#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P02638 uniprotkb:Q15208 intact:EBI-458452|ensembl:ENSBTAP00000006275|ensembl:ENSBTAP00000063447|uniprotkb:A4IFR6|uniprotkb:Q3ZBY1 intact:EBI-458376|ensembl:ENSP00000229812|uniprotkb:Q503A1 psi-mi:s100b_bovin(display_long)|uniprotkb:S100B(gene name)|psi-mi:S100B(display_short)|uniprotkb:S100 calcium-binding protein B(gene name synonym)|uniprotkb:S-100 protein subunit beta(gene name synonym)|uniprotkb:S-100 protein beta chain(gene name synonym) psi-mi:stk38_human(display_long)|uniprotkb:NDR1(gene name synonym)|uniprotkb:STK38(gene name)|psi-mi:STK38(display_short)|uniprotkb:NDR1 protein kinase(gene name synonym)|uniprotkb:Nuclear Dbf2-related kinase 1(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Bhattacharya et al. (2003) pubmed:14661952 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-458388 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016310"(phosphorylation)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|ensembl:ENSBTAG00000004777(gene)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050786"(RAGE receptor binding)|ensembl:ENSBTAT00000006275(transcript)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|ensembl:ENSBTAT00000086647(transcript)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|go:"GO:0001726"(ruffle)|go:"GO:0005509"(calcium ion binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:1PSB|rcsb pdb:3CR2|rcsb pdb:3CR4|rcsb pdb:3CR5|rcsb pdb:3GK1|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:3GK2|rcsb pdb:3GK4|rcsb pdb:3IQO|rcsb pdb:3IQQ|rcsb pdb:3LK0|rcsb pdb:3LK1|rcsb pdb:3LLE|rcsb pdb:3RLZ|rcsb pdb:3RM1|rcsb pdb:4FQO|rcsb pdb:4PDZ|rcsb pdb:4PE0|rcsb pdb:4PE1|rcsb pdb:4PE4|rcsb pdb:4PE7|rcsb pdb:5DKN|rcsb pdb:5DKQ|rcsb pdb:5DKR|rcsb pdb:5ER4|rcsb pdb:5ER5|interpro:IPR018247|interpro:IPR028481|rcsb pdb:1CFP|rcsb pdb:1MHO|refseq:NP_001029727.1 ensembl:ENSG00000112079(gene)|ensembl:ENST00000229812(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:Q15208|rcsb pdb:1PSB|rcsb pdb:6BXI|reactome:R-HSA-9013418|reactome:R-HSA-9013422|refseq:NP_009202.1|refseq:XP_006715051.1|refseq:XP_006715052.1|refseq:NP_001292031.1 - - - comment:Poor folding of STK38 N-terminal domain gave low resolution spectra taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/11/26 2014/10/16 rogid:vyyQxLdEZgXSBvQWHzKEV/QdO9k9913 rogid:YHzdDrPEH6YdhOXtcnLWArqftck9606 intact-crc:3A1374E4382A6986|rigid:FuDrUZvMk9i+NnZSQIvXToqgP0U false his tag:n-n binding-associated region:1-87|ha tag:?-? 2 2 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P02638 uniprotkb:Q15208 intact:EBI-458452|ensembl:ENSBTAP00000006275|ensembl:ENSBTAP00000063447|uniprotkb:A4IFR6|uniprotkb:Q3ZBY1 intact:EBI-458376|ensembl:ENSP00000229812|uniprotkb:Q503A1 psi-mi:s100b_bovin(display_long)|uniprotkb:S100B(gene name)|psi-mi:S100B(display_short)|uniprotkb:S100 calcium-binding protein B(gene name synonym)|uniprotkb:S-100 protein subunit beta(gene name synonym)|uniprotkb:S-100 protein beta chain(gene name synonym) psi-mi:stk38_human(display_long)|uniprotkb:NDR1(gene name synonym)|uniprotkb:STK38(gene name)|psi-mi:STK38(display_short)|uniprotkb:NDR1 protein kinase(gene name synonym)|uniprotkb:Nuclear Dbf2-related kinase 1(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Bhattacharya et al. (2003) pubmed:14661952 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-458426|rcsb pdb:1PSB - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016310"(phosphorylation)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|ensembl:ENSBTAG00000004777(gene)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048156"(tau protein binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050786"(RAGE receptor binding)|ensembl:ENSBTAT00000006275(transcript)|go:"GO:0071638"(negative regulation of monocyte chemotactic protein-1 production)|ensembl:ENSBTAT00000086647(transcript)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|go:"GO:0001726"(ruffle)|go:"GO:0005509"(calcium ion binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:1PSB|rcsb pdb:3CR2|rcsb pdb:3CR4|rcsb pdb:3CR5|rcsb pdb:3GK1|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|rcsb pdb:3GK2|rcsb pdb:3GK4|rcsb pdb:3IQO|rcsb pdb:3IQQ|rcsb pdb:3LK0|rcsb pdb:3LK1|rcsb pdb:3LLE|rcsb pdb:3RLZ|rcsb pdb:3RM1|rcsb pdb:4FQO|rcsb pdb:4PDZ|rcsb pdb:4PE0|rcsb pdb:4PE1|rcsb pdb:4PE4|rcsb pdb:4PE7|rcsb pdb:5DKN|rcsb pdb:5DKQ|rcsb pdb:5DKR|rcsb pdb:5ER4|rcsb pdb:5ER5|interpro:IPR018247|interpro:IPR028481|rcsb pdb:1CFP|rcsb pdb:1MHO|refseq:NP_001029727.1 ensembl:ENSG00000112079(gene)|ensembl:ENST00000229812(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|mint:Q15208|rcsb pdb:1PSB|rcsb pdb:6BXI|reactome:R-HSA-9013418|reactome:R-HSA-9013422|refseq:NP_009202.1|refseq:XP_006715051.1|refseq:XP_006715052.1|refseq:NP_001292031.1 - - - comment:S100B binds Ca2+ at both N- and C-terminal loop taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/11/26 2014/10/16 rogid:vyyQxLdEZgXSBvQWHzKEV/QdO9k9913 rogid:YHzdDrPEH6YdhOXtcnLWArqftck9606 intact-crc:C8CE7C4907D06F6A|rigid:FuDrUZvMk9i+NnZSQIvXToqgP0U false binding-associated region:49-49|his tag:n-n|binding-associated region:54-54|binding-associated region:58-58|binding-associated region:85-85|binding-associated region:86-86|binding-associated region:89-89|binding-associated region:90-90 binding-associated region:62-87|binding-associated region:86-86|binding-associated region:76-76|binding-associated region:86-86|binding-associated region:76-76|binding-associated region:76-76|binding-associated region:86-86|binding-associated region:86-86 2 2 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)