#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P41235-2	uniprotkb:Q12772	intact:EBI-9640483|ensembl:ENSP00000412111	intact:EBI-465059|uniprotkb:Q86V36|uniprotkb:Q6GTH7|uniprotkb:Q9UH04|ensembl:ENSP00000354476|uniprotkb:Q05BD5	psi-mi:p41235-2(display_long)|uniprotkb:HNF4A(gene name)|psi-mi:HNF4A(display_short)|uniprotkb:HNF4(gene name synonym)|uniprotkb:NR2A1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group A member 1(gene name synonym)|uniprotkb:TCF14(gene name synonym)|uniprotkb:Transcription factor 14(gene name synonym)|uniprotkb:Transcription factor HNF-4(gene name synonym)|uniprotkb:HNF4-A(isoform synonym)	psi-mi:srbp2_human(display_long)|uniprotkb:SREBF2(gene name)|psi-mi:SREBF2(display_short)|uniprotkb:SREBP2(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 2(gene name synonym)|uniprotkb:BHLHD2(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Misawa et al. (2003)	pubmed:12855700|mint:MINT-5216527|imex:IM-27301	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6965279|mint:MINT-16696|imex:IM-27301-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1049011(isoform-parent)|ensembl:ENSG00000101076(gene)|ensembl:ENST00000415691(transcript)|uniprotkb:P41235-2(isoform-parent)|mint:MINT-736803(identity)	ensembl:ENSG00000198911(gene)|ensembl:ENST00000361204(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005829"(cytosol)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1UKL|reactome:R-HSA-1655829|reactome:R-HSA-1989781|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-9619665|refseq:NP_004590.2|dip:DIP-263N|mint:MINT-736800(identity)	-	isoform-comment:Produced by alternative splicing of isoform HNF4-Alpha-1.|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|figure legend:Fig. 8a|causality statement:P41235 increases activity of Q12772|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/09/29	2019/08/22	rogid:kRih/ay+T0NSN8hH1sotukrj3m49606	rogid:OkTB/ZjBgPVLKu333KVw2AKrE5M9606	intact-crc:0F1AA928555A3935|rigid:Xcir8SrM34e7VzLCJehN/Uebit8	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:1-481	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P41235-2	uniprotkb:Q12772	intact:EBI-9640483|ensembl:ENSP00000412111	intact:EBI-465059|uniprotkb:Q86V36|uniprotkb:Q6GTH7|uniprotkb:Q9UH04|ensembl:ENSP00000354476|uniprotkb:Q05BD5	psi-mi:p41235-2(display_long)|uniprotkb:HNF4A(gene name)|psi-mi:HNF4A(display_short)|uniprotkb:HNF4(gene name synonym)|uniprotkb:NR2A1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group A member 1(gene name synonym)|uniprotkb:TCF14(gene name synonym)|uniprotkb:Transcription factor 14(gene name synonym)|uniprotkb:Transcription factor HNF-4(gene name synonym)|uniprotkb:HNF4-A(isoform synonym)	psi-mi:srbp2_human(display_long)|uniprotkb:SREBF2(gene name)|psi-mi:SREBF2(display_short)|uniprotkb:SREBP2(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 2(gene name synonym)|uniprotkb:BHLHD2(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Misawa et al. (2003)	pubmed:12855700|mint:MINT-5216527|imex:IM-27301	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6965297|mint:MINT-16697|imex:IM-27301-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1049011(isoform-parent)|ensembl:ENSG00000101076(gene)|ensembl:ENST00000415691(transcript)|uniprotkb:P41235-2(isoform-parent)|mint:MINT-736813(identity)	ensembl:ENSG00000198911(gene)|ensembl:ENST00000361204(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005829"(cytosol)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1UKL|reactome:R-HSA-1655829|reactome:R-HSA-1989781|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-9619665|refseq:NP_004590.2|dip:DIP-263N|mint:MINT-736810(identity)	-	isoform-comment:Produced by alternative splicing of isoform HNF4-Alpha-1.|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|figure legend:Fig. 8b|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2003/09/29	2014/10/22	rogid:kRih/ay+T0NSN8hH1sotukrj3m49606	rogid:OkTB/ZjBgPVLKu333KVw2AKrE5M9606	intact-crc:E31F892E7EDC4BA4|rigid:Xcir8SrM34e7VzLCJehN/Uebit8	false	flag tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:2-481	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q12772	uniprotkb:P41235	intact:EBI-465059|uniprotkb:Q86V36|uniprotkb:Q6GTH7|uniprotkb:Q9UH04|ensembl:ENSP00000354476|uniprotkb:Q05BD5	intact:EBI-1049011|uniprotkb:Q92654|uniprotkb:Q92655|uniprotkb:Q99864|uniprotkb:Q9NQH0|uniprotkb:O00659|uniprotkb:O00723|uniprotkb:Q14540|uniprotkb:Q5QPB8|uniprotkb:Q6B4V5|uniprotkb:Q6B4V6|uniprotkb:Q6B4V7|uniprotkb:Q92653|uniprotkb:A5JW41|uniprotkb:B2RPP8|ensembl:ENSP00000312987	psi-mi:srbp2_human(display_long)|uniprotkb:SREBF2(gene name)|psi-mi:SREBF2(display_short)|uniprotkb:SREBP2(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 2(gene name synonym)|uniprotkb:BHLHD2(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 2(gene name synonym)	psi-mi:hnf4a_human(display_long)|uniprotkb:Transcription factor HNF-4(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group A member 1(gene name synonym)|uniprotkb:Transcription factor 14(gene name synonym)|uniprotkb:HNF4A(gene name)|psi-mi:HNF4A(display_short)|uniprotkb:HNF4(gene name synonym)|uniprotkb:NR2A1(gene name synonym)|uniprotkb:TCF14(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Misawa et al. (2003)	pubmed:12855700|mint:MINT-5216527|imex:IM-27301	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9869636|imex:IM-27301-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198911(gene)|ensembl:ENST00000361204(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005829"(cytosol)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1UKL|reactome:R-HSA-1655829|reactome:R-HSA-1989781|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-9619665|refseq:NP_004590.2|dip:DIP-263N	refseq:NP_000448.3|refseq:NP_001025174.1|refseq:NP_001025175.1|refseq:NP_787110.2|refseq:NP_849181.1|refseq:NP_001274111.1|refseq:NP_001274112.1|refseq:NP_001274113.1|refseq:NP_001245284.1|ensembl:ENSG00000101076(gene)|ensembl:ENST00000316099(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006591"(ornithine metabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007548"(sex differentiation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060398"(regulation of growth hormone receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR039067|mint:P41235|rcsb pdb:1PZL|rcsb pdb:3CBB|rcsb pdb:3FS1|rcsb pdb:4B7W|rcsb pdb:4IQR|rcsb pdb:6CHT|reactome:R-HSA-210745|reactome:R-HSA-383280|dip:DIP-499N	-	-	-	figure legend:Fig. 8c|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2003/09/29	2014/10/22	rogid:OkTB/ZjBgPVLKu333KVw2AKrE5M9606	rogid:lul0rM/fHNAVsH3ZizbMOXPPL0k9606	intact-crc:425DA75326DB4DEB|rigid:JMz9M6A4ct2v1oSGx2/5XcNe37g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12772	uniprotkb:P41235	intact:EBI-465059|uniprotkb:Q86V36|uniprotkb:Q6GTH7|uniprotkb:Q9UH04|ensembl:ENSP00000354476|uniprotkb:Q05BD5	intact:EBI-1049011|uniprotkb:Q92654|uniprotkb:Q92655|uniprotkb:Q99864|uniprotkb:Q9NQH0|uniprotkb:O00659|uniprotkb:O00723|uniprotkb:Q14540|uniprotkb:Q5QPB8|uniprotkb:Q6B4V5|uniprotkb:Q6B4V6|uniprotkb:Q6B4V7|uniprotkb:Q92653|uniprotkb:A5JW41|uniprotkb:B2RPP8|ensembl:ENSP00000312987	psi-mi:srbp2_human(display_long)|uniprotkb:SREBF2(gene name)|psi-mi:SREBF2(display_short)|uniprotkb:SREBP2(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 2(gene name synonym)|uniprotkb:BHLHD2(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 2(gene