#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P20273	uniprotkb:P27986	intact:EBI-78277|ensembl:ENSP00000085219|uniprotkb:O95699|uniprotkb:O95701|uniprotkb:O95702|uniprotkb:O95703|uniprotkb:Q01665|uniprotkb:Q92872|uniprotkb:Q92873|uniprotkb:Q9UQA6|uniprotkb:Q9UQA7|uniprotkb:Q9UQA8|uniprotkb:Q9UQA9|uniprotkb:Q9UQB0|uniprotkb:Q9Y2A6|uniprotkb:Q32M46|uniprotkb:F5H7U3|uniprotkb:F5GYU4	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	psi-mi:cd22_human(display_long)|uniprotkb:CD22(gene name)|psi-mi:CD22(display_short)|uniprotkb:Sialic acid-binding Ig-like lectin 2(gene name synonym)|uniprotkb:T-cell surface antigen Leu-14(gene name synonym)|uniprotkb:B-lymphocyte cell adhesion molecule(gene name synonym)|uniprotkb:SIGLEC2(gene name synonym)	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Tuscano et al. (1996)	pubmed:8647200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-79477	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000012124(gene)|ensembl:ENST00000085219(transcript)|go:"GO:0001791"(IgM binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030888"(regulation of B cell proliferation)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0042113"(B cell activation)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5VKJ|rcsb pdb:5VKM|go:"GO:0055037"(recycling endosome)|rcsb pdb:5VL3|reactome:R-HSA-198933|reactome:R-HSA-5690714|reactome:R-HSA-983695|refseq:NP_001172028.1|refseq:NP_001172029.1|refseq:NP_001172030.1|refseq:NP_001762.2|refseq:NP_001265346.1	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042113"(B cell activation)	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2003/12/05	2014/10/16	rogid:oW0fQLFE0bGlTEig2FuboCYuLag9606	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	intact-crc:7C11515D3B1CF7FD|rigid:NxyQ14HW4iSTN5mgPGEUNuK035E	false	sufficient binding region:707..707-847	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P20273	uniprotkb:P43405	intact:EBI-78277|ensembl:ENSP00000085219|uniprotkb:O95699|uniprotkb:O95701|uniprotkb:O95702|uniprotkb:O95703|uniprotkb:Q01665|uniprotkb:Q92872|uniprotkb:Q92873|uniprotkb:Q9UQA6|uniprotkb:Q9UQA7|uniprotkb:Q9UQA8|uniprotkb:Q9UQA9|uniprotkb:Q9UQB0|uniprotkb:Q9Y2A6|uniprotkb:Q32M46|uniprotkb:F5H7U3|uniprotkb:F5GYU4	intact:EBI-78302|ensembl:ENSP00000364898|ensembl:ENSP00000364907	psi-mi:cd22_human(display_long)|uniprotkb:CD22(gene name)|psi-mi:CD22(display_short)|uniprotkb:Sialic acid-binding Ig-like lectin 2(gene name synonym)|uniprotkb:T-cell surface antigen Leu-14(gene name synonym)|uniprotkb:B-lymphocyte cell adhesion molecule(gene name synonym)|uniprotkb:SIGLEC2(gene name synonym)	psi-mi:ksyk_human(display_long)|uniprotkb:SYK(gene name)|psi-mi:SYK(display_short)|uniprotkb:Spleen tyrosine kinase(gene name synonym)|uniprotkb:p72-Syk(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Tuscano et al. (1996)	pubmed:8647200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-79477	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000012124(gene)|ensembl:ENST00000085219(transcript)|go:"GO:0001791"(IgM binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030888"(regulation of B cell proliferation)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0042113"(B cell activation)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5VKJ|rcsb pdb:5VKM|go:"GO:0055037"(recycling endosome)|rcsb pdb:5VL3|reactome:R-HSA-198933|reactome:R-HSA-5690714|reactome:R-HSA-983695|refseq:NP_001172028.1|refseq:NP_001172029.1|refseq:NP_001172030.1|refseq:NP_001762.2|refseq:NP_001265346.1	