#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q64279	uniprotkb:P15806	intact:EBI-81361|ensembl:ENSMUSP00000046999|ensembl:ENSMUSP00000124951|uniprotkb:Q61099	intact:EBI-81370|uniprotkb:Q3U153|uniprotkb:Q8CAH9|uniprotkb:Q8VCY4|uniprotkb:Q922S2|uniprotkb:Q99MB8|uniprotkb:Q9CYJ4|ensembl:ENSMUSP00000100983	psi-mi:hand1_mouse(display_long)|uniprotkb:Hand1(gene name)|psi-mi:Hand1(display_short)|uniprotkb:Ehand(gene name synonym)|uniprotkb:Hxt(gene name synonym)|uniprotkb:Thing1(gene name synonym)|uniprotkb:Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast(gene name synonym)|uniprotkb:Thing-1(gene name synonym)	psi-mi:tfe2_mouse(display_long)|uniprotkb:Tcf3(gene name)|psi-mi:Tcf3(display_short)|uniprotkb:Alf2(gene name synonym)|uniprotkb:Me2(gene name synonym)|uniprotkb:Tcfe2a(gene name synonym)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Transcription factor A1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81382	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000036917(transcript)|ensembl:ENSMUST00000160392(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003144"(embryonic heart tube formation)|go:"GO:0003218"(cardiac left ventricle formation)|ensembl:ENSMUSG00000037335(gene)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|refseq:NP_032239.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032502"(developmental process)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|dip:DIP-455N	rcsb pdb:2QL2|reactome:R-MMU-525793|reactome:R-MMU-8939236|refseq:NP_001157620.1|refseq:NP_001157621.1|refseq:NP_001157623.1|refseq:NP_035678.3|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007369"(gastrulation)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048468"(cell development)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15806|ensembl:ENSMUSG00000020167(gene)|ensembl:ENSMUST00000105346(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|dip:DIP-30940N	go:"GO:0005667"(transcription regulator complex)	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/12/18	2014/10/16	rogid:mIjSCEpJgYJbBejXvZTSCJFoztM10090	rogid:aMvLmcfudacIqIAxOSmbNPNjsc810090	intact-crc:F36D6964D11C2374|rigid:UFkQGtrLRTxtyamhF0z6+R7Bzl8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q64279	uniprotkb:Q64279	intact:EBI-81361|ensembl:ENSMUSP00000046999|ensembl:ENSMUSP00000124951|uniprotkb:Q61099	intact:EBI-81361|ensembl:ENSMUSP00000046999|ensembl:ENSMUSP00000124951|uniprotkb:Q61099	psi-mi:hand1_mouse(display_long)|uniprotkb:Hand1(gene name)|psi-mi:Hand1(display_short)|uniprotkb:Ehand(gene name synonym)|uniprotkb:Hxt(gene name synonym)|uniprotkb:Thing1(gene name synonym)|uniprotkb:Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast(gene name synonym)|uniprotkb:Thing-1(gene name synonym)	psi-mi:hand1_mouse(display_long)|uniprotkb:Hand1(gene name)|psi-mi:Hand1(display_short)|uniprotkb:Ehand(gene name synonym)|uniprotkb:Hxt(gene name synonym)|uniprotkb:Thing1(gene name synonym)|uniprotkb:Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast(gene name synonym)|uniprotkb:Thing-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81385	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000036917(transcript)|ensembl:ENSMUST00000160392(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003144"(embryonic heart tube formation)|go:"GO:0003218"(cardiac left ventricle formation)|ensembl:ENSMUSG00000037335(gene)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|refseq:NP_032239.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032502"(developmental process)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|dip:DIP-455N	ensembl:ENSMUST00000036917(transcript)|ensembl:ENSMUST00000160392(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003144"(embryonic heart tube formation)|go:"GO:0003218"(cardiac left ventricle formation)|ensembl:ENSMUSG00000037335(gene)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|refseq:NP_032239.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032502"(developmental process)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|dip:DIP-455N	go:"GO:0005667"(transcription regulator complex)	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/12/18	2014/10/16	rogid:mIjSCEpJgYJbBejXvZTSCJFoztM10090	rogid:mIjSCEpJgYJbBejXvZTSCJFoztM10090	intact-crc:0B147AFC7AF8A6CD|rigid:jioVWzR9trixoMUb/qtwA4MwBEk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q64279	uniprotkb:Q61039	intact:EBI-81361|ensembl:ENSMUSP00000046999|ensembl:ENSMUSP00000124951|uniprotkb:Q61099	intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100	psi-mi:hand1_mouse(display_long)|uniprotkb:Hand1(gene name)|psi-mi:Hand1(display_short)|uniprotkb:Ehand(gene name synonym)|uniprotkb:Hxt(gene name synonym)|uniprotkb:Thing1(gene name synonym)|uniprotkb:Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast(gene name synonym)|uniprotkb:Thing-1(gene name synonym)	psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81399	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000036917(transcript)|ensembl:ENSMUST00000160392(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003144"(embryonic heart tube formation)|go:"GO:0003218"(cardiac left ventricle formation)|ensembl:ENSMUSG00000037335(gene)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|refseq:NP_032239.