#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9Z1P3 uniprotkb:O88498 intact:EBI-78982|uniprotkb:Q6AYY5|uniprotkb:Q9R289 intact:EBI-78989|uniprotkb:O88497|uniprotkb:Q9WUI8|ensembl:ENSRNOP00000039006 psi-mi:mcl1_rat(display_long)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short) psi-mi:b2l11_rat(display_long)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)|uniprotkb:Bod(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)|uniprotkb:Bcl-2-related ovarian death protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hsu et al. (1998) pubmed:9731710 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-78998 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|rgd:620525|refseq:NP_068618.2|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834 rgd:628774|refseq:NP_072134.1|refseq:NP_741985.1|refseq:NP_741986.1|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|ensembl:ENSRNOG00000016551(gene)|ensembl:ENSRNOT00000051069(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|reactome:R-RNO-111446|reactome:R-RNO-111453|reactome:R-RNO-193648 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2003/12/03 2014/10/16 rogid:qzZ1RBTNrN2Kn1BO+9O32U2ghjg10116 rogid:jFtj2slX+muL9h7EAtfpt9HOEgU10116 intact-crc:3453DB24A07B604D|rigid:0jLpopRZRq64QJBHcivg1xvis8Y false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88498 uniprotkb:Q9Z1P3 intact:EBI-78989|uniprotkb:O88497|uniprotkb:Q9WUI8|ensembl:ENSRNOP00000039006 intact:EBI-78982|uniprotkb:Q6AYY5|uniprotkb:Q9R289 psi-mi:b2l11_rat(display_long)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)|uniprotkb:Bod(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)|uniprotkb:Bcl-2-related ovarian death protein(gene name synonym) psi-mi:mcl1_rat(display_long)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short) psi-mi:"MI:0018"(two hybrid) Hsu et al. (1998) pubmed:9731710 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-79003 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:628774|refseq:NP_072134.1|refseq:NP_741985.1|refseq:NP_741986.1|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|ensembl:ENSRNOG00000016551(gene)|ensembl:ENSRNOT00000051069(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|reactome:R-RNO-111446|reactome:R-RNO-111453|reactome:R-RNO-193648 go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|rgd:620525|refseq:NP_068618.2|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2003/12/03 2014/10/16 rogid:jFtj2slX+muL9h7EAtfpt9HOEgU10116 rogid:qzZ1RBTNrN2Kn1BO+9O32U2ghjg10116 intact-crc:B011B1E4465B688D|rigid:0jLpopRZRq64QJBHcivg1xvis8Y false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P49950 uniprotkb:O88498 intact:EBI-79006|uniprotkb:Q62837|uniprotkb:Q64032 intact:EBI-78989|uniprotkb:O88497|uniprotkb:Q9WUI8|ensembl:ENSRNOP00000039006 psi-mi:bcl2_rat(display_long)|uniprotkb:Bcl2(gene name)|psi-mi:Bcl2(display_short)|uniprotkb:Bcl-2(gene name synonym) psi-mi:b2l11_rat(display_long)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)|uniprotkb:Bod(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)|uniprotkb:Bcl-2-related ovarian death protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hsu et al. (1998) pubmed:9731710 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-79017 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001503"(ossification)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002020"(protease binding)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002520"(immune system development)|go:"GO:0002931"(response to ischemia)|go:"GO:0003014"(renal system process)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006808"(regulation of nitrogen utilization)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007015"(actin filament organization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0007569"(cell aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009408"(response to heat)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0010559"(regulation of glycoprotein biosynthetic process)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015267"(channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016248"(channel inhibitor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031000"(response to caffeine)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031103"(axon regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032835"(glomerulus development)|go:"GO:0032848"(negative regulation of cellular pH reduction)|go:"GO:0032868"(response to insulin)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033033"(negative regulation of myeloid cell apoptotic