#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P33012	uniprotkb:P0AES4	intact:EBI-8073237|intact:MINT-226165|psi-mi:MINT-5277993|ensemblbacteria:AAC75070|ensemblbacteria:BAA15830	intact:EBI-547129|uniprotkb:P09097|ensemblbacteria:AAC75291|ensemblbacteria:BAA16048	psi-mi:sbmc_ecoli(display_long)|uniprotkb:sbmC(gene name)|psi-mi:sbmC(display_short)|uniprotkb:gyrI(gene name synonym)|uniprotkb:yeeB(gene name synonym)|uniprotkb:JW1991(locus name)|uniprotkb:b2009(locus name)	psi-mi:gyra_ecoli(display_long)|uniprotkb:hisW(gene name synonym)|uniprotkb:nalA(gene name synonym)|uniprotkb:parD(gene name synonym)|uniprotkb:b2231(locus name)|uniprotkb:gyrA(gene name)|psi-mi:gyrA(display_short)|uniprotkb:JW2225(locus name)	psi-mi:"MI:0019"(coimmunoprecipitation)	Nakanishi et al. (2002)	pubmed:11777918|mint:MINT-5214992	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8073234|mint:MINT-14309	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001105415.1|refseq:NP_416513.1|dip:DIP-9862N|ensemblbacteria:AAC75070(transcript)|ensemblbacteria:b2009(gene)|ensemblbacteria:BAA15830(gene)|ensemblbacteria:BAA15830(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008657"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity")|go:"GO:0019899"(enzyme binding)|go:"GO:2000104"(negative regulation of DNA-dependent DNA replication)|interpro:IPR010499(Bacterial transcription activator, effector binding)|interpro:IPR011256(Regulatory factor, effector, bacterial)|interpro:IPR024911|interpro:IPR029442|rcsb pdb:1JYH|mint:MINT-609580(identity)	refseq:NP_416734.1|refseq:WP_001281242.1|ensemblbacteria:AAC75291(transcript)|ensemblbacteria:b2231(gene)|ensemblbacteria:BAA16048(gene)|ensemblbacteria:BAA16048(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0016020"(membrane)|go:"GO:0034335"(DNA negative supercoiling activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0046677"(response to antibiotic)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR005743(DNA gyrase, subunit A)|interpro:IPR006691(DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR035516|rcsb pdb:1AB4|rcsb pdb:1X75|rcsb pdb:1ZI0|rcsb pdb:2Y3P|rcsb pdb:3NUH|rcsb pdb:4ELY|rcsb pdb:6RKS|rcsb pdb:6RKU|rcsb pdb:6RKV|rcsb pdb:6RKW|dip:DIP-36179N|mint:MINT-609583(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/01/08	2014/10/16	rogid:vSoA/AOu1RQeVj6GiQm3wG6XLEk83333	rogid:O5WW4A/0lHpHyyIaahw9PQkc/Ug83333	intact-crc:7434914F0C6540C8|rigid:3DyDyPOYAdN3YWt2L+Okh2NqND4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99PI8	uniprotkb:P20917	intact:EBI-7766036|ensembl:ENSMUSP00000062924|uniprotkb:Q80WQ1|intact:MINT-188355	intact:EBI-774926|uniprotkb:P16880|uniprotkb:A0A087WPR1|ensembl:ENSMUSP00000139881	psi-mi:rtn4r_mouse(display_long)|uniprotkb:Ngr1(gene name synonym)|uniprotkb:Nogo66 receptor-1(gene name synonym)|uniprotkb:Rtn4r(gene name)|psi-mi:Rtn4r(display_short)|uniprotkb:Nogor(gene name synonym)|uniprotkb:Nogo receptor(gene name synonym)|uniprotkb:Nogo-66 receptor(gene name synonym)	psi-mi:mag_mouse(display_long)|uniprotkb:Siglec-4a(gene name synonym)|uniprotkb:Mag(gene name)|psi-mi:Mag(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Nakanishi et al. (2002)	pubmed:11777918|mint:MINT-5214992	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8073261|mint:MINT-14310	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000043811(gene)|ensembl:ENSMUST00000059589(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0023041"(neuronal signal transduction)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031362"(anchored component of external side of plasma membrane)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038131"(neuregulin receptor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905576"(ganglioside GT1b binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|mint:Q99PI8|rcsb