#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0CG63	uniprotkb:P40343	intact:EBI-7000452|ensemblfungi:YLL039C|intact:MINT-545233|uniprotkb:D6VXW7|uniprotkb:P61864|uniprotkb:Q6LA96|uniprotkb:P04838	intact:EBI-20380|uniprotkb:D6W1I1|ensemblfungi:YNR006W	psi-mi:ubi4p_yeast(display_long)|uniprotkb:UBI4(gene name)|psi-mi:UBI4(display_short)|uniprotkb:SCD2(gene name synonym)|uniprotkb:YLL039C(locus name)	psi-mi:vps27_yeast(display_long)|uniprotkb:VPS27(gene name)|psi-mi:VPS27(display_short)|uniprotkb:YNR006W(locus name)|uniprotkb:N2038(orf name)|uniprotkb:DID7(gene name synonym)|uniprotkb:SSV17(gene name synonym)|uniprotkb:VPL23(gene name synonym)|uniprotkb:VPT27(gene name synonym)|uniprotkb:Golgi retention defective protein 11(gene name synonym)|uniprotkb:GRD11(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Swanson et al. (2003)	pubmed:12970172|mint:MINT-5216665	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7004035|mint:MINT-50285	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YLL039C(gene)|ensemblfungi:YLL039C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:1OTR|rcsb pdb:1Q0W|rcsb pdb:1WR1|rcsb pdb:1ZW7|rcsb pdb:2G3Q|rcsb pdb:2JT4|rcsb pdb:2JWZ|rcsb pdb:2KDI|rcsb pdb:2L00|rcsb pdb:3CMM|rcsb pdb:3L0W|rcsb pdb:3L10|rcsb pdb:3OLM|rcsb pdb:4HCN|rcsb pdb:4NNJ|rcsb pdb:4Q5E|rcsb pdb:4Q5H|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-156827|reactome:R-SCE-174113|reactome:R-SCE-1799339|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5687128|reactome:R-SCE-5689603|reactome:R-SCE-5689877|reactome:R-SCE-5689880|reactome:R-SCE-5689901|reactome:R-SCE-5696395|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-6791226|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-72649|reactome:R-SCE-72689|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72706|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8866652|reactome:R-SCE-8866654|reactome:R-SCE-8948747|reactome:R-SCE-8948751|reactome:R-SCE-901032|reactome:R-SCE-9020702|reactome:R-SCE-9033241|reactome:R-SCE-917729|reactome:R-SCE-9646399|reactome:R-SCE-975956|reactome:R-SCE-975957|reactome:R-SCE-983168|interpro:IPR000626(Ubiquitin)|sgd:S000003962|interpro:IPR019956|interpro:IPR019954|refseq:NP_013061.1|interpro:IPR029071|mint:P0CG63|mint:MINT-739541(identity)	sgd:S000005289|refseq:NP_014403.3|ensemblfungi:YNR006W(gene)|ensemblfungi:YNR006W_mRNA(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0009306"(protein secretion)|go:"GO:0010008"(endosome membrane)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0140504"(microlipophagy)|go:"GO:1903319"(positive regulation of protein maturation)|go:"GO:1904669"(ATP export)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|rcsb pdb:1O06|rcsb pdb:1Q0V|rcsb pdb:1Q0W|rcsb pdb:1VFY|rcsb pdb:2KDI|rcsb pdb:2PJW|rcsb pdb:3R42|rcsb pdb:6NJG|dip:DIP-1741N|mint:P40343|mint:MINT-739534(identity)	-	function:Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair|comment:mint|comment:"Stoichiometry: 1.0"	crc64:76C4501B0EBC9C84|comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/09/09	2014/10/16	rogid:+GNv/Jc7C11q8cgu2qZ6YkcsIeI559292	rogid:5ScB34gSI3x260kAGh/knEWupwA559292	intact-crc:20FD21EDDF65324B|rigid:hkbUZQ4D9fuLlC5NUYrrZzUePEo	false	-	binding-associated region:?-?