process)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034284"(response to monosaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035094"(response to nicotine)|go:"GO:0035265"(organ growth)|go:"GO:0036017"(response to erythropoietin)|go:"GO:0040008"(regulation of growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043375"(CD8-positive, alpha-beta T cell lineage commitment)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043473"(pigmentation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043583"(ear development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045471"(response to ethanol)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046671"(negative regulation of retinal cell programmed cell death)|go:"GO:0046688"(response to copper ion)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046930"(pore complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048087"(positive regulation of developmental pigmentation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048599"(oocyte development)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0048753"(pigment granule organization)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051400"(BH domain binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051593"(response to folic acid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0080184"(response to phenylpropanoid)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097421"(liver regeneration)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902618"(cellular response to fluoride)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013278(Apoptosis regulator, Bcl-2)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rgd:2199|refseq:NP_058689.1|reactome:R-RNO-111447|reactome:R-RNO-111453|reactome:R-RNO-844455|dip:DIP-30849N rgd:628774|refseq:NP_072134.1|refseq:NP_741985.1|refseq:NP_741986.1|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|ensembl:ENSRNOG00000016551(gene)|ensembl:ENSRNOT00000051069(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|reactome:R-RNO-111446|reactome:R-RNO-111453|reactome:R-RNO-193648 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2003/12/03 2014/10/16 rogid:WVpo/E3f4v7XQtAlqYuUk8plUCU10116 rogid:jFtj2slX+muL9h7EAtfpt9HOEgU10116 intact-crc:68021ECC34EA3890|rigid:GJTtWPGmFM6rFjio6owhSY9IS20 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88498 uniprotkb:P53563 intact:EBI-78989|uniprotkb:O88497|uniprotkb:Q9WUI8|ensembl:ENSRNOP00000039006 intact:EBI-79042|uniprotkb:P70613|uniprotkb:P70614|uniprotkb:Q52KS0|uniprotkb:Q62678|uniprotkb:Q62836|uniprotkb:Q64087|ensembl:ENSRNOP00000010762|uniprotkb:Q64128 psi-mi:b2l11_rat(display_long)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)|uniprotkb:Bod(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)|uniprotkb:Bcl-2-related ovarian death protein(gene name synonym) psi-mi:b2cl1_rat(display_long)|uniprotkb:Bcl2l1(gene name)|psi-mi:Bcl2l1(display_short)|uniprotkb:Bclx(gene name synonym)|uniprotkb:Blc2l(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hsu et al. (1998) pubmed:9731710 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-79058 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:628774|refseq:NP_072134.1|refseq:NP_741985.1|refseq:NP_741986.1|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|ensembl:ENSRNOG00000016551(gene)|ensembl:ENSRNOT00000051069(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|reactome:R-RNO-111446|reactome:R-RNO-111453|reactome:R-RNO-193648 rgd:2200|refseq:NP_001028842.1|refseq:NP_001028843.1|refseq:NP_113723.2|interpro:IPR013279(Apoptosis regulator, Bcl-X)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rcsb pdb:1AF3|rcsb pdb:4QNQ|reactome:R-RNO-111453|reactome:R-RNO-844455|reactome:R-RNO-9648002|ensembl:ENSRNOG00000007946(gene)|ensembl:ENSRNOT00000010762(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002931"(response to ischemia)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009566"(fertilization)|go:"GO:0009615"(response to virus)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010288"(response to lead ion)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030276"(clathrin binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034097"(response to cytokine)|go:"GO:0035690"|go:"GO:0036017"(response to erythropoietin)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0036466"(synaptic vesicle recycling via endosome)|go:"GO:0040008"(regulation of growth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046898"(response to cycloheximide)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051400"(BH domain binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071839"(apoptotic