#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q24218	uniprotkb:O44924	intact:EBI-74727	intact:EBI-74797	psi-mi:q24218_drome(display_long)|uniprotkb:dock(gene name)|psi-mi:dock(display_short)|uniprotkb:CG3727(orf name)	psi-mi:o44924_drome(display_long)|uniprotkb:robo1(gene name)|psi-mi:robo1(display_short)|uniprotkb:robo(gene name synonym)|uniprotkb:CG13521(orf name)	psi-mi:"MI:0018"(two hybrid)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-74812	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0010583|go:"GO:0005158"(insulin receptor binding)|go:"GO:0007411"(axon guidance)|go:"GO:0019901"(protein kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR036028|interpro:IPR036860	flybase:FBgn0005631|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0007432"(salivary gland boundary specification)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008406"(gonad development)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0071666"(Slit-Robo signaling complex)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:2000274"(regulation of epithelial cell migration, open tracheal system)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2VR9|rcsb pdb:2VRA	-	-	-	comment:"cytoplasmic domains of Robo1 (AA 939-1345) was fused to B42. Dock was fused to LexA."	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/11/10	2014/10/16	rogid:1/0GiSNvZrkPK4ZFhlLHLZZ8DmE7227	rogid:uLUQxfvRN9BQCyxNV6w22/4BtGw7227	intact-crc:93274E86334B5D20|rigid:twp9iOEADJUFfp874CCxHK035zk	false	tag:?-?	binding-associated region:939-1345|tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q24218	uniprotkb:Q9VI13	intact:EBI-74727	intact:EBI-74826|intact:EBI-123979|intact:EBI-466309|uniprotkb:Q24190|uniprotkb:Q24213|ensemblmetazoa:FBpp0081211|ensemblmetazoa:FBpp0081212|ensemblmetazoa:FBpp0081213|ensemblmetazoa:FBpp0306606|ensemblmetazoa:FBpp0306611	psi-mi:q24218_drome(display_long)|uniprotkb:dock(gene name)|psi-mi:dock(display_short)|uniprotkb:CG3727(orf name)	psi-mi:pak_drome(display_long)|uniprotkb:Pak(gene name)|psi-mi:Pak(display_short)|uniprotkb:DPAK(gene name synonym)|uniprotkb:Dpak1(gene name synonym)|uniprotkb:CG10295(orf name)	psi-mi:"MI:0018"(two hybrid)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-74841	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0010583|go:"GO:0005158"(insulin receptor binding)|go:"GO:0007411"(axon guidance)|go:"GO:0019901"(protein kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR036028|interpro:IPR036860	flybase:FBgn0267698|refseq:NP_001262309.1|refseq:NP_001262313.1|refseq:NP_524681.1|refseq:NP_731073.1|refseq:NP_731074.1|ensemblmetazoa:FBgn0267698(gene)|ensemblmetazoa:FBtr0081714(transcript)|ensemblmetazoa:FBtr0081715(transcript)|ensemblmetazoa:FBtr0081716(transcript)|ensemblmetazoa:FBtr0334539(transcript)|ensemblmetazoa:FBtr0334544(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936	-	-	-	comment:Dock was expressed as a P42 fusion product and Pak was expressed as a Lex fusion product.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/11/10	2021/06/18	rogid:1/0GiSNvZrkPK4ZFhlLHLZZ8DmE7227	rogid:B88kI/CaRk7fc0eQ5+Y4jk4zWwc7227	intact-crc:62FE32C65DCF41D6|rigid:RomjW24LZ1nALWWwsYaUA7gVbN0	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9VI13	uniprotkb:P40792	intact:EBI-74826|intact:EBI-123979|intact:EBI-466309|uniprotkb:Q24190|uniprotkb:Q24213|ensemblmetazoa:FBpp0081211|ensemblmetazoa:FBpp0081212|ensemblmetazoa:FBpp0081213|ensemblmetazoa:FBpp0306606|ensemblmetazoa:FBpp0306611	intact:EBI-74845|uniprotkb:Q9W0H7|ensemblmetazoa:FBpp0072614|ensemblmetazoa:FBpp0304252	psi-mi:pak_drome(display_long)|uniprotkb:Pak(gene name)|psi-mi:Pak(display_short)|uniprotkb:DPAK(gene name synonym)|uniprotkb:Dpak1(gene name synonym)|uniprotkb:CG10295(orf name)	psi-mi:rac1_drome(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:RacA(gene name synonym)|uniprotkb:CG2248(orf name)	psi-mi:"MI:0018"(two hybrid)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-74865	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0267698|refseq:NP_001262309.1|refseq:NP_001262313.1|refseq:NP_524681.1|refseq:NP_731073.1|refseq:NP_731074.1|ensemblmetazoa:FBgn0267698(gene)|ensemblmetazoa:FBtr0081714(transcript)|ensemblmetazoa:FBtr0081715(transcript)|ensemblmetazoa:FBtr0081716(transcript)|ensemblmetazoa:FBtr0334539(transcript)|ensemblmetazoa:FBtr0334544(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936	refseq:NP_476950.1|flybase:FBgn0010333|refseq:NP_001261247.1|ensemblmetazoa:FBgn0010333(gene)|ensemblmetazoa:FBtr0072730(transcript)|ensemblmetazoa:FBtr0331868(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002433"(immune response-regulating cell surface receptor signaling pathway involved in phagocytosis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007391"(dorsal closure)|go:"GO:0007394"(dorsal closure, elongation of leading edge cells)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007419"(ventral cord development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007516"(hemocyte