#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P40793	uniprotkb:Q9VXE5	intact:EBI-114324|uniprotkb:Q540W4|ensemblmetazoa:FBpp0074520|ensemblmetazoa:FBpp0301153|ensemblmetazoa:FBpp0301154|uniprotkb:Q9U9S3|uniprotkb:Q9U9S4|uniprotkb:Q9U9S5|uniprotkb:Q9U9S6|uniprotkb:Q9V465	intact:EBI-75994|uniprotkb:O96372|uniprotkb:Q960J8|uniprotkb:Q9TYH2|ensemblmetazoa:FBpp0074060	psi-mi:cdc42_drome(display_long)|uniprotkb:CG12530(orf name)|uniprotkb:Cdc42(gene name)|psi-mi:Cdc42(display_short)	psi-mi:pakm_drome(display_long)|uniprotkb:mbt(gene name)|psi-mi:mbt(display_short)|uniprotkb:p21-activated kinase-related protein(gene name synonym)|uniprotkb:Protein mushroom bodies tiny(gene name synonym)|uniprotkb:CG18582(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schneeberger et al. (2003)	pubmed:12490550	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-76012	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245762.1|refseq:NP_001245763.1|refseq:NP_523414.1|flybase:FBgn0010341|go:"GO:0007286"(spermatid development)|go:"GO:0007349"(cellularization)|go:"GO:0007391"(dorsal closure)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009611"(response to wounding)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016028"(rhabdomere)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016318"(ommatidial rotation)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035010"(encapsulation of foreign target)|go:"GO:0035011"(melanotic encapsulation of foreign target)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035318"(imaginal disc-derived wing hair outgrowth)|go:"GO:0042060"(wound healing)|go:"GO:0045177"(apical part of cell)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045202"(synapse)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0030027"(lamellipodium)|ensemblmetazoa:FBgn0010341(gene)|ensemblmetazoa:FBtr0074751(transcript)|ensemblmetazoa:FBtr0309214(transcript)|ensemblmetazoa:FBtr0309215(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007266"(Rho protein signal transduction)|interpro:IPR027417|interpro:IPR037874|reactome:R-DME-114604|reactome:R-DME-182971|reactome:R-DME-2029482|reactome:R-DME-389359|reactome:R-DME-3928662|reactome:R-DME-4420097|reactome:R-DME-525793|reactome:R-DME-5627123|reactome:R-DME-5663220|reactome:R-DME-5687128|reactome:R-DME-8964616|reactome:R-DME-9013148|reactome:R-DME-9013149|reactome:R-DME-9013404|reactome:R-DME-9013406|reactome:R-DME-9013409|reactome:R-DME-9013420|reactome:R-DME-9013424|reactome:R-DME-983231|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097206"(nephrocyte filtration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|dip:DIP-31003N	refseq:NP_523375.2|flybase:FBgn0025743|dip:DIP-20519N|ensemblmetazoa:FBgn0025743(gene)|ensemblmetazoa:FBtr0074285(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0016319"(mushroom body development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045315"(positive regulation of compound eye photoreceptor development)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048749"(compound eye development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000047"(regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-DME-9013149|reactome:R-DME-9013404|reactome:R-DME-9013405|reactome:R-DME-9013406|reactome:R-DME-9013407|reactome:R-DME-9013420|reactome:R-DME-9013424	-	-	-	comment:HA tagged Mbt and Myc tagged Cdc42	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2003/11/18	2014/10/16	rogid:p1Wn2f2lqp9i9DPM0uMTy/eVs+47227	rogid:ixeI6XTRWwNXaaMMITg+Ma/FMQo7227	intact-crc:E4972A6CF1AB0824|rigid:juOmKL0YBMKKT7N+AKdA822Amts	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40793	uniprotkb:Q9VXE5	intact:EBI-114324|uniprotkb:Q540W4|ensemblmetazoa:FBpp0074520|ensemblmetazoa:FBpp0301153|ensemblmetazoa:FBpp0301154|uniprotkb:Q9U9S3|uniprotkb:Q9U9S4|uniprotkb:Q9U9S5|uniprotkb:Q9U9S6|uniprotkb:Q9V465	