#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q61083	uniprotkb:Q9WVS7	intact:EBI-446134	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k2_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 2(gene name synonym)|uniprotkb:Map3k2(gene name)|psi-mi:Map3k2(display_short)|uniprotkb:Mekk2(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nakamura et al. (2003)	pubmed:12912994|mint:MINT-5216614	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-446222	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011009(Protein kinase-like)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034879|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/09/17	2014/10/16	rogid:5JLKwLioBelbHpow1mtYSJfUcsY10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:5AE76C77ED685B11|rigid:2Z+0UprZUlsV5qE7O+SQPAgFMFQ	false	glutathione s tranferase tag:?-?|sufficient binding region:35-127	his tag:?-?|sufficient binding region:10-102(IPR000270)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WVS7	uniprotkb:Q61083	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	intact:EBI-446134	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:m3k2_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 2(gene name synonym)|uniprotkb:Map3k2(gene name)|psi-mi:Map3k2(display_short)|uniprotkb:Mekk2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nakamura et al. (2003)	pubmed:12912994|mint:MINT-5216614	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-446239	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	interpro:IPR011009(Protein kinase-like)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034879|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/09/17	2014/10/16	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	rogid:5JLKwLioBelbHpow1mtYSJfUcsY10090	intact-crc:8367E45BE2F8BA30|rigid:2Z+0UprZUlsV5qE7O+SQPAgFMFQ	false	glutathione s tranferase tag:?-?|sufficient binding region:10-102(IPR000270)	his tag:?-?|sufficient binding region:35-127(IPR000270)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WVS7	uniprotkb:Q61084	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	intact:EBI-446250|ensembl:ENSMUSP00000002044	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nakamura et al. (2003)	pubmed:12912994|mint:MINT-5216614	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-446264	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/09/17	2014/10/16	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	intact-crc:91328491371DA8A6|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	sufficient binding region:10-102(IPR000270)|his tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:36-128(IPR000270)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WVS7	uniprotkb:Q61084	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	intact:EBI-446250|ensembl:ENSMUSP00000002044	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nakamura et al. (2003)	pubmed:12912994|mint:MINT-5216614	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-446274	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/09/17	2014/10/16	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	intact-crc:2B3C1F5A111EE838|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	glutathione s tranferase tag:?-?|sufficient binding region:35-127(IPR000270)	his tag:?-?|sufficient binding region:36-128(IPR000270)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61083	uniprotkb:Q9WVS7	intact:EBI-446134	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k2_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 2(gene name synonym)|uniprotkb:Map3k2(gene name)|psi-mi:Map3k2(display_short)|uniprotkb:Mekk2(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Nakamura et al. (2003)	pubmed:12912994|mint:MINT-5216614	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-446294	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011009(Protein kinase-like)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034879|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	go:"GO:0000186"(obsolete activation of MAPKK activity)	-	-	-	taxid:10090(mouse-foetal fibroblast)|taxid:10090(Mus musculus fetal fibroblast)	-	2004/09/17	2014/10/16	rogid:5JLKwLioBelbHpow1mtYSJfUcsY10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:791C628C9BB95739|rigid:2Z+0UprZUlsV5qE7O+SQPAgFMFQ	false	ha tag:?-?|mutation decreasing interaction:47-47	glutathione s tranferase tag:?-?|binding-associated region:10-102(IPR000270)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61084	uniprotkb:Q9WVS7	intact:EBI-446250|ensembl:ENSMUSP00000002044	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Nakamura et al. (2003)	pubmed:12912994|mint:MINT-5216614	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-446303	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	go:"GO:0000186"(obsolete activation of MAPKK activity)	-	-	-	taxid:10090(mouse-foetal fibroblast)|taxid:10090(Mus musculus fetal fibroblast)	-	2004/09/17	2014/10/16	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:CAB14D81FACD4540|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	ha tag:?-?	glutathione s tranferase tag:?-?|binding-associated region:10-102(IPR000270)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61083	uniprotkb:Q9WVS7	intact:EBI-446134	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k2_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 2(gene name synonym)|uniprotkb:Map3k2(gene name)|psi-mi:Map3k2(display_short)|uniprotkb:Mekk2(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Nakamura et al. (2003)	pubmed:12912994|mint:MINT-5216614	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-446324	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011009(Protein kinase-like)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034879|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	go:"GO:0000186"(obsolete activation of MAPKK activity)	-	-	-	taxid:10090(mouse-foetal fibroblast)|taxid:10090(Mus musculus fetal fibroblast)	-	2004/09/17	2014/10/16	rogid:5JLKwLioBelbHpow1mtYSJfUcsY10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:2A15AF781BE67075|rigid:2Z+0UprZUlsV5qE7O+SQPAgFMFQ	false	glutathione s tranferase tag:?-?|binding-associated region:?-?(IPR000270)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WVS7	uniprotkb:Q61084	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	intact:EBI-446250|ensembl:ENSMUSP00000002044	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Nakamura et al. (2003)	pubmed:12912994|mint:MINT-5216614	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-446332	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	go:"GO:0000186"(obsolete activation of MAPKK activity)	-	-	-	taxid:10090(mouse-foetal fibroblast)|taxid:10090(Mus musculus fetal fibroblast)	-	2004/09/17	2014/10/16	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	intact-crc:BA89A4CB6218C94D|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	-	glutathione s tranferase tag:?-?|binding-associated region:36-176(IPR000270)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)