#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08887	uniprotkb:P23458	intact:EBI-299383|ensembl:ENSP00000357470|uniprotkb:Q16202|uniprotkb:Q53EQ7|uniprotkb:Q5FWG2|uniprotkb:Q5VZ23|uniprotkb:B2R6V4|uniprotkb:A8KAE8	intact:EBI-1383438|uniprotkb:Q59GQ2|uniprotkb:Q9UD26|ensembl:ENSP00000343204|ensembl:ENSP00000499884|ensembl:ENSP00000499900|ensembl:ENSP00000500296|ensembl:ENSP00000500485|ensembl:ENSP00000500841	psi-mi:il6ra_human(display_long)|uniprotkb:IL6R(gene name)|psi-mi:IL6R(display_short)|uniprotkb:IL-6R 1(gene name synonym)|uniprotkb:Membrane glycoprotein 80(gene name synonym)	psi-mi:jak1_human(display_long)|uniprotkb:JAK1(gene name)|psi-mi:JAK1(display_short)|uniprotkb:JAK1A(gene name synonym)|uniprotkb:JAK1B(gene name synonym)|uniprotkb:Janus kinase 1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Hilkens et al. (2001)	pubmed:11557047|mint:MINT-5214538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7972948|mint:MINT-15143	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004915"(interleukin-6 receptor activity)|go:"GO:0004921"(interleukin-11 receptor activity)|ensembl:ENSG00000160712(gene)|ensembl:ENST00000368485(transcript)|go:"GO:0002384"(hepatic immune response)|go:"GO:0002446"(neutrophil mediated immunity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0005886"(plasma membrane)|go:"GO:0005896"(interleukin-6 receptor complex)|go:"GO:0006953"(acute-phase response)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0019970"(interleukin-11 binding)|go:"GO:0019981"(interleukin-6 binding)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0034097"(response to cytokine)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070110"(ciliary neurotrophic factor receptor complex)|go:"GO:0070119"(ciliary neurotrophic factor binding)|go:"GO:0070120"(ciliary neurotrophic factor-mediated signaling pathway)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901731"(positive regulation of platelet aggregation)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1N26|rcsb pdb:1N2Q|rcsb pdb:1P9M|rcsb pdb:2ARW|rcsb pdb:5FUC|rcsb pdb:7DC8|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-6785807|reactome:R-HSA-9616222|reactome:R-HSA-9679191|refseq:NP_000556.1|refseq:NP_001193795.1|refseq:NP_852004.1|dip:DIP-162N|mint:MINT-586917(identity)	refseq:NP_001308785.1|refseq:NP_002218.2|refseq:NP_001307852.1|refseq:NP_001308781.1|refseq:NP_001308782.1|refseq:NP_001308783.1|refseq:NP_001308784.1|dip:DIP-133N|reactome:R-HSA-912526|reactome:R-HSA-912694|reactome:R-HSA-9674555|reactome:R-HSA-9679191|reactome:R-HSA-9705462|reactome:R-HSA-909733|ensembl:ENSG00000162434(gene)|ensembl:ENST00000342505(transcript)|ensembl:ENST00000671929(transcript)|ensembl:ENST00000671954(transcript)|ensembl:ENST00000672179(transcript)|ensembl:ENST00000672247(transcript)|ensembl:ENST00000672434(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0016020"(membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR020776|interpro:IPR035963|interpro:IPR036860|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:P23458|rcsb pdb:3EYG|rcsb pdb:3EYH|rcsb pdb:4E4L|rcsb pdb:4E4N|rcsb pdb:4E5W|rcsb pdb:4EHZ|rcsb pdb:4EI4|rcsb pdb:4FK6|rcsb pdb:4GS0|rcsb pdb:4I5C|rcsb pdb:4IVB|rcsb pdb:4IVC|rcsb pdb:4IVD|rcsb pdb:4K6Z|rcsb pdb:4K77|rcsb pdb:4L00|rcsb pdb:4L01|rcsb pdb:5E1E|rcsb pdb:5HX8|rcsb pdb:5IXD|rcsb pdb:5IXI|rcsb pdb:5KHW|rcsb pdb:5KHX|rcsb pdb:5L04|rcsb pdb:5WO4|rcsb pdb:6AAH|rcsb pdb:6BBU|rcsb pdb:6C7Y|rcsb pdb:6DBN|rcsb pdb:6ELR|rcsb pdb:6GGH|rcsb pdb:6HZU|rcsb pdb:6N77|rcsb pdb:6N78|rcsb pdb:6N79|rcsb pdb:6N7A|rcsb pdb:6N7B|rcsb pdb:6N7C|rcsb pdb:6N7D|rcsb pdb:6RSB|rcsb pdb:6RSC|rcsb pdb:6RSD|rcsb pdb:6RSE|rcsb pdb:6RSH|rcsb pdb:6SM8|rcsb pdb:6SMB|rcsb pdb:6TPE|rcsb pdb:6TPF|rcsb pdb:6W8L|reactome:R-HSA-1059683|reactome:R-HSA-110056|reactome:R-HSA-112411|reactome:R-HSA-1169408|reactome:R-HSA-1266695|reactome:R-HSA-449836|reactome:R-HSA-5673001|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-6788467|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9020558|reactome:R-HSA-9020591|reactome:R-HSA-9020956|reactome:R-HSA-9020958|mint:MINT-586911(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/02/20	2014/10/16	rogid:qV0FIgWdLU9dOASd1U1jOhFFdt09606	rogid:gEEiBAxwXnGGFWwO7OC0l0KjmSY9606	intact-crc:DA44512ED71DBD2A|rigid:pwILWHZ1K49Dhnh9fwAidliJCJc	false	-	binding-associated region:13-427(MINT-586912)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)