(MINT-739535)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P0CG63	uniprotkb:P40343	intact:EBI-7000452|ensemblfungi:YLL039C|intact:MINT-545233|uniprotkb:D6VXW7|uniprotkb:P61864|uniprotkb:Q6LA96|uniprotkb:P04838	intact:EBI-20380|uniprotkb:D6W1I1|ensemblfungi:YNR006W	psi-mi:ubi4p_yeast(display_long)|uniprotkb:UBI4(gene name)|psi-mi:UBI4(display_short)|uniprotkb:SCD2(gene name synonym)|uniprotkb:YLL039C(locus name)	psi-mi:vps27_yeast(display_long)|uniprotkb:VPS27(gene name)|psi-mi:VPS27(display_short)|uniprotkb:YNR006W(locus name)|uniprotkb:N2038(orf name)|uniprotkb:DID7(gene name synonym)|uniprotkb:SSV17(gene name synonym)|uniprotkb:VPL23(gene name synonym)|uniprotkb:VPT27(gene name synonym)|uniprotkb:Golgi retention defective protein 11(gene name synonym)|uniprotkb:GRD11(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Swanson et al. (2003)	pubmed:12970172|mint:MINT-5216665	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7004054|mint:MINT-50288	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YLL039C(gene)|ensemblfungi:YLL039C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:1OTR|rcsb pdb:1Q0W|rcsb pdb:1WR1|rcsb pdb:1ZW7|rcsb pdb:2G3Q|rcsb pdb:2JT4|rcsb pdb:2JWZ|rcsb pdb:2KDI|rcsb pdb:2L00|rcsb pdb:3CMM|rcsb pdb:3L0W|rcsb pdb:3L10|rcsb pdb:3OLM|rcsb pdb:4HCN|rcsb pdb:4NNJ|rcsb pdb:4Q5E|rcsb pdb:4Q5H|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-156827|reactome:R-SCE-174113|reactome:R-SCE-1799339|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5687128|reactome:R-SCE-5689603|reactome:R-SCE-5689877|reactome:R-SCE-5689880|reactome:R-SCE-5689901|reactome:R-SCE-5696395|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-6791226|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-72649|reactome:R-SCE-72689|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72706|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8866652|reactome:R-SCE-8866654|reactome:R-SCE-8948747|reactome:R-SCE-8948751|reactome:R-SCE-901032|reactome:R-SCE-9020702|reactome:R-SCE-9033241|reactome:R-SCE-917729|reactome:R-SCE-9646399|reactome:R-SCE-975956|reactome:R-SCE-975957|reactome:R-SCE-983168|interpro:IPR000626(Ubiquitin)|sgd:S000003962|interpro:IPR019956|interpro:IPR019954|refseq:NP_013061.1|interpro:IPR029071|mint:P0CG63|mint:MINT-739495(identity)	sgd:S000005289|refseq:NP_014403.3|ensemblfungi:YNR006W(gene)|ensemblfungi:YNR006W_mRNA(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0009306"(protein secretion)|go:"GO:0010008"(endosome membrane)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0140504"(microlipophagy)|go:"GO:1903319"(positive regulation of protein maturation)|go:"GO:1904669"(ATP export)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|rcsb pdb:1O06|rcsb pdb:1Q0V|rcsb pdb:1Q0W|rcsb pdb:1VFY|rcsb pdb:2KDI|rcsb pdb:2PJW|rcsb pdb:3R42|rcsb pdb:6NJG|dip:DIP-1741N|mint:P40343|mint:MINT-739488(identity)	-	function:Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair|comment:mint|comment:"Stoichiometry: 1.0"	crc64:76C4501B0EBC9C84|comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/09/09	2014/10/16	rogid:+GNv/Jc7C11q8cgu2qZ6YkcsIeI559292	rogid:5ScB34gSI3x260kAGh/knEWupwA559292	intact-crc:28CC9FEEBC18B413|rigid:hkbUZQ4D9fuLlC5NUYrrZzUePEo	false	-	binding-associated region:256-278(MINT-739489)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P0CG63	uniprotkb:P40343	intact:EBI-7000452|ensemblfungi:YLL039C|intact:MINT-545233|uniprotkb:D6VXW7|uniprotkb:P61864|uniprotkb:Q6LA96|uniprotkb:P04838	