#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9HBX9 uniprotkb:P01348 intact:EBI-8088969|uniprotkb:Q3KU24|uniprotkb:Q3KU25|uniprotkb:Q3KU26|uniprotkb:Q2M215|intact:MINT-231156|uniprotkb:B4DTV2|uniprotkb:B4DHD1|ensembl:ENSP00000303248 intact:EBI-8088953|intact:MINT-231177 psi-mi:rxfp1_human(display_long)|uniprotkb:RXFP1(gene name)|psi-mi:RXFP1(display_short)|uniprotkb:LGR7(gene name synonym)|uniprotkb:Relaxin family peptide receptor 1(gene name synonym)|uniprotkb:Leucine-rich repeat-containing G-protein coupled receptor 7(gene name synonym) psi-mi:relx_pig(display_long)|uniprotkb:RLN(gene name)|psi-mi:RLN(display_short) psi-mi:"MI:0030"(cross-linking study) Hsu et al. (2002) pubmed:11809971|mint:MINT-5215063 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8088950|mint:MINT-14585 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067647.2|refseq:NP_001240657.1|refseq:NP_001240658.1|ensembl:ENSG00000171509(gene)|ensembl:ENST00000307765(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007567"(parturition)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042562"(hormone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060427"(lung connective tissue development)|go:"GO:0060658"(nipple morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008112(Relaxin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR023415|interpro:IPR032675|interpro:IPR036055|rcsb pdb:2JM4|rcsb pdb:2M7P|reactome:R-HSA-418555|reactome:R-HSA-444821|reactome:R-HSA-9660821|mint:MINT-710902(identity) rcsb pdb:4RLX|interpro:IPR022421|rcsb pdb:3RLX|rcsb pdb:2RLX|refseq:NP_999037.1|interpro:IPR022353|interpro:IPR016179(Insulin-like)|rcsb pdb:1RLX|interpro:IPR036438|go:"GO:0005576"(extracellular region)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0005179"(hormone activity)|mint:MINT-710909(identity) - function:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP|comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals|comment:"Stoichiometry: 1.0" comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2002/04/23 2014/10/16 rogid:8flEswbzhb+rQGfn16DgFOLTJlg9606 rogid:Zwq0e4fl6kToWAh2TQes09ruRC49823 intact-crc:0C0A62EB8D8CC242|rigid:xFCYV3G/l+prE8ws9Ahf+ppSvsA false binding-associated region:1-400(MINT-710903) binding-associated region:25-182(MINT-710910) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9HBX9 uniprotkb:P01348 intact:EBI-8088969|uniprotkb:Q3KU24|uniprotkb:Q3KU25|uniprotkb:Q3KU26|uniprotkb:Q2M215|intact:MINT-231156|uniprotkb:B4DTV2|uniprotkb:B4DHD1|ensembl:ENSP00000303248 intact:EBI-8088953|intact:MINT-231177 psi-mi:rxfp1_human(display_long)|uniprotkb:RXFP1(gene name)|psi-mi:RXFP1(display_short)|uniprotkb:LGR7(gene name synonym)|uniprotkb:Relaxin family peptide receptor 1(gene name synonym)|uniprotkb:Leucine-rich repeat-containing G-protein coupled receptor 7(gene name synonym) psi-mi:relx_pig(display_long)|uniprotkb:RLN(gene name)|psi-mi:RLN(display_short) psi-mi:"MI:0045"(experimental interaction detection) Hsu et al. (2002) pubmed:11809971|mint:MINT-5215063 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-8089082|mint:MINT-14586 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067647.2|refseq:NP_001240657.1|refseq:NP_001240658.1|ensembl:ENSG00000171509(gene)|ensembl:ENST00000307765(transcript)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007567"(parturition)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0042562"(hormone binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060427"(lung connective tissue development)|go:"GO:0060658"(nipple morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR008112(Relaxin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR023415|interpro:IPR032675|interpro:IPR036055|rcsb pdb:2JM4|rcsb pdb:2M7P|reactome:R-HSA-418555|reactome:R-HSA-444821|reactome:R-HSA-9660821|mint:MINT-710921(identity) rcsb pdb:4RLX|interpro:IPR022421|rcsb pdb:3RLX|rcsb pdb:2RLX|refseq:NP_999037.1|interpro:IPR022353|interpro:IPR016179(Insulin-like)|rcsb pdb:1RLX|interpro:IPR036438|go:"GO:0005576"(extracellular region)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0005179"(hormone activity)|mint:MINT-710928(identity) - function:Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP|comment:mint|comment:"Stoichiometry: 1.0" comment:mint|function:Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals|comment:"Stoichiometry: 1.0" comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2002/04/23 2014/10/16 rogid:8flEswbzhb+rQGfn16DgFOLTJlg9606 rogid:Zwq0e4fl6kToWAh2TQes09ruRC49823 intact-crc:CB918EF24E55C86E|rigid:xFCYV3G/l+prE8ws9Ahf+ppSvsA false binding-associated region:1-400(MINT-710922) binding-associated region:25-182(MINT-710929) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)