#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9XYF4	uniprotkb:Q24306	intact:EBI-108311|ensemblmetazoa:FBpp0076076	intact:EBI-456419|uniprotkb:A4V1Z9|uniprotkb:Q0E8E4|uniprotkb:Q8MRM5|uniprotkb:Q9VUX5|uniprotkb:A9UN33|ensemblmetazoa:FBpp0075254|ensemblmetazoa:FBpp0075255|ensemblmetazoa:FBpp0075256|ensemblmetazoa:FBpp0305793|ensemblmetazoa:FBpp0305794|ensemblmetazoa:FBpp0305795	psi-mi:dronc_drome(display_long)|uniprotkb:Dronc(gene name)|psi-mi:Dronc(display_short)|uniprotkb:NEDD2-like caspase(gene name synonym)|uniprotkb:Nc(gene name synonym)|uniprotkb:CG8091(orf name)	psi-mi:diap1_drome(display_long)|uniprotkb:Diap1(gene name)|psi-mi:Diap1(display_short)|uniprotkb:Apoptosis 1 inhibitor(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase th(gene name synonym)|uniprotkb:Iap1(gene name synonym)|uniprotkb:Inhibitor of apoptosis 1(gene name synonym)|uniprotkb:Protein thread(gene name synonym)|uniprotkb:th(gene name synonym)|uniprotkb:CG12284(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Diap1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chai et al. (2003)	pubmed:14517550	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-457466	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524017.1|flybase:FBgn0026404|dip:DIP-31484N|ensemblmetazoa:FBgn0026404(gene)|ensemblmetazoa:FBtr0076347(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007516"(hemocyte development)|go:"GO:0007552"(metamorphosis)|go:"GO:0008258"(head involution)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010941"(regulation of cell death)|go:"GO:0012501"(programmed cell death)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0022416"(chaeta development)|go:"GO:0031638"(zymogen activation)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0045476"(nurse cell apoptotic process)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048749"(compound eye development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1Q4Q|rcsb pdb:2FP3|rcsb pdb:3J9K|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-140342|reactome:R-DME-198323|reactome:R-DME-264870|reactome:R-DME-351906|reactome:R-DME-418889|reactome:R-DME-448706|reactome:R-DME-449836	refseq:NP_524101.2|refseq:NP_730097.1|refseq:NP_730098.1|flybase:FBgn0260635|refseq:NP_001261916.1|refseq:NP_001261917.1|refseq:NP_001261918.1|go:"GO:0006915"(apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0022416"(chaeta development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0045116"(protein neddylation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048800"(antennal morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0089720"(caspase binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|ensemblmetazoa:FBgn0260635(gene)|ensemblmetazoa:FBtr0075499(transcript)|ensemblmetazoa:FBtr0075500(transcript)|ensemblmetazoa:FBtr0075501(transcript)|ensemblmetazoa:FBtr0333617(transcript)|ensemblmetazoa:FBtr0333618(transcript)|ensemblmetazoa:FBtr0333619(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|mint:Q24306|rcsb pdb:1JD4|rcsb pdb:1JD5|rcsb pdb:1JD6|rcsb pdb:1Q4Q|rcsb pdb:1SDZ|rcsb pdb:1SE0|rcsb pdb:3SIP|rcsb pdb:3SIQ|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-3769402|reactome:R-DME-390150|reactome:R-DME-5675482|reactome:R-DME-8948747|reactome:R-DME-8948751	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/11/10	2014/10/16	rogid:5OjYCr0Yvr0eiWhfG14i20fZwNA7227	rogid:loBQ//cKQ1NYhq3gnIKwRBn5vZg7227	intact-crc:0EAE81DD25A1FD82|rigid:qalCjviB3SHZ6V5+m8m9iok9OG8	false	his tag:c-c	glutathione s tranferase tag:n-n|binding-associated region:201-324(IPR001370)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9XYF4	uniprotkb:Q24306	intact:EBI-108311|ensemblmetazoa:FBpp0076076	