#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9ESD7 uniprotkb:P07356 intact:EBI-7031166|ensembl:ENSMUSP00000132297|uniprotkb:Q80VT0|uniprotkb:Q9QXC0|uniprotkb:Q6KAR3|intact:MINT-274938 intact:EBI-738510|ensembl:ENSMUSP00000034756 psi-mi:dysf_mouse(display_long)|uniprotkb:Dysf(gene name)|psi-mi:Dysf(display_short)|uniprotkb:Fer1l1(gene name synonym)|uniprotkb:Dystrophy-associated fer-1-like protein(gene name synonym)|uniprotkb:Fer-1-like protein 1(gene name synonym) psi-mi:anxa2_mouse(display_long)|uniprotkb:Anxa2(gene name)|psi-mi:Anxa2(display_short)|uniprotkb:Anx2(gene name synonym)|uniprotkb:Cal1h(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Lennon et al. (2003) pubmed:14506282|mint:MINT-5216718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7031202|mint:MINT-17243 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001071162.1|refseq:NP_001297081.1|ensembl:ENSMUSG00000033788(gene)|ensembl:ENSMUST00000168387(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002280"(monocyte activation involved in immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042383"(sarcolemma)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0055001"(muscle cell development)|go:"GO:0061025"(membrane fusion)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098857"(membrane microdomain)|go:"GO:1901842"(negative regulation of high voltage-gated calcium channel activity)|go:"GO:1902915"(negative regulation of protein polyubiquitination)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR006614(Dysferlin, C-terminal)|interpro:IPR012560(FerA)|interpro:IPR012561(FerB)|interpro:IPR012968(FerI)|interpro:IPR029998|interpro:IPR032362|interpro:IPR035892|interpro:IPR037720|interpro:IPR037721|interpro:IPR037722|interpro:IPR037723|interpro:IPR037724|interpro:IPR037725|interpro:IPR037726|mint:Q9ESD7|reactome:R-MMU-445355|refseq:NP_067444.2|mint:MINT-740521(identity) refseq:NP_031611.1|refseq:XP_006510859.1|ensembl:ENSMUSG00000032231(gene)|ensembl:ENSMUST00000034756(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044147"(negative regulation of formation of structure involved in a symbiotic process)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0052362"(obsolete catabolism by host of symbiont protein)|go:"GO:0052405"|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097066"(response to thyroid hormone)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07356|rcsb pdb:4HRE|reactome:R-MMU-6798695|reactome:R-MMU-75205|mint:MINT-740524(identity) - comment:mint|function:Defects in Dysf are the cause of a slowly progressive muscular dystrophy observed in SJL mice. It affects primarily the proximal muscles and it is inherited as autosomal recessive trait|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2003/09/29 2014/10/16 rogid:3BBj/3m+gTLqU0VMG6RY+5Ov5Yk10090 rogid:R7GyK+r4KmwX28VH2qQZF+Y729A10090 intact-crc:DAFD00A054B64228|rigid:hXStO+Kinygum2SBugUFzRp96XE false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9ESD7 uniprotkb:P10107 intact:EBI-7031166|ensembl:ENSMUSP00000132297|uniprotkb:Q80VT0|uniprotkb:Q9QXC0|uniprotkb:Q6KAR3|intact:MINT-274938 intact:EBI-647848|ensembl:ENSMUSP00000025561|ensembl:ENSMUSP00000158305 psi-mi:dysf_mouse(display_long)|uniprotkb:Dysf(gene name)|psi-mi:Dysf(display_short)|uniprotkb:Fer1l1(gene name synonym)|uniprotkb:Dystrophy-associated fer-1-like protein(gene name synonym)|uniprotkb:Fer-1-like protein 1(gene name synonym) psi-mi:anxa1_mouse(display_long)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Anxa1(gene name)|psi-mi:Anxa1(display_short)|uniprotkb:Anx1(gene name synonym)|uniprotkb:Lpc1(gene name synonym)|uniprotkb:Lpc-1(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Lennon et al. (2003) pubmed:14506282|mint:MINT-5216718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7031228|mint:MINT-17215 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001071162.1|refseq:NP_001297081.1|ensembl:ENSMUSG00000033788(gene)|ensembl:ENSMUST00000168387(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002280"(monocyte activation involved in immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042383"(sarcolemma)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0055001"(muscle cell development)|go:"GO:0061025"(membrane fusion)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098857"(membrane microdomain)|go:"GO:1901842"(negative