intact:EBI-75994|uniprotkb:O96372|uniprotkb:Q960J8|uniprotkb:Q9TYH2|ensemblmetazoa:FBpp0074060	psi-mi:cdc42_drome(display_long)|uniprotkb:CG12530(orf name)|uniprotkb:Cdc42(gene name)|psi-mi:Cdc42(display_short)	psi-mi:pakm_drome(display_long)|uniprotkb:mbt(gene name)|psi-mi:mbt(display_short)|uniprotkb:p21-activated kinase-related protein(gene name synonym)|uniprotkb:Protein mushroom bodies tiny(gene name synonym)|uniprotkb:CG18582(orf name)	psi-mi:"MI:0096"(pull down)	Schneeberger et al. (2003)	pubmed:12490550	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-76019	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001245762.1|refseq:NP_001245763.1|refseq:NP_523414.1|flybase:FBgn0010341|go:"GO:0007286"(spermatid development)|go:"GO:0007349"(cellularization)|go:"GO:0007391"(dorsal closure)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009611"(response to wounding)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016028"(rhabdomere)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016318"(ommatidial rotation)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035010"(encapsulation of foreign target)|go:"GO:0035011"(melanotic encapsulation of foreign target)|go:"GO:0035099"(hemocyte migration)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035318"(imaginal disc-derived wing hair outgrowth)|go:"GO:0042060"(wound healing)|go:"GO:0045177"(apical part of cell)|go:"GO:0045185"(maintenance of protein location)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0045202"(synapse)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0030027"(lamellipodium)|ensemblmetazoa:FBgn0010341(gene)|ensemblmetazoa:FBtr0074751(transcript)|ensemblmetazoa:FBtr0309214(transcript)|ensemblmetazoa:FBtr0309215(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007266"(Rho protein signal transduction)|interpro:IPR027417|interpro:IPR037874|reactome:R-DME-114604|reactome:R-DME-182971|reactome:R-DME-2029482|reactome:R-DME-389359|reactome:R-DME-3928662|reactome:R-DME-4420097|reactome:R-DME-525793|reactome:R-DME-5627123|reactome:R-DME-5663220|reactome:R-DME-5687128|reactome:R-DME-8964616|reactome:R-DME-9013148|reactome:R-DME-9013149|reactome:R-DME-9013404|reactome:R-DME-9013406|reactome:R-DME-9013409|reactome:R-DME-9013420|reactome:R-DME-9013424|reactome:R-DME-983231|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048477"(oogenesis)|go:"GO:0048675"(axon extension)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051601"(exocyst localization)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097206"(nephrocyte filtration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|dip:DIP-31003N	refseq:NP_523375.2|flybase:FBgn0025743|dip:DIP-20519N|ensemblmetazoa:FBgn0025743(gene)|ensemblmetazoa:FBtr0074285(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001751"(compound eye photoreceptor cell differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0016319"(mushroom body development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045315"(positive regulation of compound eye photoreceptor development)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048749"(compound eye development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000047"(regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-DME-9013149|reactome:R-DME-9013404|reactome:R-DME-9013405|reactome:R-DME-9013406|reactome:R-DME-9013407|reactome:R-DME-9013420|reactome:R-DME-9013424	-	-	-	comment:GST tagged Cdc42 and HA tagged Mbt used in the experiment. Interaction is GTP dependent.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/18	2014/10/16	rogid:p1Wn2f2lqp9i9DPM0uMTy/eVs+47227	rogid:ixeI6XTRWwNXaaMMITg+Ma/FMQo7227	intact-crc:9B400E746AB1E6A5|rigid:juOmKL0YBMKKT7N+AKdA822Amts	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)