#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q07157 uniprotkb:P28229 intact:EBI-79553|uniprotkb:B4E3K1|ensembl:ENSP00000281537|ensembl:ENSP00000484535|uniprotkb:Q2NKP3|uniprotkb:Q4ZGJ6 intact:EBI-1767271|ensembl:ENSMUSP00000066901|ensembl:ENSMUSP00000090228|ensembl:ENSMUSP00000102690 psi-mi:zo1_human(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym) psi-mi:cxg1_mouse(display_long)|uniprotkb:Gjc1(gene name)|psi-mi:Gjc1(display_short)|uniprotkb:Cxn-45(gene name synonym)|uniprotkb:Gja7(gene name synonym)|uniprotkb:Gap junction alpha-7 protein(gene name synonym)|uniprotkb:Connexin-45(gene name synonym) psi-mi:"MI:0018"(two hybrid) Kausalya et al. (2001) pubmed:11557048|mint:MINT-5214541 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7973911|mint:MINT-16821 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000104067(gene)|ensembl:ENSG00000277401(gene)|ensembl:ENST00000346128(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENST00000621049(transcript)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000250"(negative regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|interpro:IPR035597|interpro:IPR036034|mint:Q07157|rcsb pdb:2H2B|rcsb pdb:2H2C|rcsb pdb:2H3M|rcsb pdb:2JWE|rcsb pdb:2KXR|rcsb pdb:2KXS|rcsb pdb:2RCZ|rcsb pdb:3CYY|rcsb pdb:3LH5|rcsb pdb:3SHU|rcsb pdb:3SHW|rcsb pdb:3TSV|rcsb pdb:3TSW|rcsb pdb:3TSZ|rcsb pdb:4OEO|rcsb pdb:4OEP|rcsb pdb:4Q2Q|rcsb pdb:4YYX|reactome:R-HSA-191650|reactome:R-HSA-2028269|reactome:R-HSA-351906|reactome:R-HSA-8935964|refseq:NP_003248.3|refseq:NP_783297.2|mint:MINT-586924(identity) refseq:XP_011247038.1|refseq:NP_001152854.1|refseq:NP_001152855.1|refseq:NP_032148.1|refseq:XP_006532289.1|refseq:XP_006532290.1|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016264"(gap junction assembly)|go:"GO:0045202"(synapse)|go:"GO:0048468"(cell development)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0086053"(AV node cell to bundle of His cell communication by electrical coupling)|go:"GO:0086077"(gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling)|interpro:IPR000500(Connexins)|interpro:IPR002265("Gap junction alpha-6 protein (Cx45)")|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR017990|interpro:IPR019570|interpro:IPR038359|reactome:R-MMU-112303|reactome:R-MMU-190861|ensembl:ENSMUSG00000034520(gene)|ensembl:ENSMUST00000068933(transcript)|ensembl:ENSMUST00000092567(transcript)|ensembl:ENSMUST00000107075(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005216"(ion channel activity)|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005921"(gap junction)|go:"GO:0005922"(connexin complex)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007268"(chemical synaptic transmission)|mint:MINT-586933(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2002/02/19 2014/10/16 rogid:/Yi7U3TcH6kPu4A/bQ5Nj0QeU2w9606 rogid:Nhhg8t9MCvbOYs/G8HU7FqLNrK010090 intact-crc:36B8B71A905C2155|rigid:0mz/eyq99OMzT8d1BXZ5UtAdr1E false binding-associated region:1-507(MINT-586925)|tag:?-?(MINT-586928) tag:?-?(MINT-586937)|binding-associated region:391-396(MINT-586934) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P28229 uniprotkb:O62683 intact:EBI-1767271|ensembl:ENSMUSP00000066901|ensembl:ENSMUSP00000090228|ensembl:ENSMUSP00000102690 intact:EBI-9316352 psi-mi:cxg1_mouse(display_long)|uniprotkb:Gjc1(gene name)|psi-mi:Gjc1(display_short)|uniprotkb:Cxn-45(gene name synonym)|uniprotkb:Gja7(gene name synonym)|uniprotkb:Gap junction alpha-7 protein(gene name synonym)|uniprotkb:Connexin-45(gene name synonym) psi-mi:zo3_canlf(display_long)|uniprotkb:TJP3(gene name)|psi-mi:TJP3(display_short)|uniprotkb:ZO3(gene name synonym)|uniprotkb:Tight junction protein 3(gene name synonym)|uniprotkb:Zona occludens protein 3(gene name synonym)|uniprotkb:Zonula occludens protein 3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Kausalya et al. (2001) pubmed:11557048|mint:MINT-5214541 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7973938|mint:MINT-14406 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011247038.1|refseq:NP_001152854.1|refseq:NP_001152855.1|refseq:NP_032148.1|refseq:XP_006532289.1|refseq:XP_006532290.1|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016264"(gap