#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P42282	uniprotkb:P21461	intact:EBI-77008|uniprotkb:A4V3Q3|uniprotkb:Q0KHY0|uniprotkb:Q1LZ43|uniprotkb:Q24313|uniprotkb:Q9V9V2|ensemblmetazoa:FBpp0085186|ensemblmetazoa:FBpp0085188|ensemblmetazoa:FBpp0085190|ensemblmetazoa:FBpp0292319	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	psi-mi:ttka_drome(display_long)|uniprotkb:ttk(gene name)|psi-mi:ttk(display_short)|uniprotkb:FTZ-F2(gene name synonym)|uniprotkb:CG1856(orf name)|uniprotkb:Tramtrack p88(gene name synonym)|uniprotkb:Repressor protein fushi tarazu(gene name synonym)	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77029	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001189329.1|refseq:NP_733443.1|refseq:NP_733444.1|refseq:NP_733445.1|flybase:FBgn0003870|ensemblmetazoa:FBgn0003870(gene)|ensemblmetazoa:FBtr0085825(transcript)|ensemblmetazoa:FBtr0085827(transcript)|ensemblmetazoa:FBtr0085829(transcript)|ensemblmetazoa:FBtr0303227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031208"(POZ domain binding)|go:"GO:0035001"(dorsal trunk growth, open tracheal system)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035151"(regulation of tube size, open tracheal system)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0040003"(chitin-based cuticle development)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042682"(regulation of compound eye cone cell fate specification)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045677"(negative regulation of R7 cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048053"(R1/R6 development)|go:"GO:0048626"(myoblast fate specification)|go:"GO:0048750"(compound eye corneal lens morphogenesis)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	pubmed:9267027(see-also)	-	-	comment:Sina is GST tagged.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:k0MeF2/ch3ddqz7uLHjP8aeJwoI7227	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	intact-crc:254062BCEC5BE281|rigid:JmGFe1Hey/BKCxM3CMGCYTEOMr8	false	radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21461	uniprotkb:Q27934	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:"MI:0096"(pull down)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77045	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	-	-	-	comment:Phyl is GST tagged.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	intact-crc:94C7D28320662467|rigid:P+ui+n2mQlnO4IJGO8pz4sikPeE	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q27934	uniprotkb:P21461	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:"MI:0096"(pull down)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77223	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	pubmed:9267027(see-also)	-	-	comment:From mutation analysis, residues 109-127 were found ot be important for the intraction of Phyl with Sina. Sina was GST tagged in this experiment.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	intact-crc:5C61EA0999E6DD07|rigid:P+ui+n2mQlnO4IJGO8pz4sikPeE	false	radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21461	uniprotkb:Q27934	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77049	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	-	-	-	comment:Phyl is HA tagged.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	intact-crc:BB3017E9C1BEF51D|rigid:P+ui+n2mQlnO4IJGO8pz4sikPeE	false	radiolabel:?-?	ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42282	uniprotkb:P21461	intact:EBI-77008|uniprotkb:A4V3Q3|uniprotkb:Q0KHY0|uniprotkb:Q1LZ43|uniprotkb:Q24313|uniprotkb:Q9V9V2|ensemblmetazoa:FBpp0085186|ensemblmetazoa:FBpp0085188|ensemblmetazoa:FBpp0085190|ensemblmetazoa:FBpp0292319	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	psi-mi:ttka_drome(display_long)|uniprotkb:ttk(gene name)|psi-mi:ttk(display_short)|uniprotkb:FTZ-F2(gene name synonym)|uniprotkb:CG1856(orf name)|uniprotkb:Tramtrack p88(gene name synonym)|uniprotkb:Repressor protein fushi tarazu(gene name synonym)	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77053	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001189329.1|refseq:NP_733443.1|refseq:NP_733444.1|refseq:NP_733445.1|flybase:FBgn0003870|ensemblmetazoa:FBgn0003870(gene)|ensemblmetazoa:FBtr0085825(transcript)|ensemblmetazoa:FBtr0085827(transcript)|ensemblmetazoa:FBtr0085829(transcript)|ensemblmetazoa:FBtr0303227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031208"(POZ domain binding)|go:"GO:0035001"(dorsal trunk growth, open tracheal system)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035151"(regulation of tube size, open tracheal system)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0040003"(chitin-based cuticle development)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042682"(regulation of compound eye cone cell fate specification)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045677"(negative regulation of R7 cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048053"(R1/R6 development)|go:"GO:0048626"(myoblast fate specification)|go:"GO:0048750"(compound eye corneal lens morphogenesis)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	-	-	-	comment:Ttk is HA tagged. Interaction of Ttk with Sina is weaker than its interaction with Phyl.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:k0MeF2/ch3ddqz7uLHjP8aeJwoI7227	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	intact-crc:6117FB63EDBD1E11|rigid:JmGFe1Hey/BKCxM3CMGCYTEOMr8	false	ha tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21461	uniprotkb:P21461	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77057	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	pubmed:9267027(see-also)|pubmed:9267026(see-also)|pubmed:9334332(see-also)	-	-	comment:Sina is HA tagged and the immunoprecipitation of untagged Sina observed.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	intact-crc:37209634C3A7EEF5|rigid:+vjSk86AURqxS6iRv0GVSzBuM7I	false	radiolabel:?-?	ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q27934	uniprotkb:P42282	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	intact:EBI-77008|uniprotkb:A4V3Q3|uniprotkb:Q0KHY0|uniprotkb:Q1LZ43|uniprotkb:Q24313|uniprotkb:Q9V9V2|ensemblmetazoa:FBpp0085186|ensemblmetazoa:FBpp0085188|ensemblmetazoa:FBpp0085190|ensemblmetazoa:FBpp0292319	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:ttka_drome(display_long)|uniprotkb:ttk(gene name)|psi-mi:ttk(display_short)|uniprotkb:FTZ-F2(gene name synonym)|uniprotkb:CG1856(orf name)|uniprotkb:Tramtrack p88(gene name synonym)|uniprotkb:Repressor protein fushi tarazu(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77060	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	refseq:NP_001189329.1|refseq:NP_733443.1|refseq:NP_733444.1|refseq:NP_733445.1|flybase:FBgn0003870|ensemblmetazoa:FBgn0003870(gene)|ensemblmetazoa:FBtr0085825(transcript)|ensemblmetazoa:FBtr0085827(transcript)|ensemblmetazoa:FBtr0085829(transcript)|ensemblmetazoa:FBtr0303227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031208"(POZ domain binding)|go:"GO:0035001"(dorsal trunk growth, open tracheal system)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035151"(regulation of tube size, open tracheal system)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0040003"(chitin-based cuticle development)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042682"(regulation of compound eye cone cell fate specification)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045677"(negative regulation of R7 cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048053"(R1/R6 development)|go:"GO:0048626"(myoblast fate specification)|go:"GO:0048750"(compound eye corneal lens morphogenesis)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	-	-	comment:Ttk is HA tagged.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	rogid:k0MeF2/ch3ddqz7uLHjP8aeJwoI7227	intact-crc:EBE1EB08EF7CFD20|rigid:BOVWQsZ94fnH2c3IX5GJ9XqoIwg	false	radiolabel:?-?	ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42282	uniprotkb:Q27934	intact:EBI-77008|uniprotkb:A4V3Q3|uniprotkb:Q0KHY0|uniprotkb:Q1LZ43|uniprotkb:Q24313|uniprotkb:Q9V9V2|ensemblmetazoa:FBpp0085186|ensemblmetazoa:FBpp0085188|ensemblmetazoa:FBpp0085190|ensemblmetazoa:FBpp0292319	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	psi-mi:ttka_drome(display_long)|uniprotkb:ttk(gene name)|psi-mi:ttk(display_short)|uniprotkb:FTZ-F2(gene name synonym)|uniprotkb:CG1856(orf name)|uniprotkb:Tramtrack p88(gene name synonym)|uniprotkb:Repressor protein fushi tarazu(gene name synonym)	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77063	