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032502"(developmental process)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|dip:DIP-455N	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development)	go:"GO:0005667"(transcription regulator complex)	-	-	comment:bHLH domain of HAND2 used	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/12/18	2014/10/16	rogid:mIjSCEpJgYJbBejXvZTSCJFoztM10090	rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090	intact-crc:6AEB26D48E0C635F|rigid:FO49W/PtUPNjaqs0cURjM4mqFuE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15806	uniprotkb:Q61039	intact:EBI-81370|uniprotkb:Q3U153|uniprotkb:Q8CAH9|uniprotkb:Q8VCY4|uniprotkb:Q922S2|uniprotkb:Q99MB8|uniprotkb:Q9CYJ4|ensembl:ENSMUSP00000100983	intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100	psi-mi:tfe2_mouse(display_long)|uniprotkb:Tcf3(gene name)|psi-mi:Tcf3(display_short)|uniprotkb:Alf2(gene name synonym)|uniprotkb:Me2(gene name synonym)|uniprotkb:Tcfe2a(gene name synonym)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Transcription factor A1(gene name synonym)	psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81403	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:2QL2|reactome:R-MMU-525793|reactome:R-MMU-8939236|refseq:NP_001157620.1|refseq:NP_001157621.1|refseq:NP_001157623.1|refseq:NP_035678.3|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007369"(gastrulation)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048468"(cell development)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15806|ensembl:ENSMUSG00000020167(gene)|ensembl:ENSMUST00000105346(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|dip:DIP-30940N	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development)	go:"GO:0005667"(transcription regulator complex)	-	-	comment:bHLH domain of HAND2 was used	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/12/18	2014/10/16	rogid:aMvLmcfudacIqIAxOSmbNPNjsc810090	rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090	intact-crc:16D3E9E86B657F94|rigid:9M5pTmG/TVDIZffvavrulFrOgAA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q64279	uniprotkb:Q61039	intact:EBI-81361|ensembl:ENSMUSP00000046999|ensembl:ENSMUSP00000124951|uniprotkb:Q61099	intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100	psi-mi:hand1_mouse(display_long)|uniprotkb:Hand1(gene name)|psi-mi:Hand1(display_short)|uniprotkb:Ehand(gene name synonym)|uniprotkb:Hxt(gene name synonym)|uniprotkb:Thing1(gene name synonym)|uniprotkb:Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast(gene name synonym)|uniprotkb:Thing-1(gene name synonym)	psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81405	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000036917(transcript)|ensembl:ENSMUST00000160392(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003144"(embryonic heart tube formation)|go:"GO:0003218"(cardiac left ventricle formation)|ensembl:ENSMUSG00000037335(gene)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|refseq:NP_032239.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032502"(developmental process)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|dip:DIP-455N	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development)	go:"GO:0005667"(transcription regulator complex)	-	-	comment:HAND1 expressed as GST fusion in bacteria BL21|comment:HAND2 was in vitro translated using TNT rabbit reticulocyte lysate system.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/12/18	2014/10/16	rogid:mIjSCEpJgYJbBejXvZTSCJFoztM10090	rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090	intact-crc:1B3B035172960757|rigid:FO49W/PtUPNjaqs0cURjM4mqFuE	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q64279	uniprotkb:Q64279	intact:EBI-81361|ensembl:ENSMUSP00000046999|ensembl:ENSMUSP00000124951|uniprotkb:Q61099	intact:EBI-81361|ensembl:ENSMUSP00000046999|ensembl:ENSMUSP00000124951|uniprotkb:Q61099	psi-mi:hand1_mouse(display_long)|uniprotkb:Hand1(gene name)|psi-mi:Hand1(display_short)|uniprotkb:Ehand(gene name synonym)|uniprotkb:Hxt(gene name synonym)|uniprotkb:Thing1(gene name synonym)|uniprotkb:Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast(gene name synonym)|uniprotkb:Thing-1(gene name synonym)	psi-mi:hand1_mouse(display_long)|uniprotkb:Hand1(gene name)|psi-mi:Hand1(display_short)|uniprotkb:Ehand(gene name synonym)|uniprotkb:Hxt(gene name synonym)|uniprotkb:Thing1(gene name synonym)|uniprotkb:Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast(gene name synonym)|uniprotkb:Thing-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81408	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000036917(transcript)|ensembl:ENSMUST00000160392(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003144"(embryonic heart tube formation)|go:"GO:0003218"(cardiac left ventricle formation)|ensembl:ENSMUSG00000037335(gene)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|refseq:NP_032239.