#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P62259	uniprotkb:P51003	intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993	intact:EBI-359376|uniprotkb:Q86SX4|uniprotkb:Q86TV0|uniprotkb:Q8IYF5|uniprotkb:Q9BVU2|ensembl:ENSP00000216277	psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short)	psi-mi:papoa_human(display_long)|uniprotkb:PAPOLA(gene name)|psi-mi:PAPOLA(display_short)|uniprotkb:PAP(gene name synonym)|uniprotkb:Polynucleotide adenylyltransferase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kim et al. (2003)	pubmed:14517258|mint:MINT-5216734	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7035561|mint:MINT-17872	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198|mint:MINT-740811(identity)	refseq:NP_116021.2|refseq:NP_001238935.1|refseq:NP_001238936.1|ensembl:ENSG00000090060(gene)|ensembl:ENST00000216277(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004652"(polynucleotide adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0031440"(regulation of mRNA 3'-end processing)|go:"GO:0043631"(RNA polyadenylation)|interpro:IPR002934(Nucleotidyltransferase)|interpro:IPR007010("Poly(A) polymerase, RNA-binding region")|interpro:IPR007012("Poly(A) polymerase, central region")|interpro:IPR011068(Nucleotidyltransferase, class I, C-terminal-like)|interpro:IPR014492("Poly(A) polymerase")|interpro:IPR043519|mint:P51003|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|refseq:NP_001280556.1|refseq:NP_001280557.1|refseq:NP_001280561.1|dip:DIP-27610N|dip:DIP-40865N|mint:MINT-740805(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:The interaction between PAP and 14-3-3 epsilon inhibits the polyadenyaltio activity of PAP|comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2003/10/01	2014/10/16	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090	rogid:rRMBZRE1yFjnO+pnz5g4k+u7hwo9606	intact-crc:6DB1B9878FA3DA08|rigid:XhbMiIFlSTjbA2SDh8TxA96ruFw	false	tag:?-?(MINT-740812)	tag:?-?(MINT-740806)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51003	uniprotkb:P62259	intact:EBI-359376|uniprotkb:Q86SX4|uniprotkb:Q86TV0|uniprotkb:Q8IYF5|uniprotkb:Q9BVU2|ensembl:ENSP00000216277	intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993	psi-mi:papoa_human(display_long)|uniprotkb:PAPOLA(gene name)|psi-mi:PAPOLA(display_short)|uniprotkb:PAP(gene name synonym)|uniprotkb:Polynucleotide adenylyltransferase alpha(gene name synonym)	psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Kim et al. (2003)	pubmed:14517258|mint:MINT-5216734	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7035604|mint:MINT-17874	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116021.2|refseq:NP_001238935.1|refseq:NP_001238936.1|ensembl:ENSG00000090060(gene)|ensembl:ENST00000216277(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004652"(polynucleotide adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0031440"(regulation of mRNA 3'-end processing)|go:"GO:0043631"(RNA polyadenylation)|interpro:IPR002934(Nucleotidyltransferase)|interpro:IPR007010("Poly(A) polymerase, RNA-binding region")|interpro:IPR007012("Poly(A) polymerase, central region")|interpro:IPR011068(Nucleotidyltransferase, class I, C-terminal-like)|interpro:IPR014492("Poly(A) polymerase")|interpro:IPR043519|mint:P51003|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|refseq:NP_001280556.1|refseq:NP_001280557.1|refseq:NP_001280561.1|dip:DIP-27610N|dip:DIP-40865N|mint:MINT-740823(identity)	ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198|mint:MINT-740826(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:The interaction between PAP and 14-3-3 epsilon inhibits the polyadenyaltio activity of PAP|comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2003/10/01	2014/10/16	rogid:rRMBZRE1yFjnO+pnz5g4k+u7hwo9606	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090	intact-crc:EDC92A4B090BEED5|rigid:XhbMiIFlSTjbA2SDh8TxA96ruFw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62259	uniprotkb:P51003	intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993	intact:EBI-359376|uniprotkb:Q86SX4|uniprotkb:Q86TV0|uniprotkb:Q8IYF5|uniprotkb:Q9BVU2|ensembl:ENSP00000216277	psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short)	psi-mi:papoa_human(display_long)|uniprotkb:PAPOLA(gene name)|psi-mi:PAPOLA(display_short)|uniprotkb:PAP(gene name synonym)|uniprotkb:Polynucleotide adenylyltransferase alpha(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2003)	pubmed:14517258|mint:MINT-5216734	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7035625|mint:MINT-17873	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198|mint:MINT-740838(identity)	refseq:NP_116021.2|refseq:NP_001238935.1|refseq:NP_001238936.1|ensembl:ENSG00000090060(gene)|ensembl:ENST00000216277(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004652"(polynucleotide adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031124"(mRNA 3'-end processing)|go:"GO:0031440"(regulation of mRNA 3'-end processing)|go:"GO:0043631"(RNA polyadenylation)|interpro:IPR002934(Nucleotidyltransferase)|interpro:IPR007010("Poly(A) polymerase, RNA-binding region")|interpro:IPR007012("Poly(A) polymerase, central region")|interpro:IPR011068(Nucleotidyltransferase, class I, C-terminal-like)|interpro:IPR014492("Poly(A) polymerase")|interpro:IPR043519|mint:P51003|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595|refseq:NP_001280556.1|refseq:NP_001280557.1|refseq:NP_001280561.1|dip:DIP-27610N|dip:DIP-40865N|mint:MINT-740835(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:The interaction between PAP and 14-3-3 epsilon inhibits the polyadenyaltio activity of PAP|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/10/01	2014/10/16	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090	rogid:rRMBZRE1yFjnO+pnz5g4k+u7hwo9606	intact-crc:6404365282B13351|rigid:XhbMiIFlSTjbA2SDh8TxA96ruFw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)