#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P06240	uniprotkb:P06332	intact:EBI-1401|ensembl:ENSMUSP00000066209|ensembl:ENSMUSP00000099656|uniprotkb:Q62320|uniprotkb:Q61795|uniprotkb:Q61794|uniprotkb:Q91X65	intact:EBI-1404|ensembl:ENSMUSP00000024044	psi-mi:lck_mouse(display_long)|uniprotkb:Lck(gene name)|psi-mi:Lck(display_short)|uniprotkb:Lsk-t(gene name synonym)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:cd4_mouse(display_long)|uniprotkb:Cd4(gene name)|psi-mi:Cd4(display_short)|uniprotkb:T-cell surface antigen T4/Leu-3(gene name synonym)|uniprotkb:T-cell differentiation antigen L3T4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Campbell et al. (1995)	pubmed:7664803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1416	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000000409(gene)|ensembl:ENSMUST00000067240(transcript)|ensembl:ENSMUST00000102596(transcript)|go:"GO:0000242"(pericentriolar material)|refseq:NP_001155905.1|refseq:NP_034823.1|refseq:XP_006502881.1|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003823"(antigen binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010038"(response to metal ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-6811558|reactome:R-MMU-9013407|reactome:R-MMU-9020558|reactome:R-MMU-9706374	refseq:NP_038516.1|ensembl:ENSMUSG00000023274(gene)|ensembl:ENSMUST00000024044(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006948"(induction by virus of host cell-cell fusion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035397"(helper T cell enhancement of adaptive immune response)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0042011"(interleukin-16 binding)|go:"GO:0042012"(interleukin-16 receptor activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045058"(T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000973(T-cell surface antigen CD4)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015274(CD4, extracellular)|interpro:IPR021963|interpro:IPR036179|mint:P06332|reactome:R-MMU-1462054|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-389948|reactome:R-MMU-449836|reactome:R-MMU-8856825|reactome:R-MMU-8856828	pubmed:7487703(see-also)	-	-	comment:Interaction inhibited the growth of yeast	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/08/20	2014/10/16	rogid:yjMU0fxTseBSR5/aEXmp2cR7Mts10090	rogid:80TDw5kSJXFKGKJpjZ7Rdb9gD1g10090	intact-crc:33A2F59C93B64674|rigid:GCf+pHAqMZjPE+BItD2XJL4UBpA	false	binding-associated region:2-69|mutation decreasing interaction:20-20|mutation decreasing interaction:23-23	binding-associated region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06240	uniprotkb:P01731	intact:EBI-1401|ensembl:ENSMUSP00000066209|ensembl:ENSMUSP00000099656|uniprotkb:Q62320|uniprotkb:Q61795|uniprotkb:Q61794|uniprotkb:Q91X65	intact:EBI-1433|ensembl:ENSMUSP00000068123	psi-mi:lck_mouse(display_long)|uniprotkb:Lck(gene name)|psi-mi:Lck(display_short)|uniprotkb:Lsk-t(gene name synonym)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:cd8a_mouse(display_long)|uniprotkb:Cd8a(gene name)|psi-mi:Cd8a(display_short)|uniprotkb:Lyt-2(gene name synonym)|uniprotkb:Lyt2(gene name synonym)|uniprotkb:T-cell surface glycoprotein Lyt-2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Campbell et al. (1995)	pubmed:7664803	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1444	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000000409(gene)|ensembl:ENSMUST00000067240(transcript)|ensembl:ENSMUST00000102596(transcript)|go:"GO:0000242"(pericentriolar material)|refseq:NP_001155905.1|refseq:NP_034823.1|refseq:XP_006502881.1|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003823"(antigen binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010038"(response to metal ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050856"(regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070474"(positive regulation of uterine smooth muscle contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-6811558|reactome:R-MMU-9013407|reactome:R-MMU-9020558|reactome:R-MMU-9706374	refseq:NP_001074579.1|ensembl:ENSMUSG00000053977(gene)|ensembl:ENSMUST00000066747(transcript)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023024"(MHC class I protein complex binding)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045065"(cytotoxic T cell differentiation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051607"(defense response to virus)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015468(CD8 alpha chain)|interpro:IPR036179|mint:P01731|rcsb pdb:1BQH|rcsb pdb:1NEZ|rcsb pdb:2ARJ|rcsb pdb:2ATP|rcsb pdb:3B9K|rcsb pdb:3DMM|reactome:R-MMU-198933	-	-	-	comment:In same experiment, interaction between Lck and CD8alpha chain was shown to be 8-fold weaker than between CD4 and Lck.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/08/20	2014/10/16	rogid:yjMU0fxTseBSR5/aEXmp2cR7Mts10090	rogid:YKyIbIVRaV5JMryX8MRe8C5SH9M10090	intact-crc:1A1F93DBBA416566|rigid:4ptNymuDDJfGM13DnDeO0JFbPl0	false	mutation decreasing interaction:20-20|mutation decreasing interaction:23-23|binding-associated region:2-67	binding-associated region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)