#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15991	uniprotkb:Q9UER7	intact:EBI-1559114	intact:EBI-77321|ensembl:ENSP00000266000|ensembl:ENSP00000363668|ensembl:ENSP00000372539|ensembl:ENSP00000372681|ensembl:ENSP00000382014|ensembl:ENSP00000382281|ensembl:ENSP00000394108|ensembl:ENSP00000404376|ensembl:ENSP00000404623|ensembl:ENSP00000410772|uniprotkb:O14747|uniprotkb:O15141|uniprotkb:O15208|uniprotkb:Q9BWI3|uniprotkb:B4E1I3|uniprotkb:F5H082|uniprotkb:Q5STK9|uniprotkb:F5ANJ6|uniprotkb:F5ANJ7	psi-mi:hspb1_crilo(display_long)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)	psi-mi:daxx_human(display_long)|uniprotkb:DAXX(gene name)|psi-mi:DAXX(display_short)|uniprotkb:BING2(gene name synonym)|uniprotkb:DAP6(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:Fas death domain-associated protein(gene name synonym)|uniprotkb:ETS1-associated protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Charette et al. (2000)	pubmed:11003656|mint:MINT-5213028	taxid:10030(crilo)|taxid:10030("Cricetulus longicaudatus (Long-tailed hamster)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1559121	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)	ensembl:ENSG00000206206(gene)|ensembl:ENSG00000206279(gene)|ensembl:ENSG00000227046(gene)|ensembl:ENSG00000231617(gene)|ensembl:ENSG00000204209(gene)|ensembl:ENST00000266000(transcript)|ensembl:ENST00000374542(transcript)|ensembl:ENST00000383062(transcript)|ensembl:ENST00000383194(transcript)|ensembl:ENST00000399060(transcript)|ensembl:ENST00000399344(transcript)|ensembl:ENST00000433482(transcript)|ensembl:ENST00000436311(transcript)|ensembl:ENST00000445009(transcript)|ensembl:ENST00000455860(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR005012(Daxx protein)|interpro:IPR031333|interpro:IPR038298|mint:Q9UER7|rcsb pdb:2KQS|rcsb pdb:2KZS|rcsb pdb:2KZU|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:5GRQ|rcsb pdb:5KDM|rcsb pdb:5Y18|rcsb pdb:5Y6O|reactome:R-HSA-3899300|reactome:R-HSA-6804757|reactome:R-HSA-9609690|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_001135441.1|refseq:NP_001341.1|refseq:NP_001241646.1|dip:DIP-27628N	-	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2002/06/28	2014/10/16	rogid:qPoGcopnWUPB8Sy0n/uciWnwGRI10030	rogid:lM3F/1ay7qvt8NkGWvgfSvBX1qQ9606	intact-crc:EAF4E6E4FE281CC7|rigid:br9j/G6rG3xW6DU609kNV5K++Fk	false	-	sufficient binding region:472-740	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04792	uniprotkb:Q9UER7	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	intact:EBI-77321|ensembl:ENSP00000266000|ensembl:ENSP00000363668|ensembl:ENSP00000372539|ensembl:ENSP00000372681|ensembl:ENSP00000382014|ensembl:ENSP00000382281|ensembl:ENSP00000394108|ensembl:ENSP00000404376|ensembl:ENSP00000404623|ensembl:ENSP00000410772|uniprotkb:O14747|uniprotkb:O15141|uniprotkb:O15208|uniprotkb:Q9BWI3|uniprotkb:B4E1I3|uniprotkb:F5H082|uniprotkb:Q5STK9|uniprotkb:F5ANJ6|uniprotkb:F5ANJ7	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:daxx_human(display_long)|uniprotkb:DAXX(gene name)|psi-mi:DAXX(display_short)|uniprotkb:BING2(gene name synonym)|uniprotkb:DAP6(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:Fas death domain-associated protein(gene name synonym)|uniprotkb:ETS1-associated protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Charette et al. (2000)	pubmed:11003656|mint:MINT-5213028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1559137	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	