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032502"(developmental process)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|dip:DIP-455N	ensembl:ENSMUST00000036917(transcript)|ensembl:ENSMUST00000160392(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003144"(embryonic heart tube formation)|go:"GO:0003218"(cardiac left ventricle formation)|ensembl:ENSMUSG00000037335(gene)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|refseq:NP_032239.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032502"(developmental process)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|dip:DIP-455N	go:"GO:0005667"(transcription regulator complex)	-	-	comment:HAND1 expressed as GST fusion in bacteria BL21.|comment:HAND1 was in vitro translated using TNT rabbit reticulocyte lysate system.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/12/18	2014/10/16	rogid:mIjSCEpJgYJbBejXvZTSCJFoztM10090	rogid:mIjSCEpJgYJbBejXvZTSCJFoztM10090	intact-crc:E364B881BEC94599|rigid:jioVWzR9trixoMUb/qtwA4MwBEk	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q64279	uniprotkb:P15806	intact:EBI-81361|ensembl:ENSMUSP00000046999|ensembl:ENSMUSP00000124951|uniprotkb:Q61099	intact:EBI-81370|uniprotkb:Q3U153|uniprotkb:Q8CAH9|uniprotkb:Q8VCY4|uniprotkb:Q922S2|uniprotkb:Q99MB8|uniprotkb:Q9CYJ4|ensembl:ENSMUSP00000100983	psi-mi:hand1_mouse(display_long)|uniprotkb:Hand1(gene name)|psi-mi:Hand1(display_short)|uniprotkb:Ehand(gene name synonym)|uniprotkb:Hxt(gene name synonym)|uniprotkb:Thing1(gene name synonym)|uniprotkb:Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast(gene name synonym)|uniprotkb:Thing-1(gene name synonym)	psi-mi:tfe2_mouse(display_long)|uniprotkb:Tcf3(gene name)|psi-mi:Tcf3(display_short)|uniprotkb:Alf2(gene name synonym)|uniprotkb:Me2(gene name synonym)|uniprotkb:Tcfe2a(gene name synonym)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Transcription factor A1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81411	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000036917(transcript)|ensembl:ENSMUST00000160392(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003144"(embryonic heart tube formation)|go:"GO:0003218"(cardiac left ventricle formation)|ensembl:ENSMUSG00000037335(gene)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|refseq:NP_032239.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032502"(developmental process)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|dip:DIP-455N	rcsb pdb:2QL2|reactome:R-MMU-525793|reactome:R-MMU-8939236|refseq:NP_001157620.1|refseq:NP_001157621.1|refseq:NP_001157623.1|refseq:NP_035678.3|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007369"(gastrulation)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048468"(cell development)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15806|ensembl:ENSMUSG00000020167(gene)|ensembl:ENSMUST00000105346(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|dip:DIP-30940N	go:"GO:0005667"(transcription regulator complex)	-	-	comment:HAND1 expressed as GST fusion in bacteria BL21.|comment:TCF3 was in vitro translated using TNT rabbit reticulocyte lysate system.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/12/18	2014/10/16	rogid:mIjSCEpJgYJbBejXvZTSCJFoztM10090	rogid:aMvLmcfudacIqIAxOSmbNPNjsc810090	intact-crc:77EA87CD2B48483E|rigid:UFkQGtrLRTxtyamhF0z6+R7Bzl8	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q64279	uniprotkb:Q9QUS4	intact:EBI-81361|ensembl:ENSMUSP00000046999|ensembl:ENSMUSP00000124951|uniprotkb:Q61099	intact:EBI-81414|uniprotkb:Q3TZ99|uniprotkb:Q8CD44|ensembl:ENSMUSP00000019924	psi-mi:hand1_mouse(display_long)|uniprotkb:Hand1(gene name)|psi-mi:Hand1(display_short)|uniprotkb:Ehand(gene name synonym)|uniprotkb:Hxt(gene name synonym)|uniprotkb:Thing1(gene name synonym)|uniprotkb:Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast(gene name synonym)|uniprotkb:Thing-1(gene name synonym)	psi-mi:hey2_mouse(display_long)|uniprotkb:Hey2(gene name)|psi-mi:Hey2(display_short)|uniprotkb:Chf1(gene name synonym)|uniprotkb:Hrt2(gene name synonym)|uniprotkb:Herp(gene name synonym)|uniprotkb:Herp1(gene name synonym)|uniprotkb:Hesr2(gene name synonym)|uniprotkb:Hairy and enhancer of split-related protein 2(gene name synonym)|uniprotkb:Hairy-related transcription factor 2(gene name synonym)|uniprotkb:Protein gridlock homolog(gene name synonym)|uniprotkb:HES-related repressor protein 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81429	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000036917(transcript)|ensembl:ENSMUST00000160392(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003144"(embryonic heart tube formation)|go:"GO:0003218"(cardiac left ventricle formation)|ensembl:ENSMUSG00000037335(gene)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|refseq:NP_032239.