#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P62262	uniprotkb:Q61083	intact:EBI-7462230|intact:MINT-87834|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSOARP00020014847	intact:EBI-446134	psi-mi:1433e_sheep(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:m3k2_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 2(gene name synonym)|uniprotkb:Map3k2(gene name)|psi-mi:Map3k2(display_short)|uniprotkb:Mekk2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676323|mint:MINT-15983	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSOARG00020011717(gene)|ensembl:ENSOART00020017982(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042470"(melanosome)|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:MINT-1531372(identity)	interpro:IPR011009(Protein kinase-like)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034879|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|mint:MINT-1531375(identity)	-	function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2001/02/22	2014/10/16	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9940	rogid:5JLKwLioBelbHpow1mtYSJfUcsY10090	intact-crc:4E6512C0D65D0251|rigid:6L95JepsrXZ8RX3ZLN3Toir18oo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62262	uniprotkb:Q61084	intact:EBI-7462230|intact:MINT-87834|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSOARP00020014847	intact:EBI-446250|ensembl:ENSMUSP00000002044	psi-mi:1433e_sheep(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676343|mint:MINT-14718	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSOARG00020011717(gene)|ensembl:ENSOART00020017982(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042470"(melanosome)|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:MINT-1531561(identity)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702|mint:MINT-1531555(identity)	-	function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2001/02/22	2014/10/16	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9940	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	intact-crc:5F0F10B506E9BF24|rigid:/jIZTRWRJmFu6jB+NyF5pAKlKvs	false	-	binding-associated region:4-361(MINT-1531556)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62262	uniprotkb:P53349	intact:EBI-7462230|intact:MINT-87834|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSOARP00020014847	intact:EBI-447913|uniprotkb:Q60831|uniprotkb:Q9R0U3|uniprotkb:Q9R256	psi-mi:1433e_sheep(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:m3k1_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676333|mint:MINT-15729	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSOARG00020011717(gene)|ensembl:ENSOART00020017982(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042470"(melanosome)|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:MINT-1531547(identity)	go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|dip:DIP-32487N|mint:P53349|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-166058|reactome:R-MMU-2871796|reactome:R-MMU-975138|reactome:R-MMU-975871|interpro:IPR000719(Protein kinase, core)|mint:MINT-1531550(identity)	-	function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2001/02/22	2014/10/16	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9940	rogid:DR/c3qeWhJ76oKsNMEVhcUPmpXE10090	intact-crc:9D26773BC4CBA79A|rigid:HSDTwyoHJagRWKZas2OUHAmCz24	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62262	uniprotkb:Q99759	intact:EBI-7462230|intact:MINT-87834|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSOARP00020014847	intact:EBI-307281|uniprotkb:Q5BKZ6|intact:EBI-1384243|uniprotkb:B2RCW2|uniprotkb:Q8N3I9|uniprotkb:D3DU15|ensembl:ENSP00000354485	psi-mi:1433e_sheep(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:m3k3_human(display_long)|uniprotkb:MAP3K3(gene name)|psi-mi:MAP3K3(display_short)|uniprotkb:MAPKKK3(gene name synonym)|uniprotkb:MEKK3(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676407|mint:MINT-18266	