#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62925	uniprotkb:Q12851	intact:EBI-636664	intact:EBI-49783|uniprotkb:Q86VU3|ensembl:ENSP00000294066	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:m4k2_human(display_long)|uniprotkb:MAPK/ERK kinase kinase kinase 2(gene name synonym)|uniprotkb:Germinal center kinase(gene name synonym)|uniprotkb:Rab8-interacting protein(gene name synonym)|uniprotkb:B lymphocyte serine/threonine-protein kinase(gene name synonym)|uniprotkb:MAP4K2(gene name)|psi-mi:MAP4K2(display_short)|uniprotkb:GCK(gene name synonym)|uniprotkb:RAB8IP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chadee et al. (2002)	pubmed:11784851	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-49950	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_004570.2|refseq:NP_001294919.1|ensembl:ENSG00000168067(gene)|ensembl:ENST00000294066(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006955"(immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160	go:"GO:0007165"(signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0045859"(regulation of protein kinase activity)	-	-	resulting-ptm:Autophosphorylation and activation of MEKK1	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2003/09/03	2014/10/16	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:UBzaZ9UYKmUXyRbPy6rqnf/lHeM9606	intact-crc:40F4D1535F70DBCA|rigid:Xuk1in8ahQ/tgikET0ooHB+qAWE	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q16584	uniprotkb:Q12851	intact:EBI-49961|uniprotkb:Q53H00|uniprotkb:Q59F06|uniprotkb:Q6P2G4|uniprotkb:B4DS76|ensembl:ENSP00000309597	intact:EBI-49783|uniprotkb:Q86VU3|ensembl:ENSP00000294066	psi-mi:m3k11_human(display_long)|uniprotkb:MAP3K11(gene name)|psi-mi:MAP3K11(display_short)|uniprotkb:Mixed lineage kinase 3(gene name synonym)|uniprotkb:Src-homology 3 domain-containing proline-rich kinase(gene name synonym)|uniprotkb:SPRK(gene name synonym)|uniprotkb:PTK1(gene name synonym)|uniprotkb:MLK3(gene name synonym)	psi-mi:m4k2_human(display_long)|uniprotkb:MAPK/ERK kinase kinase kinase 2(gene name synonym)|uniprotkb:Germinal center kinase(gene name synonym)|uniprotkb:Rab8-interacting protein(gene name synonym)|uniprotkb:B lymphocyte serine/threonine-protein kinase(gene name synonym)|uniprotkb:MAP4K2(gene name)|psi-mi:MAP4K2(display_short)|uniprotkb:GCK(gene name synonym)|uniprotkb:RAB8IP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chadee et al. (2002)	pubmed:11784851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-49968	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002410.1|ensembl:ENSG00000173327(gene)|ensembl:ENST00000309100(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016231(Mitogen-activated protein kinase kinase kinase, 9/10/11)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035779|interpro:IPR036028|mint:Q16584|rcsb pdb:5K26|rcsb pdb:5K28|rcsb pdb:6AQB|rcsb pdb:6CQ7|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-9013148|reactome:R-HSA-9013408|reactome:R-HSA-9649948	refseq:NP_004570.2|refseq:NP_001294919.1|ensembl:ENSG00000168067(gene)|ensembl:ENST00000294066(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006955"(immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160	go:"GO:0045859"(regulation of protein kinase activity)	-	-	resulting-ptm:Results in activation of MLK3	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2003/09/03	2014/10/16	rogid:njuMQIbuVFlWXNggegg3zYAKmS49606	rogid:UBzaZ9UYKmUXyRbPy6rqnf/lHeM9606	intact-crc:AC401640CF2AD093|rigid:kQ/z3MtfH12uRsR3xxbeEockiww	false	flag tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:279-820	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q62925	uniprotkb:Q62925	intact:EBI-636664	intact:EBI-636664	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chadee et al. (2002)	pubmed:11784851	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636884	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0007165"(signal transduction)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0042802"(identical protein binding)	-	-	comment:Results in oliger formation|stimulant:MAP4K2	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2003/09/03	2014/10/16	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:9093425568C35A63|rigid:smd4JsfkiCxiwg3aVWn4tJVT9rc	