#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P35609 uniprotkb:Q9Y561 intact:EBI-77797|uniprotkb:Q86TF4|ensembl:ENSP00000355537|uniprotkb:Q86TI8|uniprotkb:B1ANE4|intact:EBI-928705|uniprotkb:B2RCS5 intact:EBI-296693|uniprotkb:B4DRQ2|uniprotkb:A8K137|ensembl:ENSP00000276654 psi-mi:actn2_human(display_long)|uniprotkb:ACTN2(gene name)|psi-mi:ACTN2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym) psi-mi:lrp12_human(display_long)|uniprotkb:ST7(gene name synonym)|uniprotkb:LRP12(gene name)|psi-mi:LRP12(display_short)|uniprotkb:Suppressor of tumorigenicity 7 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Battle et al. (2003) pubmed:12809483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-353709 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001094.1|ensembl:ENSG00000077522(gene)|ensembl:ENST00000366578(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0007155"(cell adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:0030374"(nuclear receptor coactivator activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:P35609|rcsb pdb:1H8B|rcsb pdb:1HCI|rcsb pdb:1QUU|rcsb pdb:4D1E|rcsb pdb:5A36|rcsb pdb:5A37|rcsb pdb:5A38|rcsb pdb:5A4B|rcsb pdb:6SWT|rcsb pdb:6TS3|rcsb pdb:7A8T|rcsb pdb:7A8U|reactome:R-HSA-114608|go:"GO:2001259"(positive regulation of cation channel activity)|reactome:R-HSA-373753|reactome:R-HSA-390522|reactome:R-HSA-442982|reactome:R-HSA-5673001|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-438066|refseq:NP_001265272.1|refseq:NP_001265273.1|dip:DIP-383N refseq:NP_001129175.1|refseq:NP_038465.1|ensembl:ENSG00000147650(gene)|ensembl:ENST00000276654(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0040008"(regulation of growth)|interpro:IPR000859(CUB)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR023415|interpro:IPR035914|interpro:IPR036055|reactome:R-HSA-975634 - - - negative:This interaction does not occur under these experimental conditions.|comment:ST7 was V5/His tagged and ACTN2 was HA tagged.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2004/02/19 2014/10/16 rogid:9jws8DZxpttkzqPfDxEzORNnwcE9606 rogid:If6W5MknSGJo7Jx7ZcLHHI3tvrI9606 intact-crc:0DBADF72D1C0E150|rigid:Vtlw/Epjja87AMZp2sBOWBuYJdA true ha tag:?-? v5 tag:?-?|his tag:?-? - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:Q9Y561 uniprotkb:Q9UBF9 intact:EBI-296693|uniprotkb:B4DRQ2|uniprotkb:A8K137|ensembl:ENSP00000276654 intact:EBI-296701|uniprotkb:A0A4R6|uniprotkb:B4DT79 psi-mi:lrp12_human(display_long)|uniprotkb:ST7(gene name synonym)|uniprotkb:LRP12(gene name)|psi-mi:LRP12(display_short)|uniprotkb:Suppressor of tumorigenicity 7 protein(gene name synonym) psi-mi:myoti_human(display_long)|uniprotkb:MYOT(gene name)|psi-mi:MYOT(display_short)|uniprotkb:TTID(gene name synonym)|uniprotkb:Titin immunoglobulin domain protein(gene name synonym)|uniprotkb:Myofibrillar titin-like Ig domains protein(gene name synonym)|uniprotkb:57 kDa cytoskeletal protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Battle et al. (2003) pubmed:12809483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-353714 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129175.1|refseq:NP_038465.1|ensembl:ENSG00000147650(gene)|ensembl:ENST00000276654(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0040008"(regulation of growth)|interpro:IPR000859(CUB)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR023415|interpro:IPR035914|interpro:IPR036055|reactome:R-HSA-975634 go:"GO:0030424"(axon)|go:"GO:0042383"(sarcolemma)|go:"GO:0043025"(neuronal cell body)|go:"GO:0050808"(synapse organization)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0030018"(Z disc)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0015629"(actin cytoskeleton)|refseq:NP_001129412.1|refseq:NP_006781.1|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|rcsb pdb:2KDG|rcsb pdb:2KKQ|refseq:NP_001287840.1|interpro:IPR036179 - - - negative:This interaction does not occur under these experimental conditions.|comment:ST7 was V5/His tagged and TTID was HA tagged.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2004/02/19 2014/10/16 rogid:If6W5MknSGJo7Jx7ZcLHHI3tvrI9606 rogid:y7p/HY416pf0hNjpo0B5cRolBAk9606 intact-crc:E71F5E3252F017C5|rigid:b8T0uHT+LE5YCd36VK1Frnf3BYA true v5 tag:?-?|his tag:?-? ha tag:?-? - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot) uniprotkb:O95295 uniprotkb:Q9Y561 intact:EBI-296723|ensembl:ENSP00000357674|uniprotkb:Q5SXU8|uniprotkb:D3DV56 intact:EBI-296693|uniprotkb:B4DRQ2|uniprotkb:A8K137|ensembl:ENSP00000276654 psi-mi:snapn_human(display_long)|uniprotkb:SNAPIN(gene name)|psi-mi:SNAPIN(display_short)|uniprotkb:SNAP25BP(gene name synonym)|uniprotkb:SNAPAP(gene name synonym)|uniprotkb:Synaptosomal-associated protein 25-binding protein(gene name synonym)|uniprotkb:BLOC1S7(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 7(gene name synonym) psi-mi:lrp12_human(display_long)|uniprotkb:ST7(gene name synonym)|uniprotkb:LRP12(gene name)|psi-mi:LRP12(display_short)|uniprotkb:Suppressor of tumorigenicity 7 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Battle et al. (2003) pubmed:12809483 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-353721 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000143553(gene)|ensembl:ENST00000368685(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002177"(manchette)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0030141"(secretory granule)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0032438"(melanosome organization)|go:"GO:0034629"|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0051604"(protein maturation)|go:"GO:0072553"(terminal button organization)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0099078"(BORC complex)|go:"GO:1902774"(late endosome to lysosome transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR017246(Snapin)|interpro:IPR028119|reactome:R-HSA-432722|refseq:NP_036569.1 refseq:NP_001129175.1|refseq:NP_038465.1|ensembl:ENSG00000147650(gene)|ensembl:ENST00000276654(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0040008"(regulation of growth)|interpro:IPR000859(CUB)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR023415|interpro:IPR035914|interpro:IPR036055|reactome:R-HSA-975634 - - - negative:This interaction does not occur under these experimental conditions.|comment:ST7 was V5/His tagged and SNAP25BP was HA tagged.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2004/02/19 2014/10/16 rogid:V43p5MNgzla9VrcFKxPEIGWxYCM9606 rogid:If6W5MknSGJo7Jx7ZcLHHI3tvrI9606 intact-crc:8EEA427105F7D152|rigid:sVv0C2rwXIBRC3TPWrxfv+7G8C0 true ha tag:?-? v5 tag:?-?|his tag:?-? - - psi-mi:"MI:0072"(monoclonal antibody western blot) psi-mi:"MI:0072"(monoclonal antibody western blot)