ensembl:ENSG00000206206(gene)|ensembl:ENSG00000206279(gene)|ensembl:ENSG00000227046(gene)|ensembl:ENSG00000231617(gene)|ensembl:ENSG00000204209(gene)|ensembl:ENST00000266000(transcript)|ensembl:ENST00000374542(transcript)|ensembl:ENST00000383062(transcript)|ensembl:ENST00000383194(transcript)|ensembl:ENST00000399060(transcript)|ensembl:ENST00000399344(transcript)|ensembl:ENST00000433482(transcript)|ensembl:ENST00000436311(transcript)|ensembl:ENST00000445009(transcript)|ensembl:ENST00000455860(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR005012(Daxx protein)|interpro:IPR031333|interpro:IPR038298|mint:Q9UER7|rcsb pdb:2KQS|rcsb pdb:2KZS|rcsb pdb:2KZU|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:5GRQ|rcsb pdb:5KDM|rcsb pdb:5Y18|rcsb pdb:5Y6O|reactome:R-HSA-3899300|reactome:R-HSA-6804757|reactome:R-HSA-9609690|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_001135441.1|refseq:NP_001341.1|refseq:NP_001241646.1|dip:DIP-27628N	-	crc64:1B4DC44A6F6606D5	-	figure legend:1 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2002/06/28	2014/10/16	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	rogid:lM3F/1ay7qvt8NkGWvgfSvBX1qQ9606	intact-crc:F4B593C0BAF8CE43|rigid:E+cYkDn9DqRUToZAL4MreUn33Cs	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UER7	uniprotkb:P04792	intact:EBI-77321|ensembl:ENSP00000266000|ensembl:ENSP00000363668|ensembl:ENSP00000372539|ensembl:ENSP00000372681|ensembl:ENSP00000382014|ensembl:ENSP00000382281|ensembl:ENSP00000394108|ensembl:ENSP00000404376|ensembl:ENSP00000404623|ensembl:ENSP00000410772|uniprotkb:O14747|uniprotkb:O15141|uniprotkb:O15208|uniprotkb:Q9BWI3|uniprotkb:B4E1I3|uniprotkb:F5H082|uniprotkb:Q5STK9|uniprotkb:F5ANJ6|uniprotkb:F5ANJ7	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:daxx_human(display_long)|uniprotkb:DAXX(gene name)|psi-mi:DAXX(display_short)|uniprotkb:BING2(gene name synonym)|uniprotkb:DAP6(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:Fas death domain-associated protein(gene name synonym)|uniprotkb:ETS1-associated protein 1(gene name synonym)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Charette et al. (2000)	pubmed:11003656|mint:MINT-5213028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1559144	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000206206(gene)|ensembl:ENSG00000206279(gene)|ensembl:ENSG00000227046(gene)|ensembl:ENSG00000231617(gene)|ensembl:ENSG00000204209(gene)|ensembl:ENST00000266000(transcript)|ensembl:ENST00000374542(transcript)|ensembl:ENST00000383062(transcript)|ensembl:ENST00000383194(transcript)|ensembl:ENST00000399060(transcript)|ensembl:ENST00000399344(transcript)|ensembl:ENST00000433482(transcript)|ensembl:ENST00000436311(transcript)|ensembl:ENST00000445009(transcript)|ensembl:ENST00000455860(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR005012(Daxx protein)|interpro:IPR031333|interpro:IPR038298|mint:Q9UER7|rcsb pdb:2KQS|rcsb pdb:2KZS|rcsb pdb:2KZU|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:5GRQ|rcsb pdb:5KDM|rcsb pdb:5Y18|rcsb pdb:5Y6O|reactome:R-HSA-3899300|reactome:R-HSA-6804757|reactome:R-HSA-9609690|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_001135441.1|refseq:NP_001341.1|refseq:NP_001241646.1|dip:DIP-27628N	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	-	crc64:1B4DC44A6F6606D5	figure legend:1 C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2002/06/28	2014/10/16	rogid:lM3F/1ay7qvt8NkGWvgfSvBX1qQ9606	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	intact-crc:228074D9869286B4|rigid:E+cYkDn9DqRUToZAL4MreUn33Cs	false	glutathione s tranferase tag:?