#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q99933 uniprotkb:P19120 intact:EBI-1030678|uniprotkb:O75315|uniprotkb:Q14414|uniprotkb:Q96TG2|uniprotkb:Q9Y2V4|uniprotkb:Q53H32|uniprotkb:Q5VZE8|uniprotkb:Q5VZE9|uniprotkb:Q5VZF0|ensembl:ENSP00000489189 intact:EBI-907802|ensembl:ENSBTAP00000017497|uniprotkb:A5D968|uniprotkb:Q3MHM4 psi-mi:bag1_human(display_long)|uniprotkb:BAG1(gene name)|psi-mi:BAG1(display_short)|uniprotkb:Bcl-2-associated athanogene 1(gene name synonym)|uniprotkb:HAP(gene name synonym) psi-mi:hsp7c_bovin(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Sondermann et al. (2001) pubmed:11222862|mint:MINT-5213584 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-1030705|rcsb pdb:1HX1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165886.1|refseq:NP_004314.5|ensembl:ENSG00000107262(gene)|ensembl:ENST00000634734(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|interpro:IPR017093(Molecular chaperone regulator BAG-1)|interpro:IPR029071|interpro:IPR036533|interpro:IPR039773|mint:Q99933|rcsb pdb:1HX1|rcsb pdb:1WXV|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|reactome:R-HSA-3371453|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|dip:DIP-3341N ensembl:ENSBTAG00000013162(gene)|ensembl:ENSBTAT00000017497(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030425"(dendrite)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0043195"(terminal bouton)|refseq:NP_776770.2|dip:DIP-35481N|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P19120|rcsb pdb:1ATR|rcsb pdb:1ATS|rcsb pdb:1BA0|rcsb pdb:1BA1|rcsb pdb:1BUP|rcsb pdb:1HPM|rcsb pdb:1HX1|rcsb pdb:1KAX|rcsb pdb:1KAY|rcsb pdb:1KAZ|rcsb pdb:1NGA|rcsb pdb:1NGB|rcsb pdb:1NGC|rcsb pdb:1NGE|rcsb pdb:1NGF|rcsb pdb:1NGG|rcsb pdb:1NGH|rcsb pdb:1NGI|rcsb pdb:1NGJ|rcsb pdb:1Q2G|rcsb pdb:1QQM|rcsb pdb:1QQN|rcsb pdb:1QQO|rcsb pdb:1YUW|rcsb pdb:2BUP|rcsb pdb:2QW9|rcsb pdb:2QWL|rcsb pdb:2QWM|rcsb pdb:2QWN|rcsb pdb:2QWO|rcsb pdb:2QWP|rcsb pdb:2QWQ|rcsb pdb:2QWR|rcsb pdb:3C7N|rcsb pdb:3HSC|rcsb pdb:4FL9|rcsb pdb:6H54|rcsb pdb:1NGD - - - assembly:dimeric, multimeric|3d-r-factors:working 76.600%, free 72.100%|3d-resolution:1.9A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/02/12 2014/10/16 rogid:wDyAGECTy45td5tL4mnwa1txPO49606 rogid:2jGKck/hDN0JJS+fla4JiYuPSJ89913 intact-crc:1AF80065F74E0E66|rigid:0qetd1OltqFVYoOtWxHdnWNCVZA false sufficient binding region:151-263 sufficient binding region:4-381 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)