#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32577	uniprotkb:Q61152	intact:EBI-7482976|intact:MINT-1535121|uniprotkb:Q4G003|ensembl:ENSRNOP00000026358|ensembl:ENSRNOP00000068638	intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3	psi-mi:csk_rat(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)	psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wang et al. (2001)	pubmed:11158295|mint:MINT-5213454|doi:10.1128/MCB.21.4.1077-1088.2001	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7483040|mint:MINT-8311284	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001025210.1|rgd:1308800|refseq:XP_006243225.1|refseq:XP_006243226.1|ensembl:ENSRNOG00000019374(gene)|ensembl:ENSRNOT00000026358(transcript)|ensembl:ENSRNOT00000091223(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1K9A|rcsb pdb:2RSY|reactome:R-RNO-180292|reactome:R-RNO-202427|reactome:R-RNO-354192|reactome:R-RNO-389948|reactome:R-RNO-5674135|reactome:R-RNO-9013407|reactome:R-RNO-9706369|mint:MINT-8311290(identity)|uniprotkb:P32577(original identifier)	ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311285(identity)|uniprotkb:Q61152(original identifier)	-	function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases|comment:mint|comment:homomint	comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells	figure legend:F3B F3C|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2002/04/17	2014/10/16	rogid:q6Bbf/thuK3VxDXvpKdgO/8yGEA10116	rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090	intact-crc:EAF63359A73EB895|rigid:bpkdE0p1wUOMRs9p7PlLD044QgY	false	glutathione s tranferase tag:?-?(MINT-8311293)	trapping mutant:229-229(MINT-8311288)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61152	uniprotkb:P32577	intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3	intact:EBI-7482976|intact:MINT-1535121|uniprotkb:Q4G003|ensembl:ENSRNOP00000026358|ensembl:ENSRNOP00000068638	psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym)	psi-mi:csk_rat(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wang et al. (2001)	pubmed:11158295|mint:MINT-5213454|doi:10.1128/MCB.21.4.1077-1088.2001	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7483024|mint:MINT-8311272	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311276(identity)|uniprotkb:Q61152(original identifier)	refseq:NP_001025210.1|rgd:1308800|refseq:XP_006243225.1|refseq:XP_006243226.1|ensembl:ENSRNOG00000019374(gene)|ensembl:ENSRNOT00000026358(transcript)|ensembl:ENSRNOT00000091223(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1K9A|rcsb pdb:2RSY|reactome:R-RNO-180292|reactome:R-RNO-202427|reactome:R-RNO-354192|reactome:R-RNO-389948|reactome:R-RNO-5674135|reactome:R-RNO-9013407|reactome:R-RNO-9706369	-	comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells	function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases|comment:mint|comment:homomint	figure legend:F1A|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:4932(baker's yeast-l40)|taxid:4932(Saccharomyces cerevisiae)	-	2002/04/17	2014/10/16	rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090	rogid:q6Bbf/thuK3VxDXvpKdgO/8yGEA10116	intact-crc:CF78F459AD3D5474|rigid:bpkdE0p1wUOMRs9p7PlLD044QgY	false	binding-associated region:343-429(MINT-8311279)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61152	uniprotkb:P32577	intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3	intact:EBI-7482976|intact:MINT-1535121|uniprotkb:Q4G003|ensembl:ENSRNOP00000026358|ensembl:ENSRNOP00000068638	psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym)	psi-mi:csk_rat(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2001)	pubmed:11158295|mint:MINT-5213454|doi:10.1128/MCB.21.4.1077-1088.2001	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7483071|mint:MINT-8311931	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311932(identity)|uniprotkb:Q61152(original identifier)	refseq:NP_001025210.1|rgd:1308800|refseq:XP_006243225.1|refseq:XP_006243226.1|ensembl:ENSRNOG00000019374(gene)|ensembl:ENSRNOT00000026358(transcript)|ensembl:ENSRNOT00000091223(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1K9A|rcsb pdb:2RSY|reactome:R-RNO-180292|reactome:R-RNO-202427|reactome:R-RNO-354192|reactome:R-RNO-389948|reactome:R-RNO-5674135|reactome:R-RNO-9013407|reactome:R-RNO-9706369|mint:MINT-8311937(identity)|uniprotkb:P32577(original identifier)	-	comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells	function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases|comment:mint|comment:homomint	figure legend:F2 F3A|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2002/04/17	2014/10/16	rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090	rogid:q6Bbf/thuK3VxDXvpKdgO/8yGEA10116	intact-crc:14E3DB7C0BF3D2B2|rigid:bpkdE0p1wUOMRs9p7PlLD044QgY	false	trapping mutant:229-229(MINT-8311935)	binding-associated region:82-171(MINT-8311940)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32577	uniprotkb:Q61152	intact:EBI-7482976|intact:MINT-1535121|uniprotkb:Q4G003|ensembl:ENSRNOP00000026358|ensembl:ENSRNOP00000068638	intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3	psi-mi:csk_rat(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)	psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2001)	pubmed:11158295|mint:MINT-5213454|doi:10.1128/MCB.21.4.1077-1088.2001	