junction assembly)|go:"GO:0045202"(synapse)|go:"GO:0048468"(cell development)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0086053"(AV node cell to bundle of His cell communication by electrical coupling)|go:"GO:0086077"(gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling)|interpro:IPR000500(Connexins)|interpro:IPR002265("Gap junction alpha-6 protein (Cx45)")|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR017990|interpro:IPR019570|interpro:IPR038359|reactome:R-MMU-112303|reactome:R-MMU-190861|ensembl:ENSMUSG00000034520(gene)|ensembl:ENSMUST00000068933(transcript)|ensembl:ENSMUST00000092567(transcript)|ensembl:ENSMUST00000107075(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005216"(ion channel activity)|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005921"(gap junction)|go:"GO:0005922"(connexin complex)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007268"(chemical synaptic transmission)|mint:MINT-586980(identity) refseq:NP_001003202.1|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR008144(Guanylate kinase)|interpro:IPR027417|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001452(Src homology-3)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005420(Zona occludens protein ZO-3)|interpro:IPR036028|interpro:IPR036034|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0009986"(cell surface)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070160"(tight junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:0098609"(cell-cell adhesion)|mint:MINT-586989(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" - taxid:-4(in vivo)|taxid:-4(in vivo) - 2002/02/19 2014/10/16 rogid:Nhhg8t9MCvbOYs/G8HU7FqLNrK010090 rogid:D2nB/ViSvbeASWtqv/VMIxD5yMk9615 intact-crc:86483AD90DAAAEED|rigid:FRhZ6jXG3DfclDygG5Q9wn6UoAU false tag:?-?(MINT-586984)|binding-associated region:391-396(MINT-586981) binding-associated region:1-467(MINT-586990)|tag:?-?(MINT-586993) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P28229 uniprotkb:Q07157 intact:EBI-1767271|ensembl:ENSMUSP00000066901|ensembl:ENSMUSP00000090228|ensembl:ENSMUSP00000102690 intact:EBI-79553|uniprotkb:B4E3K1|ensembl:ENSP00000281537|ensembl:ENSP00000484535|uniprotkb:Q2NKP3|uniprotkb:Q4ZGJ6 psi-mi:cxg1_mouse(display_long)|uniprotkb:Gjc1(gene name)|psi-mi:Gjc1(display_short)|uniprotkb:Cxn-45(gene name synonym)|uniprotkb:Gja7(gene name synonym)|uniprotkb:Gap junction alpha-7 protein(gene name synonym)|uniprotkb:Connexin-45(gene name synonym) psi-mi:zo1_human(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kausalya et al. (2001) pubmed:11557048|mint:MINT-5214541 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7973990|mint:MINT-16822 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011247038.1|refseq:NP_001152854.1|refseq:NP_001152855.1|refseq:NP_032148.1|refseq:XP_006532289.1|refseq:XP_006532290.1|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016264"(gap junction assembly)|go:"GO:0045202"(synapse)|go:"GO:0048468"(cell development)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0086053"(AV node cell to bundle of His cell communication by electrical coupling)|go:"GO:0086077"(gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling)|interpro:IPR000500(Connexins)|interpro:IPR002265("Gap junction alpha-6 protein (Cx45)")|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR017990|interpro:IPR019570|interpro:IPR038359|reactome:R-MMU-112303|reactome:R-MMU-190861|ensembl:ENSMUSG00000034520(gene)|ensembl:ENSMUST00000068933(transcript)|ensembl:ENSMUST00000092567(transcript)|ensembl:ENSMUST00000107075(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005216"(ion channel activity)|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005921"(gap junction)|go:"GO:0005922"(connexin complex)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007268"(chemical synaptic transmission)|mint:MINT-586952(identity) ensembl:ENSG00000104067(gene)|ensembl:ENSG00000277401(gene)|ensembl:ENST00000346128(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENST00000621049(transcript)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000250"(negative regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|interpro:IPR035597|interpro:IPR036034|mint:Q07157|rcsb pdb:2H2B|rcsb pdb:2H2C|rcsb pdb:2H3M|rcsb pdb:2JWE|rcsb pdb:2KXR|rcsb pdb:2KXS|rcsb pdb:2RCZ|rcsb pdb:3CYY|rcsb pdb:3LH5|rcsb pdb:3SHU|rcsb pdb:3SHW|rcsb pdb:3TSV|rcsb pdb:3TSW|rcsb pdb:3TSZ|rcsb pdb:4OEO|rcsb pdb:4OEP|rcsb pdb:4Q2Q|rcsb pdb:4YYX|reactome:R-HSA-191650|reactome:R-HSA-2028269|reactome:R-HSA-351906|reactome:R-HSA-8935964|refseq:NP_003248.3|refseq:NP_783297.2|mint:MINT-586946(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2002/02/19 2014/10/16 rogid:Nhhg8t9MCvbOYs/G8HU7FqLNrK010090 rogid:/Yi7U3TcH6kPu4A/bQ5Nj0QeU2w9606 intact-crc:AA3E08F8A27391A3|rigid:0mz/eyq99OMzT8d1BXZ5UtAdr1E false binding-associated region:391-396(MINT-586953) binding-associated region:1-507(MINT-586947) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28229 uniprotkb:Q07157 intact:EBI-1767271|ensembl:ENSMUSP00000066901|ensembl:ENSMUSP00000090228|ensembl:ENSMUSP00000102690 intact:EBI-79553|uniprotkb:B4E3K1|ensembl:ENSP00000281537|ensembl:ENSP00000484535|uniprotkb:Q2NKP3|uniprotkb:Q4ZGJ6 psi-mi:cxg1_mouse(display_long)|uniprotkb:Gjc1(gene name)|psi-mi:Gjc1(display_short)|uniprotkb:Cxn-45(gene name synonym)|uniprotkb:Gja7(gene name synonym)|uniprotkb:Gap junction alpha-7 protein(gene name synonym)|uniprotkb:Connexin-45(gene name synonym) psi-mi:zo1_human(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Kausalya et al. (2001) pubmed:11557048|mint:MINT-5214541 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-7974019|mint:MINT-16823 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011247038.1|refseq:NP_001152854.1|refseq:NP_001152855.1|refseq:NP_032148.1|refseq:XP_006532289.1|refseq:XP_006532290.1|go:"GO:0007507"(heart development)|go:"GO:0007601"(visual perception)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016264"(gap junction assembly)|go:"GO:0045202"(synapse)|go:"GO:0048468"(cell development)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0086053"(AV node cell to bundle of His cell communication by electrical coupling)|go:"GO:0086077"(gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling)|interpro:IPR000500(Connexins)|interpro:IPR002265("Gap junction alpha-6 protein (Cx45)")|interpro:IPR013092(Connexin, N-terminal)|interpro:IPR017990|interpro:IPR019570|interpro:IPR038359|reactome:R-MMU-112303|reactome:R-MMU-190861|ensembl:ENSMUSG00000034520(gene)|ensembl:ENSMUST00000068933(transcript)|ensembl:ENSMUST00000092567(transcript)|ensembl:ENSMUST00000107075(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005216"(ion channel activity)|go:"GO:0005243"(gap junction channel activity)|go:"GO:0005921"(gap junction)|go:"GO:0005922"(connexin complex)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007268"(chemical synaptic transmission)|mint:MINT-586970(identity) ensembl:ENSG00000104067(gene)|ensembl:ENSG00000277401(gene)|ensembl:ENST00000346128(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENST00000621049(transcript)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000250"(negative regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|interpro:IPR035597|interpro:IPR036034|mint:Q07157|rcsb pdb:2H2B|rcsb pdb:2H2C|rcsb pdb:2H3M|rcsb pdb:2JWE|rcsb pdb:2KXR|rcsb pdb:2KXS|rcsb pdb:2RCZ|rcsb pdb:3CYY|rcsb pdb:3LH5|rcsb pdb:3SHU|rcsb pdb:3SHW|rcsb pdb:3TSV|rcsb pdb:3TSW|rcsb pdb:3TSZ|rcsb pdb:4OEO|rcsb pdb:4OEP|rcsb pdb:4Q2Q|rcsb pdb:4YYX|reactome:R-HSA-191650|reactome:R-HSA-2028269|reactome:R-HSA-351906|reactome:R-HSA-8935964|refseq:NP_003248.3|refseq:NP_783297.2|mint:MINT-586962(identity) go:"GO:0005923"(bicellular tight junction) comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3|comment:homomint|comment:mint taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells") - 2002/02/19 2014/10/16 rogid:Nhhg8t9MCvbOYs/G8HU7FqLNrK010090 rogid:/Yi7U3TcH6kPu4A/bQ5Nj0QeU2w9606 intact-crc:F690ABA4366FCB70|rigid:0mz/eyq99OMzT8d1BXZ5UtAdr1E false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)