process in bone marrow cell)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0098793"(presynapse)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1904579"(cellular response to thapsigargin)|go:"GO:1905218"(cellular response to astaxanthin)|go:"GO:1990646"(cellular response to prolactin)|go:"GO:2000302"(positive regulation of synaptic vesicle exocytosis)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|refseq:XP_006235327.1|dip:DIP-29698N - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2003/12/03 2014/10/16 rogid:jFtj2slX+muL9h7EAtfpt9HOEgU10116 rogid:m7nX0kI88bULKwTHnxoTthhv8ZY10116 intact-crc:C11DBB58334E12DF|rigid:POh5SSp/6KkMr3L04nwam5D5U1g false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88498 uniprotkb:O88996 intact:EBI-78989|uniprotkb:O88497|uniprotkb:Q9WUI8|ensembl:ENSRNOP00000039006 intact:EBI-79061|ensembl:ENSRNOP00000020409 psi-mi:b2l11_rat(display_long)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)|uniprotkb:Bod(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)|uniprotkb:Bcl-2-related ovarian death protein(gene name synonym) psi-mi:o88996_rat(display_long)|uniprotkb:Bcl2l2(gene name)|psi-mi:Bcl2l2(display_short)|uniprotkb:bcl-w(gene name synonym)|uniprotkb:rCG_23437(orf name) psi-mi:"MI:0018"(two hybrid) Hsu et al. (1998) pubmed:9731710 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-79070 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:628774|refseq:NP_072134.1|refseq:NP_741985.1|refseq:NP_741986.1|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|ensembl:ENSRNOG00000016551(gene)|ensembl:ENSRNOT00000051069(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|reactome:R-RNO-111446|reactome:R-RNO-111453|reactome:R-RNO-193648 ensembl:ENSRNOG00000015732(gene)|ensembl:ENSRNOT00000020409(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|rgd:620717|refseq:NP_068622.1|refseq:XP_006252078.1|refseq:XP_017455283.1 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2003/12/03 2014/10/16 rogid:jFtj2slX+muL9h7EAtfpt9HOEgU10116 rogid:KFNuKmXonDyk57imSu/ooITu9OI10116 intact-crc:4F0B82E4A58F8957|rigid:Lhbhjy8LxEoASYXB8uoOSYjzWyc false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O88498 uniprotkb:Q925A9 intact:EBI-78989|uniprotkb:O88497|uniprotkb:Q9WUI8|ensembl:ENSRNOP00000039006 intact:EBI-79073 psi-mi:b2l11_rat(display_long)|uniprotkb:Bcl2l11(gene name)|psi-mi:Bcl2l11(display_short)|uniprotkb:Bim(gene name synonym)|uniprotkb:Bod(gene name synonym)|uniprotkb:Bcl2-interacting mediator of cell death(gene name synonym)|uniprotkb:Bcl-2-related ovarian death protein(gene name synonym) psi-mi:q925a9_rat(display_long)|uniprotkb:Bcl2a1(gene name)|psi-mi:Bcl2a1(display_short)|uniprotkb:Bcl2a1d(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hsu et al. (1998) pubmed:9731710 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-79081 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:628774|refseq:NP_072134.1|refseq:NP_741985.1|refseq:NP_741986.1|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|ensembl:ENSRNOG00000016551(gene)|ensembl:ENSRNOT00000051069(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001822"(kidney development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007127"(meiosis I)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030879"(mammary gland development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035148"(tube formation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043583"(ear development)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048070"(regulation of developmental pigmentation)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048563"(post-embryonic animal organ morphogenesis)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0070242"(thymocyte apoptotic process)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1902110"(positive regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|interpro:IPR014771(Apoptosis, Bim N-terminal)|interpro:IPR015040(Bcl-x interacting)|interpro:IPR017288(Apoptosis, Bcl-2-like protein 11)|reactome:R-RNO-111446|reactome:R-RNO-111453|reactome:R-RNO-193648 interpro:IPR020726|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007568"(aging)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|rgd:620621|refseq:NP_596907.1|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR026298|interpro:IPR036834 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2003/12/03 2014/10/16 rogid:jFtj2slX+muL9h7EAtfpt9HOEgU10116 rogid:dMgvp1fy7oMM/I+bxsKciCJj1NU10116 intact-crc:28A97D9D97574547|rigid:RPKES1Qo/hjiTxZibNyIq8UUPFQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)