intact:EBI-20380|uniprotkb:D6W1I1|ensemblfungi:YNR006W	psi-mi:ubi4p_yeast(display_long)|uniprotkb:UBI4(gene name)|psi-mi:UBI4(display_short)|uniprotkb:SCD2(gene name synonym)|uniprotkb:YLL039C(locus name)	psi-mi:vps27_yeast(display_long)|uniprotkb:VPS27(gene name)|psi-mi:VPS27(display_short)|uniprotkb:YNR006W(locus name)|uniprotkb:N2038(orf name)|uniprotkb:DID7(gene name synonym)|uniprotkb:SSV17(gene name synonym)|uniprotkb:VPL23(gene name synonym)|uniprotkb:VPT27(gene name synonym)|uniprotkb:Golgi retention defective protein 11(gene name synonym)|uniprotkb:GRD11(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Swanson et al. (2003)	pubmed:12970172|mint:MINT-5216665	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7004078|mint:MINT-50286	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YLL039C(gene)|ensemblfungi:YLL039C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:1OTR|rcsb pdb:1Q0W|rcsb pdb:1WR1|rcsb pdb:1ZW7|rcsb pdb:2G3Q|rcsb pdb:2JT4|rcsb pdb:2JWZ|rcsb pdb:2KDI|rcsb pdb:2L00|rcsb pdb:3CMM|rcsb pdb:3L0W|rcsb pdb:3L10|rcsb pdb:3OLM|rcsb pdb:4HCN|rcsb pdb:4NNJ|rcsb pdb:4Q5E|rcsb pdb:4Q5H|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-156827|reactome:R-SCE-174113|reactome:R-SCE-1799339|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5687128|reactome:R-SCE-5689603|reactome:R-SCE-5689877|reactome:R-SCE-5689880|reactome:R-SCE-5689901|reactome:R-SCE-5696395|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-6791226|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-72649|reactome:R-SCE-72689|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72706|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8866652|reactome:R-SCE-8866654|reactome:R-SCE-8948747|reactome:R-SCE-8948751|reactome:R-SCE-901032|reactome:R-SCE-9020702|reactome:R-SCE-9033241|reactome:R-SCE-917729|reactome:R-SCE-9646399|reactome:R-SCE-975956|reactome:R-SCE-975957|reactome:R-SCE-983168|interpro:IPR000626(Ubiquitin)|sgd:S000003962|interpro:IPR019956|interpro:IPR019954|refseq:NP_013061.1|interpro:IPR029071|mint:P0CG63|mint:MINT-739511(identity)	sgd:S000005289|refseq:NP_014403.3|ensemblfungi:YNR006W(gene)|ensemblfungi:YNR006W_mRNA(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0009306"(protein secretion)|go:"GO:0010008"(endosome membrane)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0140504"(microlipophagy)|go:"GO:1903319"(positive regulation of protein maturation)|go:"GO:1904669"(ATP export)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|rcsb pdb:1O06|rcsb pdb:1Q0V|rcsb pdb:1Q0W|rcsb pdb:1VFY|rcsb pdb:2KDI|rcsb pdb:2PJW|rcsb pdb:3R42|rcsb pdb:6NJG|dip:DIP-1741N|mint:P40343|mint:MINT-739504(identity)	-	function:Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair|comment:mint|comment:"Stoichiometry: 1.0"	crc64:76C4501B0EBC9C84|comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|kd:277 micromolar|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/09/09	2014/10/16	rogid:+GNv/Jc7C11q8cgu2qZ6YkcsIeI559292	rogid:5ScB34gSI3x260kAGh/knEWupwA559292	intact-crc:EEC465A3AD88DF17|rigid:hkbUZQ4D9fuLlC5NUYrrZzUePEo	false	-	binding-associated region:256-278(MINT-739505)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P0CG63	uniprotkb:P40343	intact:EBI-7000452|ensemblfungi:YLL039C|intact:MINT-545233|uniprotkb:D6VXW7|uniprotkb:P61864|uniprotkb:Q6LA96|uniprotkb:P04838	