#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P42573	uniprotkb:Q8STE5	intact:EBI-494247|uniprotkb:P45435|uniprotkb:Q9GQQ4|uniprotkb:Q9NAQ8|ensemblmetazoa:C48D1.2a.1	intact:EBI-6390460|ensemblmetazoa:Y106G6E.5a.1|ensemblmetazoa:Y106G6E.5a.2	psi-mi:ced3_caeel(display_long)|uniprotkb:ced-3(gene name)|psi-mi:ced-3(display_short)|uniprotkb:Caspase ced-3(gene name synonym)|uniprotkb:C48D1.2(orf name)	psi-mi:ced12_caeel(display_long)|uniprotkb:ced-12(gene name)|psi-mi:ced-12(display_short)|uniprotkb:Y106G6E.5(orf name)	psi-mi:"MI:0018"(two hybrid)	Gumienny et al. (2001)	pubmed:11595183|mint:MINT-5214674	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8001700|mint:MINT-15403	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001255708.1|wormbase:C48D1.2a|reactome:R-CEL-111465|reactome:R-CEL-198323|reactome:R-CEL-264870|reactome:R-CEL-448706|dip:DIP-244N|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0012501"(programmed cell death)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0040028"(regulation of vulval development)|go:"GO:0040034"(regulation of development, heterochronic)|go:"GO:0042659"(regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0098793"(presynapse)|go:"GO:1901046"(positive regulation of oviposition)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1904747"(positive regulation of apoptotic process involved in development)|go:"GO:1905803"(negative regulation of cellular response to manganese ion)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905845"(positive regulation of cellular response to gamma radiation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:4M9R|rcsb pdb:4M9S|rcsb pdb:4M9X|rcsb pdb:4M9Y|rcsb pdb:4M9Z|ensemblmetazoa:C48D1.2a.1(transcript)|ensemblmetazoa:WBGene00000417(gene)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008303"(caspase complex)|reactome:R-CEL-140342|reactome:R-CEL-351906|reactome:R-CEL-418889|mint:MINT-592493(identity)	wormbase:Y106G6E.5a|ensemblmetazoa:Y106G6E.5a.1(transcript)|ensemblmetazoa:Y106G6E.5a.2(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|ensemblmetazoa:WBGene00000426(gene)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0035262"(gonad morphogenesis)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0060097"(cytoskeletal rearrangement involved in phagocytosis, engulfment)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070986"(left/right axis specification)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1902742"(apoptotic process involved in development)|go:"GO:1903356"(positive regulation of distal tip cell migration)|reactome:R-CEL-8849471|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR006816(Engulfment and cell motility, ELM)|refseq:NP_492693.1|mint:MINT-592487(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/06/27	2014/10/16	rogid:HFfz1WjirXjAkC5PNlCcB2NqcKE6239	rogid:aIsYGCpsZ5EuKPyLamW1iL1CPps6239	intact-crc:0C344414562AEBD1|rigid:WYvLB4PX+18QrmxNwlapn53iQyo	false	tag:?-?(MINT-592494)	tag:?-?(MINT-592488)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q14185	uniprotkb:Q8BPU7	intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333	intact:EBI-644143|uniprotkb:Q8BSY9|uniprotkb:Q8K2C5|uniprotkb:Q91ZU3|ensembl:ENSMUSP00000072334	psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short)	psi-mi:elmo1_mouse(display_long)|uniprotkb:Protein ced-12 homolog(gene name synonym)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Gumienny et al. (2001)	pubmed:11595183|mint:MINT-5214674	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8001741|mint:MINT-16390	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1|mint:MINT-592506(identity)	refseq:NP_525027.1|refseq:XP_006516610.1|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030029"(actin filament-based process)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0048870"(cell motility)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030715|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-8849471|refseq:NP_932761.1|dip:DIP-41244N|mint:MINT-592503(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/06/27	2014/10/16	rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	intact-crc:FA263CE05272DAE9|rigid:Oyj66cnoOLi1fWDCWOYLzDJQ7tU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)