-?|sufficient binding region:472-740	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04792	uniprotkb:P04792	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Charette et al. (2000)	pubmed:11003656|mint:MINT-5213028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1559154	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	crc64:1B4DC44A6F6606D5	crc64:1B4DC44A6F6606D5	figure legend:1  C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2002/06/28	2014/10/16	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	intact-crc:3E24A3CA0C3D02FC|rigid:67eYAIyvIlZ4GbyVG3zP7g3h5UY	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UER7	uniprotkb:P25445	intact:EBI-77321|ensembl:ENSP00000266000|ensembl:ENSP00000363668|ensembl:ENSP00000372539|ensembl:ENSP00000372681|ensembl:ENSP00000382014|ensembl:ENSP00000382281|ensembl:ENSP00000394108|ensembl:ENSP00000404376|ensembl:ENSP00000404623|ensembl:ENSP00000410772|uniprotkb:O14747|uniprotkb:O15141|uniprotkb:O15208|uniprotkb:Q9BWI3|uniprotkb:B4E1I3|uniprotkb:F5H082|uniprotkb:Q5STK9|uniprotkb:F5ANJ6|uniprotkb:F5ANJ7	intact:EBI-494743|uniprotkb:Q14292|uniprotkb:Q14293|uniprotkb:Q14294|uniprotkb:Q14295|uniprotkb:Q16652|uniprotkb:Q6SSE9|uniprotkb:Q5T9P1|uniprotkb:Q5T9P2|uniprotkb:A9UJX4|uniprotkb:B6VNV4|uniprotkb:Q5T9P3|ensembl:ENSP00000498466	psi-mi:daxx_human(display_long)|uniprotkb:DAXX(gene name)|psi-mi:DAXX(display_short)|uniprotkb:BING2(gene name synonym)|uniprotkb:DAP6(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:Fas death domain-associated protein(gene name synonym)|uniprotkb:ETS1-associated protein 1(gene name synonym)	psi-mi:tnr6_human(display_long)|uniprotkb:FASLG receptor(gene name synonym)|uniprotkb:Apoptosis-mediating surface antigen FAS(gene name synonym)|uniprotkb:Apo-1 antigen(gene name synonym)|uniprotkb:FAS(gene name)|psi-mi:FAS(display_short)|uniprotkb:APT1(gene name synonym)|uniprotkb:TNFRSF6(gene name synonym)|uniprotkb:FAS1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Charette et al. (2000)	pubmed:11003656|mint:MINT-5213028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1559162	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000206206(gene)|ensembl:ENSG00000206279(gene)|ensembl:ENSG00000227046(gene)|ensembl:ENSG00000231617(gene)|ensembl:ENSG00000204209(gene)|ensembl:ENST00000266000(transcript)|ensembl:ENST00000374542(transcript)|ensembl:ENST00000383062(transcript)|ensembl:ENST00000383194(transcript)|ensembl:ENST00000399060(transcript)|ensembl:ENST00000399344(transcript)|ensembl:ENST00000433482(transcript)|ensembl:ENST00000436311(transcript)|ensembl:ENST00000445009(transcript)|ensembl:ENST00000455860(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR005012(Daxx protein)|interpro:IPR031333|interpro:IPR038298|mint:Q9UER7|rcsb pdb:2KQS|rcsb pdb:2KZS|rcsb pdb:2KZU|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:5GRQ|rcsb pdb:5KDM|rcsb pdb:5Y18|rcsb pdb:5Y6O|reactome:R-HSA-3899300|reactome:R-HSA-6804757|reactome:R-HSA-9609690|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_001135441.1|refseq:NP_001341.1|refseq:NP_001241646.1|dip:DIP-27628N	refseq:NP_000034.1|refseq:NP_690610.1|refseq:NP_690611.1|refseq:NP_001307548.1|dip:DIP-924N|ensembl:ENSG00000026103(gene)|ensembl:ENST00000652046(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019900"(kinase