regulation of high voltage-gated calcium channel activity)|go:"GO:1902915"(negative regulation of protein polyubiquitination)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR006614(Dysferlin, C-terminal)|interpro:IPR012560(FerA)|interpro:IPR012561(FerB)|interpro:IPR012968(FerI)|interpro:IPR029998|interpro:IPR032362|interpro:IPR035892|interpro:IPR037720|interpro:IPR037721|interpro:IPR037722|interpro:IPR037723|interpro:IPR037724|interpro:IPR037725|interpro:IPR037726|mint:Q9ESD7|reactome:R-MMU-445355|refseq:NP_067444.2|mint:MINT-740529(identity) refseq:NP_034860.2|ensembl:ENSMUSG00000024659(gene)|ensembl:ENSMUST00000025561(transcript)|ensembl:ENSMUST00000235280(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P10107|reactome:R-MMU-416476|reactome:R-MMU-418594|reactome:R-MMU-444473|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044849"(estrous cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|mint:MINT-740532(identity) - comment:mint|function:Defects in Dysf are the cause of a slowly progressive muscular dystrophy observed in SJL mice. It affects primarily the proximal muscles and it is inherited as autosomal recessive trait|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2003/09/29 2014/10/16 rogid:3BBj/3m+gTLqU0VMG6RY+5Ov5Yk10090 rogid:V9sZHzXdA0iCeXidE8a0ahnWFoE10090 intact-crc:CD337849AD425C7C|rigid:9DQl7mZQRD3v5un+jYbWAsdHxUU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9ESD7 uniprotkb:P07356 intact:EBI-7031166|ensembl:ENSMUSP00000132297|uniprotkb:Q80VT0|uniprotkb:Q9QXC0|uniprotkb:Q6KAR3|intact:MINT-274938 intact:EBI-738510|ensembl:ENSMUSP00000034756 psi-mi:dysf_mouse(display_long)|uniprotkb:Dysf(gene name)|psi-mi:Dysf(display_short)|uniprotkb:Fer1l1(gene name synonym)|uniprotkb:Dystrophy-associated fer-1-like protein(gene name synonym)|uniprotkb:Fer-1-like protein 1(gene name synonym) psi-mi:anxa2_mouse(display_long)|uniprotkb:Anxa2(gene name)|psi-mi:Anxa2(display_short)|uniprotkb:Anx2(gene name synonym)|uniprotkb:Cal1h(gene name synonym)|uniprotkb:Annexin-2(gene name synonym)|uniprotkb:Annexin II(gene name synonym)|uniprotkb:Lipocortin II(gene name synonym)|uniprotkb:Calpactin I heavy chain(gene name synonym)|uniprotkb:Chromobindin-8(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:Protein I(gene name synonym)|uniprotkb:Placental anticoagulant protein IV(gene name synonym)|uniprotkb:Calpactin-1 heavy chain(gene name synonym) psi-mi:"MI:0045"(experimental interaction detection) Lennon et al. (2003) pubmed:14506282|mint:MINT-5216718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7031263|mint:MINT-17244 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001071162.1|refseq:NP_001297081.1|ensembl:ENSMUSG00000033788(gene)|ensembl:ENSMUST00000168387(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002280"(monocyte activation involved in immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042383"(sarcolemma)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0055001"(muscle cell development)|go:"GO:0061025"(membrane fusion)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098857"(membrane microdomain)|go:"GO:1901842"(negative regulation of high voltage-gated calcium channel activity)|go:"GO:1902915"(negative regulation of protein polyubiquitination)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR006614(Dysferlin, C-terminal)|interpro:IPR012560(FerA)|interpro:IPR012561(FerB)|interpro:IPR012968(FerI)|interpro:IPR029998|interpro:IPR032362|interpro:IPR035892|interpro:IPR037720|interpro:IPR037721|interpro:IPR037722|interpro:IPR037723|interpro:IPR037724|interpro:IPR037725|interpro:IPR037726|mint:Q9ESD7|reactome:R-MMU-445355|refseq:NP_067444.2|mint:MINT-740539(identity) refseq:NP_031611.1|refseq:XP_006510859.1|ensembl:ENSMUSG00000032231(gene)|ensembl:ENSMUST00000034756(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001726"(ruffle)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007589"(body fluid secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032804"(negative regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0036035"(osteoclast development)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042730"(fibrinolysis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0044090"(positive regulation of vacuole organization)|go:"GO:0044147"(negative regulation of formation of structure