#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q14019	uniprotkb:P09917	intact:EBI-79926|ensembl:ENSP00000262428|uniprotkb:Q86XM5|uniprotkb:B2RDU3|uniprotkb:D3DUL9	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	psi-mi:cotl1_human(display_long)|uniprotkb:COTL1(gene name)|psi-mi:COTL1(display_short)|uniprotkb:CLP(gene name synonym)	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Provost et al. (2001)	pubmed:11297527	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-79944	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000103187(gene)|ensembl:ENST00000262428(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR029006|interpro:IPR030502|rcsb pdb:1T2L|rcsb pdb:1T3X|rcsb pdb:1T3Y|rcsb pdb:1TMW|rcsb pdb:1VFQ|rcsb pdb:1WNJ|reactome:R-HSA-6798695|go:"GO:0003779"(actin binding)|refseq:NP_066972.1|dip:DIP-30951N	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	-	-	-	comment:COTL1 was expressed as GST-fusion in E. coli.|comment:ALOX5 was purified from transformed E. coli strain MV1190.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/12/09	2014/10/16	rogid:a98Y1D7sbXDDhPfoYSgv3pdrGmU9606	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	intact-crc:B525152392307766|rigid:9vCFY+Dt4sPS+wWQHC2D9SzyF4c	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14019	uniprotkb:P09917	intact:EBI-79926|ensembl:ENSP00000262428|uniprotkb:Q86XM5|uniprotkb:B2RDU3|uniprotkb:D3DUL9	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	psi-mi:cotl1_human(display_long)|uniprotkb:COTL1(gene name)|psi-mi:COTL1(display_short)|uniprotkb:CLP(gene name synonym)	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Provost et al. (2001)	pubmed:11297527	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-79947	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000103187(gene)|ensembl:ENST00000262428(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR029006|interpro:IPR030502|rcsb pdb:1T2L|rcsb pdb:1T3X|rcsb pdb:1T3Y|rcsb pdb:1TMW|rcsb pdb:1VFQ|rcsb pdb:1WNJ|reactome:R-HSA-6798695|go:"GO:0003779"(actin binding)|refseq:NP_066972.1|dip:DIP-30951N	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	-	-	-	-	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2003/12/09	2014/10/16	rogid:a98Y1D7sbXDDhPfoYSgv3pdrGmU9606	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	intact-crc:DC97388B83AA6E9F|rigid:9vCFY+Dt4sPS+wWQHC2D9SzyF4c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14019	uniprotkb:P09917	intact:EBI-79926|ensembl:ENSP00000262428|uniprotkb:Q86XM5|uniprotkb:B2RDU3|uniprotkb:D3DUL9	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	psi-mi:cotl1_human(display_long)|uniprotkb:COTL1(gene name)|psi-mi:COTL1(display_short)|uniprotkb:CLP(gene name synonym)	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Provost et al. (2001)	pubmed:11297527	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-79950	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000103187(gene)|ensembl:ENST00000262428(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR029006|interpro:IPR030502|rcsb pdb:1T2L|rcsb pdb:1T3X|rcsb pdb:1T3Y|rcsb pdb:1TMW|rcsb pdb:1VFQ|rcsb pdb:1WNJ|reactome:R-HSA-6798695|go:"GO:0003779"(actin binding)|refseq:NP_066972.1|dip:DIP-30951N	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	-	-	-	-	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2003/12/09	2014/10/16	rogid:a98Y1D7sbXDDhPfoYSgv3pdrGmU9606	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	intact-crc:253AD28B3AB2234C|rigid:9vCFY+Dt4sPS+wWQHC2D9SzyF4c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14019	uniprotkb:P09917	intact:EBI-79926|ensembl:ENSP00000262428|uniprotkb:Q86XM5|uniprotkb:B2RDU3|uniprotkb:D3DUL9	intact:EBI-79934|ensembl:ENSP00000363512|ensembl:ENSP00000484468|uniprotkb:Q5JQ14|uniprotkb:E5FPY5|uniprotkb:E5FPY7|uniprotkb:E5FPY8|uniprotkb:B7ZLS0	psi-mi:cotl1_human(display_long)|uniprotkb:COTL1(gene name)|psi-mi:COTL1(display_short)|uniprotkb:CLP(gene name synonym)	psi-mi:lox5_human(display_long)|uniprotkb:ALOX5(gene name)|psi-mi:ALOX5(display_short)|uniprotkb:LOG5(gene name synonym)|uniprotkb:Arachidonate 5-lipoxygenase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Provost et al. (2001)	pubmed:11297527	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-79953	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000103187(gene)|ensembl:ENST00000262428(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002108(Actin-binding, cofilin/tropomyosin type)|interpro:IPR029006|interpro:IPR030502|rcsb pdb:1T2L|rcsb pdb:1T3X|rcsb pdb:1T3Y|rcsb pdb:1TMW|rcsb pdb:1VFQ|rcsb pdb:1WNJ|reactome:R-HSA-6798695|go:"GO:0003779"(actin binding)|refseq:NP_066972.1|dip:DIP-30951N	ensembl:ENSG00000012779(gene)|ensembl:ENSG00000275565(gene)|ensembl:ENST00000374391(transcript)|ensembl:ENST00000610656(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002540"(leukotriene production involved in inflammatory response)|go:"GO:0004051"(arachidonate 5-lipoxygenase activity)|go:"GO:0004052"("arachidonate 12(S)-lipoxygenase activity")|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034440"(lipid oxidation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036403"("arachidonate 8(S)-lipoxygenase activity")|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0043651"(linoleic acid metabolic process)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0005615"(extracellular space)|go:"GO:0051122"(hepoxilin biosynthetic process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0106014"(regulation of inflammatory response to wounding)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016702"(oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901753"(leukotriene A4 biosynthetic process)|go:"GO:1903426"(regulation of reactive oxygen species biosynthetic process)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:0016787"(hydrolase activity)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:2001301"(lipoxin biosynthetic process)|interpro:IPR000907(Lipoxygenase)|interpro:IPR001024(Lipoxygenase, LH2)|interpro:IPR001885(Lipoxygenase, mammalian)|interpro:IPR013819(Lipoxygenase, C-terminal)|interpro:IPR020833|interpro:IPR020834|interpro:IPR036226|interpro:IPR036392|interpro:IPR042062|rcsb pdb:2ABV|rcsb pdb:3O8Y|rcsb pdb:3V92|rcsb pdb:3V98|rcsb pdb:3V99|rcsb pdb:6N2W|rcsb pdb:6NCF|reactome:R-HSA-2142688|reactome:R-HSA-2142691|reactome:R-HSA-2142700|go:"GO:0019369"(arachidonic acid metabolic process)|reactome:R-HSA-6785807|reactome:R-HSA-9023661|reactome:R-HSA-9026286|reactome:R-HSA-9026290|reactome:R-HSA-9026403|reactome:R-HSA-9027604|reactome:R-HSA-6798695|reactome:R-HSA-9012546|reactome:R-HSA-9018676|reactome:R-HSA-9018682|reactome:R-HSA-9018896|reactome:R-HSA-9020265|refseq:NP_000689.1|refseq:NP_001307790.1|dip:DIP-30950N|refseq:NP_001243082.1|refseq:NP_001243083.1	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/12/09	2014/10/16	rogid:a98Y1D7sbXDDhPfoYSgv3pdrGmU9606	rogid:kk3yqgz7R/Po68UpJpKJ3Rp6Ws89606	intact-crc:A1F5F0E8550C22B8|rigid:9vCFY+Dt4sPS+wWQHC2D9SzyF4c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)