binding)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0036337"(Fas signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071455"(cellular response to hyperoxia)|go:"GO:0097049"(motor neuron apoptotic process)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR008063(Fas receptor)|interpro:IPR011029(DEATH-like)|interpro:IPR033998|interpro:IPR033999|mint:P25445|rcsb pdb:1BZI|rcsb pdb:1DDF|rcsb pdb:2NA7|rcsb pdb:3EWT|rcsb pdb:3THM|rcsb pdb:3TJE|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-6803211|reactome:R-HSA-69416|reactome:R-HSA-75157|rcsb pdb:3EZQ	-	-	-	figure legend:1 B, 3 A, B|caution:The range for the Death domain of Fas is that given in the UniProtKB entry P25445.|inhibition:"HSP27 - HSP27 inhibits this interaction. HSP27 (ser15ala,ser90ala) had little effect on the interaction, whereas HSP27 (ser15glu,ser90glu) was as effective, if not more effective, in blocking the interaction than wild-type HSP27."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2002/06/28	2014/10/16	rogid:lM3F/1ay7qvt8NkGWvgfSvBX1qQ9606	rogid:Yz5oIuvCmfV62Fpd/XjXGmSDZms9606	intact-crc:145C92F99DDC9C52|rigid:a/sIOzXeGMsvbttnhOROy8T8I4M	false	-	glutathione s tranferase tag:?-?|sufficient binding region:230-314	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04792	uniprotkb:P15991	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	intact:EBI-1559114	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:hspb1_crilo(display_long)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)	psi-mi:"MI:0096"(pull down)	Charette et al. (2000)	pubmed:11003656|mint:MINT-5213028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10030(crilo)|taxid:10030("Cricetulus longicaudatus (Long-tailed hamster)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1559209	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)	-	crc64:1B4DC44A6F6606D5	-	figure legend:2|comment:This indicates the mutant forms of HSP27 are functional.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2002/06/28	2014/10/16	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	rogid:qPoGcopnWUPB8Sy0n/uciWnwGRI10030	intact-crc:41E67D6358F151D1|rigid:hj32YTaudSXtIus5ZMI83jaxvUg	false	glutathione s tranferase tag:?-?	mutation:15-15,90-90|mutation:15-15,90-90	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15991	uniprotkb:Q9UER7	intact:EBI-1559114	intact:EBI-77321|ensembl:ENSP00000266000|ensembl:ENSP00000363668|ensembl:ENSP00000372539|ensembl:ENSP00000372681|ensembl:ENSP00000382014|ensembl:ENSP00000382281|ensembl:ENSP00000394108|ensembl:ENSP00000404376|ensembl:ENSP00000404623|ensembl:ENSP00000410772|uniprotkb:O14747|uniprotkb:O15141|uniprotkb:O15208|uniprotkb:Q9BWI3|uniprotkb:B4E1I3|uniprotkb:F5H082|uniprotkb:Q5STK9|uniprotkb:F5ANJ6|uniprotkb:F5ANJ7	psi-mi:hspb1_crilo(display_long)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)	psi-mi:daxx_human(display_long)|uniprotkb:DAXX(gene name)|psi-mi:DAXX(display_short)|uniprotkb:BING2(gene name synonym)|uniprotkb:DAP6(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:Fas death domain-associated protein(gene name synonym)|uniprotkb:ETS1-associated protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Charette et al. (2000)	pubmed:11003656|mint:MINT-5213028	taxid:10030(crilo)|taxid:10030("Cricetulus longicaudatus (Long-tailed hamster)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1559223	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)	