development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007613"(memory)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0008258"(head involution)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0016028"(rhabdomere)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016203"(muscle attachment)|go:"GO:0016358"(dendrite development)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035010"(encapsulation of foreign target)|go:"GO:0035011"(melanotic encapsulation of foreign target)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035320"(imaginal disc-derived wing hair site selection)|go:"GO:0042052"(rhabdomere development)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046664"(dorsal closure, amnioserosa morphology change)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048615"("embryonic anterior midgut (ectodermal) morphogenesis")|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055001"(muscle cell development)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071907"(determination of digestive tract left/right asymmetry)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097206"(nephrocyte filtration)|go:"GO:0110125"(negative regulation of myotube cell migration)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1903391"(regulation of adherens junction organization)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904059"(regulation of locomotor rhythm)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DME-114604|reactome:R-DME-1433557|reactome:R-DME-193648|reactome:R-DME-2029482|reactome:R-DME-2871796|reactome:R-DME-350376|reactome:R-DME-376172|reactome:R-DME-389359|reactome:R-DME-3928662|reactome:R-DME-3928664|reactome:R-DME-3928665|reactome:R-DME-399954|reactome:R-DME-4086400|reactome:R-DME-4420097|reactome:R-DME-445144|reactome:R-DME-5218920|reactome:R-DME-5625740|reactome:R-DME-5627123|reactome:R-DME-5663213|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-8849471|reactome:R-DME-9013149|reactome:R-DME-9013404|reactome:R-DME-9013407|reactome:R-DME-9706019|reactome:R-DME-983231	-	-	-	comment:Pak was a B42 fusion protein while Rac1 was a Lex fusion protein.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/11/10	2021/06/18	rogid:B88kI/CaRk7fc0eQ5+Y4jk4zWwc7227	rogid:nVrsdRuWmYjJp67rd4Es0mFDuUU7227	intact-crc:53FA80EE4F7AB84D|rigid:loWbXxe2q6dYxzB4+nQIlLV/SHE	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9VI13	uniprotkb:P48554	intact:EBI-74826|intact:EBI-123979|intact:EBI-466309|uniprotkb:Q24190|uniprotkb:Q24213|ensemblmetazoa:FBpp0081211|ensemblmetazoa:FBpp0081212|ensemblmetazoa:FBpp0081213|ensemblmetazoa:FBpp0306606|ensemblmetazoa:FBpp0306611	intact:EBI-74869|uniprotkb:Q540X5|uniprotkb:Q9VS69|ensemblmetazoa:FBpp0076577|ensemblmetazoa:FBpp0305023	psi-mi:pak_drome(display_long)|uniprotkb:Pak(gene name)|psi-mi:Pak(display_short)|uniprotkb:DPAK(gene name synonym)|uniprotkb:Dpak1(gene name synonym)|uniprotkb:CG10295(orf name)	psi-mi:rac2_drome(display_long)|uniprotkb:Rac2(gene name)|psi-mi:Rac2(display_short)|uniprotkb:RacB(gene name synonym)|uniprotkb:CG8556(orf name)	psi-mi:"MI:0018"(two hybrid)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-74879	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0267698|refseq:NP_001262309.1|refseq:NP_001262313.1|refseq:NP_524681.1|refseq:NP_731073.1|refseq:NP_731074.1|ensemblmetazoa:FBgn0267698(gene)|ensemblmetazoa:FBtr0081714(transcript)|ensemblmetazoa:FBtr0081715(transcript)|ensemblmetazoa:FBtr0081716(transcript)|ensemblmetazoa:FBtr0334539(transcript)|ensemblmetazoa:FBtr0334544(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936	refseq:NP_648121.1|flybase:FBgn0014011|refseq:NP_001261517.1|dip:DIP-18225N|ensemblmetazoa:FBgn0014011(gene)|ensemblmetazoa:FBtr0076867(transcript)|ensemblmetazoa:FBtr0332800(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002118"(aggressive behavior)|go:"GO:0002433"(immune response-regulating cell surface receptor signaling pathway involved in phagocytosis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007391"(dorsal closure)|go:"GO:0007394"(dorsal closure, elongation of leading edge cells)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007617"(mating behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0008258"(head involution)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0016203"(muscle attachment)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035010"(encapsulation of foreign target)|go:"GO:0035011"(melanotic encapsulation of foreign target)|go:"GO:0035099"(hemocyte migration)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903391"(regulation of adherens junction organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DME-114604|reactome:R-DME-4086400|reactome:R-DME-9013404|reactome:R-DME-9013407|reactome:R-DME-9706019	-	-	-	comment:Pak was expressed as a B42 fusion while Rac2 was expressed as a Lex fusion.