#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8WY64	uniprotkb:Q9Y2B0	intact:EBI-6952711|ensembl:ENSP00000349298|uniprotkb:Q9BU73|uniprotkb:Q9UHE7|intact:MINT-8162265|uniprotkb:Q5TIA4|uniprotkb:Q9NRL9|intact:MINT-268789	intact:EBI-1054195|uniprotkb:Q9UHE9|uniprotkb:B2R7B9|ensembl:ENSP00000273308	psi-mi:mylip_human(display_long)|uniprotkb:MYLIP(gene name)|psi-mi:MYLIP(display_short)|uniprotkb:BZF1(gene name synonym)|uniprotkb:IDOL(gene name synonym)|uniprotkb:Inducible degrader of the LDL-receptor(gene name synonym)|uniprotkb:Myosin regulatory light chain interacting protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MYLIP(gene name synonym)|uniprotkb:BM-023(orf name)|uniprotkb:PP5242(orf name)	psi-mi:cnpy2_human(display_long)|uniprotkb:TMEM4(gene name synonym)|uniprotkb:MIR-interacting saposin-like protein(gene name synonym)|uniprotkb:Transmembrane protein 4(gene name synonym)|uniprotkb:Putative secreted protein Zsig9(gene name synonym)|uniprotkb:CNPY2(gene name)|psi-mi:CNPY2(display_short)|uniprotkb:MSAP(gene name synonym)|uniprotkb:ZSIG9(gene name synonym)|uniprotkb:UNQ1943/PRO4426(orf name)	psi-mi:"MI:0096"(pull down)	Bornhauser et al. (2003)	pubmed:12826659|mint:MINT-5216495|imex:IM-27296	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6952707|mint:MINT-14706|imex:IM-27296-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007944(gene)|ensembl:ENST00000356840(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031648"(protein destabilization)|go:"GO:0032803"(regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0005886"(plasma membrane)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041790|mint:Q8WY64|rcsb pdb:2YHN|rcsb pdb:2YHO|rcsb pdb:6QLY|rcsb pdb:6QLZ|reactome:R-HSA-8866427|reactome:R-HSA-9031525|reactome:R-HSA-983168|refseq:NP_037394.2|mint:MINT-736057(identity)	refseq:NP_001177920.1|refseq:NP_055070.1|ensembl:ENSG00000257727(gene)|ensembl:ENST00000273308(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR008139(Saposin B)|interpro:IPR021852|interpro:IPR042415|mint:Q9Y2B0|dip:DIP-50705N|mint:MINT-736054(identity)	-	comment:mint|comment:homomint|function:"E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Stable or transient overexpression of MIR induces proteasomal degradation of MRLC inhibiting neurite outgrowth in presence of NGF. MIR counteracts the stabilization of MRLC by MIR-interacting saposin-like protein (MSAP/TMEM4) and reduces MSAP-stimulated neurite outgrowth"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:Fig. 2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/09/30	2015/07/23	rogid:kkDkk49icU/zPJmjNiiaQ5GIx+w9606	rogid:m8AFLt3+Fjh99ImqcKladnb00jU9606	intact-crc:C73A1CE4C2AFEFB2|rigid:A02WhqyPVh93Wsl+MTHL+bdsAlk	false	glutathione s tranferase tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8WY64	uniprotkb:Q8WY64	intact:EBI-6952711|ensembl:ENSP00000349298|uniprotkb:Q9BU73|uniprotkb:Q9UHE7|intact:MINT-8162265|uniprotkb:Q5TIA4|uniprotkb:Q9NRL9|intact:MINT-268789	intact:EBI-6952711|ensembl:ENSP00000349298|uniprotkb:Q9BU73|uniprotkb:Q9UHE7|intact:MINT-8162265|uniprotkb:Q5TIA4|uniprotkb:Q9NRL9|intact:MINT-268789	psi-mi:mylip_human(display_long)|uniprotkb:MYLIP(gene name)|psi-mi:MYLIP(display_short)|uniprotkb:BZF1(gene name synonym)|uniprotkb:IDOL(gene name synonym)|uniprotkb:Inducible degrader of the LDL-receptor(gene name synonym)|uniprotkb:Myosin regulatory light chain interacting protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MYLIP(gene name synonym)|uniprotkb:BM-023(orf name)|uniprotkb:PP5242(orf name)	psi-mi:mylip_human(display_long)|uniprotkb:MYLIP(gene name)|psi-mi:MYLIP(display_short)|uniprotkb:BZF1(gene name synonym)|uniprotkb:IDOL(gene name synonym)|uniprotkb:Inducible degrader of the LDL-receptor(gene name synonym)|uniprotkb:Myosin regulatory light chain interacting protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MYLIP(gene name synonym)|uniprotkb:BM-023(orf name)|uniprotkb:PP5242(orf name)	psi-mi:"MI:0096"(pull down)	Bornhauser et al. (2003)	pubmed:12826659|mint:MINT-5216495|imex:IM-27296	