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032502"(developmental process)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|dip:DIP-455N	go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|refseq:NP_038932.1|ensembl:ENSMUSG00000019789(gene)|ensembl:ENSMUST00000019924(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003195"(tricuspid valve formation)|go:"GO:0003199"(endocardial cushion to mesenchymal transition involved in heart valve formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0001568"(blood vessel development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007389"(pattern specification process)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0035910"(ascending aorta morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036304"(umbilical cord morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0045607"(regulation of inner ear auditory receptor cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060633"(negative regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060840"(artery development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060977"(coronary vasculature morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0072359"(circulatory system development)|go:"GO:0090102"(cochlea development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|go:"GO:2001212"(regulation of vasculogenesis)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0061314"(Notch signaling involved in heart development)	go:"GO:0005667"(transcription regulator complex)	-	-	comment:HAND1 expressed as GST fusion in bacteria BL21.|comment:CHF1 was in vitro translated using TNT rabbit reticulocyte lysate system.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/12/18	2014/10/16	rogid:mIjSCEpJgYJbBejXvZTSCJFoztM10090	rogid:1bYRhyPJtUUTS4lXJIDUKB0O28M10090	intact-crc:CF431CCE3364C2B1|rigid:JEvlzLFdVBsrP4iBm8ka0epBOko	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q64279	uniprotkb:Q9DBX7	intact:EBI-81361|ensembl:ENSMUSP00000046999|ensembl:ENSMUSP00000124951|uniprotkb:Q61099	intact:EBI-81443|uniprotkb:Q9JJV6|uniprotkb:Q9QXW8|ensembl:ENSMUSP00000040576	psi-mi:hand1_mouse(display_long)|uniprotkb:Hand1(gene name)|psi-mi:Hand1(display_short)|uniprotkb:Ehand(gene name synonym)|uniprotkb:Hxt(gene name synonym)|uniprotkb:Thing1(gene name synonym)|uniprotkb:Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast(gene name synonym)|uniprotkb:Thing-1(gene name synonym)	psi-mi:heyl_mouse(display_long)|uniprotkb:Heyl(gene name)|psi-mi:Heyl(display_short)|uniprotkb:Hesr3(gene name synonym)|uniprotkb:Hrt3(gene name synonym)|uniprotkb:Hairy-related transcription factor 3(gene name synonym)|uniprotkb:Hairy and enhancer of split-related protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81451	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000036917(transcript)|ensembl:ENSMUST00000160392(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003144"(embryonic heart tube formation)|go:"GO:0003218"(cardiac left ventricle formation)|ensembl:ENSMUSG00000037335(gene)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|refseq:NP_032239.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032502"(developmental process)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|dip:DIP-455N	ensembl:ENSMUSG00000032744(gene)|ensembl:ENSMUST00000040821(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0032835"(glomerulus development)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050683"(AF-1 domain binding)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072014"(proximal tubule development)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR003650(Orange)|refseq:NP_038933.2	go:"GO:0005667"(transcription regulator complex)	-	-	comment:HEYL was in vitro translated using TNT rabbit reticulocyte lysate system.|comment:HAND1 expressed as GST fusion in bacteria BL21.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/12/18	2014/10/16	rogid:mIjSCEpJgYJbBejXvZTSCJFoztM10090	rogid:3Xh9rZvKtIPjr+WHcaOUuYWm7vU10090	intact-crc:88CAB1DA967440E2|rigid:BW5rgHniaG5+qncZxwHCRgNrbgE	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61039	uniprotkb:Q61039	intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100	intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100	psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym)	psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81455	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development)	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development)	go:"GO:0005667"(transcription regulator complex)	-	-	comment:HAND2 was in vitro translated using TNT rabbit reticulocyte lysate system.|comment:HAND2 expressed as GST fusion in bacteria BL21.