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/11/10	2021/06/18	rogid:B88kI/CaRk7fc0eQ5+Y4jk4zWwc7227	rogid:PNIBHOg5t2eu9wEta4DW1OboF0w7227	intact-crc:DDE4B3B8667F320D|rigid:2zmq2A2iIr8GlWOW6IUl8KKDxis	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O44924	uniprotkb:Q24218	intact:EBI-74797	intact:EBI-74727	psi-mi:o44924_drome(display_long)|uniprotkb:robo1(gene name)|psi-mi:robo1(display_short)|uniprotkb:robo(gene name synonym)|uniprotkb:CG13521(orf name)	psi-mi:q24218_drome(display_long)|uniprotkb:dock(gene name)|psi-mi:dock(display_short)|uniprotkb:CG3727(orf name)	psi-mi:"MI:0018"(two hybrid)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77132	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0005631|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0007432"(salivary gland boundary specification)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008406"(gonad development)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0071666"(Slit-Robo signaling complex)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:2000274"(regulation of epithelial cell migration, open tracheal system)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2VR9|rcsb pdb:2VRA	flybase:FBgn0010583|go:"GO:0005158"(insulin receptor binding)|go:"GO:0007411"(axon guidance)|go:"GO:0019901"(protein kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR036028|interpro:IPR036860	-	-	-	comment:"cytoplasmic domains of Robo1 (AA 1084-1395) was fused to B42. Dock was fused to LexA."	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/11/10	2014/10/16	rogid:uLUQxfvRN9BQCyxNV6w22/4BtGw7227	rogid:1/0GiSNvZrkPK4ZFhlLHLZZ8DmE7227	intact-crc:3821A5EE7089B15B|rigid:twp9iOEADJUFfp874CCxHK035zk	false	binding-associated region:1084-1395|tag:?-?	tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q24218	uniprotkb:O44924	intact:EBI-74727	intact:EBI-74797	psi-mi:q24218_drome(display_long)|uniprotkb:dock(gene name)|psi-mi:dock(display_short)|uniprotkb:CG3727(orf name)	psi-mi:o44924_drome(display_long)|uniprotkb:robo1(gene name)|psi-mi:robo1(display_short)|uniprotkb:robo(gene name synonym)|uniprotkb:CG13521(orf name)	psi-mi:"MI:0018"(two hybrid)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77137	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0010583|go:"GO:0005158"(insulin receptor binding)|go:"GO:0007411"(axon guidance)|go:"GO:0019901"(protein kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR036028|interpro:IPR036860	flybase:FBgn0005631|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0007432"(salivary gland boundary specification)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008406"(gonad development)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0071666"(Slit-Robo signaling complex)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:2000274"(regulation of epithelial cell migration, open tracheal system)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2VR9|rcsb pdb:2VRA	-	-	-	comment:"cytoplasmic domains of Robo1 (AA 939-1345) was fused to B42. Dock was fused to LexA."	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/11/10	2014/10/16	rogid:1/0GiSNvZrkPK4ZFhlLHLZZ8DmE7227	rogid:uLUQxfvRN9BQCyxNV6w22/4BtGw7227	intact-crc:E6B4AB46A61E9E00|rigid:twp9iOEADJUFfp874CCxHK035zk	false	tag:?-?	tag:?-?|sufficient binding region:939-1345	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O44924	uniprotkb:Q24218	intact:EBI-74797	intact:EBI-74727	psi-mi:o44924_drome(display_long)|uniprotkb:robo1(gene name)|psi-mi:robo1(display_short)|uniprotkb:robo(gene name synonym)|uniprotkb:CG13521(orf name)	psi-mi:q24218_drome(display_long)|uniprotkb:dock(gene name)|psi-mi:dock(display_short)|uniprotkb:CG3727(orf name)	psi-mi:"MI:0018"(two hybrid)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77600	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0005631|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0007432"(salivary gland boundary specification)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008406"(gonad development)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0071666"(Slit-Robo signaling complex)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:2000274"(regulation of epithelial cell migration, open tracheal system)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2VR9|rcsb pdb:2VRA	flybase:FBgn0010583|go:"GO:0005158"(insulin receptor binding)|go:"GO:0007411"(axon guidance)|go:"GO:0019901"(protein kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR036028|interpro:IPR036860	-	-	-	comment:"Proline rich CC2 (1247-1295) and CC3 (1084-1130) motifs are important for interaction."	