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001189329.1|refseq:NP_733443.1|refseq:NP_733444.1|refseq:NP_733445.1|flybase:FBgn0003870|ensemblmetazoa:FBgn0003870(gene)|ensemblmetazoa:FBtr0085825(transcript)|ensemblmetazoa:FBtr0085827(transcript)|ensemblmetazoa:FBtr0085829(transcript)|ensemblmetazoa:FBtr0303227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031208"(POZ domain binding)|go:"GO:0035001"(dorsal trunk growth, open tracheal system)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035151"(regulation of tube size, open tracheal system)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0040003"(chitin-based cuticle development)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042682"(regulation of compound eye cone cell fate specification)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045677"(negative regulation of R7 cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048053"(R1/R6 development)|go:"GO:0048626"(myoblast fate specification)|go:"GO:0048750"(compound eye corneal lens morphogenesis)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	-	-	-	comment:Ttk is HA tagged.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:k0MeF2/ch3ddqz7uLHjP8aeJwoI7227	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	intact-crc:96CFE70FDDB6976E|rigid:ALOVyz8S+gfbsWC97cwu3msxL2Y	false	ha tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42282	uniprotkb:P21461	intact:EBI-77008|uniprotkb:A4V3Q3|uniprotkb:Q0KHY0|uniprotkb:Q1LZ43|uniprotkb:Q24313|uniprotkb:Q9V9V2|ensemblmetazoa:FBpp0085186|ensemblmetazoa:FBpp0085188|ensemblmetazoa:FBpp0085190|ensemblmetazoa:FBpp0292319	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	psi-mi:ttka_drome(display_long)|uniprotkb:ttk(gene name)|psi-mi:ttk(display_short)|uniprotkb:FTZ-F2(gene name synonym)|uniprotkb:CG1856(orf name)|uniprotkb:Tramtrack p88(gene name synonym)|uniprotkb:Repressor protein fushi tarazu(gene name synonym)	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77063	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001189329.1|refseq:NP_733443.1|refseq:NP_733444.1|refseq:NP_733445.1|flybase:FBgn0003870|ensemblmetazoa:FBgn0003870(gene)|ensemblmetazoa:FBtr0085825(transcript)|ensemblmetazoa:FBtr0085827(transcript)|ensemblmetazoa:FBtr0085829(transcript)|ensemblmetazoa:FBtr0303227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031208"(POZ domain binding)|go:"GO:0035001"(dorsal trunk growth, open tracheal system)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035151"(regulation of tube size, open tracheal system)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0040003"(chitin-based cuticle development)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042682"(regulation of compound eye cone cell fate specification)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045677"(negative regulation of R7 cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048053"(R1/R6 development)|go:"GO:0048626"(myoblast fate specification)|go:"GO:0048750"(compound eye corneal lens morphogenesis)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	-	-	-	comment:Ttk is HA tagged.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:k0MeF2/ch3ddqz7uLHjP8aeJwoI7227	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	intact-crc:96CFE70FDDB6976E|rigid:ALOVyz8S+gfbsWC97cwu3msxL2Y	false	ha tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q27934	uniprotkb:P42282	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	intact:EBI-77008|uniprotkb:A4V3Q3|uniprotkb:Q0KHY0|uniprotkb:Q1LZ43|uniprotkb:Q24313|uniprotkb:Q9V9V2|ensemblmetazoa:FBpp0085186|ensemblmetazoa:FBpp0085188|ensemblmetazoa:FBpp0085190|ensemblmetazoa:FBpp0292319	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:ttka_drome(display_long)|uniprotkb:ttk(gene name)|psi-mi:ttk(display_short)|uniprotkb:FTZ-F2(gene name synonym)|uniprotkb:CG1856(orf name)|uniprotkb:Tramtrack p88(gene name synonym)|uniprotkb:Repressor protein fushi tarazu(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77202	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	refseq:NP_001189329.1|refseq:NP_733443.1|refseq:NP_733444.1|refseq:NP_733445.1|flybase:FBgn0003870|ensemblmetazoa:FBgn0003870(gene)|ensemblmetazoa:FBtr0085825(transcript)|ensemblmetazoa:FBtr0085827(transcript)|ensemblmetazoa:FBtr0085829(transcript)|ensemblmetazoa:FBtr0303227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031208"(POZ domain binding)|go:"GO:0035001"(dorsal trunk growth, open tracheal system)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035151"(regulation