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSOARG00020011717(gene)|ensembl:ENSOART00020017982(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042470"(melanosome)|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:MINT-1531382(identity)	refseq:NP_002392.2|refseq:NP_976226.1|dip:DIP-27521N|ensembl:ENSG00000198909(gene)|ensembl:ENST00000361733(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q99759|rcsb pdb:2C60|rcsb pdb:2JRH|rcsb pdb:2O2V|rcsb pdb:2PPH|rcsb pdb:4Y5O|rcsb pdb:4YL6|reactome:R-HSA-9020702|mint:MINT-1531388(identity)	-	function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/02/22	2014/10/16	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9940	rogid:zU7/ETPtqBEvBgGHcncZviu4Ssw9606	intact-crc:71271DB859CE8AE1|rigid:hU3f0veInhZJhn76cL2euRlJyVs	false	tag:?-?(MINT-1531383)	tag:?-?(MINT-1531389)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63102	uniprotkb:Q61084	intact:EBI-354758|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q52KK1|uniprotkb:Q6IRF4|ensembl:ENSRNOP00000030885	intact:EBI-446250|ensembl:ENSMUSP00000002044	psi-mi:1433z_rat(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Msfs1(gene name synonym)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Mitochondrial import stimulation factor S1 subunit(gene name synonym)	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676367|mint:MINT-14467	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3980|refseq:NP_037143.2|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63102|reactome:R-RNO-111447|reactome:R-RNO-3769402|reactome:R-RNO-392517|reactome:R-RNO-430116|reactome:R-RNO-450604|reactome:R-RNO-512988|reactome:R-RNO-5625740|reactome:R-RNO-5628897|reactome:R-RNO-75035|reactome:R-RNO-9013700|reactome:R-RNO-9614399|refseq:XP_006241591.1|ensembl:ENSRNOG00000008195(gene)|ensembl:ENSRNOT00000035628(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|dip:DIP-36916N|mint:MINT-1531419(identity)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702|mint:MINT-1531410(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/02/22	2014/10/16	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10116	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	intact-crc:0884577E235786EB|rigid:oDKTd4+cMPHEp/8fs99Q3HAVfhw	false	tag:?-?(MINT-1531420)	tag:?-?(MINT-1531414)|binding-associated region:4-361(MINT-1531411)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P62262	uniprotkb:Q61084	intact:EBI-7462230|intact:MINT-87834|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSOARP00020014847	intact:EBI-446250|ensembl:ENSMUSP00000002044	psi-mi:1433e_sheep(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676387|mint:MINT-14717	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSOARG00020011717(gene)|ensembl:ENSOART00020017982(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042470"(melanosome)|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:MINT-1531495(identity)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702|mint:MINT-1531486(identity)	-	function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/02/22	2014/10/16	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9940	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	intact-crc:32C762806E6747F0|rigid:/jIZTRWRJmFu6jB+NyF5pAKlKvs	false	tag:?-?(MINT-1531496)	tag:?-?(MINT-1531490)|binding-associated region:4-361(MINT-1531487)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P62262	uniprotkb:Q99759	intact:EBI-7462230|intact:MINT-87834|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSOARP00020014847	intact:EBI-307281|uniprotkb:Q5BKZ6|intact:EBI-1384243|uniprotkb:B2RCW2|uniprotkb:Q8N3I9|uniprotkb:D3DU15|ensembl:ENSP00000354485	psi-mi:1433e_sheep(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:m3k3_human(display_long)|uniprotkb:MAP3K3(gene name)|psi-mi:MAP3K3(display_short)|uniprotkb:MAPKKK3(gene name synonym)|uniprotkb:MEKK3(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676423|mint:MINT-16007	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSOARG00020011717(gene)|ensembl:ENSOART00020017982(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042470"(melanosome)|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:MINT-1531457(identity)	