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/11/10	2014/10/16	rogid:uLUQxfvRN9BQCyxNV6w22/4BtGw7227	rogid:1/0GiSNvZrkPK4ZFhlLHLZZ8DmE7227	intact-crc:E02C9A1521B90CD0|rigid:twp9iOEADJUFfp874CCxHK035zk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O44924	uniprotkb:Q9VI13	intact:EBI-74797	intact:EBI-74826|intact:EBI-123979|intact:EBI-466309|uniprotkb:Q24190|uniprotkb:Q24213|ensemblmetazoa:FBpp0081211|ensemblmetazoa:FBpp0081212|ensemblmetazoa:FBpp0081213|ensemblmetazoa:FBpp0306606|ensemblmetazoa:FBpp0306611	psi-mi:o44924_drome(display_long)|uniprotkb:robo1(gene name)|psi-mi:robo1(display_short)|uniprotkb:robo(gene name synonym)|uniprotkb:CG13521(orf name)	psi-mi:pak_drome(display_long)|uniprotkb:Pak(gene name)|psi-mi:Pak(display_short)|uniprotkb:DPAK(gene name synonym)|uniprotkb:Dpak1(gene name synonym)|uniprotkb:CG10295(orf name)	psi-mi:"MI:0018"(two hybrid)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77605	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0005631|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0007432"(salivary gland boundary specification)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008406"(gonad development)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0071666"(Slit-Robo signaling complex)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:2000274"(regulation of epithelial cell migration, open tracheal system)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2VR9|rcsb pdb:2VRA	flybase:FBgn0267698|refseq:NP_001262309.1|refseq:NP_001262313.1|refseq:NP_524681.1|refseq:NP_731073.1|refseq:NP_731074.1|ensemblmetazoa:FBgn0267698(gene)|ensemblmetazoa:FBtr0081714(transcript)|ensemblmetazoa:FBtr0081715(transcript)|ensemblmetazoa:FBtr0081716(transcript)|ensemblmetazoa:FBtr0334539(transcript)|ensemblmetazoa:FBtr0334544(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936	-	-	-	comment:Domains SH3-1 and SH3-2 were found to be important for interaction. Robo AA 939-1395 was used in the studies.	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/11/10	2021/06/18	rogid:uLUQxfvRN9BQCyxNV6w22/4BtGw7227	rogid:B88kI/CaRk7fc0eQ5+Y4jk4zWwc7227	intact-crc:AE666BCE87BA74D5|rigid:4ShIozXBbMutI3TfdmIq80oqFFk	false	binding-associated region:393-1395	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O44924	uniprotkb:Q24218	intact:EBI-74797	intact:EBI-74727	psi-mi:o44924_drome(display_long)|uniprotkb:robo1(gene name)|psi-mi:robo1(display_short)|uniprotkb:robo(gene name synonym)|uniprotkb:CG13521(orf name)	psi-mi:q24218_drome(display_long)|uniprotkb:dock(gene name)|psi-mi:dock(display_short)|uniprotkb:CG3727(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-74820	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0005631|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0007432"(salivary gland boundary specification)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008406"(gonad development)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0071666"(Slit-Robo signaling complex)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:2000274"(regulation of epithelial cell migration, open tracheal system)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2VR9|rcsb pdb:2VRA	flybase:FBgn0010583|go:"GO:0005158"(insulin receptor binding)|go:"GO:0007411"(axon guidance)|go:"GO:0019901"(protein kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR036028|interpro:IPR036860	-	-	-	agonist:This interaction is stimulated by treatment of cells by Slit.	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2003/11/10	2014/10/16	rogid:uLUQxfvRN9BQCyxNV6w22/4BtGw7227	rogid:1/0GiSNvZrkPK4ZFhlLHLZZ8DmE7227	intact-crc:DB46443FD0A8475D|rigid:twp9iOEADJUFfp874CCxHK035zk	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O44924	uniprotkb:O44924	intact:EBI-74797	intact:EBI-74797	psi-mi:o44924_drome(display_long)|uniprotkb:robo1(gene name)|psi-mi:robo1(display_short)|uniprotkb:robo(gene name synonym)|uniprotkb:CG13521(orf name)	psi-mi:o44924_drome(display_long)|uniprotkb:robo1(gene name)|psi-mi:robo1(display_short)|uniprotkb:robo(gene name synonym)|uniprotkb:CG13521(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-74823	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0005631|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0007432"(salivary gland boundary specification)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008406"(gonad development)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0071666"(Slit-Robo signaling complex)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:2000274"(regulation of epithelial cell migration, open tracheal system)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2VR9|rcsb pdb:2VRA	flybase:FBgn0005631|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0007432"(salivary gland boundary specification)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008406"(gonad development)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0071666"(Slit-Robo signaling complex)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:2000274"(regulation of epithelial cell migration, open tracheal system)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2VR9|rcsb pdb:2VRA	-	-	-	comment:myc tagged Robo was used to pull down wild type Robo.	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2003/11/10	2014/10/16	rogid:uLUQxfvRN9BQCyxNV6w22/4BtGw7227	rogid:uLUQxfvRN9BQCyxNV6w22/4BtGw7227	intact-crc:D0EB35073363FAEB|rigid:nQaHtIoqzuecAcmusTTn5wHcvkk	false	myc tag:?-?	