of tube size, open tracheal system)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0040003"(chitin-based cuticle development)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042682"(regulation of compound eye cone cell fate specification)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045677"(negative regulation of R7 cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048053"(R1/R6 development)|go:"GO:0048626"(myoblast fate specification)|go:"GO:0048750"(compound eye corneal lens morphogenesis)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	-	-	comment:Fragment AA241-320 of Phyl was sufficient to interact with Ttk. Ttk was HA tagged.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	rogid:k0MeF2/ch3ddqz7uLHjP8aeJwoI7227	intact-crc:E2308144C71FDD51|rigid:BOVWQsZ94fnH2c3IX5GJ9XqoIwg	false	binding-associated region:241-320|radiolabel:?-?	ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q27934	uniprotkb:P21461	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77251	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	-	-	-	comment:Fragment AA 167-314 of Sina was sufficient to interact with Phyl. Phyl was HA tagged.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	intact-crc:842803003F0BED86|rigid:P+ui+n2mQlnO4IJGO8pz4sikPeE	false	ha tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42282	uniprotkb:Q27934	intact:EBI-77008|uniprotkb:A4V3Q3|uniprotkb:Q0KHY0|uniprotkb:Q1LZ43|uniprotkb:Q24313|uniprotkb:Q9V9V2|ensemblmetazoa:FBpp0085186|ensemblmetazoa:FBpp0085188|ensemblmetazoa:FBpp0085190|ensemblmetazoa:FBpp0292319	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	psi-mi:ttka_drome(display_long)|uniprotkb:ttk(gene name)|psi-mi:ttk(display_short)|uniprotkb:FTZ-F2(gene name synonym)|uniprotkb:CG1856(orf name)|uniprotkb:Tramtrack p88(gene name synonym)|uniprotkb:Repressor protein fushi tarazu(gene name synonym)	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77256	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001189329.1|refseq:NP_733443.1|refseq:NP_733444.1|refseq:NP_733445.1|flybase:FBgn0003870|ensemblmetazoa:FBgn0003870(gene)|ensemblmetazoa:FBtr0085825(transcript)|ensemblmetazoa:FBtr0085827(transcript)|ensemblmetazoa:FBtr0085829(transcript)|ensemblmetazoa:FBtr0303227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031208"(POZ domain binding)|go:"GO:0035001"(dorsal trunk growth, open tracheal system)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035151"(regulation of tube size, open tracheal system)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0040003"(chitin-based cuticle development)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042682"(regulation of compound eye cone cell fate specification)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045677"(negative regulation of R7 cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048053"(R1/R6 development)|go:"GO:0048626"(myoblast fate specification)|go:"GO:0048750"(compound eye corneal lens morphogenesis)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	pubmed:9267027(see-also)	-	-	comment:N-terminal 122 AA of Ttk were sufficient to interact with HA tagged Phyl.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:k0MeF2/ch3ddqz7uLHjP8aeJwoI7227	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	intact-crc:5D01C28F77B1D663|rigid:BOVWQsZ94fnH2c3IX5GJ9XqoIwg	false	radiolabel:?-?	ha tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q27934	uniprotkb:P21461	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77336	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	-	-	-	complex-properties:Possibly the complex is made up of dimer of Phyl and dimer of Sina.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	intact-crc:78D0F0566126F23C|rigid:P+ui+n2mQlnO4IJGO8pz4sikPeE	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q27934	uniprotkb:P21461	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	intact:EBI-77019|uniprotkb:A4V214|uniprotkb:Q9VVB0|ensemblmetazoa:FBpp0075091|ensemblmetazoa:FBpp0075092|ensemblmetazoa:FBpp0310636	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:sina_drome(display_long)|uniprotkb:sina(gene name)|psi-mi:sina(display_short)|uniprotkb:CG9949(orf name)|uniprotkb:Seven in absentia protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase sina(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77344	