#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q61510	uniprotkb:O70456	intact:EBI-8377742|uniprotkb:Q5SU70|intact:MINT-240797|ensembl:ENSMUSP00000103528	intact:EBI-1544118|uniprotkb:Q3TEZ1|ensembl:ENSMUSP00000050374	psi-mi:tri25_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRIM25(gene name synonym)|uniprotkb:Trim25(gene name)|psi-mi:Trim25(display_short)|uniprotkb:Efp(gene name synonym)|uniprotkb:Zfp147(gene name synonym)|uniprotkb:Znf147(gene name synonym)|uniprotkb:Zinc finger protein 147(gene name synonym)|uniprotkb:Estrogen-responsive finger protein(gene name synonym)|uniprotkb:Ubiquitin/ISG15-conjugating enzyme TRIM25(gene name synonym)|uniprotkb:Tripartite motif-containing protein 25(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase(gene name synonym)	psi-mi:1433s_mouse(display_long)|uniprotkb:Sfn(gene name)|psi-mi:Sfn(display_short)|uniprotkb:Mkrn3(gene name synonym)|uniprotkb:Stratifin(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Urano et al. (2002)	pubmed:12075357|mint:MINT-5215497	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8480450|mint:MINT-13826	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033572.2|ensembl:ENSMUSG00000000275(gene)|ensembl:ENSMUST00000107896(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016604"(nuclear body)|go:"GO:0016874"(ligase activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033280"(response to vitamin D)|go:"GO:0039552"(RIG-I binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043627"(response to estrogen)|go:"GO:0045087"(innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902186"(obsolete regulation of viral release from host cell)|go:"GO:1902187"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR042753|interpro:IPR043136|mint:Q61510|rcsb pdb:4B8E|reactome:R-MMU-1169408|reactome:R-MMU-5656169|mint:MINT-717155(identity)	refseq:NP_061224.2|ensembl:ENSMUSG00000047281(gene)|ensembl:ENSMUST00000057311(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010482"(regulation of epidermal cell division)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0031424"(keratinization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061436"(establishment of skin barrier)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR037435|mint:O70456|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-6804114|reactome:R-MMU-75035|reactome:R-MMU-9614399|go:"GO:0030307"(positive regulation of cell growth)|mint:MINT-717162(identity)	-	comment:mint|function:Mediates estrogen action in various target organs|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/08/28	2014/10/16	rogid:JcdARiyxwQkDwoYPAJUmsvH8ri810090	rogid:6B8XqFSuqdwWT6hYap/ecmwIuaY10090	intact-crc:E501615DD783CCAF|rigid:6uBPbVmCvzsH4NhJ7y6jEsCTUbM	false	binding-associated region:?-?(MINT-717156)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61510	uniprotkb:O14933	intact:EBI-8377742|uniprotkb:Q5SU70|intact:MINT-240797|ensembl:ENSMUSP00000103528	intact:EBI-2129974|uniprotkb:A6NDM6|uniprotkb:Q8N5D8|uniprotkb:A8MY53|uniprotkb:Q9UEZ0|ensembl:ENSP00000287156	psi-mi:tri25_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRIM25(gene name synonym)|uniprotkb:Trim25(gene name)|psi-mi:Trim25(display_short)|uniprotkb:Efp(gene name synonym)|uniprotkb:Zfp147(gene name synonym)|uniprotkb:Znf147(gene name synonym)|uniprotkb:Zinc finger protein 147(gene name synonym)|uniprotkb:Estrogen-responsive finger protein(gene name synonym)|uniprotkb:Ubiquitin/ISG15-conjugating enzyme TRIM25(gene name synonym)|uniprotkb:Tripartite motif-containing protein 25(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase(gene name synonym)	psi-mi:ub2l6_human(display_long)|uniprotkb:UBE2L6(gene name)|psi-mi:UBE2L6(display_short)|uniprotkb:UBCH8(gene name synonym)|uniprotkb:Ubiquitin-protein ligase L6(gene name synonym)|uniprotkb:Ubiquitin carrier protein L6(gene name synonym)|uniprotkb:UbcH8(gene name synonym)|uniprotkb:Retinoic acid-induced gene B protein(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme L6(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Urano et al. (2002)	pubmed:12075357|mint:MINT-5215497	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8480490|mint:MINT-16356	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033572.2|ensembl:ENSMUSG00000000275(gene)|ensembl:ENSMUST00000107896(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016604"(nuclear body)|go:"GO:0016874"(ligase activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033280"(response to vitamin D)|go:"GO:0039552"(RIG-I binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043627"(response to estrogen)|go:"GO:0045087"(innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902186"(obsolete regulation of viral release from host cell)|go:"GO:1902187"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR042753|interpro:IPR043136|mint:Q61510|rcsb pdb:4B8E|reactome:R-MMU-1169408|reactome:R-MMU-5656169|mint:MINT-717130(identity)	refseq:NP_004214.1|refseq:NP_937826.1|ensembl:ENSP00000287156|ensembl:ENST00000340573|ensembl:ENSP00000341980|dip:DIP-41477N|ensembl:ENSG00000156587(gene)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:O14933|rcsb pdb:1WZV|rcsb pdb:1WZW|rcsb pdb:2KJH|reactome:R-HSA-1169408|reactome:R-HSA-168928|reactome:R-HSA-5656169|ensembl:ENST00000287156(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|reactome:R-HSA-936440|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|mint:MINT-717136(identity)	-	comment:mint|function:Mediates estrogen action in various target organs|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/08/28	2014/10/16	rogid:JcdARiyxwQkDwoYPAJUmsvH8ri810090	rogid:18K+ReSJfSpKRvnLuED+kPB3beY9606	intact-crc:764A134CC5711FE5|rigid:fF680osL2weY3rpL4Ah54yq+4sE	false	binding-associated region:?