-	2	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O44924	uniprotkb:Q9VI13	intact:EBI-74797	intact:EBI-74826|intact:EBI-123979|intact:EBI-466309|uniprotkb:Q24190|uniprotkb:Q24213|ensemblmetazoa:FBpp0081211|ensemblmetazoa:FBpp0081212|ensemblmetazoa:FBpp0081213|ensemblmetazoa:FBpp0306606|ensemblmetazoa:FBpp0306611	psi-mi:o44924_drome(display_long)|uniprotkb:robo1(gene name)|psi-mi:robo1(display_short)|uniprotkb:robo(gene name synonym)|uniprotkb:CG13521(orf name)	psi-mi:pak_drome(display_long)|uniprotkb:Pak(gene name)|psi-mi:Pak(display_short)|uniprotkb:DPAK(gene name synonym)|uniprotkb:Dpak1(gene name synonym)|uniprotkb:CG10295(orf name)	psi-mi:"MI:0096"(pull down)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-74885	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0005631|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0007432"(salivary gland boundary specification)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008406"(gonad development)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0071666"(Slit-Robo signaling complex)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:2000274"(regulation of epithelial cell migration, open tracheal system)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2VR9|rcsb pdb:2VRA	flybase:FBgn0267698|refseq:NP_001262309.1|refseq:NP_001262313.1|refseq:NP_524681.1|refseq:NP_731073.1|refseq:NP_731074.1|ensemblmetazoa:FBgn0267698(gene)|ensemblmetazoa:FBtr0081714(transcript)|ensemblmetazoa:FBtr0081715(transcript)|ensemblmetazoa:FBtr0081716(transcript)|ensemblmetazoa:FBtr0334539(transcript)|ensemblmetazoa:FBtr0334544(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936	-	-	-	comment:Robo was his tagged. This activity is Slit dependent.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/10	2021/06/18	rogid:uLUQxfvRN9BQCyxNV6w22/4BtGw7227	rogid:B88kI/CaRk7fc0eQ5+Y4jk4zWwc7227	intact-crc:59F8CEDAD4C5EC85|rigid:Qi8eJYpa0pbVMYWmeP7h4TNTIKw	false	his tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O44924	uniprotkb:Q24218	intact:EBI-74797	intact:EBI-74727	psi-mi:o44924_drome(display_long)|uniprotkb:robo1(gene name)|psi-mi:robo1(display_short)|uniprotkb:robo(gene name synonym)|uniprotkb:CG13521(orf name)	psi-mi:q24218_drome(display_long)|uniprotkb:dock(gene name)|psi-mi:dock(display_short)|uniprotkb:CG3727(orf name)	psi-mi:"MI:0096"(pull down)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-74885	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0005631|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0007432"(salivary gland boundary specification)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008406"(gonad development)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0071666"(Slit-Robo signaling complex)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:2000274"(regulation of epithelial cell migration, open tracheal system)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2VR9|rcsb pdb:2VRA	flybase:FBgn0010583|go:"GO:0005158"(insulin receptor binding)|go:"GO:0007411"(axon guidance)|go:"GO:0019901"(protein kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR036028|interpro:IPR036860	-	-	-	comment:Robo was his tagged. This activity is Slit dependent.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/10	2021/06/18	rogid:uLUQxfvRN9BQCyxNV6w22/4BtGw7227	rogid:1/0GiSNvZrkPK4ZFhlLHLZZ8DmE7227	intact-crc:59F8CEDAD4C5EC85|rigid:Qi8eJYpa0pbVMYWmeP7h4TNTIKw	false	his tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9VI13	uniprotkb:P40792	intact:EBI-74826|intact:EBI-123979|intact:EBI-466309|uniprotkb:Q24190|uniprotkb:Q24213|ensemblmetazoa:FBpp0081211|ensemblmetazoa:FBpp0081212|ensemblmetazoa:FBpp0081213|ensemblmetazoa:FBpp0306606|ensemblmetazoa:FBpp0306611	intact:EBI-74845|uniprotkb:Q9W0H7|ensemblmetazoa:FBpp0072614|ensemblmetazoa:FBpp0304252	psi-mi:pak_drome(display_long)|uniprotkb:Pak(gene name)|psi-mi:Pak(display_short)|uniprotkb:DPAK(gene name synonym)|uniprotkb:Dpak1(gene name synonym)|uniprotkb:CG10295(orf name)	psi-mi:rac1_drome(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:RacA(gene name synonym)|uniprotkb:CG2248(orf name)	psi-mi:"MI:0096"(pull down)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-74892	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0267698|refseq:NP_001262309.1|refseq:NP_001262313.1|refseq:NP_524681.1|refseq:NP_731073.1|refseq:NP_731074.1|ensemblmetazoa:FBgn0267698(gene)|ensemblmetazoa:FBtr0081714(transcript)|ensemblmetazoa:FBtr0081715(transcript)|ensemblmetazoa:FBtr0081716(transcript)|ensemblmetazoa:FBtr0334539(transcript)|ensemblmetazoa:FBtr0334544(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936	refseq:NP_476950.1|flybase:FBgn0010333|refseq:NP_001261247.1|ensemblmetazoa:FBgn0010333(gene)|ensemblmetazoa:FBtr0072730(transcript)|ensemblmetazoa:FBtr0331868(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002433"(immune response-regulating cell surface receptor signaling pathway involved in phagocytosis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007391"(dorsal closure)|go:"GO:0007394"(dorsal closure, elongation of leading edge cells)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007419"(ventral cord development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007516"(hemocyte