#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q03431 uniprotkb:Q04917 intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774 intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595 psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym) psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym) psi-mi:"MI:0096"(pull down) Tazawa et al. (2003) mint:MINT-5216147|pubmed:12595070 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8606948|mint:MINT-15641 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821|mint:MINT-728424(identity) go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N|mint:MINT-728421(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:"colocalization in COS-7 cells (GFP-1433 and FLAG-PTHR)rnrn"|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2003/02/27 2014/10/16 rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606 rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606 intact-crc:61C9862557DBB9EF|rigid:NRogbxck3h/scw+yqUNTQEiBVQE false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03431 uniprotkb:Q04917 intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774 intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595 psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym) psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Tazawa et al. (2003) mint:MINT-5216147|pubmed:12595070 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8606971|mint:MINT-15642 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821|mint:MINT-728411(identity) go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N|mint:MINT-728404(identity) go:"GO:0005886"(plasma membrane) comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2003/02/27 2014/10/16 rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606 rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606 intact-crc:EE5804D4E542CF3F|rigid:NRogbxck3h/scw+yqUNTQEiBVQE false flag tag:?-?(MINT-5207089) glutathione s tranferase tag:?-?(MINT-728405) - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q03431 uniprotkb:Q04917 intact:EBI-2860297|uniprotkb:Q2M1U3|ensembl:ENSP00000321999|ensembl:ENSP00000402723|ensembl:ENSP00000411424|ensembl:ENSP00000413774 intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595 psi-mi:pth1r_human(display_long)|uniprotkb:PTH1R(gene name)|psi-mi:PTH1R(display_short)|uniprotkb:PTHR(gene name synonym)|uniprotkb:PTHR1(gene name synonym)|uniprotkb:PTH/PTHrP type I receptor(gene name synonym)|uniprotkb:Parathyroid hormone 1 receptor(gene name synonym) psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Tazawa et al. (2003) mint:MINT-5216147|pubmed:12595070 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8606993|mint:MINT-5207093 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000307.1|refseq:NP_001171673.1|refseq:XP_016862422.1|ensembl:ENSG00000160801(gene)|ensembl:ENST00000313049(transcript)|ensembl:ENST00000418619(transcript)|ensembl:ENST00000430002(transcript)|ensembl:ENST00000449590(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002076"(osteoblast development)|go:"GO:0004991"(parathyroid hormone receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0030282"(bone mineralization)|go:"GO:0031526"(brush border membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043621"(protein self-association)|go:"GO:0045453"(bone resorption)|go:"GO:0048469"(cell maturation)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR002170(GPCR, family 2, parathyroid hormone receptor)|interpro:IPR017981|interpro:IPR017983|interpro:IPR036445|rcsb pdb:1BL1|rcsb pdb:1ET2|rcsb pdb:1ET3|rcsb pdb:3C4M|rcsb pdb:3H3G|rcsb pdb:3L2J|rcsb pdb:4Z8J|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|rcsb pdb:5EMB|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|reactome:R-HSA-373080|reactome:R-HSA-418555|reactome:R-HSA-9660821|mint:MINT-5207102(identity) go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N|mint:MINT-5207095(identity) go:"GO:0005886"(plasma membrane) - - figure legend:F4|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2003/02/27 2014/10/16 rogid:zdoFjG63+GTnmdGVyNf1Gg2rf4k9606 rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606 intact-crc:2C3CDB8D1146E747|rigid:NRogbxck3h/scw+yqUNTQEiBVQE false flag tag:?-?(MINT-5207104) green fluorescent protein tag:?-?(MINT-5207098) - - psi-mi:"MI:0707"(anti tag immunostaining) psi-mi:"MI:0396"(predetermined participant)