refseq:NP_001128524.1|refseq:NP_001167638.1|refseq:NP_001167639.1|refseq:NP_003168.2|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043313"(regulation of neutrophil degranulation)|go:"GO:0043366"(beta selection)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051712"(positive regulation of killing of cells of another organism)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0071396"(cellular response to lipid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090237"(regulation of arachidonic acid secretion)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012234(Tyrosine protein kinase, SYK/ZAP-70)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR023420|interpro:IPR035838|interpro:IPR036860|mint:P43405|rcsb pdb:1A81|rcsb pdb:1CSY|rcsb pdb:1CSZ|rcsb pdb:1XBA|rcsb pdb:1XBB|rcsb pdb:1XBC|rcsb pdb:3BUW|rcsb pdb:3EMG|rcsb pdb:3FQE|rcsb pdb:3FQH|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031623"(receptor internalization)|go:"GO:0032009"(early phagosome)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032752"(positive regulation of interleukin-3 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032928"(regulation of superoxide anion generation)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0016170"(interleukin-15 receptor binding)|rcsb pdb:3FQS|rcsb pdb:3SRV|rcsb pdb:3TUB|rcsb pdb:3TUC|rcsb pdb:3TUD|rcsb pdb:3VF8|rcsb pdb:3VF9|rcsb pdb:4DFL|rcsb pdb:4DFN|rcsb pdb:4F4P|rcsb pdb:4FL1|rcsb pdb:4FL2|rcsb pdb:4FL3|rcsb pdb:4FYN|rcsb pdb:4FYO|rcsb pdb:4FZ6|rcsb pdb:4FZ7|rcsb pdb:4GFG|rcsb pdb:4I0R|ensembl:ENSG00000165025(gene)|ensembl:ENST00000375746(transcript)|ensembl:ENST00000375754(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002554"(serotonin secretion by platelet)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|rcsb pdb:4I0S|rcsb pdb:4I0T|rcsb pdb:4PUZ|rcsb pdb:4PV0|rcsb pdb:4PX6|rcsb pdb:4RSS|rcsb pdb:4RX7|rcsb pdb:4RX8|rcsb pdb:4RX9|rcsb pdb:4WNM|rcsb pdb:4XG2|rcsb pdb:4XG3|rcsb pdb:5TIU|rcsb pdb:5TR6|rcsb pdb:5TT7|rcsb pdb:5Y5T|rcsb pdb:5Y5U|rcsb pdb:6HM6|rcsb pdb:6HM7|rcsb pdb:6SSB|rcsb pdb:6VOV|rcsb pdb:6ZC0|rcsb pdb:6ZCP|rcsb pdb:6ZCQ|rcsb pdb:6ZCR|rcsb pdb:6ZCS|rcsb pdb:6ZCU|rcsb pdb:6ZCX|rcsb pdb:6ZCY|rcsb pdb:4XG4|reactome:R-HSA-114604|reactome:R-HSA-2029481|reactome:R-HSA-2029482|rcsb pdb:4XG7|rcsb pdb:4XG8|rcsb pdb:4XG9|rcsb pdb:4YJO|rcsb pdb:4YJP|rcsb pdb:4YJQ|rcsb pdb:4YJR|rcsb pdb:4YJS|rcsb pdb:4YJT|rcsb pdb:4YJU|rcsb pdb:4YJV|rcsb pdb:5C26|rcsb pdb:5C27|rcsb pdb:5CXH|rcsb pdb:5CXZ|rcsb pdb:5CY3|rcsb pdb:5GHV|rcsb pdb:5LMA|rcsb pdb:4XG6|rcsb pdb:5LMB|rcsb pdb:5T68|refseq:XP_011517248.1|refseq:XP_005252204.1|reactome:R-HSA-2029485|reactome:R-HSA-2424491|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354192|reactome:R-HSA-5607764|reactome:R-HSA-5621480|reactome:R-HSA-9020558|reactome:R-HSA-912631|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9706374|reactome:R-HSA-983695|dip:DIP-253N	go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042113"(B cell activation)	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2003/12/05	2014/10/16	rogid:oW0fQLFE0bGlTEig2FuboCYuLag9606	rogid:SAOtCMFKG07Wej573EklHjusYVA9606	intact-crc:7C11515D3B1CF7FD|rigid:NxyQ14HW4iSTN5mgPGEUNuK035E	false	sufficient binding region:707..707-847	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P20273	uniprotkb:P07948	intact:EBI-78277|ensembl:ENSP00000085219|uniprotkb:O95699|uniprotkb:O95701|uniprotkb:O95702|uniprotkb:O95703|uniprotkb:Q01665|uniprotkb:Q92872|uniprotkb:Q92873|uniprotkb:Q9UQA6|uniprotkb:Q9UQA7|uniprotkb:Q9UQA8|uniprotkb:Q9UQA9|uniprotkb:Q9UQB0|uniprotkb:Q9Y2A6|uniprotkb:Q32M46|uniprotkb:F5H7U3|uniprotkb:F5GYU4	