intact:EBI-456419|uniprotkb:A4V1Z9|uniprotkb:Q0E8E4|uniprotkb:Q8MRM5|uniprotkb:Q9VUX5|uniprotkb:A9UN33|ensemblmetazoa:FBpp0075254|ensemblmetazoa:FBpp0075255|ensemblmetazoa:FBpp0075256|ensemblmetazoa:FBpp0305793|ensemblmetazoa:FBpp0305794|ensemblmetazoa:FBpp0305795	psi-mi:dronc_drome(display_long)|uniprotkb:Dronc(gene name)|psi-mi:Dronc(display_short)|uniprotkb:NEDD2-like caspase(gene name synonym)|uniprotkb:Nc(gene name synonym)|uniprotkb:CG8091(orf name)	psi-mi:diap1_drome(display_long)|uniprotkb:Diap1(gene name)|psi-mi:Diap1(display_short)|uniprotkb:Apoptosis 1 inhibitor(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase th(gene name synonym)|uniprotkb:Iap1(gene name synonym)|uniprotkb:Inhibitor of apoptosis 1(gene name synonym)|uniprotkb:Protein thread(gene name synonym)|uniprotkb:th(gene name synonym)|uniprotkb:CG12284(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Diap1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chai et al. (2003)	pubmed:14517550	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-457476	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524017.1|flybase:FBgn0026404|dip:DIP-31484N|ensemblmetazoa:FBgn0026404(gene)|ensemblmetazoa:FBtr0076347(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007516"(hemocyte development)|go:"GO:0007552"(metamorphosis)|go:"GO:0008258"(head involution)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010941"(regulation of cell death)|go:"GO:0012501"(programmed cell death)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0022416"(chaeta development)|go:"GO:0031638"(zymogen activation)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0045476"(nurse cell apoptotic process)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048749"(compound eye development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1Q4Q|rcsb pdb:2FP3|rcsb pdb:3J9K|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-140342|reactome:R-DME-198323|reactome:R-DME-264870|reactome:R-DME-351906|reactome:R-DME-418889|reactome:R-DME-448706|reactome:R-DME-449836	refseq:NP_524101.2|refseq:NP_730097.1|refseq:NP_730098.1|flybase:FBgn0260635|refseq:NP_001261916.1|refseq:NP_001261917.1|refseq:NP_001261918.1|go:"GO:0006915"(apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0022416"(chaeta development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0045116"(protein neddylation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048800"(antennal morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0089720"(caspase binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|ensemblmetazoa:FBgn0260635(gene)|ensemblmetazoa:FBtr0075499(transcript)|ensemblmetazoa:FBtr0075500(transcript)|ensemblmetazoa:FBtr0075501(transcript)|ensemblmetazoa:FBtr0333617(transcript)|ensemblmetazoa:FBtr0333618(transcript)|ensemblmetazoa:FBtr0333619(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|mint:Q24306|rcsb pdb:1JD4|rcsb pdb:1JD5|rcsb pdb:1JD6|rcsb pdb:1Q4Q|rcsb pdb:1SDZ|rcsb pdb:1SE0|rcsb pdb:3SIP|rcsb pdb:3SIQ|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-3769402|reactome:R-DME-390150|reactome:R-DME-5675482|reactome:R-DME-8948747|reactome:R-DME-8948751	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/11/10	2014/10/16	rogid:5OjYCr0Yvr0eiWhfG14i20fZwNA7227	rogid:loBQ//cKQ1NYhq3gnIKwRBn5vZg7227	intact-crc:5857BFA2A0C17725|rigid:qalCjviB3SHZ6V5+m8m9iok9OG8	false	glutathione s tranferase tag:n-n|binding-associated region:114-125	his tag:c-c|binding-associated region:201-324(IPR001370)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9XYF4	uniprotkb:Q24306	intact:EBI-108311|ensemblmetazoa:FBpp0076076	intact:EBI-456419|uniprotkb:A4V1Z9|uniprotkb:Q0E8E4|uniprotkb:Q8MRM5|uniprotkb:Q9VUX5|uniprotkb:A9UN33|ensemblmetazoa:FBpp0075254|ensemblmetazoa:FBpp0075255|ensemblmetazoa:FBpp0075256|ensemblmetazoa:FBpp0305793|ensemblmetazoa:FBpp0305794|ensemblmetazoa:FBpp0305795	psi-mi:dronc_drome(display_long)|uniprotkb:Dronc(gene