involved in a symbiotic process)|go:"GO:0044354"(macropinosome)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044730"(bone sialoprotein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046790"(virion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0052362"(obsolete catabolism by host of symbiont protein)|go:"GO:0052405"|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097066"(response to thyroid hormone)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905597"(positive regulation of low-density lipoprotein particle receptor binding)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|go:"GO:1905602"(positive regulation of receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:1990665"(AnxA2-p11 complex)|go:"GO:1990667"(PCSK9-AnxA2 complex)|interpro:IPR001464(Annexin)|interpro:IPR002389(Annexin, type II)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P07356|rcsb pdb:4HRE|reactome:R-MMU-6798695|reactome:R-MMU-75205|mint:MINT-740543(identity) - comment:mint|function:Defects in Dysf are the cause of a slowly progressive muscular dystrophy observed in SJL mice. It affects primarily the proximal muscles and it is inherited as autosomal recessive trait|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2003/09/29 2014/10/16 rogid:3BBj/3m+gTLqU0VMG6RY+5Ov5Yk10090 rogid:R7GyK+r4KmwX28VH2qQZF+Y729A10090 intact-crc:AFA758F787FC6F66|rigid:hXStO+Kinygum2SBugUFzRp96XE false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9ESD7 uniprotkb:P10107 intact:EBI-7031166|ensembl:ENSMUSP00000132297|uniprotkb:Q80VT0|uniprotkb:Q9QXC0|uniprotkb:Q6KAR3|intact:MINT-274938 intact:EBI-647848|ensembl:ENSMUSP00000025561|ensembl:ENSMUSP00000158305 psi-mi:dysf_mouse(display_long)|uniprotkb:Dysf(gene name)|psi-mi:Dysf(display_short)|uniprotkb:Fer1l1(gene name synonym)|uniprotkb:Dystrophy-associated fer-1-like protein(gene name synonym)|uniprotkb:Fer-1-like protein 1(gene name synonym) psi-mi:anxa1_mouse(display_long)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Anxa1(gene name)|psi-mi:Anxa1(display_short)|uniprotkb:Anx1(gene name synonym)|uniprotkb:Lpc1(gene name synonym)|uniprotkb:Lpc-1(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym) psi-mi:"MI:0045"(experimental interaction detection) Lennon et al. (2003) pubmed:14506282|mint:MINT-5216718 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7031274|mint:MINT-17216 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001071162.1|refseq:NP_001297081.1|ensembl:ENSMUSG00000033788(gene)|ensembl:ENSMUST00000168387(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002280"(monocyte activation involved in immune response)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042383"(sarcolemma)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0055001"(muscle cell development)|go:"GO:0061025"(membrane fusion)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098857"(membrane microdomain)|go:"GO:1901842"(negative regulation of high voltage-gated calcium channel activity)|go:"GO:1902915"(negative regulation of protein polyubiquitination)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR006614(Dysferlin, C-terminal)|interpro:IPR012560(FerA)|interpro:IPR012561(FerB)|interpro:IPR012968(FerI)|interpro:IPR029998|interpro:IPR032362|interpro:IPR035892|interpro:IPR037720|interpro:IPR037721|interpro:IPR037722|interpro:IPR037723|interpro:IPR037724|interpro:IPR037725|interpro:IPR037726|mint:Q9ESD7|reactome:R-MMU-445355|refseq:NP_067444.2|mint:MINT-740549(identity) refseq:NP_034860.2|ensembl:ENSMUSG00000024659(gene)|ensembl:ENSMUST00000025561(transcript)|ensembl:ENSMUST00000235280(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P10107|reactome:R-MMU-416476|reactome:R-MMU-418594|reactome:R-MMU-444473|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044849"(estrous cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|mint:MINT-740553(identity) - comment:mint|function:Defects in Dysf are the cause of a slowly progressive muscular dystrophy observed in SJL mice. It affects primarily the proximal muscles and it is inherited as autosomal recessive trait|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2003/09/29 2014/10/16 rogid:3BBj/3m+gTLqU0VMG6RY+5Ov5Yk10090 rogid:V9sZHzXdA0iCeXidE8a0ahnWFoE10090 intact-crc:7ED5124C5726CE9F|rigid:9DQl7mZQRD3v5un+jYbWAsdHxUU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)