#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q99N80 uniprotkb:Q9CS84 intact:EBI-398182|uniprotkb:Q99J26 intact:EBI-399696|uniprotkb:O88722|uniprotkb:Q80Y87|uniprotkb:Q8CHE6|uniprotkb:G3UWZ9|ensembl:ENSMUSP00000124116 psi-mi:sytl1_mouse(display_long)|uniprotkb:Sytl1(gene name)|psi-mi:Sytl1(display_short)|uniprotkb:Slp1(gene name synonym)|uniprotkb:Exophilin-7(gene name synonym) psi-mi:nrx1a_mouse(display_long)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short)|uniprotkb:Neurexin I-alpha(gene name synonym)|uniprotkb:Kiaa0578(gene name synonym)|uniprotkb:Neurexin-1-alpha(gene name synonym) psi-mi:"MI:0096"(pull down) Fukuda et al. (2001) pubmed:11243866 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-399718 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR010911(Rab-binding)|interpro:IPR028378|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042470"(melanosome)|go:"GO:0070382"(exocytic vesicle)|interpro:IPR035892|reactome:R-MMU-8854214|interpro:IPR043567 refseq:NP_064648.3|refseq:NP_796258.2|refseq:XP_006523875.1|refseq:XP_006523874.1|refseq:XP_006523879.1|refseq:NP_001333891.1|ensembl:ENSMUSG00000024109(gene)|ensembl:ENSMUST00000161402(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099542"(trans-synaptic signaling by endocannabinoid)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027789|rcsb pdb:3BOD|rcsb pdb:3MW2|rcsb pdb:6PNP|rcsb pdb:6PNQ|reactome:R-MMU-6794361|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway) - - - comment:Q9CS84 was tagged with GST. Q99N80 was tagged with T7. Interaction was detected by HRP-conjugated anti-T7 tag antibody.|dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/08/17 2014/10/16 rogid:UI1Zt9BXKFPAN14MzHgS0LjH5pk10090 rogid:/fUMo/ju6izl+U1uBzDw5AaJMU010090 intact-crc:B65C3DCB58112009|rigid:3A99yWCBZQsYjSsMwpUkAmznAL0 false - glutathione s tranferase tag:?-? - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q9CS84 uniprotkb:Q99N50 intact:EBI-399696|uniprotkb:O88722|uniprotkb:Q80Y87|uniprotkb:Q8CHE6|uniprotkb:G3UWZ9|ensembl:ENSMUSP00000124116 intact:EBI-398197|uniprotkb:Q8BT37|uniprotkb:Q99J89|uniprotkb:Q99J90|uniprotkb:Q99N51|uniprotkb:Q99N52|uniprotkb:Q99N55|uniprotkb:Q99N56|ensembl:ENSMUSP00000139865|uniprotkb:B2RS48|uniprotkb:B7ZNS4 psi-mi:nrx1a_mouse(display_long)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short)|uniprotkb:Neurexin I-alpha(gene name synonym)|uniprotkb:Kiaa0578(gene name synonym)|uniprotkb:Neurexin-1-alpha(gene name synonym) psi-mi:sytl2_mouse(display_long)|uniprotkb:Sytl2(gene name)|psi-mi:Sytl2(display_short)|uniprotkb:Slp2(gene name synonym)|uniprotkb:Exophilin-4(gene name synonym) psi-mi:"MI:0096"(pull down) Fukuda et al. (2001) pubmed:11243866 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-399723 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_064648.3|refseq:NP_796258.2|refseq:XP_006523875.1|refseq:XP_006523874.1|refseq:XP_006523879.1|refseq:NP_001333891.1|ensembl:ENSMUSG00000024109(gene)|ensembl:ENSMUST00000161402(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099542"(trans-synaptic signaling by endocannabinoid)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027789|rcsb pdb:3BOD|rcsb pdb:3MW2|rcsb pdb:6PNP|rcsb pdb:6PNQ|reactome:R-MMU-6794361|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway) refseq:NP_001035174.1|refseq:NP_001035176.1|refseq:NP_001035177.1|refseq:NP_113571.2|mint:Q99N50|ensembl:ENSMUSG00000030616(gene)|ensembl:ENSMUST00000190731(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0016020"(membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042470"(melanosome)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR010911(Rab-binding)|interpro:IPR027006|interpro:IPR035892|interpro:IPR043567|refseq:NP_001276512.1|refseq:NP_001276513.1|refseq:NP_001276515.1 - - - comment:Q9CS84 was tagged with GST. Q99N50 was tagged with T7. Interaction was detected by HRP-conjugated anti-T7 tag antibody.|dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/08/17 2014/10/16 rogid:/fUMo/ju6izl+U1uBzDw5AaJMU010090 rogid:FVK87TesIR8E0y7FQh3/GwhLxyE10090 intact-crc:B0C360F472A9BAAB|rigid:dEEU6hfxQ35oOzAkq68Ftlm7ToU false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q99N48 uniprotkb:Q9CS84 intact:EBI-398260|uniprotkb:Q8C506|uniprotkb:Q99N47|uniprotkb:Q99N49|uniprotkb:Q99N54|uniprotkb:Q99N79|ensembl:ENSMUSP00000095041|uniprotkb:Q3KQQ0 intact:EBI-399696|uniprotkb:O88722|uniprotkb:Q80Y87|uniprotkb:Q8CHE6|uniprotkb:G3UWZ9|ensembl:ENSMUSP00000124116 psi-mi:sytl3_mouse(display_long)|uniprotkb:Sytl3(gene name)|psi-mi:Sytl3(display_short)|uniprotkb:Slp3(gene name synonym)|uniprotkb:Exophilin-6(gene name synonym) psi-mi:nrx1a_mouse(display_long)|uniprotkb:Nrxn1(gene name)|psi-mi:Nrxn1(display_short)|uniprotkb:Neurexin I-alpha(gene name synonym)|uniprotkb:Kiaa0578(gene name synonym)|uniprotkb:Neurexin-1-alpha(gene name synonym) psi-mi:"MI:0096"(pull down) Fukuda et al. (2001) pubmed:11243866 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-399731 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_113572.1|refseq:NP_899226.2|ensembl:ENSMUSG00000041831(gene)|ensembl:ENSMUST00000097430(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0070382"(exocytic vesicle)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028704|interpro:IPR035892|interpro:IPR041282|interpro:IPR043567|refseq:XP_006523322.1|refseq:XP_006523324.1|refseq:XP_006523326.1|refseq:XP_006523327.1|refseq:XP_011244483.1|refseq:XP_017173221.1 refseq:NP_064648.3|refseq:NP_796258.2|refseq:XP_006523875.1|refseq:XP_006523874.1|refseq:XP_006523879.1|refseq:NP_001333891.1|ensembl:ENSMUSG00000024109(gene)|ensembl:ENSMUST00000161402(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030534"(adult behavior)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071625"(vocalization behavior)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0097104"(postsynaptic membrane assembly)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097116"(gephyrin clustering involved in postsynaptic density assembly)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097119"(postsynaptic density protein 95 clustering)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099150"(regulation of postsynaptic specialization assembly)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099542"(trans-synaptic signaling by endocannabinoid)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1900020"(positive regulation of protein kinase C activity)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR027789|rcsb pdb:3BOD|rcsb pdb:3MW2|rcsb pdb:6PNP|rcsb pdb:6PNQ|reactome:R-MMU-6794361|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway) - - - comment:Q9CS84 was tagged with GST. Q99N48 was tagged with T7. Interaction was detected by HRP-conjugated anti-T7 tag antibody.|dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/08/17 2014/10/16 rogid:VIKzAhpG4xIYesswuoKoTjml5AI10090 rogid:/fUMo/ju6izl+U1uBzDw5AaJMU010090 intact-crc:CB62CABA5BF4BCD3|rigid:ecgkohRsAQgTjMGFateq9hJKGEI false - glutathione s tranferase tag:?-? - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot)