#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15172	uniprotkb:P11831	intact:EBI-488878|uniprotkb:O75321|ensembl:ENSP00000250003	intact:EBI-493034|uniprotkb:Q5T648|intact:EBI-28988887|ensembl:ENSP00000265354	psi-mi:myod1_human(display_long)|uniprotkb:Myogenic factor 3(gene name synonym)|uniprotkb:MYOD1(gene name)|psi-mi:MYOD1(display_short)|uniprotkb:MYF3(gene name synonym)|uniprotkb:MYOD(gene name synonym)|uniprotkb:BHLHC1(gene name synonym)|uniprotkb:Class C basic helix-loop-helix protein 1(gene name synonym)	psi-mi:srf_human(display_long)|uniprotkb:SRF(gene name)|psi-mi:SRF(display_short)	psi-mi:"MI:0096"(pull down)	Groisman et al. (1996)	pubmed:8617811|mint:MINT-5220973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8674553|mint:MINT-15523	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002469.2|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007517"(muscle organ development)|go:"GO:0007518"(myoblast fate determination)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0014904"(myotube cell development)|go:"GO:0014908"(myotube differentiation involved in skeletal muscle regeneration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030016"(myofibril)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042693"(muscle cell fate commitment)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0043503"(skeletal muscle fiber adaptation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000129152(gene)|ensembl:ENST00000250003(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0071453"(cellular response to oxygen levels)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1905382"(positive regulation of snRNA transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR002546(Myogenic basic muscle-specific protein)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR022032|interpro:IPR036638|interpro:IPR039704|reactome:R-HSA-525793|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|dip:DIP-704N|mint:MINT-1516091(identity)	refseq:NP_003122.1|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030168"(platelet activation)|go:"GO:0030220"(platelet formation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034097"(response to cytokine)|ensembl:ENSP00000265354|refseq:NP_001278930.1|ensembl:ENSG00000112658(gene)|ensembl:ENST00000265354(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001764"(neuron migration)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010736"(serum response element binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090398"(cellular senescence)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR033897|interpro:IPR036879|rcsb pdb:1HBX|rcsb pdb:1K6O|rcsb pdb:1SRS|reactome:R-HSA-5663220|reactome:R-HSA-9031628|reactome:R-HSA-9634638|go:"GO:0035855"(megakaryocyte development)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046016"(positive regulation of transcription by glucose)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048589"(developmental growth)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0048666"(neuron development)|go:"GO:0048821"(erythrocyte development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060324"(face development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|dip:DIP-49N|mint:MINT-1516088(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:No complex could be detected between MyoD and SRF in the absence of E12. A likely interpretation of this result is that heterodimeric formation between E12 and MyoD induces a conformational change in the proteins thatunmasks a site of interaction with SRF|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2002/10/17	2014/10/16	rogid:3VTNivTUfx8OwYeE2scVTkN11oY9606	rogid:Q5pzzfkj4XnE35QHy3bu7l9AI8Y9606	intact-crc:0CD97EADA7B4260A|rigid:i27o9v6Dfdv90bRYGg0+u0JTq9I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11831	uniprotkb:P15173	intact:EBI-493034|uniprotkb:Q5T648|intact:EBI-28988887|ensembl:ENSP00000265354	intact:EBI-3906629|uniprotkb:Q53XW6|ensembl:ENSP00000241651	psi-mi:srf_human(display_long)|uniprotkb:SRF(gene name)|psi-mi:SRF(display_short)	psi-mi:myog_human(display_long)|uniprotkb:MYOG(gene name)|psi-mi:MYOG(display_short)|uniprotkb:BHLHC3(gene name synonym)|uniprotkb:MYF4(gene name synonym)|uniprotkb:Class C basic helix-loop-helix protein 3(gene name synonym)|uniprotkb:Myogenic factor 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Groisman et al. (1996)	pubmed:8617811|mint:MINT-5220973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8674564|mint:MINT-16346	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003122.1|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030168"(platelet activation)|go:"GO:0030220"(platelet formation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034097"(response to