#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q27974	uniprotkb:P17427	intact:EBI-7907964|intact:MINT-205318	intact:EBI-775215|uniprotkb:Q8C2J5|uniprotkb:Q921V0|ensembl:ENSMUSP00000003038	psi-mi:auxi_bovin(display_long)|uniprotkb:DNAJC6(gene name)|psi-mi:DNAJC6(display_short)|uniprotkb:DnaJ homolog subfamily C member 6(gene name synonym)	psi-mi:ap2a2_mouse(display_long)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-2(gene name synonym)|uniprotkb:Alpha2-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit(gene name synonym)|uniprotkb:Alpha-adaptin C(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-C large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein C(gene name synonym)|uniprotkb:Ap2a2(gene name)|psi-mi:Ap2a2(display_short)|uniprotkb:Adtab(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Scheele et al. (2001)	pubmed:11470803|mint:MINT-5214308	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7907961|mint:MINT-14480	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777261.1|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098793"(presynapse)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|interpro:IPR036869|rcsb pdb:1N4C|rcsb pdb:1NZ6|rcsb pdb:1Q2G|rcsb pdb:1XI5|rcsb pdb:2QWN|rcsb pdb:2QWO|rcsb pdb:2QWP|dip:DIP-41952N|rcsb pdb:2QWQ|rcsb pdb:2QWR|rcsb pdb:3N0A|mint:MINT-581340(identity)	refseq:NP_031485.3|dip:DIP-32160N|ensembl:ENSMUSG00000002957(gene)|ensembl:ENSMUST00000003038(transcript)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030141"(secretory granule)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:P17427|rcsb pdb:1B9K|rcsb pdb:1KY6|rcsb pdb:1KY7|rcsb pdb:1KYD|rcsb pdb:1KYF|rcsb pdb:1KYU|rcsb pdb:1QTP|rcsb pdb:1QTS|rcsb pdb:1W80|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VJ0|rcsb pdb:3HS8|rcsb pdb:6OWO|rcsb pdb:6OXL|reactome:R-MMU-177504|reactome:R-MMU-2132295|reactome:R-MMU-416993|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-6798695|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038|mint:MINT-581346(identity)	-	comment:mint|function:Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2002/05/17	2014/10/16	rogid:ObVLLpyKilAqkbc65KHhXAwy3y49913	rogid:KlOjm5d8qxxQkcuD2Hukoj8DLss10090	intact-crc:96B8D0DA0CDE73F8|rigid:Bq+3eHrWVOs706MdSIctjxJyvEU	false	binding-associated region:547-901(MINT-581341)	binding-associated region:701-938(MINT-581347)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q27974	uniprotkb:P49951	intact:EBI-7907964|intact:MINT-205318	intact:EBI-448355|ensembl:ENSBTAP00000060092	psi-mi:auxi_bovin(display_long)|uniprotkb:DNAJC6(gene name)|psi-mi:DNAJC6(display_short)|uniprotkb:DnaJ homolog subfamily C member 6(gene name synonym)	psi-mi:clh1_bovin(display_long)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)	psi-mi:"MI:0096"(pull down)	Scheele et al. (2001)	pubmed:11470803|mint:MINT-5214308	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7908053|mint:MINT-15715	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_777261.1|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098793"(presynapse)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|interpro:IPR036869|rcsb pdb:1N4C|rcsb pdb:1NZ6|rcsb pdb:1Q2G|rcsb pdb:1XI5|rcsb pdb:2QWN|rcsb pdb:2QWO|rcsb pdb:2QWP|dip:DIP-41952N|rcsb pdb:2QWQ|rcsb pdb:2QWR|rcsb pdb:3N0A|mint:MINT-581354(identity)	refseq:NP_776448.1|dip:DIP-31603N|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:P49951|rcsb pdb:1B89|rcsb pdb:1UTC|rcsb pdb:1XI4|rcsb pdb:1XI5|rcsb pdb:3GC3|rcsb pdb:3GD1|rcsb pdb:3IYV|rcsb pdb:3LVH|rcsb pdb:3QIL|rcsb pdb:5M5R|rcsb pdb:5M5S|rcsb pdb:5M5T|rcsb pdb:5M5U|rcsb pdb:5M5V|rcsb pdb:5M61|rcsb pdb:6WCJ|rcsb pdb:3LVG|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|ensembl:ENSBTAG00000016708(gene)|ensembl:ENSBTAT00000077192(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|mint:MINT-581360(identity)	-	comment:mint|function:Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2002/05/17	2014/10/16	rogid:ObVLLpyKilAqkbc65KHhXAwy3y49913	rogid:wpLSa4t2I+sHqUBOftWeW3eCayU9913	intact-crc:405B942E44E33A59|rigid:gBir+ouu1i1mERvxw51rvAC48pc	false	binding-associated region:547-910(MINT-581355)	binding-associated region:1-579(MINT-581361)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)