-?(MINT-717131)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61510	uniprotkb:O70456	intact:EBI-8377742|uniprotkb:Q5SU70|intact:MINT-240797|ensembl:ENSMUSP00000103528	intact:EBI-1544118|uniprotkb:Q3TEZ1|ensembl:ENSMUSP00000050374	psi-mi:tri25_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRIM25(gene name synonym)|uniprotkb:Trim25(gene name)|psi-mi:Trim25(display_short)|uniprotkb:Efp(gene name synonym)|uniprotkb:Zfp147(gene name synonym)|uniprotkb:Znf147(gene name synonym)|uniprotkb:Zinc finger protein 147(gene name synonym)|uniprotkb:Estrogen-responsive finger protein(gene name synonym)|uniprotkb:Ubiquitin/ISG15-conjugating enzyme TRIM25(gene name synonym)|uniprotkb:Tripartite motif-containing protein 25(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase(gene name synonym)	psi-mi:1433s_mouse(display_long)|uniprotkb:Sfn(gene name)|psi-mi:Sfn(display_short)|uniprotkb:Mkrn3(gene name synonym)|uniprotkb:Stratifin(gene name synonym)	psi-mi:"MI:0045"(experimental interaction detection)	Urano et al. (2002)	pubmed:12075357|mint:MINT-5215497	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8480518|mint:MINT-16252	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033572.2|ensembl:ENSMUSG00000000275(gene)|ensembl:ENSMUST00000107896(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016604"(nuclear body)|go:"GO:0016874"(ligase activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033280"(response to vitamin D)|go:"GO:0039552"(RIG-I binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043627"(response to estrogen)|go:"GO:0045087"(innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902186"(obsolete regulation of viral release from host cell)|go:"GO:1902187"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR042753|interpro:IPR043136|mint:Q61510|rcsb pdb:4B8E|reactome:R-MMU-1169408|reactome:R-MMU-5656169|mint:MINT-717143(identity)	refseq:NP_061224.2|ensembl:ENSMUSG00000047281(gene)|ensembl:ENSMUST00000057311(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010482"(regulation of epidermal cell division)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0031424"(keratinization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061436"(establishment of skin barrier)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR037435|mint:O70456|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-6804114|reactome:R-MMU-75035|reactome:R-MMU-9614399|go:"GO:0030307"(positive regulation of cell growth)|mint:MINT-717148(identity)	-	comment:mint|function:Mediates estrogen action in various target organs|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/08/28	2014/10/16	rogid:JcdARiyxwQkDwoYPAJUmsvH8ri810090	rogid:6B8XqFSuqdwWT6hYap/ecmwIuaY10090	intact-crc:6BE17D7A27347210|rigid:6uBPbVmCvzsH4NhJ7y6jEsCTUbM	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61510	uniprotkb:O70456	intact:EBI-8377742|uniprotkb:Q5SU70|intact:MINT-240797|ensembl:ENSMUSP00000103528	intact:EBI-1544118|uniprotkb:Q3TEZ1|ensembl:ENSMUSP00000050374	psi-mi:tri25_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRIM25(gene name synonym)|uniprotkb:Trim25(gene name)|psi-mi:Trim25(display_short)|uniprotkb:Efp(gene name synonym)|uniprotkb:Zfp147(gene name synonym)|uniprotkb:Znf147(gene name synonym)|uniprotkb:Zinc finger protein 147(gene name synonym)|uniprotkb:Estrogen-responsive finger protein(gene name synonym)|uniprotkb:Ubiquitin/ISG15-conjugating enzyme TRIM25(gene name synonym)|uniprotkb:Tripartite motif-containing protein 25(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase(gene name synonym)	psi-mi:1433s_mouse(display_long)|uniprotkb:Sfn(gene name)|psi-mi:Sfn(display_short)|uniprotkb:Mkrn3(gene name synonym)|uniprotkb:Stratifin(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Urano et al. (2002)	pubmed:12075357|mint:MINT-5215497	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8480566|mint:MINT-13825	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033572.2|ensembl:ENSMUSG00000000275(gene)|ensembl:ENSMUST00000107896(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016604"(nuclear body)|go:"GO:0016874"(ligase activity)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033280"(response to vitamin D)|go:"GO:0039552"(RIG-I binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043627"(response to estrogen)|go:"GO:0045087"(innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902186"(obsolete regulation of viral release from host cell)|go:"GO:1902187"|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR042753|interpro:IPR043136|mint:Q61510|rcsb pdb:4B8E|reactome:R-MMU-1169408|reactome:R-MMU-5656169|mint:MINT-717110(identity)	refseq:NP_061224.2|ensembl:ENSMUSG00000047281(gene)|ensembl:ENSMUST00000057311(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010482"(regulation of epidermal cell division)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0031424"(keratinization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061436"(establishment of skin barrier)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR037435|mint:O70456|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-6804114|reactome:R-MMU-75035|reactome:R-MMU-9614399|go:"GO:0030307"(positive regulation of cell growth)|mint:MINT-717121(identity)	go:"GO:0005737"(cytoplasm)	comment:mint|function:Mediates estrogen action in various target organs|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3A|comment:homomint|comment:domino|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2002/08/28	2014/10/16	rogid:JcdARiyxwQkDwoYPAJUmsvH8ri810090	rogid:6B8XqFSuqdwWT6hYap/ecmwIuaY10090	intact-crc:1E83CF7EBE81C7EA|rigid:6uBPbVmCvzsH4NhJ7y6jEsCTUbM	false	binding-associated region:?-?(MINT-717111)	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)