cytokine)|ensembl:ENSP00000265354|refseq:NP_001278930.1|ensembl:ENSG00000112658(gene)|ensembl:ENST00000265354(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001764"(neuron migration)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010736"(serum response element binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090398"(cellular senescence)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR033897|interpro:IPR036879|rcsb pdb:1HBX|rcsb pdb:1K6O|rcsb pdb:1SRS|reactome:R-HSA-5663220|reactome:R-HSA-9031628|reactome:R-HSA-9634638|go:"GO:0035855"(megakaryocyte development)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046016"(positive regulation of transcription by glucose)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048589"(developmental growth)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0048666"(neuron development)|go:"GO:0048821"(erythrocyte development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060324"(face development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|dip:DIP-49N|mint:MINT-1516129(identity)	refseq:NP_002470.2|ensembl:ENSG00000122180(gene)|ensembl:ENST00000241651(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009629"(response to gravity)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014891"(striated muscle atrophy)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042693"(muscle cell fate commitment)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0071259"(cellular response to magnetism)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:1901739"(regulation of myoblast fusion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002546(Myogenic basic muscle-specific protein)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR039704|reactome:R-HSA-525793|dip:DIP-159N|mint:MINT-1516132(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:No complex could be detected between myogenin and SRF in the absence of E12. A likely interpretation of this result is that heterodimeric formation between E12 and myogenin induces a conformational change in the proteins that unmasks a site of interaction with SRF.|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2002/10/17	2014/10/16	rogid:Q5pzzfkj4XnE35QHy3bu7l9AI8Y9606	rogid:7r8zPLBvho1GRHTAr7SVXjDXRxg9606	intact-crc:76C599892C05F829|rigid:EHYDbJ3jLZKIN7CJjbAPhFMwxsE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15173	uniprotkb:P11831	intact:EBI-3906629|uniprotkb:Q53XW6|ensembl:ENSP00000241651	intact:EBI-493034|uniprotkb:Q5T648|intact:EBI-28988887|ensembl:ENSP00000265354	psi-mi:myog_human(display_long)|uniprotkb:MYOG(gene name)|psi-mi:MYOG(display_short)|uniprotkb:BHLHC3(gene name synonym)|uniprotkb:MYF4(gene name synonym)|uniprotkb:Class C basic helix-loop-helix protein 3(gene name synonym)|uniprotkb:Myogenic factor 4(gene name synonym)	psi-mi:srf_human(display_long)|uniprotkb:SRF(gene name)|psi-mi:SRF(display_short)	psi-mi:"MI:0018"(two hybrid)	Groisman et al. (1996)	pubmed:8617811|mint:MINT-5220973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8674583|mint:MINT-16345	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002470.2|ensembl:ENSG00000122180(gene)|ensembl:ENST00000241651(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009629"(response to gravity)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014737"(positive regulation of muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014891"(striated muscle atrophy)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042693"(muscle cell fate commitment)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070888"(E-box binding)|go:"GO:0071259"(cellular response to magnetism)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:1901739"(regulation of myoblast fusion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002546(Myogenic basic muscle-specific protein)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|interpro:IPR039704|reactome:R-HSA-525793|dip:DIP-159N|mint:MINT-1516120(identity)	refseq:NP_003122.1|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030168"(platelet activation)|go:"GO:0030220"(platelet formation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034097"(response to cytokine)|ensembl:ENSP00000265354|refseq:NP_001278930.1|ensembl:ENSG00000112658(gene)|ensembl:ENST00000265354(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001764"(neuron migration)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010736"(serum response element binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090398"(cellular senescence)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR033897|interpro:IPR036879|rcsb pdb:1HBX|rcsb pdb:1K6O|rcsb pdb:1SRS|reactome:R-HSA-5663220|reactome:R-HSA-9031628|reactome:R-HSA-9634638|go:"GO:0035855"(megakaryocyte development)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046016"(positive regulation of transcription by glucose)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048589"(developmental growth)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0048666"(neuron development)|go:"GO:0048821"(erythrocyte development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060324"(face development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|dip:DIP-49N|mint:MINT-1516114(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:No complex could be detected between myogenin and SRF in the absence of E12. A likely interpretation of this result is that heterodimeric formation between E12 and myogenin induces a conformational change in the proteins that unmasks a site of interaction with SRF.|comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/10/17	2014/10/16	rogid:7r8zPLBvho1GRHTAr7SVXjDXRxg9606	rogid:Q5pzzfkj4XnE35QHy3bu7l9AI8Y9606	intact-crc:C33AF4272829CD1D|rigid:EHYDbJ3jLZKIN7CJjbAPhFMwxsE	false	tag:?-?(MINT-1516121)	tag:?-?(MINT-1516115)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11831	uniprotkb:P15172	intact:EBI-493034|uniprotkb:Q5T648|intact:EBI-28988887|ensembl:ENSP00000265354	intact:EBI-488878|uniprotkb:O75321|ensembl:ENSP00000250003	psi-mi:srf_human(display_long)|uniprotkb:SRF(gene name)|psi-mi:SRF(display_short)	psi-mi:myod1_human(display_long)|uniprotkb:Myogenic factor 3(gene name synonym)|uniprotkb:MYOD1(gene name)|psi-mi:MYOD1(display_short)|uniprotkb:MYF3(gene name synonym)|uniprotkb:MYOD(gene name synonym)|uniprotkb:BHLHC1(gene name synonym)|uniprotkb:Class C basic helix-loop-helix protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Groisman et al. (1996)	pubmed:8617811|mint:MINT-5220973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8674600|mint:MINT-15522	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003122.1|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030168"(platelet activation)|go:"GO:0030220"(platelet formation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034097"(response to cytokine)|ensembl:ENSP00000265354|refseq:NP_001278930.1|ensembl:ENSG00000112658(gene)|ensembl:ENST00000265354(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001764"(neuron migration)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010736"(serum response element binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090398"(cellular senescence)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR033897|interpro:IPR036879|rcsb pdb:1HBX|rcsb pdb:1K6O|rcsb pdb:1SRS|reactome:R-HSA-5663220|reactome:R-HSA-9031628|reactome:R-HSA-9634638|go:"GO:0035855"(megakaryocyte development)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046016"(positive regulation of transcription by glucose)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048589"(developmental growth)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0048666"(neuron development)|go:"GO:0048821"(erythrocyte development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060324"(face development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|dip:DIP-49N|mint:MINT-1516138(identity)	refseq:NP_002469.2|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007517"(muscle organ development)|go:"GO:0007518"(myoblast fate determination)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0014904"(myotube cell development)|go:"GO:0014908"(myotube differentiation involved in skeletal muscle regeneration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030016"(myofibril)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042693"(muscle cell fate commitment)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0043503"(skeletal muscle fiber adaptation)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000129152(gene)|ensembl:ENST00000250003(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0071453"(cellular response to oxygen levels)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1905382"(positive regulation of snRNA transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR002546(Myogenic basic muscle-specific protein)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR022032|interpro:IPR036638|interpro:IPR039704|reactome:R-HSA-525793|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070888"(E-box binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|dip:DIP-704N|mint:MINT-1516144(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:No complex could be detected between MyoD and SRF in the absence of E12. A likely interpretation of this result is that heterodimeric formation between E12 and MyoD induces a conformational change in the proteins thatunmasks a site of interaction with SRF|comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/10/17	2014/10/16	rogid:Q5pzzfkj4XnE35QHy3bu7l9AI8Y9606	rogid:3VTNivTUfx8OwYeE2scVTkN11oY9606	intact-crc:7E6BF50462D9B2ED|rigid:i27o9v6Dfdv90bRYGg0+u0JTq9I	false	tag:?-?(MINT-1516139)	tag:?-?(MINT-1516145)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)