intact:EBI-20380|uniprotkb:D6W1I1|ensemblfungi:YNR006W	psi-mi:ubi4p_yeast(display_long)|uniprotkb:UBI4(gene name)|psi-mi:UBI4(display_short)|uniprotkb:SCD2(gene name synonym)|uniprotkb:YLL039C(locus name)	psi-mi:vps27_yeast(display_long)|uniprotkb:VPS27(gene name)|psi-mi:VPS27(display_short)|uniprotkb:YNR006W(locus name)|uniprotkb:N2038(orf name)|uniprotkb:DID7(gene name synonym)|uniprotkb:SSV17(gene name synonym)|uniprotkb:VPL23(gene name synonym)|uniprotkb:VPT27(gene name synonym)|uniprotkb:Golgi retention defective protein 11(gene name synonym)|uniprotkb:GRD11(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Swanson et al. (2003)	pubmed:12970172|mint:MINT-5216665	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7004095|mint:MINT-50287	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YLL039C(gene)|ensemblfungi:YLL039C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:1OTR|rcsb pdb:1Q0W|rcsb pdb:1WR1|rcsb pdb:1ZW7|rcsb pdb:2G3Q|rcsb pdb:2JT4|rcsb pdb:2JWZ|rcsb pdb:2KDI|rcsb pdb:2L00|rcsb pdb:3CMM|rcsb pdb:3L0W|rcsb pdb:3L10|rcsb pdb:3OLM|rcsb pdb:4HCN|rcsb pdb:4NNJ|rcsb pdb:4Q5E|rcsb pdb:4Q5H|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-156827|reactome:R-SCE-174113|reactome:R-SCE-1799339|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5687128|reactome:R-SCE-5689603|reactome:R-SCE-5689877|reactome:R-SCE-5689880|reactome:R-SCE-5689901|reactome:R-SCE-5696395|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-6791226|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-72649|reactome:R-SCE-72689|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72706|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8866652|reactome:R-SCE-8866654|reactome:R-SCE-8948747|reactome:R-SCE-8948751|reactome:R-SCE-901032|reactome:R-SCE-9020702|reactome:R-SCE-9033241|reactome:R-SCE-917729|reactome:R-SCE-9646399|reactome:R-SCE-975956|reactome:R-SCE-975957|reactome:R-SCE-983168|interpro:IPR000626(Ubiquitin)|sgd:S000003962|interpro:IPR019956|interpro:IPR019954|refseq:NP_013061.1|interpro:IPR029071|mint:P0CG63|mint:MINT-739526(identity)	sgd:S000005289|refseq:NP_014403.3|ensemblfungi:YNR006W(gene)|ensemblfungi:YNR006W_mRNA(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0009306"(protein secretion)|go:"GO:0010008"(endosome membrane)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0140504"(microlipophagy)|go:"GO:1903319"(positive regulation of protein maturation)|go:"GO:1904669"(ATP export)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|rcsb pdb:1O06|rcsb pdb:1Q0V|rcsb pdb:1Q0W|rcsb pdb:1VFY|rcsb pdb:2KDI|rcsb pdb:2PJW|rcsb pdb:3R42|rcsb pdb:6NJG|dip:DIP-1741N|mint:P40343|mint:MINT-739519(identity)	-	function:Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair|comment:mint|comment:"Stoichiometry: 1.0"	crc64:76C4501B0EBC9C84|comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|kd:117 micromolar|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/09/09	2014/10/16	rogid:+GNv/Jc7C11q8cgu2qZ6YkcsIeI559292	rogid:5ScB34gSI3x260kAGh/knEWupwA559292	intact-crc:9526D104E90951F6|rigid:hkbUZQ4D9fuLlC5NUYrrZzUePEo	false	-	binding-associated region:?-?