#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O57468	uniprotkb:P30310	intact:EBI-6993118|intact:MINT-92096	intact:EBI-6993099|intact:MINT-92088	psi-mi:o57468_xenla(display_long)|uniprotkb:ywhae.S(gene name)|psi-mi:ywhae.S(display_short)|uniprotkb:ywhae(gene name synonym)|uniprotkb:XELAEV_18014582mg(orf name)	psi-mi:mpip2_xenla(display_long)|uniprotkb:cdc25-2(gene name)|psi-mi:cdc25-2(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Kumagai et al. (1998)	mint:MINT-5221873|pubmed:9450960	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8675969|mint:MINT-17199	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|refseq:NP_001080705.1|interpro:IPR023410|interpro:IPR036815|mint:MINT-1531332(identity)	go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:1902751"(positive regulation of cell cycle G2/M phase transition)|interpro:IPR000751(M-phase inducer phosphatase)|interpro:IPR001763(Rhodanese-like)|refseq:NP_001165649.1|interpro:IPR036873|mint:MINT-1531327(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	function:"This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity"|comment:mint|comment:"Stoichiometry: 1.0"	comment:14-3-3 epsilon of Xenopus binds to Cdc25 phosphorylated by Chk1 or Chk2 in Serine during interphase. When bound to 14-3-3, the cdc25 is retained in the cytoplasm and, thus, cannot activate the Cdc2 mitoyic kinase.|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/06/22	2014/10/16	rogid:aheyncyigwZXhSFEKIVYAWFMk6E8355	rogid:cAjljE+NKs0KqELCHExvrzxB1Gg8355	intact-crc:4375435A00D5982C|rigid:0m/2R1m9TF8qy+aeUiesQPYUj40	false	binding-associated region:1-255(MINT-1531333)	O-phospho-L-serine:287-287(MINT-1531328)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O57468	uniprotkb:P30310	intact:EBI-6993118|intact:MINT-92096	intact:EBI-6993099|intact:MINT-92088	psi-mi:o57468_xenla(display_long)|uniprotkb:ywhae.S(gene name)|psi-mi:ywhae.S(display_short)|uniprotkb:ywhae(gene name synonym)|uniprotkb:XELAEV_18014582mg(orf name)	psi-mi:mpip2_xenla(display_long)|uniprotkb:cdc25-2(gene name)|psi-mi:cdc25-2(display_short)	psi-mi:"MI:0096"(pull down)	Kumagai et al. (1998)	mint:MINT-5221873|pubmed:9450960	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8675994|mint:MINT-17198	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|refseq:NP_001080705.1|interpro:IPR023410|interpro:IPR036815|mint:MINT-1531348(identity)	go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0007049"(cell cycle)|go:"GO:0051301"(cell division)|go:"GO:1902751"(positive regulation of cell cycle G2/M phase transition)|interpro:IPR000751(M-phase inducer phosphatase)|interpro:IPR001763(Rhodanese-like)|refseq:NP_001165649.1|interpro:IPR036873|mint:MINT-1531343(identity)	-	comment:mint|comment:"Stoichiometry: 1.0"	function:"This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity"|comment:mint|comment:"Stoichiometry: 1.0"	comment:14-3-3 epsilon of Xenopus binds to Cdc25 phosphorylated by Chk1 or Chk2 in Serine during interphase. When bound to 14-3-3, the cdc25 is retained in the cytoplasm and, thus, cannot activate the Cdc2 mitoyic kinase.|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2001/06/22	2014/10/16	rogid:aheyncyigwZXhSFEKIVYAWFMk6E8355	rogid:cAjljE+NKs0KqELCHExvrzxB1Gg8355	intact-crc:2697B74F8A39E1C9|rigid:0m/2R1m9TF8qy+aeUiesQPYUj40	false	binding-associated region:1-255(MINT-1531349)	O-phospho-L-serine:287-287(MINT-1531344)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)