#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P24394	uniprotkb:P05112	intact:EBI-367009|uniprotkb:Q96P01|uniprotkb:Q9H181|uniprotkb:Q9H182|uniprotkb:Q9H183|uniprotkb:Q9H184|uniprotkb:Q9H185|uniprotkb:Q9H186|uniprotkb:Q9H187|uniprotkb:Q9H188|uniprotkb:B4E076|uniprotkb:B9EKU8|uniprotkb:H3BSY5|ensembl:ENSP00000379111|ensembl:ENSP00000441667	intact:EBI-367025|uniprotkb:Q14630|uniprotkb:Q6NZ77|ensembl:ENSP00000231449	psi-mi:il4ra_human(display_long)|uniprotkb:IL4R(gene name)|psi-mi:IL4R(display_short)|uniprotkb:582J2.1(orf name)|uniprotkb:IL4RA(gene name synonym)	psi-mi:il4_human(display_long)|uniprotkb:IL4(gene name)|psi-mi:IL4(display_short)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:Binetrakin(gene name synonym)|uniprotkb:Pitrakinra(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Hage et al. (1999)	pubmed:10219247|mint:MINT-5211389	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-1027723|rcsb pdb:1IAR	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001244336.1|refseq:NP_000409.1|refseq:XP_011544127.1|refseq:XP_011544128.1|refseq:XP_011544129.1|refseq:NP_001244335.1|go:"GO:0045626"(negative regulation of T-helper 1 cell differentiation)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901741"(positive regulation of myoblast fusion)|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3BPO|go:"GO:1990834"(response to odorant)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015319(Interleukin-4 receptor alpha chain, N-terminal)|interpro:IPR036116|rcsb pdb:1IAR|rcsb pdb:5E4E|rcsb pdb:6OEL|rcsb pdb:1IRS|rcsb pdb:1ITE|rcsb pdb:6WGL|reactome:R-HSA-6785807|ensembl:ENSG00000077238(gene)|ensembl:ENST00000395762(transcript)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENST00000543915(transcript)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043235"(receptor complex)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043627"(response to estrogen)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0004913"(interleukin-4 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0030728"(ovulation)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042127"(regulation of cell population proliferation)|dip:DIP-3223N	refseq:NP_000580.1|refseq:NP_758858.1|ensembl:ENSG00000113520(gene)|ensembl:ENST00000231449(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006955"(immune response)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|rcsb pdb:1BBN|rcsb pdb:1BCN|rcsb pdb:1CYL|rcsb pdb:1HIJ|rcsb pdb:1HIK|rcsb pdb:1HZI|rcsb pdb:1IAR|rcsb pdb:1ILL|rcsb pdb:1ITE|rcsb pdb:1ITI|rcsb pdb:1ITL|rcsb pdb:1ITM|rcsb pdb:1RCB|rcsb pdb:2B8U|rcsb pdb:2B8X|rcsb pdb:2B8Y|rcsb pdb:2B8Z|rcsb pdb:2B90|rcsb pdb:2B91|rcsb pdb:2CYK|rcsb pdb:2D48|rcsb pdb:2INT|rcsb pdb:3BPL|rcsb pdb:3BPN|rcsb pdb:3QB7|rcsb pdb:4YDY|rcsb pdb:5FHX|rcsb pdb:6OEL|reactome:R-HSA-6785807|reactome:R-HSA-9012546|interpro:IPR018096|dip:DIP-3222N	-	-	-	assembly:dimeric, multimeric|3d-r-factors:working 78.200%, free 71.100%|3d-resolution:2.3A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/02/12	2014/10/16	rogid:18E1cLQsvHGc0WRFqUzuGssLVg09606	rogid:Jmojsmx7uQfFInaExASOKFttPFk9606	intact-crc:852A506B98D4876F|rigid:DtvGhEVCBmLTfHPis5cgG5lD46Q	false	sufficient binding region:27-232	sufficient binding region:25-153	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)