development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007613"(memory)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0008258"(head involution)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0016028"(rhabdomere)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016203"(muscle attachment)|go:"GO:0016358"(dendrite development)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035010"(encapsulation of foreign target)|go:"GO:0035011"(melanotic encapsulation of foreign target)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0035320"(imaginal disc-derived wing hair site selection)|go:"GO:0042052"(rhabdomere development)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046664"(dorsal closure, amnioserosa morphology change)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048615"("embryonic anterior midgut (ectodermal) morphogenesis")|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055001"(muscle cell development)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071907"(determination of digestive tract left/right asymmetry)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097206"(nephrocyte filtration)|go:"GO:0110125"(negative regulation of myotube cell migration)|go:"GO:1902669"(positive regulation of axon guidance)|go:"GO:1903391"(regulation of adherens junction organization)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1904059"(regulation of locomotor rhythm)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DME-114604|reactome:R-DME-1433557|reactome:R-DME-193648|reactome:R-DME-2029482|reactome:R-DME-2871796|reactome:R-DME-350376|reactome:R-DME-376172|reactome:R-DME-389359|reactome:R-DME-3928662|reactome:R-DME-3928664|reactome:R-DME-3928665|reactome:R-DME-399954|reactome:R-DME-4086400|reactome:R-DME-4420097|reactome:R-DME-445144|reactome:R-DME-5218920|reactome:R-DME-5625740|reactome:R-DME-5627123|reactome:R-DME-5663213|reactome:R-DME-5687128|reactome:R-DME-6798695|reactome:R-DME-8849471|reactome:R-DME-9013149|reactome:R-DME-9013404|reactome:R-DME-9013407|reactome:R-DME-9706019|reactome:R-DME-983231	pubmed:11672528(see-also)	-	-	comment:"myc tagged robo, HA tagged Rac1 and GST tagged Pzk (AA 77-151) were used in the experiment. The coprecipitation occured only in the presence of Slit."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/10	2021/06/18	rogid:B88kI/CaRk7fc0eQ5+Y4jk4zWwc7227	rogid:nVrsdRuWmYjJp67rd4Es0mFDuUU7227	intact-crc:06CCBC9950021D38|rigid:2DauU7Xc1Nd4F8RLaceSj2IRvv4	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9VI13	uniprotkb:O44924	intact:EBI-74826|intact:EBI-123979|intact:EBI-466309|uniprotkb:Q24190|uniprotkb:Q24213|ensemblmetazoa:FBpp0081211|ensemblmetazoa:FBpp0081212|ensemblmetazoa:FBpp0081213|ensemblmetazoa:FBpp0306606|ensemblmetazoa:FBpp0306611	intact:EBI-74797	psi-mi:pak_drome(display_long)|uniprotkb:Pak(gene name)|psi-mi:Pak(display_short)|uniprotkb:DPAK(gene name synonym)|uniprotkb:Dpak1(gene name synonym)|uniprotkb:CG10295(orf name)	psi-mi:o44924_drome(display_long)|uniprotkb:robo1(gene name)|psi-mi:robo1(display_short)|uniprotkb:robo(gene name synonym)|uniprotkb:CG13521(orf name)	psi-mi:"MI:0096"(pull down)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-74892	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0267698|refseq:NP_001262309.1|refseq:NP_001262313.1|refseq:NP_524681.1|refseq:NP_731073.1|refseq:NP_731074.1|ensemblmetazoa:FBgn0267698(gene)|ensemblmetazoa:FBtr0081714(transcript)|ensemblmetazoa:FBtr0081715(transcript)|ensemblmetazoa:FBtr0081716(transcript)|ensemblmetazoa:FBtr0334539(transcript)|ensemblmetazoa:FBtr0334544(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936	flybase:FBgn0005631|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0007432"(salivary gland boundary specification)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008406"(gonad development)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0071666"(Slit-Robo signaling complex)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:2000274"(regulation of epithelial cell migration, open tracheal system)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2VR9|rcsb pdb:2VRA	pubmed:11672528(see-also)	-	-	comment:"myc tagged robo, HA tagged Rac1 and GST tagged Pzk (AA 77-151) were used in the experiment. The coprecipitation occured only in the presence of Slit."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/10	2021/06/18	rogid:B88kI/CaRk7fc0eQ5+Y4jk4zWwc7227	rogid:uLUQxfvRN9BQCyxNV6w22/4BtGw7227	intact-crc:06CCBC9950021D38|rigid:2DauU7Xc1Nd4F8RLaceSj2IRvv4	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9VI13	uniprotkb:P48554	intact:EBI-74826|intact:EBI-123979|intact:EBI-466309|uniprotkb:Q24190|uniprotkb:Q24213|ensemblmetazoa:FBpp0081211|ensemblmetazoa:FBpp0081212|ensemblmetazoa:FBpp0081213|ensemblmetazoa:FBpp0306606|ensemblmetazoa:FBpp0306611	intact:EBI-74869|uniprotkb:Q540X5|uniprotkb:Q9VS69|ensemblmetazoa:FBpp0076577|ensemblmetazoa:FBpp0305023	psi-mi:pak_drome(display_long)|uniprotkb:Pak(gene name)|psi-mi:Pak(display_short)|uniprotkb:DPAK(gene name synonym)|uniprotkb:Dpak1(gene name