name synonym)	psi-mi:hnf4a_human(display_long)|uniprotkb:Transcription factor HNF-4(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group A member 1(gene name synonym)|uniprotkb:Transcription factor 14(gene name synonym)|uniprotkb:HNF4A(gene name)|psi-mi:HNF4A(display_short)|uniprotkb:HNF4(gene name synonym)|uniprotkb:NR2A1(gene name synonym)|uniprotkb:TCF14(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Misawa et al. (2003)	pubmed:12855700|mint:MINT-5216527|imex:IM-27301	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9836990|imex:IM-27301-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198911(gene)|ensembl:ENST00000361204(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005829"(cytosol)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1UKL|reactome:R-HSA-1655829|reactome:R-HSA-1989781|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-9619665|refseq:NP_004590.2|dip:DIP-263N	refseq:NP_000448.3|refseq:NP_001025174.1|refseq:NP_001025175.1|refseq:NP_787110.2|refseq:NP_849181.1|refseq:NP_001274111.1|refseq:NP_001274112.1|refseq:NP_001274113.1|refseq:NP_001245284.1|ensembl:ENSG00000101076(gene)|ensembl:ENST00000316099(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006591"(ornithine metabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007548"(sex differentiation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060398"(regulation of growth hormone receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR039067|mint:P41235|rcsb pdb:1PZL|rcsb pdb:3CBB|rcsb pdb:3FS1|rcsb pdb:4B7W|rcsb pdb:4IQR|rcsb pdb:6CHT|reactome:R-HSA-210745|reactome:R-HSA-383280|dip:DIP-499N	-	-	-	figure legend:Fig. 8c|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2003/09/29	2019/08/22	rogid:OkTB/ZjBgPVLKu333KVw2AKrE5M9606	rogid:lul0rM/fHNAVsH3ZizbMOXPPL0k9606	intact-crc:B211D74CACBEE050|rigid:JMz9M6A4ct2v1oSGx2/5XcNe37g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-9837510	uniprotkb:Q12772	-	intact:EBI-465059|uniprotkb:Q86V36|uniprotkb:Q6GTH7|uniprotkb:Q9UH04|ensembl:ENSP00000354476|uniprotkb:Q05BD5	psi-mi:ldlr_human_sre_dna-probe(display_short)|psi-mi:EBI-9837510(display_long)	psi-mi:srbp2_human(display_long)|uniprotkb:SREBF2(gene name)|psi-mi:SREBF2(display_short)|uniprotkb:SREBP2(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 2(gene name synonym)|uniprotkb:BHLHD2(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 2(gene name synonym)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Misawa et al. (2003)	pubmed:12855700|mint:MINT-5216527|imex:IM-27301	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9837535|imex:IM-27301-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130164(see-also)	ensembl:ENSG00000198911(gene)|ensembl:ENST00000361204(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005829"(cytosol)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1UKL|reactome:R-HSA-1655829|reactome:R-HSA-1989781|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-9619665|refseq:NP_004590.2|dip:DIP-263N	-	-	-	figure legend:Fig. 5|comment:"Competition assays were performed by adding unlabeled SRE DNA probes from the human Sterol Isomerase gene promoter (ENSG00000147155). Excess amount of SREc probe outcompeted the LDLR SRE probe, while the SREa and SREd probes had only little effect."|causality statement:Q12772 increases expression at protein level  of ENSG00000130164|causality statement:Q12772 and P41235 increases expression at protein level of ENSG00000130164|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/09/29	2019/08/22	-	rogid:OkTB/ZjBgPVLKu333KVw2AKrE5M9606	intact-crc:83EF8C65477F1B7F	false	32p radiolabel:?-?	sufficient binding region:1-481|his tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)