name)|psi-mi:Dronc(display_short)|uniprotkb:NEDD2-like caspase(gene name synonym)|uniprotkb:Nc(gene name synonym)|uniprotkb:CG8091(orf name)	psi-mi:diap1_drome(display_long)|uniprotkb:Diap1(gene name)|psi-mi:Diap1(display_short)|uniprotkb:Apoptosis 1 inhibitor(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase th(gene name synonym)|uniprotkb:Iap1(gene name synonym)|uniprotkb:Inhibitor of apoptosis 1(gene name synonym)|uniprotkb:Protein thread(gene name synonym)|uniprotkb:th(gene name synonym)|uniprotkb:CG12284(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Diap1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Chai et al. (2003)	pubmed:14517550	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-457489	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524017.1|flybase:FBgn0026404|dip:DIP-31484N|ensemblmetazoa:FBgn0026404(gene)|ensemblmetazoa:FBtr0076347(transcript)|go:"GO:0001700"(embryonic development via the syncytial blastoderm)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007516"(hemocyte development)|go:"GO:0007552"(metamorphosis)|go:"GO:0008258"(head involution)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010623"(programmed cell death involved in cell development)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010941"(regulation of cell death)|go:"GO:0012501"(programmed cell death)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0022416"(chaeta development)|go:"GO:0031638"(zymogen activation)|go:"GO:0035006"(melanization defense response)|go:"GO:0035070"(salivary gland histolysis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043293"(apoptosome)|go:"GO:0045476"(nurse cell apoptotic process)|go:"GO:0046672"(positive regulation of compound eye retinal cell programmed cell death)|go:"GO:0048749"(compound eye development)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050700"(CARD domain binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1Q4Q|rcsb pdb:2FP3|rcsb pdb:3J9K|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-140342|reactome:R-DME-198323|reactome:R-DME-264870|reactome:R-DME-351906|reactome:R-DME-418889|reactome:R-DME-448706|reactome:R-DME-449836	refseq:NP_524101.2|refseq:NP_730097.1|refseq:NP_730098.1|flybase:FBgn0260635|refseq:NP_001261916.1|refseq:NP_001261917.1|refseq:NP_001261918.1|go:"GO:0006915"(apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0022416"(chaeta development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0045116"(protein neddylation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048800"(antennal morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0089720"(caspase binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|ensemblmetazoa:FBgn0260635(gene)|ensemblmetazoa:FBtr0075499(transcript)|ensemblmetazoa:FBtr0075500(transcript)|ensemblmetazoa:FBtr0075501(transcript)|ensemblmetazoa:FBtr0333617(transcript)|ensemblmetazoa:FBtr0333618(transcript)|ensemblmetazoa:FBtr0333619(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|mint:Q24306|rcsb pdb:1JD4|rcsb pdb:1JD5|rcsb pdb:1JD6|rcsb pdb:1Q4Q|rcsb pdb:1SDZ|rcsb pdb:1SE0|rcsb pdb:3SIP|rcsb pdb:3SIQ|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-3769402|reactome:R-DME-390150|reactome:R-DME-5675482|reactome:R-DME-8948747|reactome:R-DME-8948751	-	-	-	inhibition:Hid disrupts Nc binding to th|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/11/10	2014/10/16	rogid:5OjYCr0Yvr0eiWhfG14i20fZwNA7227	rogid:loBQ//cKQ1NYhq3gnIKwRBn5vZg7227	intact-crc:94282242F27278D5|rigid:qalCjviB3SHZ6V5+m8m9iok9OG8	false	his tag:c-c|binding-associated region:1-136|mutation decreasing interaction:118-118	glutathione s tranferase tag:n-n|binding-associated region:201-324(IPR001370)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q24306	uniprotkb:Q24106	