synonym)|uniprotkb:CG10295(orf name)	psi-mi:rac2_drome(display_long)|uniprotkb:Rac2(gene name)|psi-mi:Rac2(display_short)|uniprotkb:RacB(gene name synonym)|uniprotkb:CG8556(orf name)	psi-mi:"MI:0096"(pull down)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-74898	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0267698|refseq:NP_001262309.1|refseq:NP_001262313.1|refseq:NP_524681.1|refseq:NP_731073.1|refseq:NP_731074.1|ensemblmetazoa:FBgn0267698(gene)|ensemblmetazoa:FBtr0081714(transcript)|ensemblmetazoa:FBtr0081715(transcript)|ensemblmetazoa:FBtr0081716(transcript)|ensemblmetazoa:FBtr0334539(transcript)|ensemblmetazoa:FBtr0334544(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936	refseq:NP_648121.1|flybase:FBgn0014011|refseq:NP_001261517.1|dip:DIP-18225N|ensemblmetazoa:FBgn0014011(gene)|ensemblmetazoa:FBtr0076867(transcript)|ensemblmetazoa:FBtr0332800(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002118"(aggressive behavior)|go:"GO:0002433"(immune response-regulating cell surface receptor signaling pathway involved in phagocytosis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007391"(dorsal closure)|go:"GO:0007394"(dorsal closure, elongation of leading edge cells)|go:"GO:0007424"(open tracheal system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007617"(mating behavior)|go:"GO:0007631"(feeding behavior)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0008258"(head involution)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0016203"(muscle attachment)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035010"(encapsulation of foreign target)|go:"GO:0035011"(melanotic encapsulation of foreign target)|go:"GO:0035099"(hemocyte migration)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1903391"(regulation of adherens junction organization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-DME-114604|reactome:R-DME-4086400|reactome:R-DME-9013404|reactome:R-DME-9013407|reactome:R-DME-9706019	-	-	-	comment:"Myc tagged Robo and HA tagged Rac2 were pulled down by GST tagged Pak (AA77-151) in the presence of Slit."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/10	2021/06/18	rogid:B88kI/CaRk7fc0eQ5+Y4jk4zWwc7227	rogid:PNIBHOg5t2eu9wEta4DW1OboF0w7227	intact-crc:8BB71974CB8A054B|rigid:Cby9WapzX069C+OVQg3Sj8uIWMU	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9VI13	uniprotkb:O44924	intact:EBI-74826|intact:EBI-123979|intact:EBI-466309|uniprotkb:Q24190|uniprotkb:Q24213|ensemblmetazoa:FBpp0081211|ensemblmetazoa:FBpp0081212|ensemblmetazoa:FBpp0081213|ensemblmetazoa:FBpp0306606|ensemblmetazoa:FBpp0306611	intact:EBI-74797	psi-mi:pak_drome(display_long)|uniprotkb:Pak(gene name)|psi-mi:Pak(display_short)|uniprotkb:DPAK(gene name synonym)|uniprotkb:Dpak1(gene name synonym)|uniprotkb:CG10295(orf name)	psi-mi:o44924_drome(display_long)|uniprotkb:robo1(gene name)|psi-mi:robo1(display_short)|uniprotkb:robo(gene name synonym)|uniprotkb:CG13521(orf name)	psi-mi:"MI:0096"(pull down)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-74898	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0267698|refseq:NP_001262309.1|refseq:NP_001262313.1|refseq:NP_524681.1|refseq:NP_731073.1|refseq:NP_731074.1|ensemblmetazoa:FBgn0267698(gene)|ensemblmetazoa:FBtr0081714(transcript)|ensemblmetazoa:FBtr0081715(transcript)|ensemblmetazoa:FBtr0081716(transcript)|ensemblmetazoa:FBtr0334539(transcript)|ensemblmetazoa:FBtr0334544(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936	flybase:FBgn0005631|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0007432"(salivary gland boundary specification)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008406"(gonad development)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0071666"(Slit-Robo signaling complex)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:2000274"(regulation of epithelial cell migration, open tracheal system)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2VR9|rcsb pdb:2VRA	-	-	-	comment:"Myc tagged Robo and HA tagged Rac2 were pulled down by GST tagged Pak (AA77-151) in the presence of Slit."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/10	2021/06/18	rogid:B88kI/CaRk7fc0eQ5+Y4jk4zWwc7227	rogid:uLUQxfvRN9BQCyxNV6w22/4BtGw7227	intact-crc:8BB71974CB8A054B|rigid:Cby9WapzX069C+OVQg3Sj8uIWMU	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9VI13	uniprotkb:O44924	intact:EBI-74826|intact:EBI-123979|intact:EBI-466309|uniprotkb:Q24190|uniprotkb:Q24213|ensemblmetazoa:FBpp0081211|ensemblmetazoa:FBpp0081212|ensemblmetazoa:FBpp0081213|ensemblmetazoa:FBpp0306606|ensemblmetazoa:FBpp0306611	intact:EBI-74797	psi-mi:pak_drome(display_long)|uniprotkb:Pak(gene name)|psi-mi:Pak(display_short)|uniprotkb:DPAK(gene name synonym)|uniprotkb:Dpak1(gene name synonym)|uniprotkb:CG10295(orf name)	psi-mi:o44924_drome(display_long)|uniprotkb:robo1(gene name)|psi-mi:robo1(display_short)|uniprotkb:robo(gene name synonym)|uniprotkb:CG13521(orf name)	psi-mi:"MI:0096"(pull down)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-74914	