#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P19803 uniprotkb:P60953-2 intact:EBI-603777|uniprotkb:Q3ZBA9 intact:EBI-287394|uniprotkb:P21181-4|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612 psi-mi:gdir1_bovin(display_long)|uniprotkb:Rho-GDI alpha(gene name synonym)|uniprotkb:ARHGDIA(gene name)|psi-mi:ARHGDIA(display_short) psi-mi:p60953-2(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)|uniprotkb:Placental(isoform synonym) psi-mi:"MI:0114"(x-ray crystallography) Hoffman et al. (2000) pubmed:10676816|mint:MINT-5212246 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-603770|rcsb pdb:1doa - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001772"(immunological synapse)|go:"GO:0005094"(Rho GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|refseq:NP_788823.1|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR000406(RHO protein GDP dissociation inhibitor)|rcsb pdb:1AJW|rcsb pdb:1DOA|rcsb pdb:1GDF|refseq:XP_005221068.2|rcsb pdb:5FR1|rcsb pdb:5FR2|interpro:IPR024792 intact:EBI-81752(cdc42_human)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript) - - - 3d-r-factors:working 25.7%, free 32.0%|3d-resolution:2.60A|comment:The geranylgeranyl linked to cysteine 188 of Cdc42 inserts into a hydrophobic pocket within the immunoglobulin-like domain of GDI.|caution:N-terminal GST-tag of GDI is cleaved but some amino acids remains|comment:Arg186, Tyr175, Pro166, Thr132, Tyr110, Gln130, Trp194, Leu75, Phe102, Leu88, Ile112, Leu77, Leu196, Ile177, Ile198, Leu104, Ile169, Ile14, Leu11 of GDI form the hydrophobic pocket. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/02/12 2014/10/16 rogid:oskgk4eHC8Vx/hcLZGubGRa7h0c9913 rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606 intact-crc:484EF523A6E75021|rigid:Gx2T4o8EQSYJ4WEwcrHLCYfTpqw false tag:n-n|binding-associated region:45-45|binding-associated region:47-47|binding-associated region:51-51|binding-associated region:42-42|binding-associated region:52-52|binding-associated region:30-30|binding-associated region:31-31|binding-associated region:186-186|binding-associated region:185-185|binding-associated region:149-149|binding-associated region:144-144|binding-associated region:143-143|binding-associated region:145-145|binding-associated region:131-131 tag:n-n|S-geranylgeranyl-L-cysteine:189-189|binding-associated region:1-188|binding-associated region:35-35|binding-associated region:35-35|binding-associated region:59-59|binding-associated region:64-64|binding-associated region:64-64|binding-associated region:66-66|binding-associated region:66-66|binding-associated region:66-66|binding-associated region:104-104|binding-associated region:105-105|binding-associated region:185-185|binding-associated region:187-187|binding-associated region:187-187|binding-associated region:187-187|binding-associated region:187-187|binding-associated region:187-187 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)