#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P07385	uniprotkb:P0DSW3	intact:EBI-7352675|intact:MINT-139702	intact:EBI-7352729|intact:MINT-139714|uniprotkb:P33830	psi-mi:spi2_cwpxb(display_long)|uniprotkb:CRMA(gene name)|psi-mi:CRMA(display_short)|uniprotkb:SPI-2(gene name synonym)|uniprotkb:CPXV207(locus name)|uniprotkb:ICE inhibitor(gene name synonym)|uniprotkb:Cytokine response modifier protein A(gene name synonym)|uniprotkb:Hemorrhage-inducing 38 kDa protein(gene name synonym)	psi-mi:spi2_var67(display_long)|uniprotkb:SPI-2(gene name)|psi-mi:SPI-2(display_short)|uniprotkb:B13R(orf name)|uniprotkb:B12R(orf name)|uniprotkb:B14R(orf name)	psi-mi:"MI:0114"(x-ray crystallography)	Renatus et al. (2000)	pubmed:10903953|mint:MINT-5212804	taxid:265872(cpv)|taxid:265872("Cowpox virus (strain Brighton Red)")	taxid:587200(varv)|taxid:587200("Variola virus (isolate Human/India/Ind3/1967)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7352773|mint:MINT-24864	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-5218900|reactome:R-HSA-5357905|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|rcsb pdb:1F0C|rcsb pdb:1C8O|rcsb pdb:1M93|refseq:NP_619988.1|interpro:IPR023796|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039650"(suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR042178|interpro:IPR042185|interpro:IPR036186|reactome:R-HSA-9686347|mint:MINT-428042(identity)	go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039650"(suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR015557(Protease inhibitor I4, serpin B1)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|refseq:NP_042225.1|mint:MINT-428049(identity)	-	comment:mint|function:"Specific and potent inhibitor of the interleukin-1-beta converting enzyme (ICE) thereby suppressing an interleukin-1 beta response to infection. The inhibition of ICE by crmA is an example of a \"cross-class\" interaction, in which a serpin inhibits a non-serine proteinase. Also inhibits granzyme B"|comment:"Stoichiometry: 1.0"	comment:mint|function:May be involved in the regulation of the complement cascade|comment:"Stoichiometry: 1.0"	comment:In the xray complex 1f0c, P07385 is chain A and P33830 is chain B Resolution 2.260|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/02/12	2014/10/16	rogid:HOgWuJTdXfxKh9LZIyFsPVXlO4s265872	rogid:rsF616ZeUhN5Dim22+yH9uab31g587200	intact-crc:851D6BF65E486ABE|rigid:lRPOMSd+jCx5LMSwdjCoesEIdKY	false	tag:?-?(MINT-428043)	tag:?-?(MINT-428050)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)