#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04351	uniprotkb:P34902	intact:EBI-80538|ensembl:ENSMUSP00000029275|uniprotkb:P97945|uniprotkb:Q791T3	intact:EBI-80548|ensembl:ENSMUSP00000033664	psi-mi:il2_mouse(display_long)|uniprotkb:Il2(gene name)|psi-mi:Il2(display_short)|uniprotkb:Il-2(gene name synonym)|uniprotkb:T-cell growth factor(gene name synonym)	psi-mi:il2rg_mouse(display_long)|uniprotkb:Il2rg(gene name)|psi-mi:Il2rg(display_short)|uniprotkb:p64(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)	psi-mi:"MI:0031"(protein cross-linking with a bifunctional reagent)	Kondo et al. (1993)	pubmed:8266076	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-80556	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0008083"(growth factor activity)|go:"GO:0010467"(gene expression)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031851"(kappa-type opioid receptor binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045591"(positive regulation of regulatory T cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046013"(regulation of T cell homeostatic proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050672"(negative regulation of lymphocyte proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|interpro:IPR000779(Interleukin-2)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR030477|rcsb pdb:4YQX|rcsb pdb:4YUE|go:"GO:0060999"(positive regulation of dendritic spine development)|ensembl:ENSMUSG00000027720(gene)|ensembl:ENSMUST00000029275(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005134"(interleukin-2 receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|refseq:NP_032392.1	ensembl:ENSMUSG00000031304(gene)|ensembl:ENSMUST00000033664(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0019955"(cytokine binding)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:6DG5|reactome:R-MMU-1266695|reactome:R-MMU-5673001|reactome:R-MMU-6785807|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-912526|refseq:NP_038591.1	-	-	-	comment:Il2 was affinity labelled. Proteins were crosslinked before cell lysis.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/12/12	2014/10/16	rogid:WQgLUXMJmlI/JZ1GRJv5LuopoEE10090	rogid:AyGKTLNBywo1T6oOc6QrS9J2R3U10090	intact-crc:9624A49A679A54E9|rigid:5x2BNIh38K6XalODEIdb/IlZk2w	false	radiolabel:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P34902	uniprotkb:P07750	intact:EBI-80548|ensembl:ENSMUSP00000033664	intact:EBI-80559|ensembl:ENSMUSP00000000889	psi-mi:il2rg_mouse(display_long)|uniprotkb:Il2rg(gene name)|psi-mi:Il2rg(display_short)|uniprotkb:p64(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)	psi-mi:il4_mouse(display_long)|uniprotkb:Il4(gene name)|psi-mi:Il4(display_short)|uniprotkb:Il-4(gene name synonym)|uniprotkb:B-cell stimulatory factor 1(gene name synonym)|uniprotkb:Lymphocyte stimulatory factor 1(gene name synonym)|uniprotkb:IGG1 induction factor(gene name synonym)|uniprotkb:B-cell growth factor 1(gene name synonym)|uniprotkb:B-cell IgG differentiation factor(gene name synonym)	psi-mi:"MI:0031"(protein cross-linking with a bifunctional reagent)	Kondo et al. (1993)	pubmed:8266076	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-80573	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031304(gene)|ensembl:ENSMUST00000033664(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0019955"(cytokine binding)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:6DG5|reactome:R-MMU-1266695|reactome:R-MMU-5673001|reactome:R-MMU-6785807|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-912526|refseq:NP_038591.1	ensembl:ENSMUSG00000000869(gene)|ensembl:ENSMUST00000000889(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005136"(interleukin-4 receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006914"(autophagy)|go:"GO:0008083"(growth factor activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010155"(regulation of proton transport)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031296"(B cell costimulation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045064"(T-helper 2 cell differentiation)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0042113"(B cell activation)|go:"GO:0042116"(macrophage activation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0070351"(negative regulation of white fat cell proliferation)|go:"GO:0071677"(positive regulation of mononuclear cell migration)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901857"(positive regulation of cellular respiration)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903660"(negative regulation of complement-dependent cytotoxicity)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000424"(positive regulation of eosinophil chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001325(Interleukin-4/interleukin-13)|interpro:IPR002354(Interleukin 4)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR018096|reactome:R-MMU-6785807|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|refseq:NP_067258.1	-	-	-	comment:Il4 was affinity labelled. Proteins were cross-linked before cell lysis.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/12/12	2014/10/16	rogid:AyGKTLNBywo1T6oOc6QrS9J2R3U10090	rogid:vm719cZjWp9lvF9qHjjSr1jDKIU10090	intact-crc:CA5841A3A9A22372|rigid:8DxgMGqV5W4Wu7fXrZdbT2982zU	false	-	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)