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	refseq:NP_476725.1|refseq:NP_730206.1|flybase:FBgn0003410|refseq:NP_001287089.1|dip:DIP-17392N|ensemblmetazoa:FBgn0003410(gene)|ensemblmetazoa:FBtr0075332(transcript)|ensemblmetazoa:FBtr0075333(transcript)|ensemblmetazoa:FBtr0344230(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007423"(sensory organ development)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045676"(regulation of R7 cell differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004162(Seven in absentia protein)|interpro:IPR008974(TRAF-like)|interpro:IPR013010(Zinc finger, SIAH-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018121|reactome:R-DME-373752|reactome:R-DME-5689880|reactome:R-DME-983168	-	-	-	comment:The three proteins are present in a common multiprotein complex.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	rogid:GmUKLSW+fhn/1Fkti+v7o+NWs/87227	intact-crc:80898B844B9B766F|rigid:ALOVyz8S+gfbsWC97cwu3msxL2Y	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q27934	uniprotkb:P42282	intact:EBI-77033|uniprotkb:Q9V721|uniprotkb:C0PV22|ensemblmetazoa:FBpp0086645	intact:EBI-77008|uniprotkb:A4V3Q3|uniprotkb:Q0KHY0|uniprotkb:Q1LZ43|uniprotkb:Q24313|uniprotkb:Q9V9V2|ensemblmetazoa:FBpp0085186|ensemblmetazoa:FBpp0085188|ensemblmetazoa:FBpp0085190|ensemblmetazoa:FBpp0292319	psi-mi:phyl_drome(display_long)|uniprotkb:phyl(gene name)|psi-mi:phyl(display_short)|uniprotkb:CG10108(orf name)	psi-mi:ttka_drome(display_long)|uniprotkb:ttk(gene name)|psi-mi:ttk(display_short)|uniprotkb:FTZ-F2(gene name synonym)|uniprotkb:CG1856(orf name)|uniprotkb:Tramtrack p88(gene name synonym)|uniprotkb:Repressor protein fushi tarazu(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Li et al. (2002)	pubmed:12215542	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-77344	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_725394.1|flybase:FBgn0013725|dip:DIP-29101N|ensemblmetazoa:FBgn0013725(gene)|ensemblmetazoa:FBtr0087516(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007423"(sensory organ development)|go:"GO:0007462"(R1/R6 cell fate commitment)|go:"GO:0007465"(R7 cell fate commitment)|go:"GO:0007601"(visual perception)|go:"GO:0008052"(sensory organ boundary specification)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016360"(sensory organ precursor cell fate determination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|rcsb pdb:4I7B|rcsb pdb:4I7C|rcsb pdb:4I7D	refseq:NP_001189329.1|refseq:NP_733443.1|refseq:NP_733444.1|refseq:NP_733445.1|flybase:FBgn0003870|ensemblmetazoa:FBgn0003870(gene)|ensemblmetazoa:FBtr0085825(transcript)|ensemblmetazoa:FBtr0085827(transcript)|ensemblmetazoa:FBtr0085829(transcript)|ensemblmetazoa:FBtr0303227(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005700"(polytene chromosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007426"(tracheal outgrowth, open tracheal system)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016476"(regulation of embryonic cell shape)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0031208"(POZ domain binding)|go:"GO:0035001"(dorsal trunk growth, open tracheal system)|go:"GO:0035147"(branch fusion, open tracheal system)|go:"GO:0035151"(regulation of tube size, open tracheal system)|go:"GO:0035883"(enteroendocrine cell differentiation)|go:"GO:0040003"(chitin-based cuticle development)|go:"GO:0042675"(compound eye cone cell differentiation)|go:"GO:0042682"(regulation of compound eye cone cell fate specification)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045500"(sevenless signaling pathway)|go:"GO:0045677"(negative regulation of R7 cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048053"(R1/R6 development)|go:"GO:0048626"(myoblast fate specification)|go:"GO:0048750"(compound eye corneal lens morphogenesis)|go:"GO:0060446"(branching involved in open tracheal system development)|go:"GO:1903688"(positive regulation of border follicle cell migration)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	-	-	-	comment:The three proteins are present in a common multiprotein complex.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/11/24	2014/10/16	rogid:QocGYm5CUc0c4Z8raybzOGhpt1M7227	rogid:k0MeF2/ch3ddqz7uLHjP8aeJwoI7227	intact-crc:80898B844B9B766F|rigid:ALOVyz8S+gfbsWC97cwu3msxL2Y	false	tag:?-?	tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)