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	psi-mi:cd22_human(display_long)|uniprotkb:CD22(gene name)|psi-mi:CD22(display_short)|uniprotkb:Sialic acid-binding Ig-like lectin 2(gene name synonym)|uniprotkb:T-cell surface antigen Leu-14(gene name synonym)|uniprotkb:B-lymphocyte cell adhesion molecule(gene name synonym)|uniprotkb:SIGLEC2(gene name synonym)	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Tuscano et al. (1996)	pubmed:8647200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-79477	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000012124(gene)|ensembl:ENST00000085219(transcript)|go:"GO:0001791"(IgM binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030888"(regulation of B cell proliferation)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0042113"(B cell activation)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5VKJ|rcsb pdb:5VKM|go:"GO:0055037"(recycling endosome)|rcsb pdb:5VL3|reactome:R-HSA-198933|reactome:R-HSA-5690714|reactome:R-HSA-983695|refseq:NP_001172028.1|refseq:NP_001172029.1|refseq:NP_001172030.1|refseq:NP_001762.2|refseq:NP_001265346.1	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042113"(B cell activation)	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2003/12/05	2014/10/16	rogid:oW0fQLFE0bGlTEig2FuboCYuLag9606	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	intact-crc:7C11515D3B1CF7FD|rigid:NxyQ14HW4iSTN5mgPGEUNuK035E	false	sufficient binding region:707..707-847	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07948	uniprotkb:P20273	intact:EBI-79452|ensembl:ENSP00000428924|uniprotkb:A0AVQ5|intact:EBI-6868890	intact:EBI-78277|ensembl:ENSP00000085219|uniprotkb:O95699|uniprotkb:O95701|uniprotkb:O95702|uniprotkb:O95703|uniprotkb:Q01665|uniprotkb:Q92872|uniprotkb:Q92873|uniprotkb:Q9UQA6|uniprotkb:Q9UQA7|uniprotkb:Q9UQA8|uniprotkb:Q9UQA9|uniprotkb:Q9UQB0|uniprotkb:Q9Y2A6|uniprotkb:Q32M46|uniprotkb:F5H7U3|uniprotkb:F5GYU4	psi-mi:lyn_human(display_long)|uniprotkb:JTK8(gene name synonym)|uniprotkb:Lck/Yes-related novel protein tyrosine kinase(gene name synonym)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)|uniprotkb:LYN(gene name)|psi-mi:LYN(display_short)	psi-mi:cd22_human(display_long)|uniprotkb:CD22(gene name)|psi-mi:CD22(display_short)|uniprotkb:Sialic acid-binding Ig-like lectin 2(gene name synonym)|uniprotkb:T-cell surface antigen Leu-14(gene name synonym)|uniprotkb:B-lymphocyte cell adhesion molecule(gene name synonym)|uniprotkb:SIGLEC2(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Tuscano et al. (1996)	pubmed:8647200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-79888	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104567.1|refseq:NP_002341.1|ensembl:ENSG00000254087(gene)|reactome:R-HSA-9664422|reactome:R-HSA-9670439|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-983695|reactome:R-HSA-9664323|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|ensembl:ENST00000519728(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016301"(kinase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032868"(response to insulin)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P07948|rcsb pdb:1W1F|rcsb pdb:1WA7|go:"GO:0099091"(postsynaptic specialization, intracellular component)|rcsb pdb:5XY1|rcsb pdb:6NMW|reactome:R-HSA-114604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-210990|reactome:R-HSA-2454202|reactome:R-HSA-2682334|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-389356|reactome:R-HSA-389513|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-3928665|reactome:R-HSA-5621480|rcsb