(MINT-739520)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P0CG63	uniprotkb:P40343	intact:EBI-7000452|ensemblfungi:YLL039C|intact:MINT-545233|uniprotkb:D6VXW7|uniprotkb:P61864|uniprotkb:Q6LA96|uniprotkb:P04838	intact:EBI-20380|uniprotkb:D6W1I1|ensemblfungi:YNR006W	psi-mi:ubi4p_yeast(display_long)|uniprotkb:UBI4(gene name)|psi-mi:UBI4(display_short)|uniprotkb:SCD2(gene name synonym)|uniprotkb:YLL039C(locus name)	psi-mi:vps27_yeast(display_long)|uniprotkb:VPS27(gene name)|psi-mi:VPS27(display_short)|uniprotkb:YNR006W(locus name)|uniprotkb:N2038(orf name)|uniprotkb:DID7(gene name synonym)|uniprotkb:SSV17(gene name synonym)|uniprotkb:VPL23(gene name synonym)|uniprotkb:VPT27(gene name synonym)|uniprotkb:Golgi retention defective protein 11(gene name synonym)|uniprotkb:GRD11(gene name synonym)	psi-mi:"MI:0096"(pull down)	Swanson et al. (2003)	pubmed:12970172|mint:MINT-5216665	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7004123|mint:MINT-50289	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YLL039C(gene)|ensemblfungi:YLL039C_mRNA(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:1OTR|rcsb pdb:1Q0W|rcsb pdb:1WR1|rcsb pdb:1ZW7|rcsb pdb:2G3Q|rcsb pdb:2JT4|rcsb pdb:2JWZ|rcsb pdb:2KDI|rcsb pdb:2L00|rcsb pdb:3CMM|rcsb pdb:3L0W|rcsb pdb:3L10|rcsb pdb:3OLM|rcsb pdb:4HCN|rcsb pdb:4NNJ|rcsb pdb:4Q5E|rcsb pdb:4Q5H|reactome:R-SCE-110312|reactome:R-SCE-110320|reactome:R-SCE-156827|reactome:R-SCE-174113|reactome:R-SCE-1799339|reactome:R-SCE-532668|reactome:R-SCE-5358346|reactome:R-SCE-5655862|reactome:R-SCE-5656121|reactome:R-SCE-5656169|reactome:R-SCE-5687128|reactome:R-SCE-5689603|reactome:R-SCE-5689877|reactome:R-SCE-5689880|reactome:R-SCE-5689901|reactome:R-SCE-5696395|reactome:R-SCE-6781823|reactome:R-SCE-6782135|reactome:R-SCE-6782210|reactome:R-SCE-6791226|reactome:R-SCE-68949|reactome:R-SCE-69017|reactome:R-SCE-69601|reactome:R-SCE-72649|reactome:R-SCE-72689|reactome:R-SCE-72695|reactome:R-SCE-72702|reactome:R-SCE-72706|reactome:R-SCE-75815|reactome:R-SCE-8854050|reactome:R-SCE-8866652|reactome:R-SCE-8866654|reactome:R-SCE-8948747|reactome:R-SCE-8948751|reactome:R-SCE-901032|reactome:R-SCE-9020702|reactome:R-SCE-9033241|reactome:R-SCE-917729|reactome:R-SCE-9646399|reactome:R-SCE-975956|reactome:R-SCE-975957|reactome:R-SCE-983168|interpro:IPR000626(Ubiquitin)|sgd:S000003962|interpro:IPR019956|interpro:IPR019954|refseq:NP_013061.1|interpro:IPR029071|mint:P0CG63|mint:MINT-739558(identity)	sgd:S000005289|refseq:NP_014403.3|ensemblfungi:YNR006W(gene)|ensemblfungi:YNR006W_mRNA(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0009306"(protein secretion)|go:"GO:0010008"(endosome membrane)|go:"GO:0016237"(lysosomal microautophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0140504"(microlipophagy)|go:"GO:1903319"(positive regulation of protein maturation)|go:"GO:1904669"(ATP export)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|rcsb pdb:1O06|rcsb pdb:1Q0V|rcsb pdb:1Q0W|rcsb pdb:1VFY|rcsb pdb:2KDI|rcsb pdb:2PJW|rcsb pdb:3R42|rcsb pdb:6NJG|dip:DIP-1741N|mint:P40343|mint:MINT-739550(identity)	-	function:Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair|comment:mint|comment:"Stoichiometry: 1.0"	crc64:76C4501B0EBC9C84|comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/09/09	2014/10/16	rogid:+GNv/Jc7C11q8cgu2qZ6YkcsIeI559292	rogid:5ScB34gSI3x260kAGh/knEWupwA559292	intact-crc:7EC4AE5AFABB49EC|rigid:hkbUZQ4D9fuLlC5NUYrrZzUePEo	false	mutation decreasing interaction:47-47,68-68,44-44(MINT-739559)|tag:?-?(MINT-739563)	tag:?-?(MINT-739553)|binding-associated region:?-?(MINT-739551)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)