#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04324	uniprotkb:Q10567	intact:EBI-7819965|intact:MINT-196556	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	psi-mi:nef_hv112(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:Negative factor(gene name synonym)|uniprotkb:3'ORF(gene name synonym)	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Greenberg et al. (1998)	pubmed:9811611|mint:MINT-6548320	taxid:11679(hv112)|taxid:11679("Human immunodeficiency virus type 1 group M subtype B (isolate PCV12)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8654804|mint:MINT-14371	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001558(HIV negative factor Nef)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019058"(viral life cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0045225"(negative regulation of CD4 production)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051117"(ATPase binding)|go:"GO:0052085"(suppression by symbiont of host T-cell mediated immune response)|go:"GO:0075528"(modulation by virus of host immune response)|rcsb pdb:1ZEC|interpro:IPR027480|interpro:IPR027481|rcsb pdb:1QA5|rcsb pdb:1QA4|mint:MINT-1540620(identity)	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N|mint:MINT-1540617(identity)	-	function:"Down-modulates surface MHC-I molecules. Internalized molecules are sequestred to the trans-Golgi network (TGN). Also decreases cell surface CD4 antigen by interacting with the Src family kinase LCK thereby inducing LCK-CD4 dissociation and by increasing clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Peroxisomal acyl-coenzyme A thioester hydrolase 1 (PTE1) seems to be involved in this process. May serve as a direct bridge between CD4 and the cellular endocytic machinery by interacting with beta-COP and adaptins. In consequence, surface MHC-I and CD4 are decreased and infected cells are masked for immune recognition by cytotoxic T lymphocytes. Decreasing the number of viral receptors prevents reinfection by more HIV particles"|comment:mint|function:Early protein that seems to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Enhances virus infectivity and pathogenicity|function:"Bypasses host T-cell signaling by inducing a transcriptional program nearly identical to that of anti-CD3 cell activation. Interacts with the TCR-zeta chain to up-regulate the Fas ligand (FasL). Increasing surface FasL molecules and decreasing surface MHC-I molecules send attacking cytotoxic T-cell into apoptosis"|function:Protects the infected cell from apoptosis in order to keep it alive until the next virus generation is ready to strike. Inhibits the Fas and TNFR-mediated death signals by blocking MAP3K5. Interacts with p53 and decreases the half-life of the latter, protecting the infected cell against p53-mediated apoptosis. Inhibits the apoptotic signals regulated by the Bcl-2 family proteins through the formation of a Nef/PI3-kinase/PAK2 complex that induces phosphorylation of Bad|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2001/06/22	2016/02/11	rogid:MSRHpweWrcm/+g4FYwkdcySK+aU11679	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	intact-crc:D614E8A6E9543894|rigid:/PsLieMReoUYVt+W44BeWqLPq2Y	false	binding-associated region:154-169(MINT-1540621)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04324	uniprotkb:Q10567	intact:EBI-7819965|intact:MINT-196556	intact:EBI-1171303|uniprotkb:P78436|uniprotkb:C9JRD1|uniprotkb:Q20WL3|intact:EBI-11577132|uniprotkb:F8WDL0|uniprotkb:Q86X54|ensembl:ENSP00000319361|ensembl:ENSP00000350199|ensembl:ENSP00000384194|ensembl:ENSP00000400065	psi-mi:nef_hv112(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:Negative factor(gene name synonym)|uniprotkb:3'ORF(gene name synonym)	psi-mi:ap1b1_human(display_long)|uniprotkb:Adaptor protein complex AP-1 subunit beta-1(gene name synonym)|uniprotkb:Beta-adaptin 1(gene name synonym)|uniprotkb:Beta-1-adaptin(gene name synonym)|uniprotkb:Golgi adaptor HA1/AP1 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 beta large chain(gene name synonym)|uniprotkb:AP1B1(gene name)|psi-mi:AP1B1(display_short)|uniprotkb:ADTB1(gene name synonym)|uniprotkb:BAM22(gene name synonym)|uniprotkb:CLAPB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit beta-1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Greenberg et al. (1998)	pubmed:9811611|mint:MINT-6548320	taxid:11679(hv112)|taxid:11679("Human immunodeficiency virus type 1 group M subtype B (isolate PCV12)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8654828|mint:MINT-14372	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001558(HIV negative factor Nef)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019058"(viral life cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0045225"(negative regulation of CD4 production)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051117"(ATPase binding)|go:"GO:0052085"(suppression by symbiont of host T-cell mediated immune response)|go:"GO:0075528"(modulation by virus of host immune response)|rcsb pdb:1ZEC|interpro:IPR027480|interpro:IPR027481|rcsb pdb:1QA5|rcsb pdb:1QA4|mint:MINT-1540634(identity)	refseq:NP_001118.3|refseq:NP_663782.2|refseq:NP_001159491.1|ensembl:ENSG00000100280(gene)|ensembl:ENST00000317368(transcript)|ensembl:ENST00000357586(transcript)|ensembl:ENST00000405198(transcript)|ensembl:ENST00000432560(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007507"(heart development)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000225(Armadillo)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|mint:Q10567|rcsb pdb:4HMY|rcsb pdb:4P6Z|rcsb pdb:6CM9|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|rcsb pdb:6CRI|dip:DIP-24207N|mint:MINT-1540631(identity)	-	function:"Down-modulates surface MHC-I molecules. Internalized molecules are sequestred to the trans-Golgi network (TGN). Also decreases cell surface CD4 antigen by interacting with the Src family kinase LCK thereby inducing LCK-CD4 dissociation and by increasing clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Peroxisomal acyl-coenzyme A thioester hydrolase 1 (PTE1) seems to be involved in this process. May serve as a direct bridge between CD4 and the cellular endocytic machinery by interacting with beta-COP and adaptins. In consequence, surface MHC-I and CD4 are decreased and infected cells are masked for immune recognition by cytotoxic T lymphocytes. Decreasing the number of viral receptors prevents reinfection by more HIV particles"|comment:mint|function:Early protein that seems to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Enhances virus infectivity and pathogenicity|function:"Bypasses host T-cell signaling by inducing a transcriptional program nearly identical to that of anti-CD3 cell activation. Interacts with the TCR-zeta chain to up-regulate the Fas ligand (FasL). Increasing surface FasL molecules and decreasing surface MHC-I molecules send attacking cytotoxic T-cell into apoptosis"|function:Protects the infected cell from apoptosis in order to keep it alive until the next virus generation is ready to strike. Inhibits the Fas and TNFR-mediated death signals by blocking MAP3K5. Interacts with p53 and decreases the half-life of the latter, protecting the infected cell against p53-mediated apoptosis. Inhibits the apoptotic signals regulated by the Bcl-2 family proteins through the formation of a Nef/PI3-kinase/PAK2 complex that induces phosphorylation of Bad|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/06/22	2016/02/11	rogid:MSRHpweWrcm/+g4FYwkdcySK+aU11679	rogid:D0i+5PXwzbBmOSyeCOSFKZx8fQk9606	intact-crc:8E7312E3966EC486|rigid:/PsLieMReoUYVt+W44BeWqLPq2Y	false	binding-associated region:154-169(MINT-1540635)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)