refseq:NP_002392.2|refseq:NP_976226.1|dip:DIP-27521N|ensembl:ENSG00000198909(gene)|ensembl:ENST00000361733(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q99759|rcsb pdb:2C60|rcsb pdb:2JRH|rcsb pdb:2O2V|rcsb pdb:2PPH|rcsb pdb:4Y5O|rcsb pdb:4YL6|reactome:R-HSA-9020702|mint:MINT-1531463(identity)	-	function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/02/22	2014/10/16	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9940	rogid:zU7/ETPtqBEvBgGHcncZviu4Ssw9606	intact-crc:0CDBB5697C57C0AC|rigid:hU3f0veInhZJhn76cL2euRlJyVs	false	tag:?-?(MINT-1531458)	tag:?-?(MINT-1531467)|binding-associated region:4-361(MINT-1531464)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13233	uniprotkb:P62258	intact:EBI-49776|ensembl:ENSP00000382423	intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676473|mint:MINT-16491	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871|mint:MINT-1531449(identity)	refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|mint:MINT-1531446(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/02/22	2014/10/16	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606	intact-crc:56B467DFABCCF927|rigid:XL+Yl5wmq5DFlXCzcmofmOLXauA	false	binding-associated region:1-393(MINT-1531450)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2U5	uniprotkb:P62258	intact:EBI-357393|ensembl:ENSP00000343463|ensembl:ENSP00000387246|ensembl:ENSP00000507315|uniprotkb:Q53QL9|uniprotkb:Q53S75|uniprotkb:Q59GZ6|uniprotkb:Q8NC32|uniprotkb:Q9NYK3|uniprotkb:B9EG87	intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356	psi-mi:m3k2_human(display_long)|uniprotkb:MAP3K2(gene name)|psi-mi:MAP3K2(display_short)|uniprotkb:MAPKKK2(gene name synonym)|uniprotkb:MEKK2(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase 2(gene name synonym)	psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676453|mint:MINT-14034	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169967(gene)|ensembl:ENST00000344908(transcript)|ensembl:ENST00000409947(transcript)|ensembl:ENST00000682094(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034879|mint:Q9Y2U5|rcsb pdb:2CU1|rcsb pdb:2NPT|rcsb pdb:5EX0|rcsb pdb:5HQ8|rcsb pdb:6LDV|rcsb pdb:6LDW|rcsb pdb:6LDX|rcsb pdb:6LDY|refseq:NP_006600.3|dip:DIP-39756N|mint:MINT-1531432(identity)	refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|mint:MINT-1531429(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/02/22	2014/10/16	rogid:wMiWIM12kFj36pj5WsyECABms3A9606	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606	intact-crc:CB85E888272F78EE|rigid:JEtFtkw2FlfRty2gBwCnbAKzsXE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62262	uniprotkb:Q99759	intact:EBI-7462230|intact:MINT-87834|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSOARP00020014847	intact:EBI-307281|uniprotkb:Q5BKZ6|intact:EBI-1384243|uniprotkb:B2RCW2|uniprotkb:Q8N3I9|uniprotkb:D3DU15|ensembl:ENSP00000354485	psi-mi:1433e_sheep(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:m3k3_human(display_long)|uniprotkb:MAP3K3(gene name)|psi-mi:MAP3K3(display_short)|uniprotkb:MAPKKK3(gene name synonym)|uniprotkb:MEKK3(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676463|mint:MINT-18265	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSOARG00020011717(gene)|ensembl:ENSOART00020017982(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042470"(melanosome)|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:MINT-1531437(identity)	refseq:NP_002392.2|refseq:NP_976226.1|dip:DIP-27521N|ensembl:ENSG00000198909(gene)|ensembl:ENST00000361733(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q99759|rcsb pdb:2C60|rcsb pdb:2JRH|rcsb pdb:2O2V|rcsb pdb:2PPH|rcsb pdb:4Y5O|rcsb pdb:4YL6|reactome:R-HSA-9020702|mint:MINT-1531440(identity)	-	function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/02/22	2014/10/16	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9940	rogid:zU7/ETPtqBEvBgGHcncZviu4Ssw9606	