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7483131|mint:MINT-8311955	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001025210.1|rgd:1308800|refseq:XP_006243225.1|refseq:XP_006243226.1|ensembl:ENSRNOG00000019374(gene)|ensembl:ENSRNOT00000026358(transcript)|ensembl:ENSRNOT00000091223(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1K9A|rcsb pdb:2RSY|reactome:R-RNO-180292|reactome:R-RNO-202427|reactome:R-RNO-354192|reactome:R-RNO-389948|reactome:R-RNO-5674135|reactome:R-RNO-9013407|reactome:R-RNO-9706369|mint:MINT-8311965(identity)|uniprotkb:P32577(original identifier)	ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311956(identity)|uniprotkb:Q61152(original identifier)	-	function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases|comment:mint|comment:homomint	comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells	figure legend:F4|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2002/04/17	2014/10/16	rogid:q6Bbf/thuK3VxDXvpKdgO/8yGEA10116	rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090	intact-crc:54CB20D203F36C44|rigid:bpkdE0p1wUOMRs9p7PlLD044QgY	false	-	binding-associated region:375-387(MINT-8311959)|trapping mutant:229-229(MINT-8311961)|phosphorylated residue:381-381(MINT-8311963)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32577	uniprotkb:Q61152	intact:EBI-7482976|intact:MINT-1535121|uniprotkb:Q4G003|ensembl:ENSRNOP00000026358|ensembl:ENSRNOP00000068638	intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3	psi-mi:csk_rat(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)	psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2001)	pubmed:11158295|mint:MINT-5213454|doi:10.1128/MCB.21.4.1077-1088.2001	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7483091|mint:MINT-8311942	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001025210.1|rgd:1308800|refseq:XP_006243225.1|refseq:XP_006243226.1|ensembl:ENSRNOG00000019374(gene)|ensembl:ENSRNOT00000026358(transcript)|ensembl:ENSRNOT00000091223(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1K9A|rcsb pdb:2RSY|reactome:R-RNO-180292|reactome:R-RNO-202427|reactome:R-RNO-354192|reactome:R-RNO-389948|reactome:R-RNO-5674135|reactome:R-RNO-9013407|reactome:R-RNO-9706369|mint:MINT-8311952(identity)|uniprotkb:P32577(original identifier)	ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311943(identity)|uniprotkb:Q61152(original identifier)	-	function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases|comment:mint|comment:homomint	comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells	figure legend:F4|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2002/04/17	2014/10/16	rogid:q6Bbf/thuK3VxDXvpKdgO/8yGEA10116	rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090	intact-crc:BF9BCEFBE90AA033|rigid:bpkdE0p1wUOMRs9p7PlLD044QgY	false	-	binding-associated region:348-360(MINT-8311946)|phosphorylated residue:354-354(MINT-8311950)|trapping mutant:229-229(MINT-8311948)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q61152	uniprotkb:P41241	intact:EBI-7074223|ensembl:ENSMUSP00000027302|intact:MINT-157346|uniprotkb:Q62404|uniprotkb:Q4JFH4|uniprotkb:Q922E3	intact:EBI-2553183|uniprotkb:Q80WU4|uniprotkb:Q8VCW1|ensembl:ENSMUSP00000034863|ensembl:ENSMUSP00000150590|ensembl:ENSMUSP00000150984|uniprotkb:Q03143	psi-mi:ptn18_mouse(display_long)|uniprotkb:Ptpn18(gene name)|psi-mi:Ptpn18(display_short)|uniprotkb:Flp1(gene name synonym)|uniprotkb:Ptpk1(gene name synonym)|uniprotkb:Fetal liver phosphatase 1(gene name synonym)|uniprotkb:PTP-K1(gene name synonym)	psi-mi:csk_mouse(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)|uniprotkb:Protein-tyrosine kinase MPK-2(gene name synonym)|uniprotkb:p50CSK(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2001)	pubmed:11158295|mint:MINT-5213454|doi:10.1128/MCB.21.4.1077-1088.2001	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7483208|mint:MINT-8311974	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000026126(gene)|ensembl:ENSMUST00000027302(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|reactome:R-MMU-8863795|refseq:NP_035336.2|mint:MINT-8311975(identity)|uniprotkb:Q61152(original identifier)	refseq:NP_001291690.1|go:"GO:0016740"(transferase activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005911"(cell-cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|ensembl:ENSMUSG00000032312(gene)|ensembl:ENSMUST00000034863(transcript)|ensembl:ENSMUST00000215396(transcript)|ensembl:ENSMUST00000217314(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|go:"GO:0050765"(negative regulation of phagocytosis)|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1JEG|reactome:R-MMU-180292|reactome:R-MMU-202427|reactome:R-MMU-354192|reactome:R-MMU-389948|reactome:R-MMU-5674135|reactome:R-MMU-9013407|reactome:R-MMU-9706369|refseq:NP_031809.2|refseq:XP_006510864.1|refseq:XP_006510865.1	-	comment:mint|comment:homomint|function:May be involved in growth and differentiation of hematopoietic cells	-	figure legend:F6|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:10090(mouse-hemopoietic)|taxid:10090(Mus musculus)	-	2002/04/17	2014/10/16	rogid:wtnT+7m8nDhqxJxpUlMtbUpi8tA10090	rogid:2unY4cD7qXpvYgIJ59ajuZ/FSiQ10090	intact-crc:D41335300B238188|rigid:qdJvQdmWEG/6G7kQQc3OriITj/8	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0396"(predetermined participant)