#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P31423	uniprotkb:Q8WMQ6	intact:EBI-7974891|intact:MINT-235145	intact:EBI-8293881|intact:MINT-235125	psi-mi:grm4_rat(display_long)|uniprotkb:Grm4(gene name)|psi-mi:Grm4(display_short)|uniprotkb:Gprc1d(gene name synonym)|uniprotkb:Mglur4(gene name synonym)	psi-mi:q8wmq6_bovin(display_long)	psi-mi:"MI:0018"(two hybrid)	- (2002)	pubmed:11943148|mint:MINT-5215259	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8293925|mint:MINT-18730	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2745|refseq:NP_073157.1|dip:DIP-41144N|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|mint:P31423|interpro:IPR000337(GPCR, family 3)|interpro:IPR001786(GPCR, family 3, metabotropic glutamate receptor 4)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|reactome:R-RNO-418594|reactome:R-RNO-420499|mint:MINT-713615(identity)	interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR044801|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0051015"(actin filament binding)|mint:MINT-713609(identity)	-	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint|comment:"Stoichiometry: 1.0"	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/08/21	2014/10/16	rogid:Q+SUUFPoCxp8dLjZM9SC2wvqS4M10116	rogid:mBiUlMbRZwiyZ1UkxMcr6L6BT6k9913	intact-crc:6FFBA5495B59DB31|rigid:G6cNMdTeUTG3eDvKjQjZVgg02L4	false	tag:?-?(MINT-713616)	tag:?-?(MINT-713610)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8WMQ6	uniprotkb:P35400	intact:EBI-8293881|intact:MINT-235125	intact:EBI-6936416|intact:MINT-146474	psi-mi:q8wmq6_bovin(display_long)	psi-mi:grm7_rat(display_long)|uniprotkb:Grm7(gene name)|psi-mi:Grm7(display_short)|uniprotkb:Gprc1g(gene name synonym)|uniprotkb:Mglur7(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	- (2002)	pubmed:11943148|mint:MINT-5215259	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8293878|mint:MINT-19276	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR044801|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0051015"(actin filament binding)|mint:MINT-713656(identity)	go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007614"(short-term memory)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010855"(adenylate cyclase inhibitor activity)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030534"(adult behavior)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043235"(receptor complex)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050877"(nervous system process)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061564"(axon development)|go:"GO:0070085"(glycosylation)|go:"GO:0070905"(serine binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR001883(GPCR, family 3, metabotropic glutamate receptor 7)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|rcsb pdb:2E4Z|reactome:R-RNO-418594|reactome:R-RNO-420499|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|refseq:NP_112302.1|rgd:619857|mint:P35400|dip:DIP-41145N|mint:MINT-713662(identity)	-	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/08/21	2014/10/16	rogid:mBiUlMbRZwiyZ1UkxMcr6L6BT6k9913	rogid:4p27GEshqsLLsQueJLDdVAXV6BY10116	intact-crc:E5376E80FD3CBEAB|rigid:qnJRW0t/hdxmZQpLqi/Ic01DrNs	false	tag:?-?(MINT-713657)	tag:?-?(MINT-713663)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8WMQ6	uniprotkb:P31424	intact:EBI-8293881|intact:MINT-235125	intact:EBI-2902734	psi-mi:q8wmq6_bovin(display_long)	psi-mi:grm5_rat(display_long)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	- (2002)	pubmed:11943148|mint:MINT-5215259	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8293959|mint:MINT-18489	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR044801|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0051015"(actin filament binding)|mint:MINT-713639(identity)	go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1DDV|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|rgd:2746|refseq:NP_058708.1|refseq:XP_017444267.1|refseq:XP_017444268.1|refseq:XP_017444269.1|refseq:XP_017444270.1|refseq:XP_006229721.1|dip:DIP-41263N|mint:P31424|mint:MINT-713645(identity)	-	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/08/21	2014/10/16	rogid:mBiUlMbRZwiyZ1UkxMcr6L6BT6k9913	rogid:ZXlFrgUfGF+zPgfi7QuTXqMSZvk10116	intact-crc:A707366F8F073B7E|rigid:9wPoT8zg7XnSU3bH3XvPxM94i4g	false	tag:?-?(MINT-713640)	binding-associated region:827-875(MINT-713646)|tag:?-?(MINT-713648)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8WMQ6	uniprotkb:P70579	intact:EBI-8293881|intact:MINT-235125	intact:EBI-7974461|intact:MINT-235225	psi-mi:q8wmq6_bovin(display_long)	psi-mi:grm8_rat(display_long)|uniprotkb:Grm8(gene name)|psi-mi:Grm8(display_short)|uniprotkb:Gprc1h(gene name synonym)|uniprotkb:Mglur8(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	- (2002)	pubmed:11943148|mint:MINT-5215259	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8293942|mint:MINT-18731	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR044801|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0051015"(actin filament binding)|mint:MINT-713624(identity)	interpro:IPR017978|rgd:619858|refseq:NP_071538.1|interpro:IPR017979|interpro:IPR028082|mint:P70579|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|reactome:R-RNO-418594|reactome:R-RNO-420499|interpro:IPR000144(GPCR, family 3, metabotropic glutamate receptor 8)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR038550|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001642"(group III metabotropic glutamate receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007196"(adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|mint:MINT-713630(identity)	-	comment:"fragmentation type: fragment"|comment:mint|comment:"Stoichiometry: 1.0"	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/08/21	2014/10/16	rogid:mBiUlMbRZwiyZ1UkxMcr6L6BT6k9913	rogid:R+st+0fAYUau53UFd/fwjhcfcVc10116	intact-crc:2AB96C26EBE9D28E|rigid:XA5wBeUKthDw+JD75zmRg9wTLbY	false	tag:?-?(MINT-713625)	tag:?-?(MINT-713631)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)