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10919757|imex:IM-27296-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007944(gene)|ensembl:ENST00000356840(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031648"(protein destabilization)|go:"GO:0032803"(regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0005886"(plasma membrane)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041790|mint:Q8WY64|rcsb pdb:2YHN|rcsb pdb:2YHO|rcsb pdb:6QLY|rcsb pdb:6QLZ|reactome:R-HSA-8866427|reactome:R-HSA-9031525|reactome:R-HSA-983168|refseq:NP_037394.2|mint:MINT-736054(identity)	ensembl:ENSG00000007944(gene)|ensembl:ENST00000356840(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031648"(protein destabilization)|go:"GO:0032803"(regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0005886"(plasma membrane)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041790|mint:Q8WY64|rcsb pdb:2YHN|rcsb pdb:2YHO|rcsb pdb:6QLY|rcsb pdb:6QLZ|reactome:R-HSA-8866427|reactome:R-HSA-9031525|reactome:R-HSA-983168|refseq:NP_037394.2|mint:MINT-736057(identity)	-	comment:mint|comment:homomint|function:"E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Stable or transient overexpression of MIR induces proteasomal degradation of MRLC inhibiting neurite outgrowth in presence of NGF. MIR counteracts the stabilization of MRLC by MIR-interacting saposin-like protein (MSAP/TMEM4) and reduces MSAP-stimulated neurite outgrowth"|comment:"Stoichiometry: 1.0"	comment:mint|comment:homomint|function:"E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Stable or transient overexpression of MIR induces proteasomal degradation of MRLC inhibiting neurite outgrowth in presence of NGF. MIR counteracts the stabilization of MRLC by MIR-interacting saposin-like protein (MSAP/TMEM4) and reduces MSAP-stimulated neurite outgrowth"|comment:"Stoichiometry: 1.0"	figure legend:Fig. 2Ax|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/09/30	2015/07/23	rogid:kkDkk49icU/zPJmjNiiaQ5GIx+w9606	rogid:kkDkk49icU/zPJmjNiiaQ5GIx+w9606	rigid:3A1iUcn1WTLz/ZkWXhXd+5vXPc8	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q8WY64	uniprotkb:Q9Y2B0	intact:EBI-6952711|ensembl:ENSP00000349298|uniprotkb:Q9BU73|uniprotkb:Q9UHE7|intact:MINT-8162265|uniprotkb:Q5TIA4|uniprotkb:Q9NRL9|intact:MINT-268789	intact:EBI-1054195|uniprotkb:Q9UHE9|uniprotkb:B2R7B9|ensembl:ENSP00000273308	psi-mi:mylip_human(display_long)|uniprotkb:MYLIP(gene name)|psi-mi:MYLIP(display_short)|uniprotkb:BZF1(gene name synonym)|uniprotkb:IDOL(gene name synonym)|uniprotkb:Inducible degrader of the LDL-receptor(gene name synonym)|uniprotkb:Myosin regulatory light chain interacting protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MYLIP(gene name synonym)|uniprotkb:BM-023(orf name)|uniprotkb:PP5242(orf name)	psi-mi:cnpy2_human(display_long)|uniprotkb:TMEM4(gene name synonym)|uniprotkb:MIR-interacting saposin-like protein(gene name synonym)|uniprotkb:Transmembrane protein 4(gene name synonym)|uniprotkb:Putative secreted protein Zsig9(gene name synonym)|uniprotkb:CNPY2(gene name)|psi-mi:CNPY2(display_short)|uniprotkb:MSAP(gene name synonym)|uniprotkb:ZSIG9(gene name synonym)|uniprotkb:UNQ1943/PRO4426(orf name)	psi-mi:"MI:0018"(two hybrid)	Bornhauser et al. (2003)	pubmed:12826659|mint:MINT-5216495|imex:IM-27296	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6952808|mint:MINT-14705|imex:IM-27296-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007944(gene)|ensembl:ENST00000356840(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031648"(protein destabilization)|go:"GO:0032803"(regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0005886"(plasma membrane)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041790|mint:Q8WY64|rcsb pdb:2YHN|rcsb pdb:2YHO|rcsb pdb:6QLY|rcsb pdb:6QLZ|reactome:R-HSA-8866427|reactome:R-HSA-9031525|reactome:R-HSA-983168|refseq:NP_037394.2|mint:MINT-736064(identity)	refseq:NP_001177920.1|refseq:NP_055070.1|ensembl:ENSG00000257727(gene)|ensembl:ENST00000273308(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR008139(Saposin B)|interpro:IPR021852|interpro:IPR042415|mint:Q9Y2B0|dip:DIP-50705N|mint:MINT-736070(identity)	-	comment:mint|comment:homomint|function:"E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Stable or transient overexpression of MIR induces proteasomal degradation of MRLC inhibiting neurite outgrowth in presence of NGF. MIR counteracts the stabilization of MRLC by MIR-interacting saposin-like protein (MSAP/TMEM4) and reduces MSAP-stimulated neurite outgrowth"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/09/30	2015/07/23	rogid:kkDkk49icU/zPJmjNiiaQ5GIx+w9606	rogid:m8AFLt3+Fjh99ImqcKladnb00jU9606	intact-crc:2B0A55B0BD39AF24|rigid:A02WhqyPVh93Wsl+MTHL+bdsAlk	false	tag:?