#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:F1LMY4	uniprotkb:P07221	intact:EBI-7811804|uniprotkb:Q9R272|intact:MINT-195292|uniprotkb:O35208|uniprotkb:Q9R1G1	intact:EBI-7811862|intact:MINT-195276	psi-mi:ryr1_rat(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:casq1_rabit(display_long)|uniprotkb:CASQ1(gene name)|psi-mi:CASQ1(display_short)|uniprotkb:Calsequestrin, skeletal muscle isoform(gene name synonym)|uniprotkb:Aspartactin(gene name synonym)|uniprotkb:Laminin-binding protein(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Nori et al. (2001)	pubmed:11281648|mint:MINT-5213885	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7811859|mint:MINT-49970	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0005509"(calcium ion binding)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|interpro:IPR033215|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR005821(Ion transport)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR011992(EF-Hand type)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR016093(MIR motif)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|rgd:1586637|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR043136|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|reactome:R-RNO-2672351|reactome:R-RNO-5578775|mint:MINT-472485(identity)	go:"GO:0000287"(magnesium ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0014809"(regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030955"(potassium ion binding)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0051258"(protein polymerization)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:1901341"(positive regulation of store-operated calcium channel activity)|go:"GO:2001256"(regulation of store-operated calcium entry)|interpro:IPR018233|rcsb pdb:3US3|rcsb pdb:1A8Y|rcsb pdb:3V1W|refseq:NP_001075737.1|rcsb pdb:3TRP|rcsb pdb:3TRQ|interpro:IPR036249|interpro:IPR001393(Calsequestrin)|interpro:IPR041858|interpro:IPR041859|interpro:IPR041860|mint:MINT-472478(identity)	-	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium. Also binds laminin|comment:"Stoichiometry: 1.0"	comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/06/17	2014/10/16	rogid:PqxKCrVBemfS55t3tS2vO2bK3pU10116	rogid:504SQklXQ8pUdMW6k/h+706d4Bs9986	intact-crc:42CF599054CB257C|rigid:vy9Y2qsQFiKjQR65zNknSNaEUOw	false	-	tag:?-?(MINT-472479)	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)