pdb:5O0K|rcsb pdb:5O0L|rcsb pdb:5O0M|rcsb pdb:5O0N|rcsb pdb:5O0O|rcsb pdb:5O0Q|rcsb pdb:5O0R|rcsb pdb:5O0P|refseq:NP_075358.1|mint:MINT-609591(identity)	refseq:NP_001333015.1|refseq:NP_001333016.1|refseq:NP_034888.1|refseq:XP_011248743.1|refseq:NP_001333017.1|refseq:XP_017177497.1|refseq:NP_001333013.1|refseq:NP_001333014.1|refseq:XP_006539653.1|refseq:XP_006539654.1|refseq:XP_011248740.1|refseq:XP_011248741.1|refseq:XP_011248742.1|refseq:XP_017177496.1|ensembl:ENSMUSG00000036634(gene)|ensembl:ENSMUST00000191081(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031103"(axon regeneration)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0033270"(paranode region of axon)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097453"(mesaxon)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1905576"(ganglioside GT1b binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P20917|rcsb pdb:5LF5|rcsb pdb:5LFR|rcsb pdb:5LFU|rcsb pdb:5LFV|rcsb pdb:6GZJ|rcsb pdb:6GZL|reactome:R-MMU-193634|reactome:R-MMU-210991|mint:MINT-609588(identity)	-	comment:mint|function:Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/01/08	2019/09/20	rogid:TQ/XncSvF4z/pYDIDf7gNZk8b8010090	rogid:sgxaYqIU4i2tAdeRMT9/UqKO0Qo10090	intact-crc:FE6346959B32AF24|rigid:e6NLOsOaOdQOswIann0lmmb2ZME	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33012	uniprotkb:P0AES7	intact:EBI-8073237|intact:MINT-226165|psi-mi:MINT-5277993|ensemblbacteria:AAC75070|ensemblbacteria:BAA15830	intact:EBI-8073279|intact:MINT-201713|uniprotkb:O08438|uniprotkb:P06982|ensemblbacteria:AAG58896|ensemblbacteria:BAB38057	psi-mi:sbmc_ecoli(display_long)|uniprotkb:sbmC(gene name)|psi-mi:sbmC(display_short)|uniprotkb:gyrI(gene name synonym)|uniprotkb:yeeB(gene name synonym)|uniprotkb:JW1991(locus name)|uniprotkb:b2009(locus name)	psi-mi:gyrb_eco57(display_long)|uniprotkb:gyrB(gene name)|psi-mi:gyrB(display_short)|uniprotkb:ECs4634(locus name)|uniprotkb:Z5190(locus name)	psi-mi:"MI:0428"(imaging technique)	Nakanishi et al. (2002)	pubmed:11777918|mint:MINT-5214992	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8073311|mint:MINT-18312	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001105415.1|refseq:NP_416513.1|dip:DIP-9862N|ensemblbacteria:AAC75070(transcript)|ensemblbacteria:b2009(gene)|ensemblbacteria:BAA15830(gene)|ensemblbacteria:BAA15830(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008657"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity")|go:"GO:0019899"(enzyme binding)|go:"GO:2000104"(negative regulation of DNA-dependent DNA replication)|interpro:IPR010499(Bacterial transcription activator, effector binding)|interpro:IPR011256(Regulatory factor, effector, bacterial)|interpro:IPR024911|interpro:IPR029442|rcsb pdb:1JYH|mint:MINT-609598(identity)	refseq:WP_000072067.1|interpro:IPR034160|refseq:NP_312661.1|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR020568|interpro:IPR018522|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002288(DNA topoisomerase, type IIA, subunit B, C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR011557(DNA gyrase, subunit B)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR036890|ensemblbacteria:AAG58896(transcript)|ensemblbacteria:BAB38057(transcript)|ensemblbacteria:ECs_4634(gene)|ensemblbacteria:Z5190(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006265"(DNA topological change)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|interpro:IPR041423|mint:MINT-609601(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	function:DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/01/08	2014/10/16	rogid:vSoA/AOu1RQeVj6GiQm3wG6XLEk83333	rogid:BY4faxPI0JJ1jSqwBk/ET/KnmVI83334	intact-crc:14C855B3F00CD3C2|rigid:LOQpfIpfdgB4XPUA1MUWjmKiXYw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)