#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P63097 uniprotkb:O43566 intact:EBI-8309073|ensembl:ENSBTAP00000003515|uniprotkb:Q2KJC0|uniprotkb:P04898|intact:MINT-236328|uniprotkb:P31871|uniprotkb:P11015 intact:EBI-750603|uniprotkb:O43565|uniprotkb:Q506M1|uniprotkb:Q6ZWA4|uniprotkb:Q8TD62|ensembl:ENSP00000386229 psi-mi:gnai1_bovin(display_long)|uniprotkb:GNAI1(gene name)|psi-mi:GNAI1(display_short)|uniprotkb:Adenylate cyclase-inhibiting G alpha protein(gene name synonym) psi-mi:rgs14_human(display_long)|uniprotkb:RGS14(gene name)|psi-mi:RGS14(display_short) psi-mi:"MI:0114"(x-ray crystallography) Kimple et al. (2002) pubmed:11976690|mint:MINT-5215333 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8309068|mint:MINT-14233 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSBTAG00000002714(gene)|ensembl:ENSBTAT00000003515(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0019003"(GDP binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0099738"(cell cortex region)|go:"GO:1904322"(cellular response to forskolin)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|rcsb pdb:6K42|rcsb pdb:6NBF|rcsb pdb:6NBH|rcsb pdb:6NBI|rcsb pdb:7D68|reactome:R-BTA-170670|reactome:R-BTA-392170|reactome:R-BTA-418594|refseq:NP_776749.1|refseq:XP_015324318.1|dip:DIP-41168N|mint:MINT-714490(identity) refseq:NP_006471.2|dip:DIP-41167N|ensembl:ENSG00000169220(gene)|ensembl:ENST00000408923(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008542"(visual learning)|go:"GO:0010070"(zygote asymmetric cell division)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031914"(negative regulation of synaptic plasticity)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR003109(GoLoco)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR030776|interpro:IPR036305|interpro:IPR037881|rcsb pdb:2JNU|rcsb pdb:2OM2|rcsb pdb:2XNS|rcsb pdb:3ONW|rcsb pdb:3QI2|reactome:R-HSA-418594|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|mint:MINT-714483(identity) - function:"Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli"|comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" kd:65 micromolar|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2002/05/08 2014/10/16 rogid:3yQOCXJb8Undp/Xw42xrBiG5ePE9913 rogid:KEcGh5F6Ml7JlltMf4YWgSBStTI9606 intact-crc:F881F6F730D53F72|rigid:ObX7CvojcGBsvJQdfy8nr17/pcg false binding-associated region:25-353(MINT-714491) binding-associated region:496-530(MINT-714484) 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)