intact-crc:C7F91D98284D99DB|rigid:hU3f0veInhZJhn76cL2euRlJyVs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62262	uniprotkb:Q99759	intact:EBI-7462230|intact:MINT-87834|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSOARP00020014847	intact:EBI-307281|uniprotkb:Q5BKZ6|intact:EBI-1384243|uniprotkb:B2RCW2|uniprotkb:Q8N3I9|uniprotkb:D3DU15|ensembl:ENSP00000354485	psi-mi:1433e_sheep(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:m3k3_human(display_long)|uniprotkb:MAP3K3(gene name)|psi-mi:MAP3K3(display_short)|uniprotkb:MAPKKK3(gene name synonym)|uniprotkb:MEKK3(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676487|mint:MINT-16006	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSOARG00020011717(gene)|ensembl:ENSOART00020017982(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042470"(melanosome)|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:MINT-1531474(identity)	refseq:NP_002392.2|refseq:NP_976226.1|dip:DIP-27521N|ensembl:ENSG00000198909(gene)|ensembl:ENST00000361733(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q99759|rcsb pdb:2C60|rcsb pdb:2JRH|rcsb pdb:2O2V|rcsb pdb:2PPH|rcsb pdb:4Y5O|rcsb pdb:4YL6|reactome:R-HSA-9020702|mint:MINT-1531477(identity)	-	function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/02/22	2014/10/16	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9940	rogid:zU7/ETPtqBEvBgGHcncZviu4Ssw9606	intact-crc:6C52063E3A674C7F|rigid:hU3f0veInhZJhn76cL2euRlJyVs	false	-	binding-associated region:4-361(MINT-1531478)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y2U5	uniprotkb:P62258	intact:EBI-357393|ensembl:ENSP00000343463|ensembl:ENSP00000387246|ensembl:ENSP00000507315|uniprotkb:Q53QL9|uniprotkb:Q53S75|uniprotkb:Q59GZ6|uniprotkb:Q8NC32|uniprotkb:Q9NYK3|uniprotkb:B9EG87	intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356	psi-mi:m3k2_human(display_long)|uniprotkb:MAP3K2(gene name)|psi-mi:MAP3K2(display_short)|uniprotkb:MAPKKK2(gene name synonym)|uniprotkb:MEKK2(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase 2(gene name synonym)	psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)	psi-mi:"MI:0428"(imaging technique)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676539|mint:MINT-14035	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169967(gene)|ensembl:ENST00000344908(transcript)|ensembl:ENST00000409947(transcript)|ensembl:ENST00000682094(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034879|mint:Q9Y2U5|rcsb pdb:2CU1|rcsb pdb:2NPT|rcsb pdb:5EX0|rcsb pdb:5HQ8|rcsb pdb:6LDV|rcsb pdb:6LDW|rcsb pdb:6LDX|rcsb pdb:6LDY|refseq:NP_006600.3|dip:DIP-39756N|mint:MINT-1531586(identity)	refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|mint:MINT-1531581(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/02/22	2014/10/16	rogid:wMiWIM12kFj36pj5WsyECABms3A9606	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606	intact-crc:BC59E9FB023E0E50|rigid:JEtFtkw2FlfRty2gBwCnbAKzsXE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62258	uniprotkb:Q13233	intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356	intact:EBI-49776|ensembl:ENSP00000382423	psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)	psi-mi:m3k1_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:MAP3K1(gene name)|psi-mi:MAP3K1(display_short)|uniprotkb:MAPKKK1(gene name synonym)|uniprotkb:MEKK(gene name synonym)|uniprotkb:MEKK1(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676511|mint:MINT-16492	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447|mint:MINT-1531505(identity)	refseq:NP_005912.1|ensembl:ENSP00000382423|dip:DIP-27520N|ensembl:ENSG00000095015(gene)|ensembl:ENST00000399503(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13233|rcsb pdb:6WHB|reactome:R-HSA-166058|reactome:R-HSA-2871796|reactome:R-HSA-933542|reactome:R-HSA-975138|reactome:R-HSA-975871|mint:MINT-1531510(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/02/22	2014/10/16	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606	rogid:kxdotY9M7Rd4Xr4IIlf7NVv7AC89606	