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12851	uniprotkb:Q13233	intact:EBI-49783|uniprotkb:Q86VU3|ensembl:ENSP00000294066	intact:EBI-49776|ensembl:ENSP00000382423	psi-mi:m4k2_human(display_long)|uniprotkb:MAPK/ERK kinase kinase kinase 2(gene name synonym)|uniprotkb:Germinal center kinase(gene name synonym)|uniprotkb:Rab8-interacting protein(gene name synonym)|uniprotkb:B lymphocyte serine/threonine-protein kinase(gene name synonym)|uniprotkb:MAP4K2(gene name)|psi-mi:MAP4K2(display_short)|uniprotkb:GCK(gene name synonym)|uniprotkb:RAB8IP(gene name synonym)	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chadee et al. (2002)	pubmed:11784851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-49795	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004570.2|refseq:NP_001294919.1|ensembl:ENSG00000168067(gene)|ensembl:ENST00000294066(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006955"(immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871	go:"GO:0007165"(signal transduction)	-	-	-	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2003/09/03	2014/10/16	rogid:UBzaZ9UYKmUXyRbPy6rqnf/lHeM9606	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	intact-crc:9C53619B57029501|rigid:BqatAvWoZVBFjS5m9+sp6gm53xA	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q13233	uniprotkb:Q12851	intact:EBI-49776|ensembl:ENSP00000382423	intact:EBI-49783|uniprotkb:Q86VU3|ensembl:ENSP00000294066	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:m4k2_human(display_long)|uniprotkb:MAPK/ERK kinase kinase kinase 2(gene name synonym)|uniprotkb:Germinal center kinase(gene name synonym)|uniprotkb:Rab8-interacting protein(gene name synonym)|uniprotkb:B lymphocyte serine/threonine-protein kinase(gene name synonym)|uniprotkb:MAP4K2(gene name)|psi-mi:MAP4K2(display_short)|uniprotkb:GCK(gene name synonym)|uniprotkb:RAB8IP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chadee et al. (2002)	pubmed:11784851	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636714	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871	refseq:NP_004570.2|refseq:NP_001294919.1|ensembl:ENSG00000168067(gene)|ensembl:ENST00000294066(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006955"(immune response)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160	go:"GO:0007165"(signal transduction)	-	-	-	taxid:9606(human-ramos)|taxid:9606(Human Caucasian Burkitt's lymphoma)	-	2003/09/03	2014/10/16	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	rogid:UBzaZ9UYKmUXyRbPy6rqnf/lHeM9606	intact-crc:8931EB60BDA3C810|rigid:BqatAvWoZVBFjS5m9+sp6gm53xA	false	-	-	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)
uniprotkb:Q62925	-	intact:EBI-636664	-	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Chadee et al. (2002)	pubmed:11784851	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636781	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	-	go:"GO:0007165"(signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0045859"(regulation of protein kinase activity)	-	-	resulting-ptm:Autophosphorylation and activation of MEKK1|stimulant:Binding of MAP4K2	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2003/09/03	2014/10/16	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	-	intact-crc:7B596B00A54DD551	false	ha tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	-
uniprotkb:Q62925	-	intact:EBI-636664	-	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Chadee et al. (2002)	pubmed:11784851	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-636799	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	-	go:"GO:0007165"(signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0045859"(regulation of protein kinase activity)	-	-	resulting-ptm:Autophosphorylation and activation of MEKK1 on Thr1381 and Thr1393|stimulant:"Binding of the C-terminal domain (279 to 819) of MAP4K2"|stimulant:Binding of the TRAF2 ring domain|comment:Stimulation by binding of MEKK1 and TRAF2 is not additive, and may be competitive	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/09/03	2014/10/16	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	-	intact-crc:2A59DF1B850C93D2	false	ha tag:?-?|mutation decreasing interaction:1350-1350	-	-	-	psi-mi:"MI:0396"(predetermined participant)	-