ensembl:ENSG00000206206(gene)|ensembl:ENSG00000206279(gene)|ensembl:ENSG00000227046(gene)|ensembl:ENSG00000231617(gene)|ensembl:ENSG00000204209(gene)|ensembl:ENST00000266000(transcript)|ensembl:ENST00000374542(transcript)|ensembl:ENST00000383062(transcript)|ensembl:ENST00000383194(transcript)|ensembl:ENST00000399060(transcript)|ensembl:ENST00000399344(transcript)|ensembl:ENST00000433482(transcript)|ensembl:ENST00000436311(transcript)|ensembl:ENST00000445009(transcript)|ensembl:ENST00000455860(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR005012(Daxx protein)|interpro:IPR031333|interpro:IPR038298|mint:Q9UER7|rcsb pdb:2KQS|rcsb pdb:2KZS|rcsb pdb:2KZU|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:5GRQ|rcsb pdb:5KDM|rcsb pdb:5Y18|rcsb pdb:5Y6O|reactome:R-HSA-3899300|reactome:R-HSA-6804757|reactome:R-HSA-9609690|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_001135441.1|refseq:NP_001341.1|refseq:NP_001241646.1|dip:DIP-27628N	-	-	-	figure legend:2|comment:"The authors state that HaHSP27 (ser15glu,ser90glu) interacted with the Daxx protein (aa 472-740) much more efficiently than HaHSP27 (ser15ala,ser90ala)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2002/06/28	2014/10/16	rogid:qPoGcopnWUPB8Sy0n/uciWnwGRI10030	rogid:lM3F/1ay7qvt8NkGWvgfSvBX1qQ9606	intact-crc:C753144E85BFC8B1|rigid:br9j/G6rG3xW6DU609kNV5K++Fk	false	-	glutathione s tranferase tag:?-?|sufficient binding region:472-740	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99683	uniprotkb:Q9UER7	intact:EBI-476263|uniprotkb:Q5THN3|uniprotkb:Q99461|uniprotkb:A6NIA0|uniprotkb:B4DGB2|ensembl:ENSP00000351908	intact:EBI-77321|ensembl:ENSP00000266000|ensembl:ENSP00000363668|ensembl:ENSP00000372539|ensembl:ENSP00000372681|ensembl:ENSP00000382014|ensembl:ENSP00000382281|ensembl:ENSP00000394108|ensembl:ENSP00000404376|ensembl:ENSP00000404623|ensembl:ENSP00000410772|uniprotkb:O14747|uniprotkb:O15141|uniprotkb:O15208|uniprotkb:Q9BWI3|uniprotkb:B4E1I3|uniprotkb:F5H082|uniprotkb:Q5STK9|uniprotkb:F5ANJ6|uniprotkb:F5ANJ7	psi-mi:m3k5_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 5(gene name synonym)|uniprotkb:Apoptosis signal-regulating kinase 1(gene name synonym)|uniprotkb:MAP3K5(gene name)|psi-mi:MAP3K5(display_short)|uniprotkb:ASK1(gene name synonym)|uniprotkb:MAPKKK5(gene name synonym)|uniprotkb:MEKK5(gene name synonym)	psi-mi:daxx_human(display_long)|uniprotkb:DAXX(gene name)|psi-mi:DAXX(display_short)|uniprotkb:BING2(gene name synonym)|uniprotkb:DAP6(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:Fas death domain-associated protein(gene name synonym)|uniprotkb:ETS1-associated protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Charette et al. (2000)	pubmed:11003656|mint:MINT-5213028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1559239	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005914.1|dip:DIP-29516N|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|ensembl:ENSG00000197442(gene)|ensembl:ENST00000359015(transcript)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0090398"(cellular senescence)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902911"(protein kinase complex)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR025136|interpro:IPR043969|mint:Q99683|rcsb pdb:2CLQ|rcsb pdb:3VW6|rcsb pdb:4BF2|rcsb pdb:4BHN|rcsb pdb:4BIB|rcsb pdb:4BIC|rcsb pdb:4BID|rcsb pdb:4BIE|rcsb pdb:5ULM|rcsb pdb:5UOR|rcsb pdb:5UOX|rcsb pdb:5UP3|rcsb pdb:5V19|rcsb pdb:5V24|rcsb pdb:5VIL|rcsb pdb:5VIO|rcsb