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/12/18	2014/10/16	rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090	rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090	intact-crc:F695B2135B54342E|rigid:0EvzGdu/Z11s+P/dQqNcqxcZY1I	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61039	uniprotkb:Q64279	intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100	intact:EBI-81361|ensembl:ENSMUSP00000046999|ensembl:ENSMUSP00000124951|uniprotkb:Q61099	psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym)	psi-mi:hand1_mouse(display_long)|uniprotkb:Hand1(gene name)|psi-mi:Hand1(display_short)|uniprotkb:Ehand(gene name synonym)|uniprotkb:Hxt(gene name synonym)|uniprotkb:Thing1(gene name synonym)|uniprotkb:Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast(gene name synonym)|uniprotkb:Thing-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81459	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development)	ensembl:ENSMUST00000036917(transcript)|ensembl:ENSMUST00000160392(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003144"(embryonic heart tube formation)|go:"GO:0003218"(cardiac left ventricle formation)|ensembl:ENSMUSG00000037335(gene)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|refseq:NP_032239.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032502"(developmental process)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|dip:DIP-455N	go:"GO:0005667"(transcription regulator complex)	-	-	comment:HAND2 expressed as GST fusion in bacteria BL21.|comment:HAND1 was in vitro translated using TNT rabbit reticulocyte lysate system.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/12/18	2014/10/16	rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090	rogid:mIjSCEpJgYJbBejXvZTSCJFoztM10090	intact-crc:8EE7C66B86F0A044|rigid:FO49W/PtUPNjaqs0cURjM4mqFuE	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61039	uniprotkb:P15806	intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100	intact:EBI-81370|uniprotkb:Q3U153|uniprotkb:Q8CAH9|uniprotkb:Q8VCY4|uniprotkb:Q922S2|uniprotkb:Q99MB8|uniprotkb:Q9CYJ4|ensembl:ENSMUSP00000100983	psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym)	psi-mi:tfe2_mouse(display_long)|uniprotkb:Tcf3(gene name)|psi-mi:Tcf3(display_short)|uniprotkb:Alf2(gene name synonym)|uniprotkb:Me2(gene name synonym)|uniprotkb:Tcfe2a(gene name synonym)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Transcription factor A1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81462	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development)	rcsb pdb:2QL2|reactome:R-MMU-525793|reactome:R-MMU-8939236|refseq:NP_001157620.1|refseq:NP_001157621.1|refseq:NP_001157623.1|refseq:NP_035678.3|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007369"(gastrulation)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048468"(cell development)|go:"GO:0048541"(Peyer's patch development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|mint:P15806|ensembl:ENSMUSG00000020167(gene)|ensembl:ENSMUST00000105346(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|dip:DIP-30940N	go:"GO:0005667"(transcription regulator complex)	-	-	comment:HAND2 expressed as GST fusion in bacteria BL21.|comment:TCF3 was in vitro translated using TNT rabbit reticulocyte lysate system.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/12/18	2014/10/16	rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090	rogid:aMvLmcfudacIqIAxOSmbNPNjsc810090	intact-crc:8525032444EE5B3E|rigid:9M5pTmG/TVDIZffvavrulFrOgAA	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9QUS4	uniprotkb:Q61039	intact:EBI-81414|uniprotkb:Q3TZ99|uniprotkb:Q8CD44|ensembl:ENSMUSP00000019924	intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100	psi-mi:hey2_mouse(display_long)|uniprotkb:Hey2(gene name)|psi-mi:Hey2(display_short)|uniprotkb:Chf1(gene name synonym)|uniprotkb:Hrt2(gene name synonym)|uniprotkb:Herp(gene name synonym)|uniprotkb:Herp1(gene name synonym)|uniprotkb:Hesr2(gene name synonym)|uniprotkb:Hairy and enhancer of split-related protein 2(gene name synonym)|uniprotkb:Hairy-related transcription factor 2(gene name synonym)|uniprotkb:Protein gridlock homolog(gene name synonym)|uniprotkb:HES-related repressor protein 2(gene name synonym)	psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81465	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|refseq:NP_038932.1|ensembl:ENSMUSG00000019789(gene)|ensembl:ENSMUST00000019924(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0003150"(muscular septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003195"(tricuspid valve formation)|go:"GO:0003199"(endocardial cushion to mesenchymal transition involved in heart valve formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0001568"(blood vessel development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007389"(pattern specification process)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0035910"(ascending aorta morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036304"(umbilical cord morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0045607"(regulation of inner ear auditory receptor cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060633"(negative regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060840"(artery development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060977"(coronary vasculature morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0065004"(protein-DNA complex assembly)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0072359"(circulatory system development)|go:"GO:0090102"(cochlea development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|go:"GO:2001212"(regulation of vasculogenesis)|interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0061314"(Notch signaling involved in heart development)	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development)	go:"GO:0005667"(transcription regulator complex)	-	-	comment:CHF1 was in vitro translated using TNT rabbit reticulocyte lysate system.|comment:HAND2 expressed as GST fusion in bacteria BL21	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/12/18	2014/10/16	rogid:1bYRhyPJtUUTS4lXJIDUKB0O28M10090	rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090	intact-crc:9C8FACE13BB3CEEC|rigid:IfOAsDkBWLLY0xdRDc0ewkaunRU	false	radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61039	uniprotkb:Q9WV93	intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100	intact:EBI-81432	psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym)	psi-mi:hey1_mouse(display_long)|uniprotkb:Hey1(gene name)|psi-mi:Hey1(display_short)|uniprotkb:Hesr1(gene name synonym)|uniprotkb:Herp2(gene name synonym)|uniprotkb:Hrt1(gene name synonym)|uniprotkb:Hairy and enhancer of split-related protein 1(gene name synonym)|uniprotkb:Hairy-related transcription factor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81468	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development)	interpro:IPR003650(Orange)|interpro:IPR011598(Helix-loop-helix DNA-binding)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0002076"(osteoblast development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003199"(endocardial cushion to mesenchymal transition involved in heart valve formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0036304"(umbilical cord morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045607"(regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|go:"GO:2000820"(negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation)|go:"GO:2001212"(regulation of vasculogenesis)|go:"GO:0060675"(ureteric bud morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060840"(artery development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0072049"(comma-shaped body morphogenesis)|go:"GO:0072050"(S-shaped body morphogenesis)|go:"GO:0072087"(renal vesicle development)|go:"GO:0072359"(circulatory system development)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR036638	go:"GO:0005667"(transcription regulator complex)	-	-	comment:HAND2 expressed as GST fusion in bacteria BL21|comment:HEY1 was in vitro translated using TNT rabbit reticulocyte lysate system.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/12/18	2014/10/16	rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090	rogid:qpnaJFneXQMYrC06084zPG/4K2g10090	intact-crc:350C705A2C4ABDEC|rigid:ViDEGIBcIsMnSB/Di1wo+gII+z8	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61039	uniprotkb:Q9DBX7	intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100	intact:EBI-81443|uniprotkb:Q9JJV6|uniprotkb:Q9QXW8|ensembl:ENSMUSP00000040576	psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym)	psi-mi:heyl_mouse(display_long)|uniprotkb:Heyl(gene name)|psi-mi:Heyl(display_short)|uniprotkb:Hesr3(gene name synonym)|uniprotkb:Hrt3(gene name synonym)|uniprotkb:Hairy-related transcription factor 3(gene name synonym)|uniprotkb:Hairy and enhancer of split-related protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Firulli et al. (2000)	pubmed:10924525	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-81471	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development)	ensembl:ENSMUSG00000032744(gene)|ensembl:ENSMUST00000040821(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0032835"(glomerulus development)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050683"(AF-1 domain binding)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072014"(proximal tubule development)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR003650(Orange)|refseq:NP_038933.2	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2003/12/18	2014/10/16	rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090	rogid:3Xh9rZvKtIPjr+WHcaOUuYWm7vU10090	intact-crc:1BC4C4ECAA6C827F|rigid:MPNjyF7lgTTl4nEBykvEXMGCQhw	false	glutathione s tranferase tag:?-?	radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)