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0267698|refseq:NP_001262309.1|refseq:NP_001262313.1|refseq:NP_524681.1|refseq:NP_731073.1|refseq:NP_731074.1|ensemblmetazoa:FBgn0267698(gene)|ensemblmetazoa:FBtr0081714(transcript)|ensemblmetazoa:FBtr0081715(transcript)|ensemblmetazoa:FBtr0081716(transcript)|ensemblmetazoa:FBtr0334539(transcript)|ensemblmetazoa:FBtr0334544(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936	flybase:FBgn0005631|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007411"(axon guidance)|go:"GO:0007432"(salivary gland boundary specification)|go:"GO:0008038"(neuron recognition)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0008406"(gonad development)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0070983"(dendrite guidance)|go:"GO:0071666"(Slit-Robo signaling complex)|go:"GO:0072499"(photoreceptor cell axon guidance)|go:"GO:2000274"(regulation of epithelial cell migration, open tracheal system)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:2VR9|rcsb pdb:2VRA	-	-	-	comment:"myc tagged Robo and HA tagged Mtl were pulled down by GST tagged Pak (AA 77-151) in the presence of Slit."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/10	2021/06/18	rogid:B88kI/CaRk7fc0eQ5+Y4jk4zWwc7227	rogid:uLUQxfvRN9BQCyxNV6w22/4BtGw7227	intact-crc:196E86EA69B78338|rigid:bpqORNPIoJTfBIeRBUf4/uzhADU	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9VI13	uniprotkb:Q7JWS8	intact:EBI-74826|intact:EBI-123979|intact:EBI-466309|uniprotkb:Q24190|uniprotkb:Q24213|ensemblmetazoa:FBpp0081211|ensemblmetazoa:FBpp0081212|ensemblmetazoa:FBpp0081213|ensemblmetazoa:FBpp0306606|ensemblmetazoa:FBpp0306611	intact:EBI-74904|intact:EBI-2108936|ensemblmetazoa:FBpp0084561|ensemblmetazoa:FBpp0084562|ensemblmetazoa:FBpp0084563	psi-mi:pak_drome(display_long)|uniprotkb:Pak(gene name)|psi-mi:Pak(display_short)|uniprotkb:DPAK(gene name synonym)|uniprotkb:Dpak1(gene name synonym)|uniprotkb:CG10295(orf name)	psi-mi:q7jws8_drome(display_long)|uniprotkb:Mtl(gene name)|psi-mi:Mtl(display_short)|uniprotkb:5588(gene name synonym)|uniprotkb:Dmel\CG5588(gene name synonym)|uniprotkb:MTL(gene name synonym)|uniprotkb:Mig2-like(gene name synonym)|uniprotkb:Mt1(gene name synonym)|uniprotkb:Rac(gene name synonym)|uniprotkb:Rac GTPase(gene name synonym)|uniprotkb:Rac-like(gene name synonym)|uniprotkb:dMig-2(gene name synonym)|uniprotkb:mtl(gene name synonym)|uniprotkb:Dmel_CG5588(orf name)|uniprotkb:CG5588(orf name)	psi-mi:"MI:0096"(pull down)	Fan et al. (2003)	pubmed:14527437	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-74914	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0267698|refseq:NP_001262309.1|refseq:NP_001262313.1|refseq:NP_524681.1|refseq:NP_731073.1|refseq:NP_731074.1|ensemblmetazoa:FBgn0267698(gene)|ensemblmetazoa:FBtr0081714(transcript)|ensemblmetazoa:FBtr0081715(transcript)|ensemblmetazoa:FBtr0081716(transcript)|ensemblmetazoa:FBtr0334539(transcript)|ensemblmetazoa:FBtr0334544(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0007391"(dorsal closure)|go:"GO:0007395"(dorsal closure, spreading of leading edge cells)|go:"GO:0007411"(axon guidance)|go:"GO:0007480"(imaginal disc-derived leg morphogenesis)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019991"(septate junction assembly)|go:"GO:0031252"(cell leading edge)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035072"(ecdysone-mediated induction of salivary gland cell autophagic cell death)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045887"(positive regulation of synaptic assembly at neuromuscular junction)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0097482"(muscle cell postsynaptic specialization)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936	refseq:NP_524533.1|refseq:NP_733222.1|refseq:NP_733223.1|flybase:FBgn0039532|ensemblmetazoa:FBgn0039532(gene)|ensemblmetazoa:FBtr0085191(transcript)|ensemblmetazoa:FBtr0085192(transcript)|ensemblmetazoa:FBtr0085193(transcript)|go:"GO:0001737"(establishment of imaginal disc-derived wing hair orientation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0007254"(JNK cascade)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007390"(germ-band shortening)|go:"GO:0007391"(dorsal closure)|go:"GO:0007394"(dorsal closure, elongation of leading edge cells)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0008078"(mesodermal cell migration)|go:"GO:0008258"(head involution)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035099"(hemocyte migration)|go:"GO:0042067"(establishment of ommatidial planar polarity)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0090303"(positive regulation of wound healing)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417	-	-	-	comment:"myc tagged Robo and HA tagged Mtl were pulled down by GST tagged Pak (AA 77-151) in the presence of Slit."	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/10	2021/06/18	rogid:B88kI/CaRk7fc0eQ5+Y4jk4zWwc7227	rogid:x5LZmisdfK+Fu3EyxmAzuYFzMSQ7227	intact-crc:196E86EA69B78338|rigid:bpqORNPIoJTfBIeRBUf4/uzhADU	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)