pdb:6E2M|rcsb pdb:6E2N|rcsb pdb:6E2O|rcsb pdb:6EJL|rcsb pdb:6OYT|rcsb pdb:6OYW|rcsb pdb:6VRE|rcsb pdb:6XIH|reactome:R-HSA-2559580	ensembl:ENSG00000206206(gene)|ensembl:ENSG00000206279(gene)|ensembl:ENSG00000227046(gene)|ensembl:ENSG00000231617(gene)|ensembl:ENSG00000204209(gene)|ensembl:ENST00000266000(transcript)|ensembl:ENST00000374542(transcript)|ensembl:ENST00000383062(transcript)|ensembl:ENST00000383194(transcript)|ensembl:ENST00000399060(transcript)|ensembl:ENST00000399344(transcript)|ensembl:ENST00000433482(transcript)|ensembl:ENST00000436311(transcript)|ensembl:ENST00000445009(transcript)|ensembl:ENST00000455860(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR005012(Daxx protein)|interpro:IPR031333|interpro:IPR038298|mint:Q9UER7|rcsb pdb:2KQS|rcsb pdb:2KZS|rcsb pdb:2KZU|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:5GRQ|rcsb pdb:5KDM|rcsb pdb:5Y18|rcsb pdb:5Y6O|reactome:R-HSA-3899300|reactome:R-HSA-6804757|reactome:R-HSA-9609690|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_001135441.1|refseq:NP_001341.1|refseq:NP_001241646.1|dip:DIP-27628N	-	-	-	figure legend:3 C, D|inhibition:"HSP27 - HSP27 inhibits this interaction. HSP27 (ser15ala,ser90ala) had little effect on the interaction, whereas HSP27 (ser15glu,ser90glu) was as effective, if not more effective, in blocking the interaction than wild-type HSP27."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2002/06/28	2014/10/16	rogid:/txMHg7GSCpK8ij48YDHGARX3es9606	rogid:lM3F/1ay7qvt8NkGWvgfSvBX1qQ9606	intact-crc:A17D6A31E326EBA0|rigid:OG1X8f4nBYPQFpw0wPAVMH377X8	false	ha tag:?-?	sufficient binding region:472-740|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UER7	uniprotkb:P04792	intact:EBI-77321|ensembl:ENSP00000266000|ensembl:ENSP00000363668|ensembl:ENSP00000372539|ensembl:ENSP00000372681|ensembl:ENSP00000382014|ensembl:ENSP00000382281|ensembl:ENSP00000394108|ensembl:ENSP00000404376|ensembl:ENSP00000404623|ensembl:ENSP00000410772|uniprotkb:O14747|uniprotkb:O15141|uniprotkb:O15208|uniprotkb:Q9BWI3|uniprotkb:B4E1I3|uniprotkb:F5H082|uniprotkb:Q5STK9|uniprotkb:F5ANJ6|uniprotkb:F5ANJ7	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:daxx_human(display_long)|uniprotkb:DAXX(gene name)|psi-mi:DAXX(display_short)|uniprotkb:BING2(gene name synonym)|uniprotkb:DAP6(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:Fas death domain-associated protein(gene name synonym)|uniprotkb:ETS1-associated protein 1(gene name synonym)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Charette et al. (2000)	pubmed:11003656|mint:MINT-5213028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1559182	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000206206(gene)|ensembl:ENSG00000206279(gene)|ensembl:ENSG00000227046(gene)|ensembl:ENSG00000231617(gene)|ensembl:ENSG00000204209(gene)|ensembl:ENST00000266000(transcript)|ensembl:ENST00000374542(transcript)|ensembl:ENST00000383062(transcript)|ensembl:ENST00000383194(transcript)|ensembl:ENST00000399060(transcript)|ensembl:ENST00000399344(transcript)|ensembl:ENST00000433482(transcript)|ensembl:ENST00000436311(transcript)|ensembl:ENST00000445009(transcript)|ensembl:ENST00000455860(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR005012(Daxx protein)|interpro:IPR031333|interpro:IPR038298|mint:Q9UER7|rcsb pdb:2KQS|rcsb pdb:2KZS|rcsb pdb:2KZU|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:5GRQ|rcsb pdb:5KDM|rcsb pdb:5Y18|rcsb