-?(MINT-736065)	tag:?-?(MINT-736071)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8WY64	uniprotkb:Q9Y2B0	intact:EBI-6952711|ensembl:ENSP00000349298|uniprotkb:Q9BU73|uniprotkb:Q9UHE7|intact:MINT-8162265|uniprotkb:Q5TIA4|uniprotkb:Q9NRL9|intact:MINT-268789	intact:EBI-1054195|uniprotkb:Q9UHE9|uniprotkb:B2R7B9|ensembl:ENSP00000273308	psi-mi:mylip_human(display_long)|uniprotkb:MYLIP(gene name)|psi-mi:MYLIP(display_short)|uniprotkb:BZF1(gene name synonym)|uniprotkb:IDOL(gene name synonym)|uniprotkb:Inducible degrader of the LDL-receptor(gene name synonym)|uniprotkb:Myosin regulatory light chain interacting protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MYLIP(gene name synonym)|uniprotkb:BM-023(orf name)|uniprotkb:PP5242(orf name)	psi-mi:cnpy2_human(display_long)|uniprotkb:TMEM4(gene name synonym)|uniprotkb:MIR-interacting saposin-like protein(gene name synonym)|uniprotkb:Transmembrane protein 4(gene name synonym)|uniprotkb:Putative secreted protein Zsig9(gene name synonym)|uniprotkb:CNPY2(gene name)|psi-mi:CNPY2(display_short)|uniprotkb:MSAP(gene name synonym)|uniprotkb:ZSIG9(gene name synonym)|uniprotkb:UNQ1943/PRO4426(orf name)	psi-mi:"MI:0018"(two hybrid)	Bornhauser et al. (2003)	pubmed:12826659|mint:MINT-5216495|imex:IM-27296	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10919731|imex:IM-27296-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000007944(gene)|ensembl:ENST00000356840(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007399"(nervous system development)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031648"(protein destabilization)|go:"GO:0032803"(regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0005886"(plasma membrane)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041790|mint:Q8WY64|rcsb pdb:2YHN|rcsb pdb:2YHO|rcsb pdb:6QLY|rcsb pdb:6QLZ|reactome:R-HSA-8866427|reactome:R-HSA-9031525|reactome:R-HSA-983168|refseq:NP_037394.2|mint:MINT-736064(identity)	refseq:NP_001177920.1|refseq:NP_055070.1|ensembl:ENSG00000257727(gene)|ensembl:ENST00000273308(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010988"(regulation of low-density lipoprotein particle clearance)|go:"GO:1905599"(positive regulation of low-density lipoprotein receptor activity)|interpro:IPR008139(Saposin B)|interpro:IPR021852|interpro:IPR042415|mint:Q9Y2B0|dip:DIP-50705N|mint:MINT-736070(identity)	-	comment:mint|comment:homomint|function:"E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Stable or transient overexpression of MIR induces proteasomal degradation of MRLC inhibiting neurite outgrowth in presence of NGF. MIR counteracts the stabilization of MRLC by MIR-interacting saposin-like protein (MSAP/TMEM4) and reduces MSAP-stimulated neurite outgrowth"|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|figure legend:Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/09/30	2015/07/23	rogid:kkDkk49icU/zPJmjNiiaQ5GIx+w9606	rogid:m8AFLt3+Fjh99ImqcKladnb00jU9606	rigid:A02WhqyPVh93Wsl+MTHL+bdsAlk	false	tag:?-?(MINT-736065)	tag:?-?(MINT-736071)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-10919780	intact:EBI-10919783	-	-	psi-mi:mylip_chlae_protein(display_short)|psi-mi:EBI-10919780(display_long)	psi-mi:cnpy2_chlae_protein(display_short)|psi-mi:EBI-10919783(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bornhauser et al. (2003)	pubmed:12826659|mint:MINT-5216495|imex:IM-27296	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10919781|imex:IM-27296-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	-	-	-	-	figure legend:Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2003/09/30	2015/07/23	-	-	-	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)