pdb:3A4O|reactome:R-HSA-5621575|reactome:R-HSA-5690714|reactome:R-HSA-69231|reactome:R-HSA-75892|reactome:R-HSA-9006335|reactome:R-HSA-9027276|reactome:R-HSA-9027277|reactome:R-HSA-9027283|reactome:R-HSA-9027284|reactome:R-HSA-912631|refseq:XP_016868905.1|dip:DIP-1056N	ensembl:ENSG00000012124(gene)|ensembl:ENST00000085219(transcript)|go:"GO:0001791"(IgM binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030888"(regulation of B cell proliferation)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033691"(sialic acid binding)|go:"GO:0042113"(B cell activation)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:5VKJ|rcsb pdb:5VKM|go:"GO:0055037"(recycling endosome)|rcsb pdb:5VL3|reactome:R-HSA-198933|reactome:R-HSA-5690714|reactome:R-HSA-983695|refseq:NP_001172028.1|refseq:NP_001172029.1|refseq:NP_001172030.1|refseq:NP_001762.2|refseq:NP_001265346.1	go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042113"(B cell activation)	-	-	dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2003/12/05	2014/10/16	rogid:SqXPSC+g2ZuGHy6TAPV4HcpXe6U9606	rogid:oW0fQLFE0bGlTEig2FuboCYuLag9606	intact-crc:2DDB8C5F651F085E|rigid:X4Q+s3ACyNX7w0ddHvwQ0A7gego	false	-	O4'-phospho-L-tyrosine:?-?|binding-associated region:803-826	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q92569	uniprotkb:P15391	intact:EBI-79893|intact:EBI-28975437|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|uniprotkb:O60482|uniprotkb:Q5T4P2|uniprotkb:B2R9C1|uniprotkb:Q5T4P1|uniprotkb:D3DQ12	intact:EBI-79902|uniprotkb:A0N0P9|ensembl:ENSP00000437940|uniprotkb:Q96S68|uniprotkb:Q9BRD6|uniprotkb:F5H635	psi-mi:p55g_human(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:PIK3R3(gene name)|psi-mi:PIK3R3(display_short)|uniprotkb:p55PIK(gene name synonym)	psi-mi:cd19_human(display_long)|uniprotkb:CD19(gene name)|psi-mi:CD19(display_short)|uniprotkb:Differentiation antigen CD19(gene name synonym)|uniprotkb:B-lymphocyte surface antigen B4(gene name synonym)|uniprotkb:T-cell surface antigen Leu-12(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Tuscano et al. (1996)	pubmed:8647200	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-79912	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9670439|ensembl:ENSG00000117461(gene)|ensembl:ENST00000262741(transcript)|ensembl:ENST00000372006(transcript)|ensembl:ENST00000420542(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR036860|mint:Q92569|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-512988|reactome:R-HSA-6811558|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-HSA-8853659|reactome:R-HSA-9009391|refseq:NP_001107644.1|refseq:NP_003620.3|ensembl:ENSP00000262741|ensembl:ENSP00000361075|ensembl:ENSP00000412546|ensembl:ENST00000423209|ensembl:ENSP00000391431|dip:DIP-30925N|refseq:NP_001290358.1|refseq:XP_016858103.1	ensembl:ENSG00000177455(gene)|ensembl:ENST00000538922(transcript)|go:"GO:0001923"(B-1 B cell differentiation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042341|mint:P15391|rcsb pdb:6AL5|rcsb pdb:7JIC|reactome:R-HSA-1257604|reactome:R-HSA-198933|reactome:R-HSA-2219530|reactome:R-HSA-6811558|reactome:R-HSA-977606|reactome:R-HSA-983695|refseq:NP_001171569.1|refseq:NP_001761.3	go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042113"(B cell activation)	-	-	agonist:Cells stimulated by cross-linking CD19|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2003/12/05	2014/10/16	rogid:oIVTuGRhg/Kn3h+Br1EfiAtiAQQ9606	rogid:RXBn8jYrGc1LM3POARtQeEzKWoI9606	intact-crc:BFCA79775EB00244|rigid:/JcSY2k+RJIv85xEbmAPz71gI2Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)