#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NZ08	uniprotkb:P08887	intact:EBI-299412|uniprotkb:O60278|uniprotkb:Q6UWY6|uniprotkb:Q8NEL4|uniprotkb:Q8TAD0|uniprotkb:Q9UHF8|uniprotkb:Q9UKY2|ensembl:ENSP00000406304	intact:EBI-299383|ensembl:ENSP00000357470|uniprotkb:Q16202|uniprotkb:Q53EQ7|uniprotkb:Q5FWG2|uniprotkb:Q5VZ23|uniprotkb:B2R6V4|uniprotkb:A8KAE8	psi-mi:erap1_human(display_long)|uniprotkb:ERAP1(gene name)|psi-mi:ERAP1(display_short)|uniprotkb:APPILS(gene name synonym)|uniprotkb:KIAA0525(gene name synonym)|uniprotkb:UNQ584/PRO1154(orf name)|uniprotkb:ARTS1(gene name synonym)|uniprotkb:Adipocyte-derived leucine aminopeptidase(gene name synonym)|uniprotkb:ARTS-1(gene name synonym)|uniprotkb:Aminopeptidase PILS(gene name synonym)|uniprotkb:Puromycin-insensitive leucyl-specific aminopeptidase(gene name synonym)|uniprotkb:Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator(gene name synonym)	psi-mi:il6ra_human(display_long)|uniprotkb:IL6R(gene name)|psi-mi:IL6R(display_short)|uniprotkb:IL-6R 1(gene name synonym)|uniprotkb:Membrane glycoprotein 80(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Cui et al. (2003)	pubmed:12748171	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-299444	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035548.1|refseq:NP_001185470.1|refseq:NP_057526.3|refseq:XP_011541788.1|refseq:XP_016865071.1|ensembl:ENSG00000164307(gene)|ensembl:ENST00000443439(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005151"(interleukin-1, type II receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007165"(signal transduction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0042277"(peptide binding)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001930(Peptidase M1, membrane alanine aminopeptidase)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR024571|interpro:IPR027268|interpro:IPR033520|interpro:IPR034016|interpro:IPR042097|rcsb pdb:2YD0|rcsb pdb:3MDJ|rcsb pdb:3QNF|rcsb pdb:3RJO|rcsb pdb:5J5E|rcsb pdb:6M8P|rcsb pdb:6MGQ|rcsb pdb:6Q4R|rcsb pdb:6RQX|rcsb pdb:6RYF|rcsb pdb:6T6R|reactome:R-HSA-983170	go:"GO:0004915"(interleukin-6 receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|ensembl:ENSG00000160712(gene)|ensembl:ENST00000368485(transcript)|go:"GO:0002384"(hepatic immune response)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0006953"(acute-phase response)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0019981"(interleukin-6 binding)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034097"(response to cytokine)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070119"(ciliary neurotrophic factor binding)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1N26|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:2ARW|rcsb pdb:5FUC|rcsb pdb:7DC8|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6785807|reactome:R-HSA-9616222|reactome:R-HSA-9679191|refseq:NP_000556.1|refseq:NP_001193795.1|refseq:NP_852004.1|dip:DIP-162N	go:"GO:0005515"(protein binding)|pubmed:12748171(see-also)	-	-	comment:Arts1 interacts with the ectodomain of IL-6 receptor alpha,  which then cleaves by proteolysis and causes receptor shedding.|comment:Interaction between ARTS1 and the IL-6 receptor alpha ectodomain  promotes receptor shedding.	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2004/03/11	2014/10/16	rogid:YwzMurZ0SwOYFuQPNgMsr26YcMk9606	rogid:qV0FIgWdLU9dOASd1U1jOhFFdt09606	intact-crc:2BCF759B51083B45|rigid:OJzn7nv1Agi0HIB037TDjt+IdWU	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)