intact:EBI-456419|uniprotkb:A4V1Z9|uniprotkb:Q0E8E4|uniprotkb:Q8MRM5|uniprotkb:Q9VUX5|uniprotkb:A9UN33|ensemblmetazoa:FBpp0075254|ensemblmetazoa:FBpp0075255|ensemblmetazoa:FBpp0075256|ensemblmetazoa:FBpp0305793|ensemblmetazoa:FBpp0305794|ensemblmetazoa:FBpp0305795	intact:EBI-135509|uniprotkb:Q9VVP1|ensemblmetazoa:FBpp0074899|ensemblmetazoa:FBpp0305084	psi-mi:diap1_drome(display_long)|uniprotkb:Diap1(gene name)|psi-mi:Diap1(display_short)|uniprotkb:Apoptosis 1 inhibitor(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase th(gene name synonym)|uniprotkb:Iap1(gene name synonym)|uniprotkb:Inhibitor of apoptosis 1(gene name synonym)|uniprotkb:Protein thread(gene name synonym)|uniprotkb:th(gene name synonym)|uniprotkb:CG12284(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Diap1(gene name synonym)	psi-mi:hid_drome(display_long)|uniprotkb:hid(gene name)|psi-mi:hid(display_short)|uniprotkb:Protein head involution defective(gene name synonym)|uniprotkb:Protein wrinkled(gene name synonym)|uniprotkb:W(gene name synonym)|uniprotkb:CG5123(orf name)	psi-mi:"MI:0071"(molecular sieving)	Chai et al. (2003)	pubmed:14517550	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-457505	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_524101.2|refseq:NP_730097.1|refseq:NP_730098.1|flybase:FBgn0260635|refseq:NP_001261916.1|refseq:NP_001261917.1|refseq:NP_001261918.1|go:"GO:0006915"(apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0022416"(chaeta development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0045116"(protein neddylation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048800"(antennal morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0089720"(caspase binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|ensemblmetazoa:FBgn0260635(gene)|ensemblmetazoa:FBtr0075499(transcript)|ensemblmetazoa:FBtr0075500(transcript)|ensemblmetazoa:FBtr0075501(transcript)|ensemblmetazoa:FBtr0333617(transcript)|ensemblmetazoa:FBtr0333618(transcript)|ensemblmetazoa:FBtr0333619(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|mint:Q24306|rcsb pdb:1JD4|rcsb pdb:1JD5|rcsb pdb:1JD6|rcsb pdb:1Q4Q|rcsb pdb:1SDZ|rcsb pdb:1SE0|rcsb pdb:3SIP|rcsb pdb:3SIQ|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-3769402|reactome:R-DME-390150|reactome:R-DME-5675482|reactome:R-DME-8948747|reactome:R-DME-8948751	refseq:NP_524136.2|flybase:FBgn0003997|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007548"(sex differentiation)|go:"GO:0008219"(cell death)|go:"GO:0008258"(head involution)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010114"(response to red light)|go:"GO:0012501"(programmed cell death)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035071"(salivary gland cell autophagic cell death)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035096"(larval midgut cell programmed cell death)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048800"(antennal morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1990525"(BIR domain binding)|go:"GO:2000685"(positive regulation of cellular response to X-ray)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|rcsb pdb:1JD6|ensemblmetazoa:FBgn0003997(gene)|ensemblmetazoa:FBtr0075133(transcript)|ensemblmetazoa:FBtr0332862(transcript)|go:"GO:0002165"(instar larval or pupal development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|refseq:NP_001262010.1|dip:DIP-20052N	-	-	-	inhibition:Hid disrupts Nc binding to th|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/11/10	2014/10/16	rogid:loBQ//cKQ1NYhq3gnIKwRBn5vZg7227	rogid:x/Jsu6gdz5rnLlOny3LOrreZP2c7227	intact-crc:75D5B07F6DE7C8CA|rigid:/Z8/PY4Z0kOqpEkt1M5o+hUp57g	false	binding-associated region:201-324(IPR001370)|glutathione s tranferase tag:n-n	his tag:c-c|binding-associated region:1-10	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)