intact-crc:280122C36B36982F|rigid:XL+Yl5wmq5DFlXCzcmofmOLXauA	false	-	binding-associated region:1-393(MINT-1531511)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62262	uniprotkb:Q99759	intact:EBI-7462230|intact:MINT-87834|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSOARP00020014847	intact:EBI-307281|uniprotkb:Q5BKZ6|intact:EBI-1384243|uniprotkb:B2RCW2|uniprotkb:Q8N3I9|uniprotkb:D3DU15|ensembl:ENSP00000354485	psi-mi:1433e_sheep(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)	psi-mi:m3k3_human(display_long)|uniprotkb:MAP3K3(gene name)|psi-mi:MAP3K3(display_short)|uniprotkb:MAPKKK3(gene name synonym)|uniprotkb:MEKK3(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:9940(sheep)|taxid:9940("Ovis aries (Sheep)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676525|mint:MINT-16008	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSOARG00020011717(gene)|ensembl:ENSOART00020017982(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042470"(melanosome)|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:MINT-1531566(identity)	refseq:NP_002392.2|refseq:NP_976226.1|dip:DIP-27521N|ensembl:ENSG00000198909(gene)|ensembl:ENST00000361733(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q99759|rcsb pdb:2C60|rcsb pdb:2JRH|rcsb pdb:2O2V|rcsb pdb:2PPH|rcsb pdb:4Y5O|rcsb pdb:4YL6|reactome:R-HSA-9020702|mint:MINT-1531571(identity)	-	function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner|comment:mint|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:mint|partial coverage:partial coverage|curation depth:rapid curation	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/02/22	2014/10/16	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9940	rogid:zU7/ETPtqBEvBgGHcncZviu4Ssw9606	intact-crc:8BC12ABCFFE34B82|rigid:hU3f0veInhZJhn76cL2euRlJyVs	false	-	binding-associated region:4-361(MINT-1531572)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99759	uniprotkb:P62259	intact:EBI-307281|uniprotkb:Q5BKZ6|intact:EBI-1384243|uniprotkb:B2RCW2|uniprotkb:Q8N3I9|uniprotkb:D3DU15|ensembl:ENSP00000354485	intact:EBI-356480|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q63631|ensembl:ENSMUSP00000070993	psi-mi:m3k3_human(display_long)|uniprotkb:MAP3K3(gene name)|psi-mi:MAP3K3(display_short)|uniprotkb:MAPKKK3(gene name synonym)|uniprotkb:MEKK3(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)	psi-mi:1433e_mouse(display_long)|uniprotkb:Ywhae(gene name)|psi-mi:Ywhae(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Fanger et al. (1998)	mint:MINT-5221876|pubmed:9452471	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8676558|mint:MINT-8005240	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002392.2|refseq:NP_976226.1|dip:DIP-27521N|ensembl:ENSG00000198909(gene)|ensembl:ENST00000361733(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q99759|rcsb pdb:2C60|rcsb pdb:2JRH|rcsb pdb:2O2V|rcsb pdb:2PPH|rcsb pdb:4Y5O|rcsb pdb:4YL6|reactome:R-HSA-9020702|mint:MINT-8005244(identity)|uniprotkb:Q99759(original identifier)	ensembl:ENSMUSG00000020849(gene)|ensembl:ENSMUST00000067664(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001764"(neuron migration)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0006605"(protein targeting)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|refseq:NP_033562.3|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62259|reactome:R-MMU-111447|reactome:R-MMU-2028269|reactome:R-MMU-205025|reactome:R-MMU-2565942|reactome:R-MMU-3371453|reactome:R-MMU-3371511|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-8854518|reactome:R-MMU-8876198|mint:MINT-8005241(identity)|uniprotkb:P62259(original identifier)	-	-	-	comment:homomint|comment:domino|comment:mint|figure legend:2|partial coverage:partial coverage|curation depth:rapid curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2001/02/22	2014/10/16	rogid:zU7/ETPtqBEvBgGHcncZviu4Ssw9606	rogid:mnuAjdnQZbMFojll2PnV3xFklXQ10090	intact-crc:AAD6B49F2A4FDE44|rigid:XWFCV8PqCD3lhzo6oJ0veJbFxZM	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)