pdb:5Y6O|reactome:R-HSA-3899300|reactome:R-HSA-6804757|reactome:R-HSA-9609690|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_001135441.1|refseq:NP_001341.1|refseq:NP_001241646.1|dip:DIP-27628N	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	-	crc64:1B4DC44A6F6606D5	figure legend:1 D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2002/06/28	2014/10/16	rogid:lM3F/1ay7qvt8NkGWvgfSvBX1qQ9606	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	intact-crc:4601AFE72C3D7E57|rigid:E+cYkDn9DqRUToZAL4MreUn33Cs	false	sufficient binding region:626-740	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UER7	uniprotkb:P15991	intact:EBI-77321|ensembl:ENSP00000266000|ensembl:ENSP00000363668|ensembl:ENSP00000372539|ensembl:ENSP00000372681|ensembl:ENSP00000382014|ensembl:ENSP00000382281|ensembl:ENSP00000394108|ensembl:ENSP00000404376|ensembl:ENSP00000404623|ensembl:ENSP00000410772|uniprotkb:O14747|uniprotkb:O15141|uniprotkb:O15208|uniprotkb:Q9BWI3|uniprotkb:B4E1I3|uniprotkb:F5H082|uniprotkb:Q5STK9|uniprotkb:F5ANJ6|uniprotkb:F5ANJ7	intact:EBI-1559114	psi-mi:daxx_human(display_long)|uniprotkb:DAXX(gene name)|psi-mi:DAXX(display_short)|uniprotkb:BING2(gene name synonym)|uniprotkb:DAP6(gene name synonym)|uniprotkb:Daxx(gene name synonym)|uniprotkb:Fas death domain-associated protein(gene name synonym)|uniprotkb:ETS1-associated protein 1(gene name synonym)	psi-mi:hspb1_crilo(display_long)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Charette et al. (2000)	pubmed:11003656|mint:MINT-5213028	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10030(crilo)|taxid:10030("Cricetulus longicaudatus (Long-tailed hamster)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1559199	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000206206(gene)|ensembl:ENSG00000206279(gene)|ensembl:ENSG00000227046(gene)|ensembl:ENSG00000231617(gene)|ensembl:ENSG00000204209(gene)|ensembl:ENST00000266000(transcript)|ensembl:ENST00000374542(transcript)|ensembl:ENST00000383062(transcript)|ensembl:ENST00000383194(transcript)|ensembl:ENST00000399060(transcript)|ensembl:ENST00000399344(transcript)|ensembl:ENST00000433482(transcript)|ensembl:ENST00000436311(transcript)|ensembl:ENST00000445009(transcript)|ensembl:ENST00000455860(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042393"(histone binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0072738"(cellular response to diamide)|go:"GO:0140037"(sumo-dependent protein binding)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903936"(cellular response to sodium arsenite)|interpro:IPR005012(Daxx protein)|interpro:IPR031333|interpro:IPR038298|mint:Q9UER7|rcsb pdb:2KQS|rcsb pdb:2KZS|rcsb pdb:2KZU|rcsb pdb:4H9N|rcsb pdb:4H9O|rcsb pdb:4H9P|rcsb pdb:4H9Q|rcsb pdb:4H9R|rcsb pdb:4H9S|rcsb pdb:4HGA|rcsb pdb:5GRQ|rcsb pdb:5KDM|rcsb pdb:5Y18|rcsb pdb:5Y6O|reactome:R-HSA-3899300|reactome:R-HSA-6804757|reactome:R-HSA-9609690|reactome:R-HSA-9670095|reactome:R-HSA-9670613|reactome:R-HSA-9670615|refseq:NP_001135441.1|refseq:NP_001341.1|refseq:NP_001241646.1|dip:DIP-27628N	interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)	-	-	-	figure legend:1 E|delivery method:P15991; Q9UER7 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2002/06/28	2014/10/16	rogid:lM3F/1ay7qvt8NkGWvgfSvBX1qQ9606	rogid:qPoGcopnWUPB8Sy0n/uciWnwGRI10030	intact-crc:895CF67C37F90F94|rigid:br9j/G6rG3xW6DU609kNV5K++Fk	false	myc tag:?-?|sufficient binding region:626-740	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)