome-ovary)|taxid:7227(Drosophila melanogaster ovary)	-	2004/03/19	2014/10/16	rogid:qN9bybi82EScbklfgAdPnCZV/G07227	rogid:htX4CrNeZ/TE59IjlVxQ9GeQdxk7227	intact-crc:3993EAD513E5F9E0|rigid:9gRNkK4LkKd9WHE5lC1XiseDGyE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)